DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and lamc3

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:XP_687343.5 Gene:lamc3 / 558958 ZFINID:ZDB-GENE-060531-121 Length:1643 Species:Danio rerio


Alignment Length:2831 Identity:523/2831 - (18%)
Similarity:817/2831 - (28%) Gaps:1376/2831 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LLVILAISY--------CQAE------LTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANT 61
            ||::.|..|        |..|      ..|.:.|.|....:..:..||..   ||.||...|:. 
Zfish    10 LLLLFASVYFVFAGMDSCYDENGVPSLCLPKFENAAFNHSVMVSNMCGIP---PEDYCMQTGST- 70

  Fly    62 EHDHIDYSVIQGQVCDYCDPTVPERNHPPENA-------IDGTEAWWQSPPLSRGMKF-NEVNLT 118
                        :.|.:||....|.|   .||       .|....||||..:..|::: |.||:|
Zfish    71 ------------RSCHHCDAFDSELN---RNATYLTDFHTDEEPTWWQSQSMFYGVQYPNSVNIT 120

  Fly   119 INFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDT---YKPI 180
            ::..:.|.:.|:.::...| ||..:.:.|.||....|.|:|::|   |.|...:|:|.   .:|.
Zfish   121 LHLGKAFEITYVRLKFYTS-RPESFAIYKRTDENGPWQPYQYYS---ASCRKTYGRDNKGFIRPG 181

  Fly   181 TRDDDVICTTEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGH 245
            ..:...:||.|:|.|.||..|.:....|..|||:.|:..|.|||:|..||::.|.|.|. |..|.
Zfish   182 DNERTPLCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDQSLVLQDWVTATDILISLDRL-NTFGD 245

  Fly   246 LMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNEC 310
            ...   :|..|.|.|||:|.|.|:||||.|||||..|.|.:....|    |.|:|:|.|:.|..|
Zfish   246 EFF---KDAKVLRSYFYAISDFSVGGRCKCNGHASECVVNEEGRSV----CVCEHNTAGVDCQLC 303

  Fly   311 CPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTV 375
            .|.::.:.|.:.|......|..|||.|.::||.:|.|..|.         ...||.|..|:.||.
Zfish   304 APFYQDRPWARATAHSANECVRCNCSGLADECVFDVEQYRS---------TGQGGRCLGCRENTA 359

  Fly   376 GINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYY 440
            |.:|.:|:..|:|                                   .:|.||           
Zfish   360 GPHCEQCRENYFR-----------------------------------SSALQP----------- 378

  Fly   441 GYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITN 505
                                                               |:.|.||.:||:: 
Zfish   379 ---------------------------------------------------CQNCNCNALGSVS- 391

  Fly   506 DCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPR 570
                                                                             
Zfish   392 ----------------------------------------------------------------- 391

  Fly   571 CDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCD 635
                                                                             
Zfish   392 ----------------------------------------------------------------- 391

  Fly   636 SHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELC 700
                  :.|::||.|:|.|:..|.:||.||.||::.                  |.|        
Zfish   392 ------LQCDADGVCVCWPSVSGVKCDICKSGFHSL------------------GPG-------- 424

  Fly   701 KCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQ 765
                                       ||.:|||...|::.   .|:::.|:|.||.:.:|:.|.
Zfish   425 ---------------------------GCRLCDCDERGSVG---VCSAEDGRCHCKANVEGQSCN 459

  Fly   766 ECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQF 830
            .|:.|:|:|...:..||..|.| .|.|                    |||               
Zfish   460 RCKPGSFNLQLENPDGCNKCFC-FGHS--------------------LAC--------------- 488

  Fly   831 QYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNA 895
                                      |||..|                                 
Zfish   489 --------------------------FSSNQY--------------------------------- 494

  Fly   896 ENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVM 960
                ..|.:|||                                  .:.||..:           
Zfish   495 ----TPIYITSD----------------------------------FLEDPDGW----------- 510

  Fly   961 LDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVET 1025
                                                    ..|||.|....:|.:..:       
Zfish   511 ----------------------------------------KGVFSRAHEQSLIWKEGE------- 528

  Fly  1026 YTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNF---PDSYYINLKLKD 1087
                                                  ::::.|..:..|   ||.|..|:.|. 
Zfish   529 --------------------------------------VYLLPYREENGFYKAPDKYLGNMLLS- 554

  Fly  1088 NPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVD 1152
                          |.   ||      :..||....|:|.|..::..:|...    :||:|    
Zfish   555 --------------YG---RT------LSMSFTAELEELLPRSVTVRLEGSG----MSVSA---- 588

  Fly  1153 QWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDS 1217
                         .:|.||                             .||:.|::         
Zfish   589 -------------DLHTQQ-----------------------------EPYSQLEK--------- 602

  Fly  1218 QNEATIVIESKVDATKPNLFVILV--KYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCR 1280
                          |..|.|.:.:  |:..||...:                             
Zfish   603 --------------TPINSFSLRLTEKHVNPSVSSF----------------------------- 624

