DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanA and lamb2l

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:XP_005162178.1 Gene:lamb2l / 553337 ZFINID:ZDB-GENE-030131-4205 Length:1836 Species:Danio rerio


Alignment Length:2807 Identity:567/2807 - (20%)
Similarity:876/2807 - (31%) Gaps:1163/2807 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRKIYAT--ATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVP---- 84
            |...||..||.|..|  :|||  .||||.||.:       .|:..|    :.|..||...|    
Zfish    34 PATGNLLIGRAINLTTSSTCG--LDGPEPYCIV-------SHLKDS----EKCFICDSENPYDAN 85

  Fly    85 --ERNHPPENAI-----DGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGL 142
              ..:|..||.|     .|...|||:   ..|.:  .|::.:|.|.|||..:|.::. .:.||..
Zfish    86 YHRDSHRVENVIYPMDSTGELTWWQA---VNGEE--NVSVRLNLEAEFHFTHLIMKF-KTFRPAA 144

  Fly   143 WTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPVML 207
            ..:|:|:|:|:||..:::|:   .:|...|.:.....:...|:|||...||.|.|..:||:...:
Zfish   145 MIIERSSDFGRTWRIYRYFA---YNCTKTFPRVPAHSLRFIDEVICEERYSDIEPSTDGEVIYKV 206

  Fly   208 LN-----ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDI 267
            |:     :.|.|.:      :|:..|.||:||...:...|..:|:.   :.|.|.::|:|::.::
Zfish   207 LDPAIHVKDPYSLD------IQDLLRITNLRINFTKLHTLGDNLLD---RRPDVLQKYYYALYEL 262

  Fly   268 SIGGRCMCNGHADTCDVKDPKSPVRILA----------CRCQHHTCGIQCNECCPGFEQKKWRQN 322
            .:.|.|.|.|||..|      :||..:.          |.|:|:|.|:.|..|...:....||..
Zfish   263 VVRGSCFCYGHASEC------APVPGVTTRDSGMIHGRCVCKHNTVGLNCERCRDFYHDAPWRPA 321

  Fly   323 TNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYY 387
            .......|..|||:||||:|.:|       :::.:......||||.||.|||:|.||..|||.||
Zfish   322 ETDNAHTCRECNCNGHSNQCHFD-------MAVYLATGNVSGGVCNNCLHNTMGRNCESCKPFYY 379

  Fly   388 RPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNL 452
            :...|...:...|.||.||                                              
Zfish   380 QDPEKDIRDPAACVPCDCD---------------------------------------------- 398

  Fly   453 NGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCL 517
                                                          .:||:.             
Zfish   399 ----------------------------------------------PVGSVE------------- 404

  Fly   518 TNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYP 582
                                                             ||.             
Zfish   405 -------------------------------------------------GGV------------- 407

  Fly   583 DCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSH-----GSQGV 642
                                                               ||||     |..| 
Zfish   408 ---------------------------------------------------CDSHTDLDLGMIG- 420

  Fly   643 SCNSDGQCLCQPNFDGRQCDSCKEGFYNFP-----SCEDCNCDPAGVIDKFAGCGSVPVGELCKC 702
                 |||.|:.|..|::||.||||.|...     .|:.|||||.|:......|..:. |: |.|
Zfish   421 -----GQCRCKQNVRGQRCDYCKEGHYGLSLDDPLGCQPCNCDPRGITTLGVPCDQIS-GD-CSC 478

  Fly   703 KERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQEC 767
            |..||||.||:|.|.||.|                                              
Zfish   479 KRYVTGRYCNQCLPEYWGL---------------------------------------------- 497

  Fly   768 RDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQY 832
                    |..|.||:.|:||.||:..|.|...||||.|.|.:.|..|::.....|..:|..::|
Zfish   498 --------SHDLAGCRPCNCDFGGATSSRCMMDSGQCDCRPHLIGRQCSEVQPAFFCASLDYYKY 554

