DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanA and Megf8

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster


Alignment Length:2533 Identity:507/2533 - (20%)
Similarity:739/2533 - (29%) Gaps:986/2533 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 CDYCDPTVPERNHPPENAIDG-TEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPR 139
            |.:|.......:......|.| :..||       |.|..|:.                      |
  Fly   736 CTWCVQNAKCHHRDDNYGICGDSSGWW-------GDKGTEIR----------------------R 771

  Fly   140 PGLWTLEKSTDY--GKTWTPWQHF--SDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVP--- 197
            |.|.|   |||.  |.|:..: ||  :.|..|   |.|            ::..|......|   
  Fly   772 PSLCT---STDRRPGLTYIKY-HFPINYTMPD---YVG------------IVNATMVDFASPPFT 817

  Fly   198 ------LENGEIPVMLLN-ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQD-- 253
                  || ||:...|:. .||.  :.:|::.:|..|..::..:|.....| |..|::|..|.  
  Fly   818 TYFEHKLE-GEMLARLVGFVRPQ--HQWNNSAIQVCTSYSSAVLRAGLGLN-LDELVNVTTQSSN 878

  Fly   254 ---------PTV---------TRRYFYSIKDISIGGRCMCNGH----------------ADTCDV 284
                     ||.         |||        .|||..:.|.:                |.|.:.
  Fly   879 QSYCSNVQLPTTEQPFTIDFQTRR--------RIGGNGIYNAYQKTKMELQHLHNGQLNAFTFEY 935

  Fly   285 KDPKSPVRILACRCQHHTCGIQC--NECCPGFEQKKWRQNTNARPFNCEPCNCHGHS-NE---CK 343
            .:|     ..:.:|..::..:.|  :..|      .|...||.         ||..| ||   ||
  Fly   936 LEP-----YYSGKCTQYSNCLHCLTDASC------AWCPLTNI---------CHLRSVNETEVCK 980

  Fly   344 YDEEVNRKGLSLD-IHGHY--DGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCS---- 401
            .:        :|| .|..|  .....|.||   |..::|..|...   .:.:.|.|...|.    
  Fly   981 ME--------TLDTFHWSYLISQPSQCSNC---TNYVSCEACARS---GECEWWTEDARCGRIGK 1031

  Fly   402 -----------PCQCDYFFSTGHCEEETGNCE-CRAAFQPPSCDSCAY--GYYGYPNCRECECNL 452
                       |..|........|..|.|.|. |.|:.|   |.|.:.  ..|.:..|||....:
  Fly  1032 TNSSVRAVEHCPRSCRERHGCQECLGERGRCVWCEASAQ---CFSFSVYTSEYQFGMCREWVDQV 1093

  Fly   453 NGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKAC----EC-------NKIGSI--T 504
            .............||.|   :|....||.|.:    ...|.:|    .|       |.|..|  .
  Fly  1094 VSRQTQEIADHKPQQTP---HFLQQQCKSCEQ----HRNCSSCLRTLSCGWCFDRDNPIEGICMQ 1151

  Fly   505 NDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYC-----DCDNQGTESEICNKQ-SGQCICR 563
            .|.:.:.|.|....|  ..:....:..|...|....|     ||..   |::..|.| |..|.||
  Fly  1152 GDFSYSAGNCSLALN--SSSHHDAEWAYAQCPDVDECGLGLHDCHK---EAKCTNTQGSYNCHCR 1211

  Fly   564 EGFGGPRCDQCLPGFYNYPDCKPCNCSS------------TGSS---AITCDNTGKCN------- 606
            .|:.|.....|:...|..  |:..|||.            ||:.   :..|:|...||       
  Fly  1212 RGYIGDGKFSCVRTCYEL--CQNGNCSGPPDYTCRCALGWTGADCGLSCGCNNHSTCNERLGKCD 1274

  Fly   607 -CLNNFAGKQCTLCTAGYYSYP----DCLPCHCDSHGSQGVS-CN-SDGQCLCQPNFDGRQCDSC 664
             |.:...|::|..|..|.|...    .||||.|:.||:|.:. || |:|:|.|:.|..|..|:.|
  Fly  1275 QCQDWSEGEKCERCRQGSYGNATAPHGCLPCECNGHGNQDLGVCNVSNGECYCKDNTQGLNCELC 1339

