DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and lamb1b

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_001264059.1 Gene:lamb1b / 556605 ZFINID:ZDB-GENE-041210-197 Length:1767 Species:Danio rerio


Alignment Length:2860 Identity:580/2860 - (20%)
Similarity:893/2860 - (31%) Gaps:1257/2860 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 ALLVILAI----------SYC-QAELTPPYFNLATGR--KIYATATCGQDTDGPELYCKLVGANT 61
            ||::.:|:          ..| :....|...:|..||  ::.|::|||  .:.||.:|.:     
Zfish     8 ALVISIALHTLAQLPDHNDMCAEGSCYPATGDLLIGRAHRLTASSTCG--LNSPEEFCMV----- 65

  Fly    62 EHDHIDYSVIQGQVCDYCDP--TVPERNHPPENAIDGT---------EAWWQSPPLSRGMKFNEV 115
                   ::::..||..||.  ...|..||..:.|:..         :.||||   ..|::  .|
Zfish    66 -------NILEDTVCFECDSRRLYNEFTHPDSHTIENVVTTFAPNRLKTWWQS---ENGVE--NV 118

  Fly   116 NLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPI 180
            .:.::.|.|||..:|.:.. .:.||....:|:|.|||:||..:::::   .:|:..:......||
Zfish   119 TIQLDLEAEFHFTHLIMTF-RTFRPAAMLIERSADYGRTWQVYRYYA---FNCDESYPHVPKGPI 179

  Fly   181 TRDDDVICTTEYSKIVPLENGEIPVMLLNER-----PSSTNYFNSTVLQEWTRATNVRIRLLRTK 240
            .:.|||||.:.||.:.|...||:...:|:..     |.|.:      :|...:.||:||.:.:. 
Zfish   180 KKVDDVICDSRYSGMEPSTEGEVIFRVLDPAFKIPDPYSPH------IQNLLKITNLRIAMEKL- 237

  Fly   241 NLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILA---CRCQHHT 302
            :.||.|.:..::   ..::|||::.|:.|.|.|.|.|||..|.....::.|..:.   |.|.|||
Zfish   238 HKLGDLSNYRKE---ARKKYFYAVYDMVIRGNCFCYGHASKCAPIGNEAGVEGMVHGHCMCNHHT 299

  Fly   303 CGIQCNECCPGFEQKKWR----QNTNARPFNCEPCNCHGHSNECKYDEEV-----NRKGLSLDIH 358
            .|:.|.||...::.:.||    :.|||    |:.|.|:.||:.|.:|..|     ||        
Zfish   300 TGLNCEECEDFYQDQPWRPAVGRETNA----CKKCECNRHSDSCHFDMAVYLSSGNR-------- 352

  Fly   359 GHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCEC 423
                .||||.:|:|||.|..|..|||.||:...:...:..:|.||.||                .
Zfish   353 ----SGGVCDDCEHNTQGQWCENCKPFYYKHPQRDIRDPRICEPCDCD----------------P 397

  Fly   424 RAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYG 488
            |.:.....|||                   .||... :..:| ||.||.|..|..|..|.:|:||
Zfish   398 RGSLYEGLCDS-------------------ATNVMR-DMIAG-QCHCKANVEGQRCDHCKKGHYG 441

  Fly   489 FPE----CKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTE 549
            ..:    |::|.||.:|::.                                             
Zfish   442 LSDDPLGCRSCSCNPLGTLP--------------------------------------------- 461

  Fly   550 SEICNKQSGQCICREGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGK 614
                             ||..||                 ..|||                    
Zfish   462 -----------------GGTPCD-----------------IQTGS-------------------- 472

  Fly   615 QCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNC 679
                                                                             
Zfish   473 ----------------------------------------------------------------- 472

  Fly   680 DPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALD 744
                                |.||..||||.|::|.|.:|.|: ::.:||..|||...|.::  :
Zfish   473 --------------------CYCKRLVTGRNCDQCLPQHWGLS-NDMDGCRPCDCDVGGALN--N 514

