DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and Lama4

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_001296376.1 Gene:Lama4 / 309816 RGDID:1560062 Length:1817 Species:Rattus norvegicus


Alignment Length:2082 Identity:498/2082 - (23%)
Similarity:807/2082 - (38%) Gaps:477/2082 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1779 PPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSG 1843
            ||     :.|.|..|::|..||.    |.||:|||:|..|...:|.|..||..|.|:|||||::|
  Rat    61 PP-----AAERCDAGFFRTSSGE----CSPCDCNGNSHECLDGSGFCLHCQRNTTGEHCERCLAG 116

  Fly  1844 YYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPE 1908
            |.|::..|.|..|..|.||||..: |||.|| ..::| .:.|.||..|.||.||.||.|:||.|.
  Rat   117 YIGDSIRGAPRFCQPCPCPLPHLA-NFAESC-FRKNG-AVRCMCKENYAGPNCERCAPGYYGNPL 178

  Fly  1909 SIGQVCKPCECSGNINP----EDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQS 1969
            .||..||.|:||||.:|    ||   ||..||:|..||.||.|..|..||||:||||...|||..
  Rat   179 LIGSTCKKCDCSGNSDPNLIFED---CDEITGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAV 240

  Fly  1970 CDCDDLGTQTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPHTGH 2034
            |:|   |...||...|.|.                ..|||...|                     
  Rat   241 CNC---GGGPCDSVTGECL----------------EEGFELPTG--------------------- 265

  Fly  2035 CACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPN 2099
                       ||:|.                                                 
  Rat   266 -----------CDKCV------------------------------------------------- 270

  Fly  2100 RWVLIKDEGCQECNNCHHALLDVTDRMRYQIDSVLE-------------------DFNSVTLAFF 2145
             |                   |:||.:|....|:.|                   |.||......
  Rat   271 -W-------------------DLTDDLRLAALSIEESKSGLLSVSSGAAAHRHVTDMNSTIHLLK 315

  Fly  2146 T--SQKLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRER 2208
            |  |::.|.|..              ..:.::.|:.....|.||.:...::.::.......:.:.
  Rat   316 TRLSERENQYTL--------------RKIQINNSENTLRSLLSDVEELDEKGSRASRKGTLVEKE 366

  Fly  2209 SSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIEL 2273
            |:.|:...|...::|....|:.:|..:.:....:|.|.... :|...|..||.:|.:|......|
  Rat   367 STDTIDQATQLVEQAHSMRDKIQEINSKMLYYGENQELGPE-EIAEKLVLAQKMLDEIRSRQPFL 430

  Fly  2274 TPNEQVLEKA-------------RKLYEEVNTLVLPIKAQ-----NKSLNALKNDIGEFSDHLED 2320
            |..|.|.|:|             ::|:.:..:| ||:..:     |..|:.|:..|.:..||:.|
  Rat   431 THRELVDEEADEVQELLSQAENWQRLHNDTRSL-LPVVLEQLDDYNAKLSDLQESINQALDHVRD 494

  Fly  2321 LFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLTLNQINQK 2385
            ..:.:.|..:|..|.|:::            :.|.||......::..:.:.||...|||.::::.
  Rat   495 AEDMNRAITSKQRDHEKQH------------ERVKEQMEAVGTSLSLSADSLITPRLTLEELDEI 547

  Fly  2386 LDN-------LRDALNELNSFNKNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYT 2443
            :.|       :..|.|||.....|:..   :..|..:||.......:|:|.||:.....     :
  Rat   548 IKNASGIYAEIDGAKNELQGKLSNLSN---LSHDLVQEAVDHAYNLQQEANELSRNLHS-----S 604

  Fly  2444 DMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRA 2508
            ||....:.|:.|:..|..|...|..|.:.::.|::......|...||:.:.......|.:||.:|
  Rat   605 DMNGLVQKALDASNVYENIANYVSEANETAELALNITDRIYDAVSGIDTQIVYHKDESDNLLNQA 669

  Fly  2509 RQSLQKVQDDLEPRLNASAGKVQKISAVNNA--TEHQLKD-INKLIDQLPAESQRDMWKNSNANA 2570
            |: ||...|.......|...:     .|..|  .:..|:| :.:.:.||.|           |..
  Rat   670 RE-LQAKADSSSDEAVADTSR-----RVGGALWRKGALRDKLTEAVKQLQA-----------AER 717

  Fly  2571 SDALEILKNVLEILEPVS--------VQTPKELEKAHGI-NRDLDLTNKDVSQANKQLDDVEGSV 2626
            .||.:.|.....|:|..:        |.||    .|:.: |...:|...|.|..|..::....:|
  Rat   718 GDAHQRLGQTKLIIEEANKTTMAVQQVTTP----MANNLSNWSQNLQTFDSSAYNTAVNSARDAV 778

  Fly  2627 SKLSELAEDIEEQQHRVGSQSR---QLGQEIENLKAQVEAARQLANSIKVGVNFKPSTILELKTP 2688
            ..|:|:...:..|...| .|.|   .:...|:.::..:...|.:|:.|:|.:.|...:.:|:...
  Rat   779 RNLTEVVPRLLGQLRTV-EQKRPASNVSASIQRVRELIAQTRSVASKIQVSMLFDGHSAVEVHPK 842

