DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanA and lamb2

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:XP_005162102.1 Gene:lamb2 / 337767 ZFINID:ZDB-GENE-081030-4 Length:1794 Species:Danio rerio


Alignment Length:2796 Identity:581/2796 - (20%)
Similarity:866/2796 - (30%) Gaps:1204/2796 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRK--IYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCD---PTVPE 85
            |...:|..||:  :.|::|||.....|  ||.:       .|:.    :.:.|..||   |..|:
Zfish    33 PATGDLLVGREANLKASSTCGLRRREP--YCIV-------SHLQ----EEKKCFQCDSRRPYDPQ 84

  Fly    86 RN---HPPENAI-----DGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGL 142
            .|   |..||.|     ...::||||   ..|.  ::|.|.::.|.|||..:|.:.. .:.||..
Zfish    85 SNPVSHRIENVITTFKPHRKKSWWQS---ENGK--SDVYLQLDLEAEFHFTHLIMTF-KTFRPAA 143

  Fly   143 WTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPVML 207
            ..:|:|.|:|::|..:::|::   |||:.|...:...:.:.|||||.:.||.|.|...||:...:
Zfish   144 MLIERSADFGRSWQVYRYFAN---DCESIFPGISQDSLRKVDDVICESRYSDIEPSTEGEVIFRV 205

  Fly   208 LN-----ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDI 267
            |:     |.|.|..      :|...:.||:|:.|.:...|..:|:.   ..|.:..:|:|::.::
Zfish   206 LDPAIRIEDPYSPR------IQNQLKITNLRLNLTKLHTLGDNLLD---SRPEIKEKYYYAMYEL 261

  Fly   268 SIGGRCMCNGHADTC----DVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWR----QNTN 324
            .:.|.|.|.|||..|    .::|....:....|.|:|:|.|:.|.:|...:....||    :|||
Zfish   262 VVRGNCFCYGHASECAPIEGIRDDIEGMVHGRCVCKHNTKGLNCEQCDDFYNDLPWRPAEGRNTN 326

  Fly   325 ARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRP 389
            |    |:.|||:||||:|.:|..|.....::       .||||.||.|||:|.||..|||.||:.
Zfish   327 A----CKKCNCNGHSNQCHFDMAVYLATGNI-------SGGVCDNCLHNTMGSNCESCKPFYYQD 380

  Fly   390 KGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNG 454
            ..:...:..||..|.||                                    |:        ..
Zfish   381 PTRDIRDPGVCVACDCD------------------------------------PD--------GS 401

  Fly   455 TNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTN 519
            .||..|:   |...|                             .:|.|                
Zfish   402 KNGGVCD---GHDDP-----------------------------SLGMI---------------- 418

  Fly   520 FGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPDC 584
                                                 :|||.|::...|.|||:|.|||:     
Zfish   419 -------------------------------------AGQCRCKDNVEGSRCDKCKPGFF----- 441

  Fly   585 KPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQ 649
                    |.||                                     .|..|           
Zfish   442 --------GLSA-------------------------------------SDPRG----------- 450

  Fly   650 CLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNEC 714
              |||                      |.|||.|.:...:.|.  ||...|.||..|||..||:|
Zfish   451 --CQP----------------------CKCDPRGTVSGSSQCD--PVSGDCFCKRLVTGHSCNQC 489

  Fly   715 KPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASL 779
            .|.:|                      ||...||                               
Zfish   490 LPEHW----------------------ALSHDTS------------------------------- 501

  Fly   780 FGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQ 844
             ||:.|.|||||:.::.|...:|||:|...:.|..|.|..:.:||..|..:.||.|...|..|  
Zfish   502 -GCRGCDCDVGGATENQCSMETGQCQCRSHMIGRQCNQVESGYFFMALDHYIYEAETAKLGQG-- 563

  Fly   845 VRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNP 909
                                            :||:...|:                        
Zfish   564 --------------------------------SVFEEREYQ------------------------ 572

