DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and lamc1

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_775384.1 Gene:lamc1 / 286832 ZFINID:ZDB-GENE-021226-3 Length:1593 Species:Danio rerio


Alignment Length:2771 Identity:563/2771 - (20%)
Similarity:809/2771 - (29%) Gaps:1333/2771 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGAN--TEHDHIDYSVIQGQVCDYCDPT------ 82
            |.:.|.|....:.||.|||..   ||.:|...|..  |:..||         |:..||.      
Zfish    36 PEFVNAAFNATVVATNTCGSP---PEEFCVQTGVTGVTKSCHI---------CNAADPRLHHGAV 88

  Fly    83 -VPERNHPPENAIDGTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTL 145
             :.:.|.|.:      ..||||..:..|::: |.:|||::..:.|.:.|:.::...| ||..:.:
Zfish    89 YLTDYNQPVQ------PTWWQSQTMLAGIQYPNSINLTLHLGKSFDITYVRLKFHTS-RPESFAI 146

  Fly   146 EKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDD---VICTTEYSKIVPLENGEIPVML 207
            .|.:.....|||:|::|   ..||..:.|:....|...:|   .:||.|:|.|.||..|.:....
Zfish   147 YKRSSEDGPWTPYQYYS---GSCEKTYSKNNRGFIRTGEDEQQALCTDEFSDISPLYGGNVAFST 208

  Fly   208 LNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGR 272
            |..|||:.|:.||.|||:|..||::|:    |.|.|.........||.|.:.|:|:|.|.::|||
Zfish   209 LEGRPSAYNFDNSPVLQDWVTATDIRV----TLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGR 269

  Fly   273 CMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHG 337
            |.|||||..| ||:..|.   |.|.|:|:|.|..||.|.|.:..:.||:.|...|..|.||||:|
Zfish   270 CKCNGHASEC-VKNEYSK---LVCNCKHNTEGADCNVCKPFYNDRPWRRATAENPNECLPCNCNG 330

  Fly   338 HSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSP 402
            .|.||.:|.|:.|      ..||   ||.|:||..||.|..|.:|...|||              
Zfish   331 KSAECYFDPELYR------ATGH---GGHCRNCADNTDGPKCERCLANYYR-------------- 372

  Fly   403 CQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQ 467
                                                                      || |||:
Zfish   373 ----------------------------------------------------------EA-SGQR 378

  Fly   468 CPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGY 532
                                    |.:|.||.:||::.                           
Zfish   379 ------------------------CLSCGCNPVGSLST--------------------------- 392

  Fly   533 FNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPD--CKPCNCSSTGSS 595
                     .|||           :|:|.|:.|..|.:||:|.||:::..:  |:||:|:..||:
Zfish   393 ---------QCDN-----------TGRCSCKPGVMGDKCDRCQPGYHSLSEAGCRPCSCNPAGST 437

  Fly   596 AITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQ 660
                              ::|.:.|                           |:|.|:.|.||..
Zfish   438 ------------------QECDVQT---------------------------GRCQCKENVDGFN 457

  Fly   661 CDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISN 725
            ||.||.|                                                  |:||:..|
Zfish   458 CDRCKLG--------------------------------------------------YFNLDPQN 472

  Fly   726 TEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVG 790
            .:||..|.|:...|:     |.|..|....|           ...|||.|               
Zfish   473 PQGCTPCFCFQHSTV-----CESADGYSVHK-----------ITSTFDRD--------------- 506

  Fly   791 GSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFP 855
                                                                       ||    
Zfish   507 -----------------------------------------------------------DE---- 508

  Fly   856 GFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLL 920
            |:..|        |.|                                         |..|.|..
Zfish   509 GWKGK--------QRD-----------------------------------------DSSVPVQW 524

  Fly   921 QPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPC 985
            .|:|        |.:.:                     :..|||                     
Zfish   525 SPSS--------GEISL---------------------ISEDYF--------------------- 539

  Fly   986 ELGNMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNE 1050
                            .::..|...|:                  |.|::               
Zfish   540 ----------------PIYFVAPDKFL------------------HNQLL--------------- 555

  Fly  1051 LHYIVDVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGM 1115
                                       ||..||.|                              
Zfish   556 ---------------------------SYGQNLTL------------------------------ 563

  Fly  1116 EKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSV 1180
              :|.|.:.|.:   :||                                               
Zfish   564 --NFRIQRHDAR---LSA----------------------------------------------- 576

  Fly  1181 PDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQ 1245
                        ||                            :|:|                   
Zfish   577 ------------ED----------------------------VVLE------------------- 582

  Fly  1246 PSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVW 1310
                                          .||.|                              
Zfish   583 ------------------------------GSGLR------------------------------ 587

  Fly  1311 LDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPC 1375
                |.|||                                                        
Zfish   588 ----VAVPL-------------------------------------------------------- 592

  Fly  1376 NCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPP 1440
                                                                             
Zfish   593 ----------------------------------------------------------------- 592