  Fly  1281 GVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGHD 1345
                                                                    ||:      
Zfish   625 --------------------------------------------------------EFL------ 627

  Fly  1346 HFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRS 1410
                         :.:::|||.:.|.|                  |||                 
Zfish   628 -------------RMLYNLTALHISNA------------------GGQ----------------- 644

  Fly  1411 RYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIAN 1475
                                                                            |
Zfish   645 ----------------------------------------------------------------N 645

  Fly  1476 GNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVV 1540
            ..||..        |.::|                                              
Zfish   646 YTSQLS--------RVSLE---------------------------------------------- 656

  Fly  1541 GRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKFD 1605
                                               ||..:.|:..:|.|.               
Zfish   657 -----------------------------------SAVQKAYHPDVLPHA--------------- 671

  Fly  1606 MWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDG 1670
            :|                                                               
Zfish   672 LW--------------------------------------------------------------- 673

  Fly  1671 KYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVI 1735
                                                                             
Zfish   674 ----------------------------------------------------------------- 673

  Fly  1736 FIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRD--P 1798
                                                 ||.||||.|::|..|:.||||:.|:  .
Zfish   674 -------------------------------------VEVCSCPAGFAGQFCQLCAPGFTRETPD 701

  Fly  1799 SGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPL 1863
            .||:.. |:||.||.|. ||...||:|: |...|.|.|||||..||||||..|:||||:.|.|| 
Zfish   702 GGPFSP-CVPCNCNQHG-TCHPETGVCA-CTDFTTGRHCERCEDGYYGNALTGSPGDCLPCPCP- 762

  Fly  1864 PFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIG---QVCKPCECSGNINP 1925
                 :..|..::.|:||.|...|..|..|.|||.|.:||||.|...|   |.|..|:|:||::.
Zfish   763 -----DRTTCAQVPETGDVICTNCPTGQRGVRCELCEDGFYGNPLGWGGTVQPCVKCQCNGNVDA 822

  Fly  1926 EDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAI-----KLKNCQSCDCDDLGT----QTCD 1981
            ...|.||..||.||:||.:|.|..|..|..|:||:|:     ..:.|:.|.|:..||    ..|.
Zfish   823 NAVGVCDHMTGRCLKCLGHTTGDHCEKCRLGYYGNALANQLNPERKCKPCACNVAGTSGSPNDCH 887

  Fly  1982 PFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCG-AASNSTQCDPHTGHCACKSGVTGRQ 2045
            |..|.|.|..:|.|..|.:|:..::..:.|:||..|:|. ..|.|:.|.|.||.|.|::||.|..
Zfish   888 PNTGNCVCLGHVTGRDCGQCEAGYFNLQPGLGCEMCNCNPIGSLSSACHPITGQCMCRTGVEGMS 952

  Fly  2046 CDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIK-DEGC 2109
            ||.|.:..:.:...||..|||:...|....|: |.|.|.|..|.:|.:||.|...:...: ...|
Zfish   953 CDTCRMGFFGFSSRGCRACNCDPMGSTSMQCH-NNGTCSCRNGFVGYKCDKCEQNYYQNRLSHQC 1016

  Fly  2110 QECNNCHHALLDVTDRMRYQIDSVLE------DFNSVTLAFFTSQKLNYY----------DQLAD 2158
            :||..|:..:.|...:::.::.. ||      |.|..:..:...|:..:.          ||:.|
Zfish  1017 EECPVCYSIIRDQASKLKARLQE-LELLLSSYDCNRYSRQYRGHQQHRHQHNDLDNHIQKDQVED 1080

  Fly  2159 ELEPKVKLLDPNSV-DLSPSKKAN-------SELESDAK------------------SYAK---- 2193
            .|        ||:: ||...::|.       |:||:.|:                  ::||    
Zfish  1081 YL--------PNALEDLLAIQEAREAFIKQFSQLETSAQTLQLQLRNIATALNCNLTNFAKHPEE 1137

  Fly  2194 -----------QVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKE------AIASVEALS 2241
                       ::..||:.|.:::::    |..:||..:.....|...||      .:...|.|.
Zfish  1138 GKTQKVENECRELVDTLSTALNMQDQ----LQKMTVELNSMAIPAVIPKEPNKWNAIVNESEVLV 1198

  Fly  2242 KNLEAAASTKIDAALEQ-AQHILGQINGTSIEL--------TPNE-----QVLEKARKLYE---- 2288
            |     :.|.:.|.:|| |:.:....|.|.::|        |.:.     :.||:.::|.|    
Zfish  1199 K-----SHTDMAAHIEQVAEDVFKMANRTYLQLVTLLEDNSTESHIQDLTEKLEEMQQLKENLTL 1258

  Fly  2289 EVN-TLVLPIKAQ-------------NKSLNALKNDIGEFSDHLEDLFNWSEASQAKSADVERRN 2339
            ||| |||..:..|             ..||:.|:...|.|:..:|:. |.:..||.       .|
Zfish  1259 EVNETLVTHLSLQKHNAEIADILHNITASLSELRRTDGNFTLVVEET-NMTSFSQT-------FN 1315

