DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanA and LAMC1

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_002284.3	Gene:	LAMC1 / 3915	HGNCID:	6492	Length:	1609	Species:	Homo sapiens

Alignment Length:	2754	Identity:	535/2754 - (19%)
Similarity:	820/2754 - (29%)	Gaps:	1299/2754 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQG--QVCDYCDPTVPERNH 88
            |.:.|.|....:.||.|||..   ||.||...|            :.|  :.|..||...|...|
Human    52 PEFVNAAFNVTVVATNTCGTP---PEEYCVQTG------------VTGVTKSCHLCDAGQPHLQH 101

  Fly    89 PP------ENAIDGTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLE 146
            ..      .|..|.|  ||||..:..|::: :.:|||::..:.|.:.|:.::...| ||..:.:.
Human   102 GAAFLTDYNNQADTT--WWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTS-RPESFAIY 163

  Fly   147 KSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITR--------DDDVICTTEYSKIVPLENGEI 203
            |.|.....|.|:|::|   ..||     :||....|        :...:||.|:|.|.||..|.:
Human   164 KRTREDGPWIPYQYYS---GSCE-----NTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNV 220

  Fly   204 PVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDIS 268
            ....|..|||:.|:.||.|||||..||::|:    |.|.|.........||.|.:.|:|:|.|.:
Human   221 AFSTLEGRPSAYNFDNSPVLQEWVTATDIRV----TLNRLNTFGDEVFNDPKVLKSYYYAISDFA 281

  Fly   269 IGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPC 333
            :||||.|||||..|    .|:....|.|.|:|:|.|:.|.:|.|.|..:.||:.|......|.||
Human   282 VGGRCKCNGHASEC----MKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPC 342

  Fly   334 NCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETD 398
            :|:|.|.||.:|.|:.|.      .||   ||.|.|||.||.|.:|.:|:..::|
Human   343 DCNGRSQECYFDPELYRS------TGH---GGHCTNCQDNTDGAHCERCRENFFR---------- 388

  Fly   399 VCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAE 463
                               .||.|.
Human   389 -------------------LGNNEA---------------------------------------- 394

  Fly   464 SGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERC 528
                                        |.:|.|:.:||::..|:
Human   395 ----------------------------CSSCHCSPVGSLSTQCD-------------------- 411

  Fly   529 KHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPDCKPCNCSSTG 593
                      ||                 |:|.|:.|..|.:||:|.|||:
Human   412 ----------SY-----------------GRCSCKPGVMGDKCDRCQPGFH-------------- 435

  Fly   594 SSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDG 658
                                   :|..||
Human   436 -----------------------SLTEAG------------------------------------ 441

  Fly   659 RQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNI 723
                           |..|:|||:|.||:
Human   442 ---------------CRPCSCDPSGSIDE------------------------------------ 455

  Fly   724 SNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCD 788
                                  |..::|:|.||.:.:|..|:.|:.|.|:|:|::..||..|.|
Human   456 ----------------------CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFC- 497

  Fly   789 VGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAA 853
            .|.|  |||.
Human   498 FGHS--SVCT------------------------------------------------------- 505

  Fly   854 FPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDN-PLEVDQHVK 917
                ::.||.|:                               ::::|..:..|. ..|.....:
Human   506 ----NAVGYSVY-------------------------------SISSTFQIDEDGWRAEQRDGSE 535

  Fly   918 VLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHIS 982
            ..|:.:||.|
Human   536 ASLEWSSERQ------------------------------------------------------- 545

  Fly   983 NPCELGNMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGS 1047
                                                                     ||.|:|.|
Human   546 ---------------------------------------------------------DIAVISDS 553

  Fly  1048 QNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNE 1112
            ....::|......|:.:.            ||..||..
Human   554 YFPRYFIAPAKFLGKQVL------------SYGQNLSF--------------------------- 579

  Fly  1113 DGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKF 1177
                 ||.:::.|.:   :||
Human   580 -----SFRVDRRDTR---LSA-------------------------------------------- 592

  Fly  1178 RSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVK 1242
                           ||                            :|:|
Human   593 ---------------ED----------------------------LVLE---------------- 598

  Fly  1243 YYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQ 1307
                                             .:|.|
Human   599 ---------------------------------GAGLR--------------------------- 603

  Fly  1308 SVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGA 1372
                   |.|||
Human   604 -------VSVPL----------------------------------------------------- 608

  Fly  1373 LPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECM 1437

Human   609 ----------------------------------------------------------------- 608

  Fly  1438 CPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCS 1502
                                               ||.|||
Human   609 -----------------------------------IAQGNS------------------------ 614

