DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and ntn1a

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_571104.1	Gene:	ntn1a / 30227	ZFINID:	ZDB-GENE-990415-169	Length:	603	Species:	Danio rerio

Alignment Length:	488	Identity:	150/488 - (30%)
Similarity:	231/488 - (47%)	Gaps:	79/488 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |.:.|.|.|:::.|::|||:.   |..||.:.....|         :.:.|..||.:.|::||||
Zfish    52 PDFVNAAFGKEVRASSTCGKT---PSRYCVVTEKGDE---------RHRNCHTCDASDPKKNHPP 104

  Fly    91 ENAIDGTE----AWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTD 150
            ....|...    ..|||   ...::: ..|.||::..::|.|.|:.::. .||||....:.||.|
Zfish   105 AYLTDLNNPHNLTCWQS---DNYLQYPQNVTLTLSLGKKFEVTYVSLQF-CSPRPESMAIFKSMD 165

  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITR--DDDVICTTEYSKIVPLENGEIPVMLLNERPS 213
            |||:|.|:|::|   ..|...:.|.:...||:  :.:.|||..::.:.||..|.|....|:.|||
Zfish   166 YGKSWVPFQYYS---TQCRKMYNKPSKATITKQNEQEAICTDSHTDMHPLSGGLIAFSTLDGRPS 227

  Fly   214 STNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRR--YFYSIKDISIGGRCMCN 276
            :.::.||.|||:|..||::::...|.     |......:|.:...|  |||::.|:.:||||.||
Zfish   228 AHDFDNSPVLQDWVTATDIKVTFSRL-----HTFGDENEDDSELARDSYFYAVSDLQVGGRCKCN 287

  Fly   277 GHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNE 341
            |||..| |||....   |.|.|:|:|.|.:|:.|.|....:.|::.|......|..|||:.|:..
Zfish   288 GHASRC-VKDRDGN---LVCECKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARR 348

  Fly   342 CKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCD 406
            |:::.|:.:      :.|. ..||||.||:|||.|.:|:.||..|||...|..:....|..|.|.
Zfish   349 CRFNMELYK------LSGR-KSGGVCLNCRHNTAGRHCHYCKEGYYRDMSKPISHRKACKACDCH 406

  Fly   407 YFFSTGH-CEEETGNCECRAAFQPPSCDSCAYGYYGYPN----C------------------REC 448
            ...:.|. |.:.||.|.|:......:|:.||.||....:    |                  .:|
Zfish   407 PVGAAGKTCNQTTGQCPCKDGVTGITCNRCANGYQQSRSPIAPCIKIPIAPPTTTASSTEEPSDC 471

  Fly   449 ECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQ 481
            |.        :|:|..|:   .|||.. .|||:
Zfish   472 ES--------YCKASKGK---LKINMK-KYCKK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	75/253 (30%)
		EGF_Lam	272..>314	CDD:238012	20/41 (49%)
		EGF_Lam	332..389	CDD:238012	22/56 (39%)
		EGF_Lam	402..443	CDD:238012	13/41 (32%)
		EGF_Lam	448..491	CDD:238012	11/34 (32%)
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntn1a	NP_571104.1	LamNT	45..282	CDD:214532	75/253 (30%)
		EGF_Lam	283..328	CDD:238012	21/48 (44%)
		Laminin_EGF	340..393	CDD:278482	23/59 (39%)
		EGF_Lam	402..450	CDD:238012	13/47 (28%)
		NTR_netrin-1_like	486..600	CDD:239634	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910