  Fly   745 TCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPR 809
            .|:.::|||.||.|..||||.:.:.|                                       
Zfish   515 NCSQETGQCACKEHMFGRRCDQLQSG--------------------------------------- 540

  Fly   810 ITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRN 874
                        ::|..|..:.||.|                     |:|.|..|          
Zfish   541 ------------YYFAALDHYIYEAE---------------------FASFGPAV---------- 562

  Fly   875 EVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKP 939
                      ::|.|                   ||..|:      :||     .|..|      
Zfish   563 ----------KVVQR-------------------PLPQDR------KPT-----WTGTG------ 581

  Fly   940 SAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVF 1004
                                    ||.:|    |...||.:|:|                     
Zfish   582 ------------------------FVNVP----EGETLTFNINN--------------------- 597

  Fly  1005 SPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDY 1069
                                                                .|||..|..:|.|
Zfish   598 ----------------------------------------------------FPRSMEYNLMIRY 610

  Fly  1070 ISDRNFPDSY-YINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISA 1133
              :...||.: .:.:||:...|.:         .||.|.|:.:::.|                 .
Zfish   611 --EPLLPDEWEQVIVKLERPRDID---------QSTHCTTTYDDEQM-----------------V 647

  Fly  1134 DIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIAT 1198
            .:..|||:.::                |:|||:                      ||.....:..
Zfish   648 SLHPGSRYVVV----------------PNPVCL----------------------ETGQNYTLKI 674

  Fly  1199 NKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQ 1263
            :.|.|:|.:..        .:..|:|          :..|:|        |:.|.......|.:|
Zfish   675 SFPQYSSYNYH--------SSPRTLV----------DSLVLL--------PEVQDLDLFCGGDHQ 713

  Fly  1264 YDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLV 1328
                                    :.::|:..:::   ..:|||||     :.:||         
Zfish   714 ------------------------QKNWEMFQKYR---CLERSQSV-----IKIPL--------- 737

  Fly  1329 EETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQ 1393
                                     :|.||..:||::|..::|||.|.||..||.|..|.|.|||
Zfish   738 -------------------------TDICKDYIFSVSALLHNGALECKCDPRGSLSTVCDPIGGQ 777

  Fly  1394 CQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFH 1458
            |||:                                          |||.|..|:.|||.||.|.
Zfish   778 CQCR------------------------------------------PNVSGKNCDACAPATYLFG 800

  Fly  1459 QVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTEL 1523
            . .||..|.|||:|..|      ||                                ||      
Zfish   801 P-SGCRACDCNPLGSQN------LF--------------------------------CH------ 820

  Fly  1524 EVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLK 1588
                                                                             
Zfish   821 ----------------------------------------------------------------- 820

  Fly  1589 HVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISA 1653
                                                                             
Zfish   821 ----------------------------------------------------------------- 820

  Fly  1654 YGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGK 1718
                                                     ||..:                   
Zfish   821 -----------------------------------------PSNGQ------------------- 825

  Fly  1719 PVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYS 1783
                                                                     |.|.||..
Zfish   826 ---------------------------------------------------------CLCVPGAF 833

  Fly  1784 GHSCEDCAPGYYRDPSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNA 1848
            |..|.:|.|.::..|:      |.||.|||:||.|...||.|..|:..|.|.:||||.|||:.:.
Zfish   834 GRQCGNCKPNHWGYPT------CKPCSCNGNSEQCHPLTGKCLNCRGHTSGHNCERCESGYHRST 892

  Fly  1849 TNGTPGDCMICACPL-PFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQ 1912
            ..|:...|..|.||. |.....|:.||..:.:..|:.|.|..||.||:||.||:|:||.....|.
Zfish   893 LLGSRDQCRPCMCPNGPGSGMQFSESCYQNPNTLQMVCVCNAGYKGPKCEECASGYYGNTRVPGG 957

  Fly  1913 VCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGT 1977
            .|.||:|:||||.:|..|||.|||.||:||.:|.|..|..|:.|:|||| :.:||:.|.|:.:|:
Zfish   958 RCHPCQCNGNINMQDPESCDARTGACLKCLFHTDGTECQYCSRGYYGDA-RSQNCRRCMCNLVGS 1021

