DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and ntn1b

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_571073.1 Gene:ntn1b / 30192 ZFINID:ZDB-GENE-990415-168 Length:602 Species:Danio rerio


Alignment Length:488 Identity:149/488 - (30%)
Similarity:231/488 - (47%) Gaps:79/488 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |.:.|.|.|:.:..::|||..   |...|::.....|         :.:.|:.||.|.|::.|||
Zfish    52 PDFVNSAFGKDVRVSSTCGSP---PSRCCRVTEKGEE---------RSRDCNICDATDPKKTHPP 104

  Fly    91 ENAIDGTE----AWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTD 150
            ....|...    ..|||   ...::: ..|.||::..::|.|.|:.::. .||||....:.||.|
Zfish   105 AYLTDLNNPHNLTCWQS---ENYVQYPQNVTLTLSLGKKFEVTYVSLQF-CSPRPESMAIFKSMD 165

  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITR--DDDVICTTEYSKIVPLENGEIPVMLLNERPS 213
            |||||.|:|.:|   ..|:..:.|.:...||:  :.:.|||..::.:.||..|.|....|:.|||
Zfish   166 YGKTWVPFQFYS---TQCKKMYNKPSKAAITKQNEQEAICTDSHTDMQPLTGGLIAFSTLDGRPS 227

  Fly   214 STNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRR--YFYSIKDISIGGRCMCN 276
            :.::.||.|||:|..||::::    |.|.| |......:|.:...|  |||::.|:.:||||.||
Zfish   228 AHDFDNSPVLQDWVTATDIKV----TFNRL-HTFGDENEDDSELARDSYFYAVSDLQVGGRCKCN 287

  Fly   277 GHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNE 341
            |||..| |||.:..   |.|.|:|:|.|.:|:.|.|....:.|::.|......|..|:|:.|:..
Zfish   288 GHASKC-VKDREGN---LVCECKHNTAGPECDRCKPFHYDRPWQRATAREANECVACHCNLHARR 348

  Fly   342 CKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCD 406
            |:::.|:.:      :.|. ..||||.||:|||.|.:|:.||..|||...|..:....|..|.|.
Zfish   349 CRFNMELYK------LSGR-RSGGVCLNCRHNTAGRHCHYCKEGYYRDMSKAISHRRACKACDCH 406

  Fly   407 YFFSTGH-CEEETGNCECRAAFQPPSCDSCAYGY---------------------YGYPN-CREC 448
            ...:.|. |.:.||.|.|:......:|:.||.||                     |..|: ..:|
Zfish   407 PVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAAPTSSYSSPDGPTDC 471

  Fly   449 ECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQ 481
            :.        ||:|..|:.   |:... .|||:
Zfish   472 DS--------HCKAPKGKM---KVTMK-KYCKK 492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 76/253 (30%)
EGF_Lam 272..>314 CDD:238012 20/41 (49%)
EGF_Lam 332..389 CDD:238012 21/56 (38%)
EGF_Lam 402..443 CDD:238012 14/62 (23%)
Laminin_EGF 448..497 CDD:395007 9/34 (26%)
Laminin_EGF 495..543 CDD:395007
Laminin_EGF 541..589 CDD:395007
Laminin_EGF 587..634 CDD:395007
Laminin_EGF 632..679 CDD:395007
Laminin_EGF 677..729 CDD:395007
Laminin_EGF 732..782 CDD:395007
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:395007
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:395007
Laminin_EGF 1514..1562 CDD:395007
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:395007
EGF_Lam 1808..1851 CDD:238012
EGF_Lam 1859..1907 CDD:214543
EGF_Lam 1916..1968 CDD:238012
EGF_Lam 1969..2015 CDD:238012
EGF_Lam 2016..>2054 CDD:238012
EGF_Lam 2063..>2097 CDD:238012
Laminin_I 2134..2385 CDD:310534
SMC_prok_B 2356..>2705 CDD:274008
Laminin_II 2566..2700 CDD:368703
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
ntn1bNP_571073.1 LamNT 45..282 CDD:214532 76/253 (30%)
EGF_Lam 283..328 CDD:238012 21/48 (44%)
Laminin_EGF 340..389 CDD:395007 21/55 (38%)
EGF_Lam 402..450 CDD:238012 13/47 (28%)
NTR_netrin-1_like 486..602 CDD:239634 3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

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