Protein Alignment LanA and Ntng1

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: NP_001099935.1
• Gene: Ntng1 / 295382
• RGDID: 1563465
• Length: 539
• Species: Rattus norvegicus
• Alignment Length: 534
• Identity: 147/534 - (27%)
• Similarity: 217/534 - (40%)
• Gaps: 128/534 - (23%)

  Fly    19 YCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVG---ANTEHDHIDYSVIQGQVCDYCD 80
            |.:.:|.||            ..|||   |.||.:|.:..   .|.|                ||
  Rat    60 YLKVKLDPP------------DITCG---DPPESFCAMGNPYMCNNE----------------CD 93

  Fly    81 PTVPERNHPPENAID----GTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPG 141
            .:.||..||||...|    ....:|||.......|..:||:|:::.:...:....:....|.||.
  Rat    94 ASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPD 158

  Fly   142 LWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKD--TYKPITRDD--DVICTTEY-------SKI 195
            ...||||.|||:||.|:|:::   .||...|..|  :.|.:::..  ::|||.||       |||
  Rat   159 QMILEKSLDYGRTWQPYQYYA---TDCLHAFHMDPKSVKDLSQHTVLEIICTEEYSTGYSTNSKI 220

  Fly   196 VPLENGEIPVMLLNER------PSSTNYFN-------STVLQEWTRATNVRIRLLRTKNLLGHLM 247
            :..|        :.:|      |...|..:       :..|:::...|::||||||.  .:|.:.
  Rat   221 IHFE--------IKDRFAFFAGPRLRNMASLYGQLDTTKKLRDFFTVTDLRIRLLRP--AVGEIF 275

  Fly   248 SVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCP 312
                .|.....||||:|.||.:.|||.||.||..|...:.|     |.|.|:|:|.|..|.:|..
  Rat   276 ----VDELHLARYFYAISDIKVRGRCKCNLHATMCVYDNSK-----LTCECEHNTTGPDCGKCKK 331

  Fly   313 GFEQKKWRQNT-----NARPFNCEP-------CNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGG 365
            .::.:.|...:     ......|.|       |.|.||||.|.|.:.:|..
  Rat   332 NYQGRPWSPGSYLPIPKGTANTCIPSISSIGNCECFGHSNRCSYIDLLNTV-------------- 382

  Fly   366 VCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPP 430
            :|.:|:|||.|.:|..|:..|:|......::.:||..|.|:...|.......:|.|||:.....|
  Rat   383 ICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGP 447

  Fly   431 SCDSCAYG---YYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPEC 492
            .||.|..|   |||      |:.|:......||  ::|..|...:...      |.:.|.|. .|
  Rat   448 KCDECLPGNSWYYG------CQPNVCDNELLHC--QNGGTCHNNVRCV------CPDAYTGI-LC 497

  Fly   493 KACECNKIGSITND 506
            :...|.:.||..:|
  Rat   498 EKLRCEEAGSCGSD 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	77/282 (27%)
		EGF_Lam	272..>314	CDD:238012	16/41 (39%)
		EGF_Lam	332..389	CDD:238012	19/63 (30%)
		EGF_Lam	402..443	CDD:238012	15/43 (35%)
		Laminin_EGF	448..497	CDD:395007	10/48 (21%)
		Laminin_EGF	495..543	CDD:395007	4/12 (33%)
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:395007
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534
		SMC_prok_B	2356..>2705	CDD:274008
		Laminin_II	2566..2700	CDD:368703
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
Ntng1	NP_001099935.1	Laminin_N	50..295	CDD:459653	77/282 (27%)
		EGF_Lam	296..342	CDD:238012	17/50 (34%)
		EGF_Lam	364..412	CDD:238012	19/61 (31%)
		EGF_Lam	420..467	CDD:214543	17/52 (33%)
		EGF_CA	<474..498	CDD:238011	6/32 (19%)