  Fly   665 KEGFYNFP----SCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISN 725
            ..|:|..|    .|. ..|:..|::   ...|...:|.....:......:  |.|...|.|....
  Fly  1340 APGYYGDPRGGGKCY-YQCESRGIL---TNIGKSAIGSYQSYRSPWGASL--EVKECLWILQPKT 1398

  Fly   726 TEGCE------------ICDCWTDGTISALDTCTSKSGQCP--------CKPHTQGR-------- 762
            .:..:            ..|| .:..:...|:....:|...        |.|::..|        
  Fly  1399 LQAEKSLLQLEFQWQSLAMDC-DENAVYIYDSLPDLTGATQQNQLLAVVCAPYSSPRIIEARSSH 1462

  Fly   763 ------RCQECRDGTFDLDSASLFGCKDCSCDVGGSWQS--VCDKISGQCKCHPRITGLACTQPL 819
                  :..|.|...|:    :|:...:|   |.||..|  :|| ...:|.|.....|.:|    
  Fly  1463 VTVHYKQGSERRHFGFN----ALYSVMNC---VAGSCISPHICD-AQQRCVCPAGYVGASC---- 1515

  Fly   820 TTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGY---VVFNA----------IQND 871
                           |....||....:      ...||....|   :..||          :|.:
  Fly  1516 ---------------EIEICPSNCNAK------RMQGFCDTEYGRCICSNANYAGADCGTLVQRN 1559

  Fly   872 VRNEVNVFKSSLYRIVLRYVNPNAENVTATI-----SVTSD---------------NPL----EV 912
            ......:|.:.|       ::.:.|::..||     ||.:|               .||    :.
  Fly  1560 HLVMTELFNTQL-------LSESLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQF 1617

  Fly   913 DQHVKVLLQPTSEPQFVTVAGPLG---------VKPSAIVLDPGRYVFTTKANKNVMLDYFVLL- 967
            |......||.|.|........|||         ||...|.:..|     ..||..::.|:::.. 
  Fly  1618 DTKNSTWLQVTVESSTPEDRMPLGRYFHASEIYVKKQIIYIYGG-----IGANSQLLNDFWMFSI 1677

  Fly   968 --------------PAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIG---- 1014
                          |.|.||..:       |..|....| .|.:|...|      :..::|    
  Fly  1678 QNQRWSQIKVEVEPPEADYEVDV-------PPPLAGHTL-THIRYQEHE------SLILLGGLSL 1728

  Fly  1015 ENSKPTNPVETYTDPEHLQIVSHVG-DIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDS 1078
            ..|:|....|...|....|.::.|| .:|||.|..:..|                          
  Fly  1729 NKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTSVYH-------------------------- 1767

  Fly  1079 YYINLKLKDNPDSET-SVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFP 1142
                        .|| ||.|:.. |||           |....:...|||.:             
  Fly  1768 ------------QETNSVYLFGG-YST-----------EPQSNLYALDLQKL------------- 1795

  Fly  1143 IISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLD 1207
                      .|:                 ..|.||.:                  |.|  |||.
  Fly  1796 ----------SWT-----------------ELPSFREL------------------NSP--ASLL 1813

  Fly  1208 ERVKLVHLDSQNEATIVIESKVDATKP-NLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQ 1271
            .|.:..|.....|..:::..  ..|:| |...:|:.|         ||                 
  Fly  1814 PRARYFHSAVTTEHYMILYG--GRTQPFNGTDVLIAY---------VY----------------- 1850

  Fly  1272 HCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTK 1336
                  .|...:|                :|.|      ::.:..||...|.:|:.::   ..|.
  Fly  1851 ------ACNQWVR----------------LTED------VELIGRVPASSYAEDMAID---PDTG 1884

  Fly  1337 EFIQNCGHD----HFHITHNA--SDFCKKSVFSLTADYNSGALPC----NCDYA---GSTSFECH 1388
            ......|.|    |.|:|...  .|.|:.        :::|...|    .|.|.   .:.|:..|
  Fly  1885 AIYVIGGWDGSSTHSHVTKITLPDDICQL--------WSNGKYQCRHYMGCSYCTIQNTYSYSSH 1941