  Fly  1503 NGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFC 1567
                 :|
Human   615 -----YP---------------------------------------------------------- 616

  Fly  1568 FGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVND 1632
                                                             :|||:|..|.|.|..|
Human   617 -------------------------------------------------SETTVKYVFRLHEATD 632

  Fly  1633 E--RPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQP 1695
            .  |||.
Human   633 YPWRPAL---------------------------------------------------------- 639

  Fly  1696 SRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADE 1760
               .||                      :|..:|.:|..|.||..|.|:: ..:|.||.|..|
Human   640 ---TPF----------------------EFQKLLNNLTSIKIRGTYSERS-AGYLDDVTLASA-- 676

  Fly  1761 DADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRD-PS-GPYGGYCIPCECNGHSETCDCATG 1823
             ..|.| .....||.|:||.||.|..||.|..||.|: |: |||.. |:.|.|||||||||..||
Human   677 -RPGPG-VPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSP-CVLCACNGHSETCDPETG 738

  Fly  1824 ICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHC-EC 1887
            :|: |:..|.|.|||:|..||||::|.||..||..|.||       ..:||.:.....::.| .|
Human   739 VCN-CRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP-------GGSSCAVVPKTKEVVCTNC 795

  Fly  1888 KPGYTGPRCESCANGFYGEPESIG-----QVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFG 1947
            ..|.||.|||.|.:|::|:|  :|     ::|:.|:||.||:|...|:|:..|||||:|:.||.|
Human   796 PTGTTGKRCELCDDGYFGDP--LGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAG 858

  Fly  1948 AACNLCAPGFYGDAI---KLKNCQSCDCDDLGT----QTCDPFVGVCTCHENVIGDRCDRCKPDH 2005
            ..|:.|..||:|:.:   ....|::|:|:..||    .:|:|..|.|.|..:|.|..|..|.|..
Human   859 FYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGF 923

  Fly  2006 YGFESGVGCRACDCGA-ASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQG 2069
            |..:||.||..|||.| .|.:.|||..||.|.|:.|:||:.|:||.|:|:.:..:||.||:|:..
Human   924 YNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPE 988

  Fly  2070 YSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKD-EGCQECNNCHHALLDVTDRMRYQIDSV 2133
            .|....|. :.|:|:|..|.:|:|||.|...:...:. .|||||..|:..:.|.....|.:
Human   989 GSLSLQCK-DDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVK---- 1048

  Fly  2134 LEDFNSVTLAFFTSQKLNYYDQLADE-LEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQ 2197
            |::..|:.....|..::     :.|: .|.::|..:...:||....:...:::.:.....::||.
Human  1049 LQELESLIANLGTGDEM-----VTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNN 1108

  Fly  2198 TLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHI 2262
            ||::..       :.|.||....:|....|:||:   |.||...:.:|.|:     ..||:|:..
Human  1109 TLSSQI-------SRLQNIRNTIEETGNLAEQAR---AHVENTERLIEIAS-----RELEKAKVA 1158

  Fly  2263 LGQINGTSIELT--PNEQVL--EKARKLYE----EVNTLVLPIKAQNKSLNALKN---------- 2309
            ...::.|..|.|  ||...|  |:||||.|    |.:.:|...|..|.:.....|
Human  1159 AANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGEN 1223

  Fly  2310 ----DIGEFSDHLEDLFNWSEASQAKSADV-ERRNVANQKAFDNSKFDTVSE-QKLQAEKNIKDA 2368
                :|.|.:...|...|.|:..:.::|.| |....|..||.:  .:.:|:: ..|.:|....:|
Human  1224 QTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVE--IYASVAQLSPLDSETLENEA 1286

  Fly  2369 GNFLINGDLTLNQINQKLDNLRDALNELNSFNKNVDEELPVREDQHKEADAL---TDQAEQKAAE 2430
            .|..:..:.....|:|||.:..|...::......|...|...:.:.:.||.|   .|.|:..|.|
Human  1287 NNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEE 1351

  Fly  2431 LAIKAQDLAAQYTDM---------------TASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAA 2480
            .|.|.:|...:..|:               ||:.|...|.......|.||.|..::..|...|||
Human  1352 AAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAA 1416

  Fly  2481 GNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQ------KISAVNNA 2539
            .:||:    .:.:||.|        :|...::||         ||::.|.:      :::.::|.
Human  1417 ADATE----AKNKAHEA--------ERIASAVQK---------NATSTKAEAERTFAEVTDLDNE 1460

