DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanA and CCDC158

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_001381883.1	Gene:	CCDC158 / 339965	HGNCID:	26374	Length:	1117	Species:	Homo sapiens

Alignment Length:	809	Identity:	150/809 - (18%)
Similarity:	291/809 - (35%)	Gaps:	234/809 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2153 YDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTL---- 2213
            |:...:|||.::.|             ||||| ::|::...|.:|...|..|..::....|
Human   340 YEDKTEELEKQLVL-------------ANSEL-TEARTERDQFSQESGNLDDQLQKLLADLHKRE 390

  Fly  2214 ------------------GNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKID---AALE 2257
                              || ::..|...:..|.....:..:|||.|.|::....:::   ||::
Human   391 KELSLEKEQNKRLWDRDTGN-SITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQ 454

  Fly  2258 QAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLEDLF 2322
            .....|.:::..:.:|   |...|..||:.||:....:.:::..::::.|...:
Human   455 GKNESLEKVSSLTAQL---ESTKEMLRKVVEELTAKKMTLESSERTISDLTTSL----------- 505

  Fly  2323 NWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLIN------------- 2374
                  |.|...:|..|....|.  .|:.|.    |||..:::|:.|:.|.|
Human   506 ------QEKERAIEATNAEITKL--RSRVDL----KLQELQHLKNEGDHLRNVQTECEALKLQMT 558

  Fly  2375 -GDLTLNQINQKLDNLRDALNE-------LNSFNKNVDEELPVREDQHKEADALTDQAEQKAAEL 2431
             .|..:..:.|:::|:...:.:       :......:::|:..|..:.||...|.|:.:.|..||
Human   559 EKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIREL 623

  Fly  2432 AIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHL 2496
            ..:..||..:          .:|...|.|   |.:.|.:.:.|                 ||..|
Human   624 EARVSDLELE----------KVKLVNAGS---ERLRAVKDIKQ-----------------ERDQL 658

  Fly  2497 ADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQLKDINKLIDQLPAESQRD 2561
            .:...|     :|..|..:.::.|........|.:::....|..:.|||
Human   659 LNEVKT-----SRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLK---------------- 702

  Fly  2562 MWKNSNANASDALEILKNVLEILE-------PVSVQTPKELEKAHG----INRDLDLTNKDVSQA 2615
                   :|...||..:|.|:.:|       .|::...|::....|    :...:....:.::.|
Human   703 -------SAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNA 760

  Fly  2616 NKQLDDVEGSVSKLSELAEDIEEQQHRVG-------SQSRQLGQEIENLKAQVEAA--------- 2664
            ||:...::...||||:....:..:::::.       ||.|:|.:::.|::..::.|
Human   761 NKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQD 825

  Fly  2665 ---RQLANSIKVGVNFKPSTILELKTPE-------KTKLL----ATRTNLSTYFRTTEPSGFLLY 2715
               ||...|:::.:. ....|.||:.|.       |.:||    .||:: |....:...:.||.:
Human   826 IIQRQEQESVRLKLQ-HTLDIKELQGPGYTSNSSLKPRLLQPASVTRSH-SNVPSSQSTASFLSH 888

  Fly  2716 LGNDNKTAQKN--NDFVAV-----EIVNGYPILTIDLGNGPERITSDKYVADGRWYQAVVDRMGP 2773
            ......|.:::  .|...:     .::|..|.:::      .:...|...:.|..|.||.||:
Human   889 HSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSL------SKTEEDGRTSLGALYVAVEDRV-- 945

  Fly  2774 NAKLTIREELPNGDVVEHSKSGY---LEGSQN---------ILHV---DKNSRLFV---GGYPGI 2820
              :..|.|.....|:...|.:..   .|||::         .||.   :..|..|.   ...|.:
Human   946 --RDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSV 1008

  Fly  2821 SD-----FNAPP------DLTTNSFSGDI 2838
            .:     ||:.|      .|.|:|..|.|
Human  1009 KNSASRSFNSSPKKSPVHSLLTSSVEGSI 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		EGF_Lam	448..491	CDD:238012
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627	51/270 (19%)
		Tar	2278..2662	CDD:223910	73/422 (17%)
		Laminin_II	2566..2700	CDD:283628	34/174 (20%)
		LamG	2674..2843	CDD:238058	43/212 (20%)
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
CCDC158	NP_001381883.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..902		11/54 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..1066		17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810