  Fly  1978 Q---------TCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAA-SNSTQCDPHT 2032
            .         .||...|.|.|...|.|..||||.|:.:...||.||:.|.|... |.|:.||..:
Zfish  1022 SRQSCVDGLCECDRISGQCPCLPGVEGQLCDRCAPNTWNINSGRGCQPCRCHPEHSYSSSCDLLS 1086

  Fly  2033 GHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFG---CNPNTGKCQCLPGVIGDRC 2094
            |.|:||.|..|:.|:.|....|...:..|..|:|:   .||..   ||..:|.|.|:.||.|.||
Zfish  1087 GQCSCKPGFGGKTCEECRELFWGDPEVECHACDCD---PRGIATQQCNKTSGDCVCIEGVAGRRC 1148

  Fly  2095 DACPNRWVLIKDEGC-QECNNCHHALL-------DVTDRMRYQIDSVLEDFNSVTLAFFTSQKLN 2151
            |.|...:|     |. .:|..||:...       ::|:..:..:|:|.|..:|            
Zfish  1149 DTCGRGFV-----GTFPDCEACHYCFREWDVNVGELTNHTQRLVDTVEEMKDS------------ 1196

  Fly  2152 YYDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLGNI 2216
               .:|...:..:|.||      ..|::....||.|      :|.||.|:...:.:::|.|...:
Zfish  1197 ---GVATPYKDIIKSLD------DESRQLREILEDD------KVQQTFAHTQRMMKKASETASLL 1246

  Fly  2217 TVAYDEAVKSADQAK----EAIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNE 2277
            ..:.|.:....|...    .||..:::|:|               :||::.        |:|.::
Zfish  1247 RKSMDRSETDLDMVSTDHHRAIKDLKSLTK---------------EAQNLQ--------EITSDK 1288

  Fly  2278 QVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLEDLFNWS-----EASQAKSADVER 2337
                                  |.:.||...:|.....|.:.|.:..|     ..|||.|..| |
Zfish  1289 ----------------------QQQVLNIKHSDPRGAVDSIRDYYRESAEADFRVSQAISEPV-R 1330

  Fly  2338 RNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALN--ELNSFN 2400
            ::...:|       ||  |.||:..:|     .|.:...|    ..|:|..:...||  :|:..:
Zfish  1331 QSALLRK-------DT--EAKLERTEN-----EFNLKHQL----YTQRLSKIETELNSTDLSRLS 1377

  Fly  2401 KNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEA 2465
            :.|... ....|..|:...|..:.|...:....:..|     |.:|.|.:...||......::..
Zfish  1378 RQVCGG-AAGLDGCKDCGGLGCKHEDGMSHCGGEGCD-----TIVTRSQDSLNKAKNLDQEVLHT 1436

  Fly  2466 VEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQS--------------LQKVQ 2516
            ::...||::....|.|           ||..|...:.|:|.||.||              :|:::
Zfish  1437 LKEVDKLNRMVSDARG-----------RADEAKLSAQDVLLRANQSKARVEQTNEDLRNLIQQIR 1490

  Fly  2517 D----DLEP-RLNASAGKVQKIS------AVNNAT----EH--QLKDINKLIDQLP-----AESQ 2559
            |    :.:| |:...|.:|.|:|      |:.|.|    :|  :|.::..::.|..     ||..
Zfish  1491 DFLTNETDPKRIEEVANEVMKLSLPVSSGALKNMTTEIRKHVARLTNVEDILSQTAEKTRNAERL 1555

  Fly  2560 RDMWKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVE- 2623
            .:..|.:|..|:........|.:.||..........||.....|||:.||:.::....:.:..| 
Zfish  1556 LEQAKAANKKATTLKHTSDEVKKTLEDTDRAQTAANEKIKAAERDLNQTNQQITSVQSKTEATEF 1620