  Fly  2540 TEHQLKDINKLIDQLPA---ESQRDMW---------KNSNANASDALEILKNVLEILEPVSVQTP 2592
            ..:.||.:.:...:|..   ::.:||.         :.:..||..|...:.::|.|:..:
Human  1461 VNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDL----- 1520

  Fly  2593 KELEKAHGINR-DLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIEN 2656
              ||:...::. ||:..|:.....||..|:::  ||.|.....|:|.:..:..:......::||.
Human  1521 --LEQLGQLDTVDLNKLNEIEGTLNKAKDEMK--VSDLDRKVSDLENEAKKQEAAIMDYNRDIEE 1581

  Fly  2657 LKAQVEAARQLANSIKVGVNFKPS 2680
            :...:.....:..::..|....||
Human  1582 IMKDIRNLEDIRKTLPSGCFNTPS 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	79/261 (30%)
		EGF_Lam	272..>314	CDD:238012	18/41 (44%)
		EGF_Lam	332..389	CDD:238012	23/56 (41%)
		EGF_Lam	402..443	CDD:238012	3/40 (8%)
		EGF_Lam	448..491	CDD:238012	0/42 (0%)
		Laminin_EGF	495..543	CDD:278482	7/47 (15%)
		Laminin_EGF	541..589	CDD:278482	11/47 (23%)
		Laminin_EGF	587..634	CDD:278482	3/46 (7%)
		EGF_Lam	631..673	CDD:238012	0/41 (0%)
		Laminin_EGF	677..729	CDD:278482	7/51 (14%)
		Laminin_EGF	732..782	CDD:278482	12/49 (24%)
		EGF_Lam	785..828	CDD:238012	7/42 (17%)
		CBM6-CBM35-CBM36_like	831..966	CDD:271143	10/135 (7%)
		Laminin_EGF	1375..1423	CDD:278482	0/47 (0%)
		EGF_Lam	1420..1457	CDD:238012	0/36 (0%)
		Laminin_EGF	1466..1516	CDD:278482	6/49 (12%)
		Laminin_EGF	1514..1562	CDD:278482	0/47 (0%)
		LamB	1632..1760	CDD:214597	19/129 (15%)
		Laminin_EGF	<1775..1801	CDD:278482	13/27 (48%)
		EGF_Lam	1808..1851	CDD:238012	25/42 (60%)
		EGF_Lam	1859..1907	CDD:214543	16/48 (33%)
		EGF_Lam	1916..1968	CDD:238012	22/54 (41%)
		EGF_Lam	1969..2015	CDD:238012	18/49 (37%)
		EGF_Lam	2016..>2054	CDD:238012	19/38 (50%)
		EGF_Lam	2063..>2097	CDD:238012	13/33 (39%)
		Laminin_I	2129..2385	CDD:283627	61/280 (22%)
		Tar	2278..2662	CDD:223910	95/442 (21%)
		Laminin_II	2566..2700	CDD:283628	23/116 (20%)
		LamG	2674..2843	CDD:238058	3/7 (43%)
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
LAMC1	NP_002284.3	Domain VI	34..285		80/262 (31%)
		LamNT	44..284	CDD:214532	79/261 (30%)
		EGF_Lam	285..330	CDD:238012	20/48 (42%)
		Domain V	286..509		100/587 (17%)
		Laminin_EGF	342..396	CDD:278482	26/159 (16%)
		Laminin_EGF	398..445	CDD:278482	22/181 (12%)
		Laminin_EGF	445..492	CDD:278482	19/104 (18%)
		Domain IV	510..689		70/915 (8%)
		LamB	553..678	CDD:214597	54/717 (8%)
		Domain III	690..1030		145/351 (41%)
		EGF_Lam	724..771	CDD:238012	28/47 (60%)
		EGF_Lam	772..820	CDD:238012	18/56 (32%)
		Laminin_EGF	828..875	CDD:278482	22/46 (48%)
		EGF_Lam	883..933	CDD:238012	18/49 (37%)
		EGF_Lam	935..980	CDD:214543	20/44 (45%)
		EGF_Lam	982..1029	CDD:238012	15/47 (32%)
		Domain I/II	1031..1609		134/631 (21%)
		t_SNARE	1072..1155	CDD:197699	22/97 (23%)
		MA	1091..1302	CDD:214599	53/227 (23%)
		MCP_signal	1123..1255	CDD:304920	36/139 (26%)
		V_Alix_like	1180..>1336	CDD:187408	34/157 (22%)
		Laminin_I	1287..1530	CDD:283627	55/270 (20%)
		SH3BP5	1361..1592	CDD:283045	50/260 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810