  Fly   910 LEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEA 974
                                                |||.:..|...       |...|    |.
Zfish   573 ------------------------------------PGRPISWTGTG-------FARAP----EG 590

  Fly   975 GILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVG 1039
            |.|...|:|                                                   :.:..
Zfish   591 GTLEFAINN---------------------------------------------------IPYSM 604

  Fly  1040 DIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYST 1104
            :..||      :.|.:.:||....:.|:                .::..|...:|    ||    
Zfish   605 EYDVL------IRYELQMPRDWEEVRVV----------------VIRPGPIPTSS----PC---- 639

  Fly  1105 ICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHD 1169
                         ...|..:||..|.:|:    |:||.::                |.|||:   
Zfish   640 -------------GNTIPADDLLTVSLSS----GARFVVL----------------PQPVCL--- 668

  Fly  1170 QQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKP 1234
                                   |..:        |...||:|:....:|  :|:       |..
Zfish   669 -----------------------ESGV--------SYKLRVELIRYADRN--SII-------TST 693

  Fly  1235 NLFVILVKYYQPSHPKYQVYYTLTAG------KNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEI 1293
            |.||::...  ...|:|......|||      :.|   .|:...|..::  :.|.||        
Zfish   694 NAFVLVDSI--ALLPRYLSLEMFTAGDPASVARKQ---SFERYRCHETA--KSVSRP-------- 743

  Fly  1294 DDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCK 1358
                                                                      ..|:.|.
Zfish   744 ----------------------------------------------------------QMSEVCA 750

  Fly  1359 KSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKC 1423
            |.:.|::|..|.|||.|.||..||.|.||...||||:|:                          
Zfish   751 KLITSMSALINDGALACECDPQGSLSSECDVRGGQCRCR-------------------------- 789

  Fly  1424 PNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQ---CDLFNG 1485
                            ||:.|..||||||..|||.. .||:.|.|:..|     ||   |||::|
Zfish   790 ----------------PNISGRRCEKCAPGAYGFGP-SGCKLCECSLEG-----SQSRFCDLYSG 832

  Fly  1486 TCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDG 1550
            .|.||....|:.||.|..|::.||:|.                                      
Zfish   833 QCPCRPGAYGQRCDGCQAGHWGFPNCR-------------------------------------- 859

  Fly  1551 TYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEIL 1615
                                                                             
Zfish   860 ----------------------------------------------------------------- 859

  Fly  1616 LNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVIL 1680
                                                                             
Zfish   860 ----------------------------------------------------------------- 859

  Fly  1681 FSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQT 1745
                                                                             
Zfish   860 ----------------------------------------------------------------- 859

  Fly  1746 LVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCE 1810
                                                                          ||:
Zfish   860 --------------------------------------------------------------PCQ 862

  Fly  1811 CNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPL-PFDSNNFATSC 1874
            ||||::.|...||.|..|:..|.||.||||.:|||||...|....|..|.||. |....:||.||
Zfish   863 CNGHADECHQRTGACLNCRSNTAGDKCERCANGYYGNPVLGLGSQCRPCPCPEGPNSGRHFAASC 927

  Fly  1875 EISESGDQIHCECKPGYTG------------PRCESCANGFYGEPESIGQVCKPCECSGNINPED 1927
            .......|:.|.|..||||            |||:.||.|::|:|...|..|:||.||.||:..|
Zfish   928 YQDNRSQQVVCNCNQGYTGTVKRSAGAVLNRPRCDECAPGYFGDPSKPGGQCQPCRCSNNIDLSD 992

  Fly  1928 QGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQ----------TCDP 1982
            ..|||.|||:||:||.||.|..|::|..|:||||.: :||:.|.|:.|||:          .|..
Zfish   993 PESCDKRTGQCLKCLYNTEGPDCSVCRSGYYGDASR-RNCRKCTCNFLGTERSQCLSRDDCVCQR 1056