  Fly   833 EYED--GSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNA 895
            |.|.  |..|         ::...||                                       
Zfish   555 EAEAVMGRSP---------EDLTLPG--------------------------------------- 571

  Fly   896 ENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVM 960
                        :|           :|.:|...|                               
Zfish   572 ------------SP-----------RPQAETDCV------------------------------- 582

  Fly   961 LDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAA---------TPFV--IG 1014
                              :|::|       :|.||.::..:.....||         ||.|  :.
Zfish   583 ------------------QHLNN-------QLRRHRRHRHIAQQQRAALRRIRQLQQTPSVSSVH 622

  Fly  1015 ENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHY-IVDVPRSGRYIFVIDYISDRNFPDS 1078
            ...:|...| |:|.|...::....|           |.: |.::|.:..|..:|.|         
Zfish   623 RERQPGQMV-TWTGPGFARVKDGAG-----------LEFAISNIPYAMEYDIMIRY--------- 666

  Fly  1079 YYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPI 1143
                     .|:|...   :..|.|.   ||||                   :...:..|:..|.
Zfish   667 ---------EPESTED---WEALVSV---TSVN-------------------LPISLRCGNMLPT 697

  Fly  1144 ISVTAIPVDQWSIDYIN-PSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLD 1207
            ..:..:|:.. ::.||. |.|.|                      ||.::...::.....:|   
Zfish   698 EQLYTVPMPH-NVRYIKMPKPFC----------------------FEPNNRYVVSIRFQRHA--- 736

  Fly  1208 ERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQH 1272
              |...||    .|.|:|:|          ::|:       |:|:                    
Zfish   737 --VSHRHL----TAFILIDS----------LVLI-------PRYE-------------------- 758

  Fly  1273 CPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKE 1337
              ..:|.:|     .||:    ||.:   ..:....:.|:..:.:|:..                
Zfish   759 --ELTGFQG-----DEGA----DERR---RQEMESYMCLESFMTMPMPA---------------- 793

  Fly  1338 FIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIE 1402
                           .::.|...:.|::|..::|||.|.||..||.|.||...||||:||     
Zfish   794 ---------------LAELCTSLICSISAIMHNGALGCQCDPQGSLSAECDRVGGQCRCK----- 838

  Fly  1403 RTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECA 1467
                                                 |||||..|.:|||.||||          
Zfish   839 -------------------------------------PNVIGRKCNQCAPGTYGF---------- 856

  Fly  1468 CNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGA 1532
             .|.|                                      |..|.||..|:....||.:.|.
Zfish   857 -GPYG--------------------------------------CTVCDCHSQGSVGHHCDPVTGQ 882

  Fly  1533 CFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEF 1597
            |.|:...:||.|.:|..|                                               
Zfish   883 CMCRHGAIGRQCSECQPG----------------------------------------------- 900

  Fly  1598 HEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTL 1662
                    .|..|                                                    
Zfish   901 --------QWGFP---------------------------------------------------- 905

  Fly  1663 HFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMM 1727
                                                                             
Zfish   906 ----------------------------------------------------------------- 905

  Fly  1728 VLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAP 1792
                                                                             
Zfish   906 ----------------------------------------------------------------- 905

  Fly  1793 GYYRDPSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCM 1857
                        .|..|:||.|:|:||..:|.|..|:..|.|..|||||.|||||...|:...|.
Zfish   906 ------------NCRQCQCNSHAESCDPESGACYDCRDNTAGQLCERCVDGYYGNPALGSGEHCR 958

  Fly  1858 ICACP-LPFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSG 1921
            .|.|| .|...::...|||:..:.:||.|:|..||.||||:.||.|:||:||..|..|:||:|:|
Zfish   959 PCPCPGHPDSGHSNGASCEVDYASNQILCQCGQGYAGPRCDRCAPGYYGDPEHPGGSCRPCQCNG 1023