  Fly  2340 VANQKAFDNSKFDTVSEQKLQAEKNIK---DAGNFLINGDLTLNQINQKLDNLRDAL---NELNS 2398
            ..|..|..|.:. |.||..:....|:.   .:...|:|  .|..:|...:|:.::.|   .||..
Zfish  1316 QTNVTAAQNPQL-TESEDLMNRTTNLDISVQSKEHLVN--KTREEIQPDMDSAKNNLKTVQELKQ 1377

  Fly  2399 FNKNVDEELPVREDQHKEADALTDQAEQKAAELAI-----KAQDLAAQYTDMTASAEPAIKAATA 2458
            ....| |.|.|        .|::.....|..|..|     ..||:...:..:...::..:|....
Zfish  1378 LTAAV-EGLKV--------SAVSSVVTGKEVEAEILSLQKSLQDMEQDWPQLPTLSKSFLKREKM 1433

  Fly  2459 YS--GIVEA---VEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDD 2518
            .:  .:||.   |:..:|:.:.::.   ||||.....::....|||.:.|    |:.|..:.:  
Zfish  1434 LNEKTLVEVKKRVKQTEKMIKPSVE---NATDADSTAKQAEASADTVAKD----AKASFTQGK-- 1489

  Fly  2519 LEPRLNASAGKVQKISAVNNATEHQLKDINK--LIDQLPAESQRDMWKNSNANASDALEILKNVL 2581
               |:..::|:::  ||: :.|..||.::..  .:.|...|::.||  .|:::..|::|..||.|
Zfish  1490 ---RIKHASGQLR--SAL-DVTLEQLSELESQTALKQATLEAEEDM--VSSSSVIDSMETAKNQL 1546

  Fly  2582 EILEPVSVQTPKELEKAHGINRDLDLTNKD-----------VSQANKQLDDVEGSVSKLSELAED 2635
            |....:......::|      .|:.|.|.|           |.|...:...:.|.:.:|...|.|
Zfish  1547 ESFTDMLTLLLSQME------ADVVLENYDRILNETAVRLRVLQGAVESPSLTGKIQRLRNAASD 1605

  Fly  2636 IEEQQHRVGSQSRQLGQEIENLKAQVEAARQLANSI 2671
            .|:|.       :.|.:.:::::.:.::...:|.::
Zfish  1606 QEKQM-------QNLEESLQDIRKERDSLTDIAQNL 1634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 81/277 (29%)
EGF_Lam 272..>314 CDD:238012 18/41 (44%)
EGF_Lam 332..389 CDD:238012 19/56 (34%)
EGF_Lam 402..443 CDD:238012 3/40 (8%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 5/47 (11%)
Laminin_EGF 541..589 CDD:278482 0/47 (0%)
Laminin_EGF 587..634 CDD:278482 0/46 (0%)
EGF_Lam 631..673 CDD:238012 13/41 (32%)
Laminin_EGF 677..729 CDD:278482 2/51 (4%)
Laminin_EGF 732..782 CDD:278482 15/49 (31%)
EGF_Lam 785..828 CDD:238012 7/42 (17%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 10/134 (7%)
Laminin_EGF 1375..1423 CDD:278482 3/47 (6%)
EGF_Lam 1420..1457 CDD:238012 0/36 (0%)
Laminin_EGF 1466..1516 CDD:278482 5/49 (10%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 0/127 (0%)
Laminin_EGF <1775..1801 CDD:278482 12/27 (44%)
EGF_Lam 1808..1851 CDD:238012 24/42 (57%)
EGF_Lam 1859..1907 CDD:214543 19/47 (40%)
EGF_Lam 1916..1968 CDD:238012 21/56 (38%)
EGF_Lam 1969..2015 CDD:238012 15/49 (31%)
EGF_Lam 2016..>2054 CDD:238012 16/38 (42%)
EGF_Lam 2063..>2097 CDD:238012 13/33 (39%)
Laminin_I 2129..2385 CDD:283627 73/353 (21%)
Tar 2278..2662 CDD:223910 93/430 (22%)
Laminin_II 2566..2700 CDD:283628 22/117 (19%)
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamc3XP_687343.5 Laminin_N 46..268 CDD:278484 75/248 (30%)
EGF_Lam 269..314 CDD:238012 19/48 (40%)
Laminin_EGF 326..382 CDD:278482 24/161 (15%)
EGF_Lam 382..426 CDD:214543 20/233 (9%)
Laminin_EGF 429..476 CDD:278482 15/49 (31%)
Laminin_B 540..659 CDD:278481 46/507 (9%)
EGF_Lam 710..751 CDD:238012 24/42 (57%)
Laminin_EGF 814..861 CDD:278482 21/46 (46%)
EGF_Lam 871..921 CDD:238012 15/49 (31%)
Laminin_EGF 923..971 CDD:278482 18/47 (38%)
EGF_Lam 970..1010 CDD:238012 14/40 (35%)
ApoLp-III_like 1233..1386 CDD:304399 39/164 (24%)
PspA 1388..1607 CDD:224755 50/241 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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