Protein Alignment LanA and NTN3

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: NP_006172.1
• Gene: NTN3 / 4917
• HGNCID: 8030
• Length: 580
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 122/428 - (28%)
• Similarity: 190/428 - (44%)
• Gaps: 72/428 - (16%)

  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |...|.|.||::.|::|||:...                         :.||..|   |.|.|.|
Human    42 PGLVNAALGREVLASSTCGRPAT-------------------------RACDASD---PRRAHSP 78

  Fly    91 E--NAIDGTEA--WWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDY 151
            .  .:..||.:  .|:|..|.|...  .|.||:...:.|.:.::.:|..::| |....|.||.|:
Human    79 ALLTSPGGTASPLCWRSESLPRAPL--NVTLTVPLGKAFELVFVSLRFCSAP-PASVALLKSQDH 140

  Fly   152 GKTWTPWQHFSDTPADCETYFGK---DTYKPITRDDDVICTTEYSKIVPLE----NGEIPVMLLN 209
            |::|.|...||   :.|:..:|:   ....|.....:.:|..     .||.    :|.:...:.:
Human   141 GRSWAPLGFFS---SHCDLDYGRLPAPANGPAGPGPEALCFP-----APLAQPDGSGLLAFSMQD 197

  Fly   210 ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVA--RQDPTVTRRYFYSIKDISIGGR 272
            ..|...:..:|.|||:|..||:||:.|.|.        |.|  .:|......|.|:..|:.:|||
Human   198 SSPPGLDLDSSPVLQDWVTATDVRVVLTRP--------STAGDPRDMEAVVPYSYAATDLQVGGR 254

  Fly   273 CMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHG 337
            |.|||||..| :.|.:..   |.|.|:|.|.|..|..|.|.:..:.|::.|......|..|:|:|
Human   255 CKCNGHASRC-LLDTQGH---LICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNG 315

  Fly   338 HSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSP 402
            |:..|:::.|:.|      :.|. ..||||.||:|||.|.:|:.|:..:||..|:..::...|..
Human   316 HARRCRFNMELYR------LSGR-RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRA 373

  Fly   403 CQCDYFFSTGH-CEEETGNCECRAAFQPPSCDSCAYGY 439
            |.|....:.|. |.:.||.|.|:......:|:.||.|:
Human   374 CDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGF 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	63/257 (25%)
		EGF_Lam	272..>314	CDD:238012	18/41 (44%)
		EGF_Lam	332..389	CDD:238012	21/56 (38%)
		EGF_Lam	402..443	CDD:238012	12/39 (31%)
		Laminin_EGF	448..497	CDD:395007
		Laminin_EGF	495..543	CDD:395007
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:395007
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534
		SMC_prok_B	2356..>2705	CDD:274008
		Laminin_II	2566..2700	CDD:368703
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
NTN3	NP_006172.1	LamNT	34..253	CDD:214532	63/257 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..83		7/48 (15%)
		EGF_Lam	254..299	CDD:238012	19/48 (40%)
		Laminin_EGF	311..362	CDD:395007	22/57 (39%)
		EGF_Lam	373..422	CDD:238012	12/39 (31%)
		NTR_like	456..562	CDD:470599
		Cell attachment site, atypical. /evidence=ECO:0000255	500..502