  Fly  1441 NVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGY 1505
                                            ||.|||.                          
Zfish   593 --------------------------------IAQGNSY-------------------------- 599

  Fly  1506 FNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGK 1570
                         ||.|                                        |..|.|  
Zfish   600 -------------PGEE----------------------------------------TQTFVF-- 609

  Fly  1571 TSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERP 1635
                                                        .|::||               
Zfish   610 --------------------------------------------RLHDTT--------------- 615

  Fly  1636 AYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEP 1700
                  ||                                                   |.|   
Zfish   616 ------DY---------------------------------------------------PWR--- 620

  Fly  1701 FTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGT 1765
                             ..:..|||..:|.:|..|.||..|..|: ..:|.:|.|..|.......
Zfish   621 -----------------PTIKHADFQKLLYNLTSIMIRGTYSAQS-AGYLDNVSLVTARRGPGTP 667

  Fly  1766 GEYQFLAVERCSCPPGYSGHSCEDCAPGYYRD-PSGPYGGYCIPCECNGHSETCDCATGICSKCQ 1829
            ..:    ||:|:||.||.|..||.|..|:.|. |.......|..|.|||||:|||..||:|: ||
Zfish   668 ARW----VEKCTCPQGYLGQHCEQCDQGFRRSRPELRRFSTCERCNCNGHSDTCDPETGMCN-CQ 727

  Fly  1830 HGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHC-ECKPGYTG 1893
            |.|.|..||||..|:||::|.|:..||..|.||.       ..:|.:....:::.| .|..|.||
Zfish   728 HNTAGLSCERCKDGFYGDSTVGSSSDCKACPCPA-------GATCAVVPKTNEVVCTNCPTGTTG 785

  Fly  1894 PRCESCANGFYGEPESIGQ-----VCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLC 1953
            .|||.|.:||:|:|  :|:     .|:.|.|:.||.|...|:|:..:||||:|:.||.|..|:.|
Zfish   786 KRCELCDDGFFGDP--LGEKGPVRACRACSCNNNIEPNAVGNCNRESGECLKCIYNTAGVFCDRC 848

  Fly  1954 APGFYGDAIKLKN----CQSCDCDDLGT---QT-CDPFVGVCTCHENVIGDRCDRCKPDHYGFES 2010
            ..|||||| :..|    |:.|.|...||   || |....|.|.|..:||...|..|:...|..:|
Zfish   849 KQGFYGDA-RAANVADKCKPCKCSPYGTVDRQTACSQVTGQCPCLPHVINRDCGACELGFYNLQS 912

  Fly  2011 GVGCRACDCG-AASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGF 2074
            |.||..|:|. ..|.:.|||..:|.|.|:.||||:.|:||.|:.:.:...||.||:|:...|...
Zfish   913 GKGCERCNCNPIGSTNGQCDIVSGQCECQPGVTGQHCERCEVNFFGFSSSGCKPCDCDPEGSESA 977

  Fly  2075 GCNPNTGKCQCLPGVIGDRCDACPNRWVLIKD-EGCQECNNCHHALLDVTDRMRYQIDSVLEDFN 2138
            .|..: |:|.|.||.:|.|||.|...:...:. .|||:|.||:..:.|..::.|           
Zfish   978 QCKED-GRCHCRPGFVGSRCDMCEENYFYNRSTPGCQQCPNCYSLVRDKVNQQR----------- 1030

  Fly  2139 SVTLAFFTSQKLNYYDQLADEL------------EPKVKLLDPNSVDLSPSKKANSELESDAKSY 2191
                     |||.....|.|.|            |.::|..:...:||....:|:.|::......
Zfish  1031 ---------QKLLDLQNLIDSLDNTETTVSDKAFEDRLKEAEKTIMDLLEEAQASKEVDKGLLDR 1086

  Fly  2192 AKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAAL 2256
            ...:|:||.|.::       .|.||....|.....||:|:..:...|    ||...|..::|.|.
Zfish  1087 LNNINKTLNNQWN-------RLQNIKNTVDNTGAQADRARNRVRDAE----NLINTAREELDKAK 1140

  Fly  2257 EQAQHILGQINGTSIELTPNEQVL--EKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLE 2319
            |....:..:|..||.:  ||...|  |:||||.|:       .||....:..:..|..:.|....
Zfish  1141 EAISKVDIKIPTTSGD--PNNMTLLAEEARKLSEK-------HKADADQIEKIAKDANDTSTKAY 1196

  Fly  2320 DLFNWS-EASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGN--FLINGDLT-LN 2380
            ::...: :.....|:|::..|....:|.|.:|  .:.:|..:.....::|||  ..|..:|| |.
Zfish  1197 NMLKKALDGENKTSSDIDELNRKYLEAKDLAK--NLEKQAAKVHAEAEEAGNKALKIYANLTSLP 1259