  Fly  1983 FVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQ-CDPHTGHCACKSGVTGRQC 2046
            ..|.|.|..||||..||.|.|:.:...||.||..|.|...:..|. |:..||.|.|:.|..|:.|
Zfish  1057 ATGQCQCLPNVIGQTCDHCAPNSWNLASGQGCEPCACDPNNAYTSACNEFTGQCQCRVGFGGKTC 1121

  Fly  2047 DRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKDEGC-Q 2110
            ..|..:||...:..|..|:|:........||..||.|.|..||.|.|||.|...:     .|. .
Zfish  1122 TDCQENHWGDPRVLCRACDCDPRGIESSQCNRMTGHCVCQQGVSGVRCDQCARGF-----SGTFP 1181

  Fly  2111 ECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLS 2175
            :|..||....|                               :|::..:|..:.|.|...:    
Zfish  1182 DCKPCHQCFGD-------------------------------WDRIVQDLATRTKALTDRA---- 1211

  Fly  2176 PSKKANSELESDAKSYA-----KQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIA 2235
                  .||::...:.|     |::...||.|.||                  |.:.:...||:.
Zfish  1212 ------KELQTTGLTRAFERRFKELEDMLAQARDI------------------VNARNATAEAVT 1252

  Fly  2236 SVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQ 2300
            ::..:.:.|.|......| .|.|.:..|..:..::.|.:.....||:..|   |:|   |.....
Zfish  1253 TLMGMIEVLRAQIGETTD-TLNQQEGDLTAVQDSNYEASNALSTLEREAK---ELN---LNADQL 1310

  Fly  2301 NKSLNALKND--IGEFSDHLEDLFNWSEASQAKSADVERR---------NVANQKAFDNSKFDTV 2354
            |:.|:.|||.  :|.:..        ..||..||.|.|.|         :..:|.|....|.:.:
Zfish  1311 NRQLDILKNSNFLGAYDS--------IRASYNKSRDAEHRSNRSTTDTPSTVSQSADTRKKTERL 1367

  Fly  2355 SEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFNKNV---DEELPVREDQHKE 2416
            ..|| :.:.|.|:|.|     ..||..:|.|:.||     :|...|:.|   ..:....:.....
Zfish  1368 IGQK-RDDFNRKNAAN-----KRTLTDLNAKVQNL-----DLKKINEKVCGAPGDAQCVDSPCGG 1421

  Fly  2417 ADALTDQAEQKAAEL----AIKAQDLAAQYTDMTASAEPAIKAATAYSGIVE----AVEAAQKLS 2473
            |....|:.:::...|    |:...|.|   .|.:..||..:..|   .|:||    .|..|:..:
Zfish  1422 AGCRDDEGKRRCGGLNCNGAVAVADTA---LDRSKHAEKELDKA---MGVVEELFKQVADAKTKA 1480

  Fly  2474 QDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEP-RLNASAGKVQKISAVN 2537
            |:|...|..|.:|....:.:...::....||:::.||.|  :|:..:| .:.|.|.:|.::|...
Zfish  1481 QEAKDRAQAALEKASDTKNKVDHSNNDLRDLIKQIRQFL--MQEGADPDSIEAVANRVLELSIPA 1543

  Fly  2538 NATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGIN 2602
            :.     |.|..|.|::     :|..| |.:|....||..:|.:...|.:.:...|...||.|:.
Zfish  1544 SP-----KQIRHLADEI-----KDRVK-SLSNVDAILEQTQNDVRKAEQLLLDAKKARNKAEGVK 1597

  Fly  2603 RDLDLTNKDVSQANKQLDDVEGSVSK----LSELAEDIEEQQHRVGSQSRQLGQEIE---NLKAQ 2660
            ...:...|.::.|::.....|.::.|    :......:.:.|....:..|.|...::   :|:.|
Zfish  1598 NTAESVKKALNDASRAQAAAEKAIQKAKNDIGLTQNQLAQIQSETSASERDLNDAVDRLGDLERQ 1662