  Fly  1922 NINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQ-------- 1978
            ||:|:|..|||.|||.||:||.||.|.:|:.|..|:||:|: :::|:.|.|...||.        
Zfish  1024 NIDPQDPESCDPRTGLCLKCLYNTDGDSCSECKLGYYGNAL-IQDCRRCTCVTAGTLPNSCTDGV 1087

  Fly  1979 -TCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASN-STQCDPHTGHCACKSGV 2041
             .||...|.|.|.:|:||..||:|..:|:.|.|..||..|.|...:. ||.|:..:|.|.|:.|.
Zfish  1088 CQCDKQTGQCPCKQNIIGHNCDQCATNHWNFGSDCGCEPCGCVQPNALSTHCNMFSGQCHCQPGF 1152

  Fly  2042 TGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKD 2106
            .||||:.|...||...:..|..|||:...|....|:..||.|.|..|..|.|||.|...:.    
Zfish  1153 GGRQCNECEAFHWGDPRVQCEECNCHPLGSETSQCDRTTGACVCKDGASGQRCDECARGFT---- 1213

  Fly  2107 EG----CQECNNCHHALLDVTDRMRYQ-------IDSVLE--------DFNSVTL--AFFTSQKL 2150
             |    |..|:.|.....||..::|..       |..:||        |...:.|  ....:|:|
Zfish  1214 -GNFPKCVPCHPCFQLWDDVVCQVRRDLTHFRDIIAMILEKGEVPGVSDKRILELEKKLAQAQEL 1277

  Fly  2151 ----------NYYDQLADELEPKVKLLDPNSV----DLSPSKKANSELESDAKSYAKQVNQTLAN 2201
                      |...|..|:|..::.|.|...:    ||:.:...|::|:.:..:..|::......
Zfish  1278 VRDGDREGTFNLISQTVDDLRAEIALTDGRLMGVIRDLNVTTDHNNDLKQNLTALEKELKDLNNT 1342

  Fly  2202 AFDIRERSSTTL--------GNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQ 2258
            ...:|......|        .|:...|..::.|..:..   |||......:|.:..|:       
Zfish  1343 LHQLRRELENYLTAGLAEQFANVLKYYQRSLNSEQRCN---ASVYGPQSPVEQSQDTR------- 1397

  Fly  2259 AQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALK---NDIGEFSDHLED 2320
                    |.|        :.|.|.:|     ::|:....|.||||:.|:   ::|.....||.:
Zfish  1398 --------NRT--------EALLKDKK-----DSLLRTATANNKSLSELEGKAHEINRKVHHLSN 1441

  Fly  2321 LFNWSEASQAKSADVERRNV------------------------ANQKAFDNS-----KFDTVSE 2356
            ......|:...:...|....                        |:.||.||:     ....|||
Zfish  1442 KVCGGHANGNVNGSCEESPCGGAGCRGSDGVLKCGGRGCNGTVGASVKALDNADEVHKNLTAVSE 1506

  Fly  2357 QKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFNKNVDEELPVREDQHKEADALT 2421
            :.....|.::|.............:...|..|.:|...:.|...||..:::   :|...|..|..
Zfish  1507 ELQTMAKKLRDIATLTQTVKTQAKETLDKAQNKKDMFEKSNKMLKNFIQKI---KDFLNEEGADP 1568

  Fly  2422 DQAEQKAAE-LAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATD 2485
            :..|:.|.: |||..........::....:.:|...|...|:............|.:..|.:|..
Zfish  1569 ESIEKVAQQVLAISLPVNRTVIVNLVEQIKDSIVNLTNVEGVFNHTSEQLAKVNDLLKKAQDAKT 1633

  Fly  2486 KTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAV---------NNATE 2541
            :.||:.:..:    .:.:.|:.::.:::|.::::...|. :...:|.|:|:         ||.|:
Zfish  1634 QADGVSDNIN----KTKEALETSQNAIKKAEEEMSTALK-NLKNIQNITAMVDDKLLNLDNNLTD 1693