  Fly  1389 PFG-GQCQC---KPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEK 1449
            .|. |:..|   ...::.....||...:....:|.     :.|.|    |.|:.           
  Fly  1942 CFSHGRTPCANHNGTLVVNNGAACDDDWMASRNCS-----SFATC----GACLA----------- 1986

  Fly  1450 CAPNTYGFHQVIG-----CEECA----CNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGY 1505
                .:..||.:.     |::|.    |.|.|:       |....:..|.:.:......:|.   
  Fly  1987 ----AWPTHQEVAPVCHWCDDCGIRGRCVPAGV-------DCGRRSAWCNKELSVGVLGLCP--- 2037

  Fly  1506 FNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCV------DGTYNLQESNPDGCTT 1564
              .|.|.|.||       |.| .:...|...:|.:|  ..:|:      ...|.:.||.|..|.|
  Fly  2038 --LPQCYQLSC-------ESC-MLQPQCNWARNELG--TVECIAKELVEKNQYRVVESCPLPCHT 2090

  Fly  1565 CFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEE---SIKFDMWPVPADEILLNETTLKADFT 1626
               :...|.|               :|.|..:.|:|   |...::...|:.:.||          
  Fly  2091 ---YENCSLC---------------LSQTPTQDHQECKWSTMLNLCLTPSSQPLL---------- 2127

  Fly  1627 LREVNDERPAYFGVLDYLLNQNN--------HISAYGGDLAYTLH----FTSGFDGKYIVAPDVI 1679
                     ...||...:|..:.        |:...........|    ...||:|..|..    
  Fly  2128 ---------CAGGVCGLVLEASELQRCPEPCHVYTQCSSCLEHAHCGWCAREGFNGDGICT---- 2179

  Fly  1680 LFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQ 1744
                ..||.| ..|.||.                       |..|           .|.|::...
  Fly  2180 ----EGALEH-KQEHPSG-----------------------STCD-----------LIYASWRND 2205

  Fly  1745 TLVTHLSDV----YLTLADEDADGTGEYQFLAV-ERCSCPPGYSGHSCEDCAPGYYRDPSGPYGG 1804
            :.:|| :||    |:....|:....|.:....| |:|.......|:.|. ||.||..:.     |
  Fly  2206 SQLTH-ADVVSWHYVQCPAENECINGHHNCDTVSEQCIDLDTAVGYKCV-CAQGYREEQ-----G 2263

  Fly  1805 YCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMI-CACPLPFDSN 1868
            .|:|....|      |..|.|      ...|.|: |..||.|       .:|.| |.|       
  Fly  2264 ACLPVCSQG------CVRGNC------VSPDQCQ-CDFGYVG-------ANCSIQCLC------- 2301

  Fly  1869 NFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPC--ECSG--------NI 1923
            |..::||.|...| |..:|.....|.:||.|...|.|.|.. |..|:||  .|.|        :.
  Fly  2302 NGHSNCESSSRLD-ICLKCHNNTMGEQCEKCQPLFVGNPRE-GHACQPCLDYCHGHSDVCVAYDA 2364

  Fly  1924 NPE-------------DQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKL-KNCQSCDCDD 1974
            :|.             .:|.....|  ||||.|:|.|..|:.|..|::..:..| |.|:.|.|..
  Fly  2365 DPAVFNMTRSELERILQEGPAYNAT--CLRCGNHTAGDRCDSCLTGYFRGSEDLHKECRPCQCHG 2427

  Fly  1975 LGTQTCDPFVG-VCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPHTGHCACK 2038
            .| ..|||..| .|.|..|...|                  ..|..|...||.|.          
  Fly  2428 HG-NICDPVTGEKCNCANNTESD------------------ATCTAGGGKNSAQL---------- 2463

  Fly  2039 SGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGD--RC-DACPNR 2100
                      |    |..:   |:.|.      ..:..||..|. ||...:..:  .| ||.|  
  Fly  2464 ----------C----WMVQ---CSKCR------DSYAGNPTDGH-QCYKQITVESRMCFDAKP-- 2502