  Fly  2661 VEA--ARQLANSIKVGVNFKPSTILELKTPEKTKLLATRTNLSTYFRTTEPSGFLLYLGNDNKTA 2723
            :||  .::..||:......:.:|:...|..|..::|  ...||..:||.:.     .:.|..||.
Zfish  1663 IEALKTKRANNSLDAARAEETATMARDKANEAKEIL--DGELSDKYRTVQG-----LMDNKAKTM 1720

  Fly  2724 Q 2724
            |
Zfish  1721 Q 1721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 71/262 (27%)
EGF_Lam 272..>314 CDD:238012 14/45 (31%)
EGF_Lam 332..389 CDD:238012 27/56 (48%)
EGF_Lam 402..443 CDD:238012 3/40 (8%)
EGF_Lam 448..491 CDD:238012 5/42 (12%)
Laminin_EGF 495..543 CDD:278482 2/47 (4%)
Laminin_EGF 541..589 CDD:278482 12/47 (26%)
Laminin_EGF 587..634 CDD:278482 3/46 (7%)
EGF_Lam 631..673 CDD:238012 5/41 (12%)
Laminin_EGF 677..729 CDD:278482 19/51 (37%)
Laminin_EGF 732..782 CDD:278482 4/49 (8%)
EGF_Lam 785..828 CDD:238012 16/42 (38%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 13/134 (10%)
Laminin_EGF 1375..1423 CDD:278482 13/47 (28%)
EGF_Lam 1420..1457 CDD:238012 10/36 (28%)
Laminin_EGF 1466..1516 CDD:278482 20/52 (38%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 0/127 (0%)
Laminin_EGF <1775..1801 CDD:278482 0/25 (0%)
EGF_Lam 1808..1851 CDD:238012 23/42 (55%)
EGF_Lam 1859..1907 CDD:214543 22/60 (37%)
EGF_Lam 1916..1968 CDD:238012 28/51 (55%)
EGF_Lam 1969..2015 CDD:238012 20/55 (36%)
EGF_Lam 2016..>2054 CDD:238012 12/38 (32%)
EGF_Lam 2063..>2097 CDD:238012 14/33 (42%)
Laminin_I 2129..2385 CDD:283627 54/271 (20%)
Tar 2278..2662 CDD:223910 93/413 (23%)
Laminin_II 2566..2700 CDD:283628 27/142 (19%)
LamG 2674..2843 CDD:238058 12/51 (24%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamb2XP_005162102.1 Laminin_N 41..265 CDD:278484 69/254 (27%)
EGF_Lam 267..319 CDD:238012 15/51 (29%)
EGF_Lam 331..383 CDD:238012 27/58 (47%)
Laminin_EGF 394..451 CDD:278482 28/248 (11%)
EGF_Lam 453..504 CDD:238012 25/128 (20%)
EGF_Lam 506..544 CDD:214543 14/37 (38%)
EGF_Lam 767..812 CDD:214543 25/87 (29%)
Laminin_EGF 815..863 CDD:278482 22/347 (6%)
EGF_Lam 860..905 CDD:238012 24/44 (55%)
EGF_Lam 910..980 CDD:238012 24/69 (35%)
Laminin_EGF 982..1027 CDD:278482 25/44 (57%)
Laminin_EGF 1034..1088 CDD:278482 19/53 (36%)
Laminin_EGF 1091..1139 CDD:278482 15/47 (32%)
Laminin_EGF 1139..>1178 CDD:278482 15/43 (35%)
FlgN 1228..1336 CDD:298847 30/140 (21%)
MscS_porin 1471..1694 CDD:289559 49/235 (21%)
DUF4795 1472..1620 CDD:292662 37/160 (23%)
ApoLp-III_like 1571..1748 CDD:304399 31/158 (20%)
PspA_IM30 1603..1786 CDD:281941 25/126 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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