  Fly  2689 EKTKLLATRTNLSTYF----RTTEPSG------FLLYLGNDNKTAQKNNDFVAVEIVNGYPILTI 2743
            .....|...|::|.|.    :..||:|      |:||||  :|||:|  :::.:.|.|...:...
  Rat   843 VSVDDLKAFTSISLYMKPPPKPAEPTGAWVEDQFVLYLG--SKTAKK--EYMGLAIKNDNLVYVY 903

  Fly  2744 DLGNGPERITSD-KYVADGRWYQAVV--DRMGPNAK--LTIREELPNGDVVEHSKSGYLEGSQNI 2803
            :||.....|..| |.|:....|.::|  :|:|.:.|  ||: ..|.:....:..|.|...|..::
  Rat   904 NLGTKDVEILLDSKPVSSWPAYFSIVKIERVGKHGKVFLTV-PSLSSTAEEKFIKKGEFAGDDSL 967

  Fly  2804 LHVDKNSRLF-VGGYPGISDFNAPPDLTTNSFSGDIEDLKIGDESVGLWNF--VYGDDNDQGAR- 2864
            |.:.....:| |||.|  ::|..|..|...|:||.:|...:.::.:.|:||  :|..|..:... 
  Rat   968 LDLTPEDTVFYVGGVP--ANFKLPASLNLPSYSGCLELATLNNDVISLYNFKHIYNMDPAKSVPC 1030

  Fly  2865 ERDVLLEKKKPVTGLRFKGNGY-VQLNATSNLKSRSSIQFSFKADKDTSNGLLFFYGRDKHYMSI 2928
            .||.|...:.......|.|:.| |..:.|...|.....:|..:......|||:..          
  Rat  1031 ARDKLAFTQSRAASYFFDGSSYAVVRDITRRGKFGQVTRFDIEIRTPADNGLVLL---------- 1085

  Fly  2929 EMIDGAIFFNISLGEG-------GGVQSG--------SQDRYNDNQWHKVQAERENRNGLLKVDD 2978
             |::|::||::.:..|       .|..:|        .:.:.||.::|::.....|...::    
  Rat  1086 -MVNGSMFFSLEMRNGYLHVFYDFGFSNGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMI---- 1145

  Fly  2979 IVISRTNAPLEADLELPKL--RRLYFGGHP------RRLNTSISLQPNFDGCIDNVVINQGVVDL 3035
            :|:.|.:.. ..|.|..|:  ..:|.||.|      |.|...:.|..||.||:......:...:|
  Rat  1146 LVVDRRHVK-STDNEKKKIPFTDIYIGGAPQEVLQSRTLRAHLPLDINFRGCMKGFQFQKKDFNL 1209

  Fly  3036 TEYVTGGGVEEGCSAKFSTVVSYAPHEYG---FLRMNNVSSDNNLHVVLHFKTTQPNGVLFYAAN 3097
            .|.....||..||..  .:::|...:..|   ......:|..:......:|:|.||||:|||.|:
  Rat  1210 LEQKETLGVGYGCPE--DSLISRRAYFNGQSFIASTQKISFFDGFEGGFNFRTLQPNGLLFYYAS 1272

  Fly  3098 HDQSSTIGLSLQDGLLKLNSMGSQLVIDDRILNDGEDH--VVTVQHTQGELRLTVDDVDNKRLGS 3160
             .......:||.:|.:.::..|.::...|:..:||..|  |.||..|:.||     .||..||||
  Rat  1273 -GSDDVFSISLDNGTVVMDVKGIKVKSADKQYHDGLSHFVVTTVSATRYEL-----VVDKSRLGS 1331

  Fly  3161 PQPLILEG---------GDIFFAGLPDNYRTPRNALASLAYFVGCISDVTVNE-----EIINFAN 3211
            ..|  .:|         ...:|.|.|.:        ...|.|.||||:.....     |:.:|..
  Rat  1332 KNP--TKGKAEPTQTTEKKFYFGGSPIS--------PQYANFTGCISNAYFTRLDRDVEVEDFQR 1386

  Fly  3212 SAEKKNGNINGCP----PHVLAYEP---SLVPSYYPSGDNEVESP-WSNADTLPPLKPDIESTLP 3268
            .:||.:.::..||    |..|.::.   |..|.....|:...::| |                  
  Rat  1387 YSEKVHTSLYECPIESSPLFLLHKKGKNSSKPKTNKQGEKSKDAPSW------------------ 1433

  Fly  3269 PTTPTTTTTTTTTTTSTTTTSTTTTTTTPSPIVIDEEKEIEAKTPQKILTTRPPAKLNLPSDERC 3333
                                         .||.:   |.:|.|..:               |..|
  Rat  1434 -----------------------------DPIGL---KFLERKASR---------------DSHC 1451

