DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and ntn4

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	XP_009301345.1	Gene:	ntn4 / 561440	ZFINID:	ZDB-GENE-050310-1	Length:	639	Species:	Danio rerio

Alignment Length:	566	Identity:	155/566 - (27%)
Similarity:	222/566 - (39%)	Gaps:	131/566 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AISYCQAELTPPYF-NLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYC 79
            |.|.|...:..|.. |||.||.|...:.||  :..||.:|..        ..|..|:.   |:.|
Zfish    70 ACSGCVNRVCNPRMGNLAVGRPIQTVSQCG--STSPEQFCMY--------RPDSCVLD---CEIC 121

  Fly    80 DPTVPERNHPPENAIDG----TEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRP 140
            |.:|.:..|.|.:..|.    ...||||.|   |....  .|.::.|.||:..:|.| :..||||
Zfish   122 DASVSQHAHSPSSMTDSPFKQPLTWWQSAP---GTAIE--TLQLDLEVEFYFTHLII-IFMSPRP 180

  Fly   141 GLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPV 205
            ....:::|.|:|:||:....||...::..:.           :|...||.:||...|..|||:..
Zfish   181 AAMAIDRSRDFGQTWSLLMLFSHNCSEVSSL-----------EDGQRCTAKYSSAEPCTNGEVIY 234

  Fly   206 MLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIG 270
            ..|:.......|  ||..:.....||||||||:..:....:.......|.      |:|.|:.:.
Zfish   235 RALSPYERLDPY--STDARSLLGVTNVRIRLLQPHSCPCPIADANAATPR------YAISDLILK 291

  Fly   271 GRCMCNGHADTCDVKDPKSPVRILA-------CRCQHHTCGIQCNECCPGFEQKKWR--QNTNAR 326
            |.|:|:||||.|.....|...:...       |.|:|||.|..|..|...:..:.||  ......
Zfish   292 GGCLCHGHADQCVPTGGKHNSKTFGKHVVHGKCLCRHHTAGDHCERCHRLYNDRPWRAADGLTGE 356

  Fly   327 PFNCEPCNCHGHSNECKYDEEV-NRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPK 390
            ...|..|.|:||:..|.:||.| .|.|        ...|||| :|.|||.|.:|..|:..:||..
Zfish   357 ANQCVECKCNGHAESCHFDESVWLRSG--------QQHGGVC-DCLHNTTGQHCQHCQSGFYRDP 412

  Fly   391 GKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGT 455
            .|.....|.|:||.|::..|:
Zfish   413 EKPSTAPDSCTPCMCNHVGSS-------------------------------------------- 433

  Fly   456 NGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPE--CKACECNKIGSITNDCNVTTGECKCLT 518
               :|:.::| :|.||...||.:|:||..||:|..|  ||.|:|      ..||:..||:| .:.
Zfish   434 ---YCKPDNG-ECVCKPGVAGRHCEQCMLGYWGLDEYGCKPCQC------AGDCDPYTGDC-MIR 487

  Fly   519 NFGGDNCERCKHGY--------FNYPTCSYCDCDNQ--GTESEICN 554
            :...||.....|.:        .::|  ..|.|..|  |.....||
Zfish   488 SESDDNSTAENHLFRTEELFSALSHP--DKCICKQQALGNSKVFCN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	71/257 (28%)
		EGF_Lam	272..>314	CDD:238012	16/48 (33%)
		EGF_Lam	332..389	CDD:238012	22/57 (39%)
		EGF_Lam	402..443	CDD:238012	4/40 (10%)
		EGF_Lam	448..491	CDD:238012	13/42 (31%)
		Laminin_EGF	495..543	CDD:278482	12/55 (22%)
		Laminin_EGF	541..589	CDD:278482	6/16 (38%)
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntn4	XP_009301345.1	Laminin_N	89..292	CDD:278484	65/240 (27%)
		EGF_Lam	294..351	CDD:238012	18/56 (32%)
		Laminin_EGF	363..422	CDD:278482	25/67 (37%)
		EGF_Lam	425..468	CDD:214543	17/90 (19%)
		NTR_netrin-4_like	526..637	CDD:239633	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910