  Fly  2101 WVLIKDEGCQECNNCHHAL----------------------LDVTDR-----MRYQIDSVLEDFN 2138
                    .:||.:...||                      :|||..     |..|.||.:.:.|
  Fly  2503 --------IEECKSKPAALKPGQTVFFVIQPRFMNVDIRIIIDVTQGELDVFMSPQDDSFIVETN 2559

  Fly  2139 SVTLAFFTSQKLNYYDQLAD---ELEPKVKLLDPNSVDL------------SPSKK--------- 2179
            ..|         .|::...|   ...||:|...|.:|.|            ||.::         
  Fly  2560 ETT---------GYHEIFLDNRYNWGPKIKREHPLNVALPRHDNVTIQKLFSPERRIGGGGLGGG 2615

  Fly  2180 ------ANS----ELESDAKS-----------YAKQVN--------QTLANAFDIRERSSTTL 2213
                  ||:    :|: |.||           :||.::        .||...|.::.|...||
  Fly  2616 GGERIGANTYYVPQLQ-DCKSHGGHNFIVKDQHAKDLSTHVTLNHCNTLLRLFGLKNRLVLTL 2677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 48/229 (21%)
EGF_Lam 272..>314 CDD:238012 7/59 (12%)
EGF_Lam 332..389 CDD:238012 17/63 (27%)
EGF_Lam 402..443 CDD:238012 12/43 (28%)
EGF_Lam 448..491 CDD:238012 7/42 (17%)
Laminin_EGF 495..543 CDD:278482 12/65 (18%)
Laminin_EGF 541..589 CDD:278482 15/53 (28%)
Laminin_EGF 587..634 CDD:278482 19/73 (26%)
EGF_Lam 631..673 CDD:238012 19/47 (40%)
Laminin_EGF 677..729 CDD:278482 8/51 (16%)
Laminin_EGF 732..782 CDD:278482 11/71 (15%)
EGF_Lam 785..828 CDD:238012 11/44 (25%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 34/180 (19%)
Laminin_EGF 1375..1423 CDD:278482 11/58 (19%)
EGF_Lam 1420..1457 CDD:238012 4/36 (11%)
Laminin_EGF 1466..1516 CDD:278482 10/53 (19%)
Laminin_EGF 1514..1562 CDD:278482 12/53 (23%)
LamB 1632..1760 CDD:214597 24/143 (17%)
Laminin_EGF <1775..1801 CDD:278482 7/25 (28%)
EGF_Lam 1808..1851 CDD:238012 11/42 (26%)
EGF_Lam 1859..1907 CDD:214543 15/47 (32%)
EGF_Lam 1916..1968 CDD:238012 19/75 (25%)
EGF_Lam 1969..2015 CDD:238012 11/46 (24%)
EGF_Lam 2016..>2054 CDD:238012 6/37 (16%)
EGF_Lam 2063..>2097 CDD:238012 8/36 (22%)
Laminin_I 2129..2385 CDD:283627 29/138 (21%)
Tar 2278..2662 CDD:223910
Laminin_II 2566..2700 CDD:283628
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Megf8NP_609180.3 CUB 33..141 CDD:238001
KELCH repeat 228..268 CDD:276965
Kelch_4 369..414 CDD:290154
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1220 CDD:289699 12/36 (33%)
EGF_Lam 1257..1302 CDD:238012 10/44 (23%)
EGF_Lam 1304..1354 CDD:238012 19/49 (39%)
CUB 1372..1484 CDD:238001 16/118 (14%)
Kelch_4 1584..1628 CDD:290154 8/43 (19%)
KELCH repeat 1585..1638 CDD:276965 10/52 (19%)
KELCH repeat 1642..1685 CDD:276965 7/47 (15%)
Kelch_3 1656..1710 CDD:290151 12/66 (18%)
KELCH repeat 1760..1813 CDD:276965 22/162 (14%)
Kelch_4 1760..1802 CDD:290154 15/131 (11%)
KELCH repeat 1817..1867 CDD:276965 13/105 (12%)
EGF_Lam 2299..2346 CDD:238012 17/55 (31%)
EGF_Lam 2422..2487 CDD:238012 24/117 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445165
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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