DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and LAMB3

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_000219.2 Gene:LAMB3 / 3914 HGNCID:6490 Length:1172 Species:Homo sapiens


Alignment Length:617 Identity:194/617 - (31%)
Similarity:277/617 - (44%) Gaps:107/617 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRK--IYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQV-CDYCDPTVPER- 86
            ||..:|..||.  :.|::|||  ...||.||...|             :.|: |..||...|.. 
Human    28 PPVGDLLVGRTRFLRASSTCG--LTKPETYCTQYG-------------EWQMKCCKCDSRQPHNY 77

  Fly    87 -NHPPEN--AIDGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKS 148
             :|..||  :..|...||||.     ...|.|:|.::.::.|.:..:.:.. ..|.|....:|:|
Human    78 YSHRVENVASSSGPMRWWQSQ-----NDVNPVSLQLDLDRRFQLQEVMMEF-QGPMPAGMLIERS 136

  Fly   149 TDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRD------DDVICTTEYSKIVP------LENG 201
            :|:||||..:|:.:   |||.:.|      |..|.      .||.|.:     :|      |..|
Human   137 SDFGKTWRVYQYLA---ADCTSTF------PRVRQGRPQSWQDVRCQS-----LPQRPNARLNGG 187

  Fly   202 EIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRY-----F 261
            ::.:.|: :..|......|..:||....||:|:...|..             |...|.|     :
Human   188 KVQLNLM-DLVSGIPATQSQKIQEVGEITNLRVNFTRLA-------------PVPQRGYHPPSAY 238

  Fly   262 YSIKDISIGGRCMCNGHADTCDVK-----DPKSPVRIL-ACRCQHHTCGIQCNECCPGFEQKKWR 320
            |::..:.:.|.|.|:||||.|..|     .|.:.|::. .|.|||:|.|..|..|.|.:..:.||
Human   239 YAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWR 303

  Fly   321 QNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPK 385
            .........|:.|:|:|||..|.:|..|....     .|.|  ||||.||:.:|.|.||.:|:..
Human   304 PAEGQDAHECQRCDCNGHSETCHFDPAVFAAS-----QGAY--GGVCDNCRDHTEGKNCERCQLH 361

  Fly   386 YYRPKGKHWNETDVCSPCQCDYFFST--GHCEEETGNCECRAAFQPPSCDSCAYGYYG--YPN-- 444
            |:|.:....:..:.|..|:||...:.  ..|:..||.|.|:...|...||.|..|:.|  |.|  
Human   362 YFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQ 426

  Fly   445 -CRECECNLNGT-NGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPE---CKACECNKIGSIT 504
             |..|:||:.|: ....|:.||| :|.|..|..|..|.|||..::....   |:.|.|:...|::
Human   427 GCHRCDCNILGSRRDMPCDEESG-RCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLS 490

  Fly   505 NDCNVTTGECKCLTNFGGDNC-----ERC-KHGYFNYPT-CSYCDCDNQGTESEICNKQSGQCIC 562
            ..||..||:|.|...|||..|     .:| ...|.:..| |..||||.:|||...|:|.||:|:|
Human   491 PQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLC 555

  Fly   563 REGFGGPRCDQCLPGFYN-YPDCKPCN-CSST 592
            |.|..|||||||..|:.| ||.|..|: |..|
Human   556 RPGLTGPRCDQCQRGYCNRYPVCVACHPCFQT 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 66/268 (25%)
EGF_Lam 272..>314 CDD:238012 19/47 (40%)
EGF_Lam 332..389 CDD:238012 22/56 (39%)
EGF_Lam 402..443 CDD:238012 14/44 (32%)
Laminin_EGF 448..497 CDD:395007 18/52 (35%)
Laminin_EGF 495..543 CDD:395007 18/54 (33%)
Laminin_EGF 541..589 CDD:395007 28/49 (57%)
Laminin_EGF 587..634 CDD:395007 3/7 (43%)
Laminin_EGF 632..679 CDD:395007
Laminin_EGF 677..729 CDD:395007
Laminin_EGF 732..782 CDD:395007
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:395007
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:395007
Laminin_EGF 1514..1562 CDD:395007
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:395007
EGF_Lam 1808..1851 CDD:238012
EGF_Lam 1859..1907 CDD:214543
EGF_Lam 1916..1968 CDD:238012
EGF_Lam 1969..2015 CDD:238012
EGF_Lam 2016..>2054 CDD:238012
EGF_Lam 2063..>2097 CDD:238012
Laminin_I 2134..2385 CDD:310534
SMC_prok_B 2356..>2705 CDD:274008
Laminin_II 2566..2700 CDD:368703
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
LAMB3NP_000219.2 LamNT 20..248 CDD:214532 66/268 (25%)
EGF_Lam 249..304 CDD:238012 20/54 (37%)
Laminin_EGF 316..366 CDD:395007 23/56 (41%)
Laminin_EGF 379..428 CDD:395007 16/48 (33%)
Laminin_EGF 431..478 CDD:395007 16/47 (34%)
Laminin_EGF 481..534 CDD:395007 17/52 (33%)
EGF_Lam 534..576 CDD:214543 24/41 (59%)
Domain II 579..785 3/9 (33%)
GumC 626..>980 CDD:442439
Domain alpha 786..816
Domain I 817..1170
Smc <838..>1092 CDD:440809
cc_LAMB3_C 1102..1172 CDD:411974
Blue background indicates that the domain is not in the aligned region.

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