DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and Ntn4

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_001100250.1	Gene:	Ntn4 / 299737	RGDID:	1565947	Length:	630	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	170/604 - (28%)
Similarity:	246/604 - (40%)	Gaps:	143/604 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HGVASIGALLVILAISYCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHID 67
            :||:.:.        |.|:....|...|||.|||:.|..||||  :..||:|      ...::.|
  Rat    21 NGVSGVN--------SRCEKACNPRMGNLALGRKLQADTTCGQ--NATELFC------FYSENAD 69

  Fly    68 YSVIQGQVCDYCDPTVPERNHPPENAIDGT----EAWWQSPPLSRGMKFNEVNLTINFEQEFHVA 128
            .:..|.: ||.|:.......|||....|.:    ..||||     ....:...:.::.|.||:..
  Rat    70 LTCRQPK-CDKCNGAHSHLAHPPSAMADSSFRFPRTWWQS-----AEDVHREKIQLDLEAEFYFT 128

  Fly   129 YLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDV-----IC 188
            :| |.:..||||....|::|.|:||||.|:::|:   .:|...||        .:|||     ||
  Rat   129 HL-IMVFKSPRPAAMVLDRSQDFGKTWKPYKYFA---TNCSATFG--------LEDDVVKKGAIC 181

  Fly   189 TTEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQD 253
            |:.||...|...||:....|:......|.:::.| ||..:.||:|:|||:.::     ....|.|
  Rat   182 TSRYSNPFPCTGGEVIFRALSPPYDIENPYSAKV-QEQLKITNLRVRLLKRQS-----CPCQRND 240

  Fly   254 PTVTRRYF--YSIKDISIGGRCMCNGHADTCDVKDPKSPVRILA--------CRCQHHTCGIQCN 308
            ......:|  |:|.|..:.|.|.||||||.|...:...||:...        |.|:|:|.|..|.
  Rat   241 LNAKPHHFTHYAIYDFIVKGSCFCNGHADQCLPVEGFRPVKAPGAFHVVHGKCMCKHNTAGSHCQ 305

  Fly   309 ECCPGFEQKKWR--QNTNARPFNCEPCNCHGHSNECKYDEEV-----NRKGLSLDIHGHYDGGGV 366
            .|.|.:..:.|.  ......|..|..|.|:||::.|.:|..|     ||            .|||
  Rat   306 HCAPLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHFDINVWEASGNR------------SGGV 358

  Fly   367 CQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCD-------YFFSTGHCEEETGNCECR 424
            |.||||||.|.:|.:|||.:||...:.::..|.|..|.|.       .|.|...|:...|:|.|:
  Rat   359 CNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFSSVTFCDPSNGDCPCK 423

  Fly   425 AAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGF 489
            .....|.||.|..||:|:                                          |.||
  Rat   424 PGVAGPHCDRCMVGYWGF------------------------------------------GDYG- 445

  Fly   490 PECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCK--HGYFNYPTCSYCDCDNQGTESEI 552
              |:.|:|      ...|:..||:| ..:|...|......  |...|.....:...|.||..:
  Rat   446 --CRPCDC------AGSCDPLTGDC-ISSNADVDWYHEVPAFHSLHNKSEPGWEWEDEQGFSA-- 499

  Fly   553 CNKQSGQCICREG-FGGPR 570
             .:.||:|.|:|. .|.|:
  Rat   500 -LRHSGKCECKEQVLGNPK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	79/263 (30%)
		EGF_Lam	272..>314	CDD:238012	18/49 (37%)
		EGF_Lam	332..389	CDD:238012	25/61 (41%)
		EGF_Lam	402..443	CDD:238012	15/47 (32%)
		EGF_Lam	448..491	CDD:238012	3/42 (7%)
		Laminin_EGF	495..543	CDD:278482	10/49 (20%)
		Laminin_EGF	541..589	CDD:278482	10/31 (32%)
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
Ntn4	NP_001100250.1	Laminin_N	43..260	CDD:278484	73/248 (29%)
		EGF_Lam	261..320	CDD:238012	19/58 (33%)
		Laminin_EGF	332..392	CDD:278482	27/71 (38%)
		Laminin_EGF	395..449	CDD:278482	19/98 (19%)
		NTR_netrin-4_like	517..626	CDD:239633	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910