  Fly  3334 KLPEQPNFDVDFTEAGYRFYGLREQRLQINSLPVKVRRHHDIGISFRTERPNGLLIYAGSKQRDD 3398
            .|...|.    ..|..|::.|....|.:...:...........|..:|...:|::.|...::.:|
  Rat  1452 HLSSSPR----AIEHAYQYGGTANSRQEFEHIQGDFGEKSQFAIRLKTRSSHGMIFYVSDQEEND 1512

  Fly  3399 FIAVYLLDGRVTYEIRVGAQLQAKITTEAELNDGTWHTVEVVRTQRKVSLLIDKLEQPGSVDLNA 3463
            |:.::|..||:.:...||.: :.||.::.:.:||.||.|..:|.:....|:||.|.      :..
  Rat  1513 FMTLFLAHGRLVFMFNVGHK-KLKIRSQEKYSDGLWHDVIFIREKSSGRLVIDGLR------VLE 1570

  Fly  3464 ERSAPVLA---VELPIYLGGVNKFLESEVKNLTDFKTEVPYFNGCLKNIKFDAMDLETPPEEFGV 3525
            ||..|..|   ::.|||||||..  ...|||:.  ...|..|:|||.|::.:...:.:..:.|.|
  Rat  1571 ERLPPSDAAWKIKGPIYLGGVAP--GRAVKNVQ--INSVYSFSGCLGNLQLNGASIASASQTFSV 1631

  Fly  3526 VPCSE-QVERGLFFNNQKAFVKIFDHFDVGTEMKISFDFRPRDPNGLL----------FSVHGKN 3579
            .||.| .:|.|.:|:.:..:|.:.:.|::|.:.:|:|:.|||..:|.|          .:||.|:
  Rat  1632 TPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKS 1696

  Fly  3580 SYAILELVDNTLYFTVKTDLKNIVSTNYKLPNNESFCDGKTRNVQAIKSKFVINIAVDFISSNPG 3644
            ...|:::.:....|:.....|            ::.|||:...:..|:...|:.:.|| ...|..
  Rat  1697 GQVIVKVNNGVRDFSTSVTPK------------QNLCDGRWHRITVIRDSNVVQLDVD-SEVNHV 1748

  Fly  3645 VGNEGSVITRTNRPLFLGGHVAFQRAPGIKTKKSFKGCISKVEVNQRMINIT-PNMVVGDIWQGY 3708
            ||...........|:|:||.......|.:...|.|.|||....::.|.::.: ..:|.|.:....
  Rat  1749 VGPLNPKPVDHREPVFVGGVPESLLTPRLTPSKPFTGCIRHFVIDGRPVSFSKAALVSGAVSINS 1813

  Fly  3709 CP 3710
            ||
  Rat  1814 CP 1815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
EGF_Lam 448..491 CDD:238012
Laminin_EGF 495..543 CDD:278482
Laminin_EGF 541..589 CDD:278482
Laminin_EGF 587..634 CDD:278482
EGF_Lam 631..673 CDD:238012
Laminin_EGF 677..729 CDD:278482
Laminin_EGF 732..782 CDD:278482
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:278482
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:278482
Laminin_EGF 1514..1562 CDD:278482
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:278482 7/21 (33%)
EGF_Lam 1808..1851 CDD:238012 21/42 (50%)
EGF_Lam 1859..1907 CDD:214543 24/47 (51%)
EGF_Lam 1916..1968 CDD:238012 29/55 (53%)
EGF_Lam 1969..2015 CDD:238012 11/45 (24%)
EGF_Lam 2016..>2054 CDD:238012 3/37 (8%)
EGF_Lam 2063..>2097 CDD:238012 0/33 (0%)
Laminin_I 2129..2385 CDD:283627 56/294 (19%)
Tar 2278..2662 CDD:223910 90/423 (21%)
Laminin_II 2566..2700 CDD:283628 31/145 (21%)
LamG 2674..2843 CDD:238058 50/184 (27%)
LamG 2878..3029 CDD:238058 37/174 (21%)
LamG 3078..3205 CDD:214598 41/142 (29%)
LamG 3349..3512 CDD:238058 46/165 (28%)
LamG 3535..3689 CDD:238058 38/163 (23%)
Lama4NP_001296376.1 EGF_Lam 81..130 CDD:238012 23/48 (48%)
EGF_Lam 131..185 CDD:238012 27/56 (48%)
EGF_Lam 187..238 CDD:238012 28/53 (53%)
Laminin_I 289..547 CDD:283627 54/285 (19%)
SPEC 314..523 CDD:295325 46/236 (19%)
ApoLp-III_like 610..798 CDD:304399 46/209 (22%)
Laminin_II 727..854 CDD:283628 27/131 (21%)
LamG 853..1008 CDD:214598 46/161 (29%)
LamG 1044..1202 CDD:238058 37/173 (21%)
LamG 1232..1372 CDD:238058 43/155 (28%)
LamG 1483..1618 CDD:238058 43/145 (30%)
LamG 1642..1793 CDD:238058 38/163 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 60 1.000 Domainoid score I10319
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1919at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
65.780

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