  Fly  2381 QINQKLDNLRDALN----ELNSFNKNVD----EELPVRED---QHKEADALTD--QAEQKAAELA 2432
            .||.|  .|.|..|    |.:..:|.:|    |...:|||   :..|...|.|  :.||:.|:..
Zfish  1260 PINTK--TLEDDANKIKKEASDLDKLIDKTEKEYNDLREDLRGKETEVRKLLDKGKTEQQTADQL 1322

  Fly  2433 IKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKL-------------SQDA------IS 2478
            :...|.|      .|.||.|.|...  |...||.:....|             ::||      |:
Zfish  1323 LARADAA------KALAEEAAKKGK--STFQEAQDILNNLRDFDKRVNDNKTAAEDAMRRIPQIN 1379

  Fly  2479 AAGN-ATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEH 2542
            |..| |.|||...|.....|...:.|...:|.:: :|:.:|           |||.||...|...
Zfish  1380 ATINEANDKTRRAEAALGNAAADAKDAKAKAEEA-EKIAND-----------VQKGSAKTKADAE 1432

  Fly  2543 QL--------KDINKLIDQL----------PAESQRDMWKNSNA--NASDA-----------LEI 2576
            :.        ||::|::|||          .||:..||...|.|  ||.||           .|:
Zfish  1433 KAFEDTMKLDKDVDKMMDQLTAAEKELEKKKAEADTDMMMASMASDNAKDAEGNARKAKSAVREV 1497

  Fly  2577 LKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDV--SQANKQLDDVEGSVSKLSELAEDIEEQ 2639
            |..:..:|..:......:|.|.:.|:..|    ||.  ..|..:||      .||.||.:..:.|
Zfish  1498 LNTINALLGQLGNIDKVDLSKLNQIDNAL----KDAKDKMAGSELD------RKLKELNDIAKSQ 1552

  Fly  2640 QHRVGSQSRQLGQEIENLKAQVEAARQLANSIKVGVNFKPS 2680
            :..:....||    |:.::|.:.....:.|::..|....||
Zfish  1553 EDMISDYDRQ----IQEIRADIANLNDIKNTLPEGCFNTPS 1589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 77/257 (30%)
EGF_Lam 272..>314 CDD:238012 21/41 (51%)
EGF_Lam 332..389 CDD:238012 25/56 (45%)
EGF_Lam 402..443 CDD:238012 0/40 (0%)
EGF_Lam 448..491 CDD:238012 5/42 (12%)
Laminin_EGF 495..543 CDD:278482 5/47 (11%)
Laminin_EGF 541..589 CDD:278482 16/49 (33%)
Laminin_EGF 587..634 CDD:278482 6/46 (13%)
EGF_Lam 631..673 CDD:238012 11/41 (27%)
Laminin_EGF 677..729 CDD:278482 4/51 (8%)
Laminin_EGF 732..782 CDD:278482 11/49 (22%)
EGF_Lam 785..828 CDD:238012 0/42 (0%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 15/134 (11%)
Laminin_EGF 1375..1423 CDD:278482 0/47 (0%)
EGF_Lam 1420..1457 CDD:238012 0/36 (0%)
Laminin_EGF 1466..1516 CDD:278482 5/49 (10%)
Laminin_EGF 1514..1562 CDD:278482 3/47 (6%)
LamB 1632..1760 CDD:214597 18/127 (14%)
Laminin_EGF <1775..1801 CDD:278482 12/26 (46%)
EGF_Lam 1808..1851 CDD:238012 25/42 (60%)
EGF_Lam 1859..1907 CDD:214543 16/48 (33%)
EGF_Lam 1916..1968 CDD:238012 24/55 (44%)
EGF_Lam 1969..2015 CDD:238012 18/49 (37%)
EGF_Lam 2016..>2054 CDD:238012 17/38 (45%)
EGF_Lam 2063..>2097 CDD:238012 14/33 (42%)
Laminin_I 2129..2385 CDD:283627 62/273 (23%)
Tar 2278..2662 CDD:223910 113/455 (25%)
Laminin_II 2566..2700 CDD:283628 31/130 (24%)
LamG 2674..2843 CDD:238058 3/7 (43%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamc1NP_775384.1 LamNT 30..268 CDD:214532 77/257 (30%)
EGF_Lam 269..314 CDD:238012 22/48 (46%)
Laminin_EGF 326..379 CDD:278482 30/158 (19%)
Laminin_EGF 382..429 CDD:278482 19/93 (20%)
Laminin_EGF 429..476 CDD:278482 21/141 (15%)
Laminin_B 537..662 CDD:295357 60/797 (8%)
EGF_Lam 707..749 CDD:238012 25/42 (60%)
Laminin_EGF 812..856 CDD:278482 21/43 (49%)
EGF_Lam 867..917 CDD:238012 18/49 (37%)
EGF_Lam 919..964 CDD:214543 17/44 (39%)
Laminin_EGF 967..1013 CDD:278482 15/46 (33%)
Domain II and I. /evidence=ECO:0000250 1014..1593 157/654 (24%)
SPEC 1033..1233 CDD:295325 50/221 (23%)
Taxilin 1035..1308 CDD:286771 71/296 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 65 1.000 Domainoid score I10039
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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