  Fly  2624 ---GSVSKLSELAEDIEEQQHRVGSQSR---QLGQEIENLKAQVEAAR-----------QLANSI 2671
               .|..::..|..|:::.|.:....||   |..::.|:..|::|...           |||:.:
Zfish  1621 KLSSSTGRMVNLEGDLDDLQRKTAETSRSADQTQRQAEDTTAELEHTERDLDTLVLPKYQLASGL 1685

  Fly  2672 ---KVGVNFKPSTILELKTPEKTKLLATRTNLSTYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVE 2733
               |....|......|....|...||...||.....|..|.|    :..|.:....|:.:...:|
Zfish  1686 IDQKAAGVFDARQKAEQLQQEAKDLLIDATNKLQRLRELERS----FAANQHILMGKSQELEGLE 1746

  Fly  2734  2733
            Zfish  1747  1746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 69/271 (25%)
EGF_Lam 272..>314 CDD:238012 16/44 (36%)
EGF_Lam 332..389 CDD:238012 24/61 (39%)
EGF_Lam 402..443 CDD:238012 8/40 (20%)
Laminin_EGF 448..497 CDD:395007 16/52 (31%)
Laminin_EGF 495..543 CDD:395007 4/47 (9%)
Laminin_EGF 541..589 CDD:395007 4/47 (9%)
Laminin_EGF 587..634 CDD:395007 3/46 (7%)
Laminin_EGF 632..679 CDD:395007 0/46 (0%)
Laminin_EGF 677..729 CDD:395007 12/51 (24%)
Laminin_EGF 732..782 CDD:395007 16/49 (33%)
EGF_Lam 785..828 CDD:238012 1/42 (2%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 17/134 (13%)
Laminin_EGF 1375..1423 CDD:395007 14/47 (30%)
EGF_Lam 1420..1457 CDD:238012 10/36 (28%)
Laminin_EGF 1466..1516 CDD:395007 8/49 (16%)
Laminin_EGF 1514..1562 CDD:395007 2/47 (4%)
LamB 1632..1760 CDD:214597 2/127 (2%)
Laminin_EGF <1775..1801 CDD:395007 9/25 (36%)
EGF_Lam 1808..1851 CDD:238012 21/42 (50%)
EGF_Lam 1859..1907 CDD:214543 21/48 (44%)
EGF_Lam 1916..1968 CDD:238012 28/51 (55%)
EGF_Lam 1969..2015 CDD:238012 18/54 (33%)
EGF_Lam 2016..>2054 CDD:238012 14/38 (37%)
EGF_Lam 2063..>2097 CDD:238012 15/36 (42%)
Laminin_I 2134..2385 CDD:310534 48/259 (19%)
SMC_prok_B 2356..>2705 CDD:274008 86/407 (21%)
Laminin_II 2566..2700 CDD:368703 33/154 (21%)
LamG 2674..2843 CDD:238058 13/60 (22%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamb1bNP_001264059.1 Laminin_N 33..265 CDD:459653 68/264 (26%)
EGF_Lam 267..318 CDD:238012 17/50 (34%)
EGF_CA 330..380 CDD:473889 24/61 (39%)
EGF_Lam 392..450 CDD:238012 22/94 (23%)
EGF_Lam 451..502 CDD:238012 24/235 (10%)
EGF_Lam 504..542 CDD:214543 16/90 (18%)
EGF_Lam 759..804 CDD:214543 25/87 (29%)
Laminin_EGF 807..855 CDD:395007 24/344 (7%)
EGF_Lam 852..890 CDD:238012 21/37 (57%)
EGF_Lam 902..957 CDD:238012 21/54 (39%)
EGF_Lam 961..1012 CDD:238012 28/51 (55%)
Laminin_EGF 1014..1067 CDD:395007 17/52 (33%)
Laminin_EGF 1070..1118 CDD:395007 16/47 (34%)
EGF_Lam 1118..1162 CDD:214543 18/51 (35%)
SMC_prok_B <1179..1757 CDD:274008 137/680 (20%)
cc_LAMB1_C 1695..1767 CDD:411971 12/56 (21%)
Blue background indicates that the domain is not in the aligned region.

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