  Fly  2542 HQLKDIN--KLIDQL--PAESQRDMWKNSNA---NASDALEILKNVLEILEPVSVQTPKELEKAH 2599
            ..::.:|  ..:|.|  ..|..|:|.|.:.|   ||:...|.|:..|...|.:..|..::::.|.
Zfish  1694 VMMRLVNLSNGVDLLKNKTEQNREMAKEAKAQSDNATREAEGLQEELTNAETLYKQLKEKVDSAG 1758

  Fly  2600 GINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIENLKAQVEAA 2664
            |...  ...|:...:..|:.:|:....:...|..:.:|.:.::...:.:|...|:.:|:..|...
Zfish  1759 GTGE--GNVNQKAIEMKKEAEDLLKKATMGMETLKKLERKFNKNEQKMQQQRDELTDLEKNVTGI 1821

  Fly  2665 RQLANSIKVGVN 2676
            |:...|..:..|
Zfish  1822 REYIRSKVLAYN 1833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 74/262 (28%)
EGF_Lam 272..>314 CDD:238012 15/51 (29%)
EGF_Lam 332..389 CDD:238012 26/56 (46%)
EGF_Lam 402..443 CDD:238012 4/40 (10%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 2/47 (4%)
Laminin_EGF 541..589 CDD:278482 2/47 (4%)
Laminin_EGF 587..634 CDD:278482 0/46 (0%)
EGF_Lam 631..673 CDD:238012 19/51 (37%)
Laminin_EGF 677..729 CDD:278482 22/51 (43%)
Laminin_EGF 732..782 CDD:278482 2/49 (4%)
EGF_Lam 785..828 CDD:238012 16/42 (38%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 11/136 (8%)
Laminin_EGF 1375..1423 CDD:278482 14/47 (30%)
EGF_Lam 1420..1457 CDD:238012 11/36 (31%)
Laminin_EGF 1466..1516 CDD:278482 4/49 (8%)
Laminin_EGF 1514..1562 CDD:278482 14/47 (30%)
LamB 1632..1760 CDD:214597 0/127 (0%)
Laminin_EGF <1775..1801 CDD:278482 0/25 (0%)
EGF_Lam 1808..1851 CDD:238012 22/42 (52%)
EGF_Lam 1859..1907 CDD:214543 22/48 (46%)
EGF_Lam 1916..1968 CDD:238012 27/51 (53%)
EGF_Lam 1969..2015 CDD:238012 19/54 (35%)
EGF_Lam 2016..>2054 CDD:238012 14/38 (37%)
EGF_Lam 2063..>2097 CDD:238012 14/33 (42%)
Laminin_I 2129..2385 CDD:283627 55/326 (17%)
Tar 2278..2662 CDD:223910 81/432 (19%)
Laminin_II 2566..2700 CDD:283628 22/114 (19%)
LamG 2674..2843 CDD:238058 1/3 (33%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamb2lXP_005162178.1 Laminin_N 41..266 CDD:306548 71/255 (28%)
EGF_Lam 267..320 CDD:238012 16/58 (28%)
EGF_Lam 332..384 CDD:238012 26/58 (45%)
Laminin_EGF 395..452 CDD:278482 26/280 (9%)
EGF_Lam 454..505 CDD:238012 25/106 (24%)
EGF_Lam 506..>545 CDD:238012 15/38 (39%)
EGF_Lam 816..861 CDD:214543 29/135 (21%)
Laminin_EGF 864..912 CDD:278482 18/296 (6%)
Laminin_EGF 910..957 CDD:278482 23/46 (50%)
Laminin_EGF 960..1016 CDD:278482 25/55 (45%)
Laminin_EGF 1019..1063 CDD:278482 25/43 (58%)
Laminin_EGF <1089..1129 CDD:278482 17/39 (44%)
Laminin_EGF 1122..1175 CDD:278482 19/52 (37%)
Laminin_EGF 1175..1215 CDD:278482 15/44 (34%)
SMC_N <1243..1826 CDD:330553 113/623 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.