DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and lamb1a

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_775382.1 Gene:lamb1a / 286830 ZFINID:ZDB-GENE-021226-1 Length:1785 Species:Danio rerio


Alignment Length:2844 Identity:583/2844 - (20%)
Similarity:865/2844 - (30%) Gaps:1325/2844 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGR--KIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQ----VCD----YCD 80
            |...:|..||  ::.||:|||  ...||.:|.:            |.:|.:    |||    |.:
Zfish    33 PATGDLLIGRAQQLLATSTCG--VHKPEPFCIV------------SHLQEEKKCFVCDSRQAYNE 83

  Fly    81 PTVPERNHPPENAI-----DGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRP 140
            ......:|..||.:     :..:.||||   ..|::  .|.:.::.|.|||..:|.:.. .:.||
Zfish    84 TAHQVTSHSIENVVTTFAPNRLKTWWQS---ENGLE--NVTIQLDLEAEFHFTHLIMTF-KTFRP 142

  Fly   141 GLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPV 205
            ....:|:|.|:|.||..:::|:   .|||:.|...::.|:|:.|||||.|.||.|.|...||:..
Zfish   143 AAMVIERSADFGNTWQVYRYFA---YDCESSFPSVSHGPMTKVDDVICDTRYSDIEPSTEGEVIF 204

  Fly   206 MLLN-----ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIK 265
            .:|:     |.|.|..      :|...:.||:|::..:...|..:|:....:   :..:|:|:|.
Zfish   205 RVLDPAFRIEDPYSPR------IQNMLKITNLRVKFTKLHTLGDNLLDSRIE---IKEKYYYAIY 260

  Fly   266 DISIGGRCMCNGHADTC-DVKDPKSPVRILA---CRCQHHTCGIQCNECCPGFEQKKWR----QN 322
            |:.:.|.|.|.|||..| .|......|..:.   |.|.|:|.|:.|..|...:....||    :|
Zfish   261 DMVVRGNCFCYGHASECAPVDGTGEAVEGMVHGHCMCNHNTIGLNCERCQDFYHDLPWRPAEGRN 325

  Fly   323 TNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYY 387
            |||    |:.|:|:.||:.|.:|..|.|...::       .||||.:|||||:|.||.:|||.::
Zfish   326 TNA----CKKCHCNHHSHSCHFDMAVYRASGNV-------SGGVCDDCQHNTMGHNCEQCKPFFH 379

  Fly   388 RPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNL 452
            :...|...:.::|.||.||                                              
Zfish   380 QHPEKDIRDPNICEPCNCD---------------------------------------------- 398

  Fly   453 NGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCL 517
                                                          .:||:..      |.|..:
Zfish   399 ----------------------------------------------PVGSLNG------GVCDPM 411

  Fly   518 TNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYP 582
            |:..                               ....||||.|:....|.|||||..|.|...
Zfish   412 TDVS-------------------------------LGLISGQCRCKPNVEGERCDQCKQGHYGLS 445

  Fly   583 D----CKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVS 643
            :    |:||.|::.|                               :.|...||..||..     
Zfish   446 EDPLGCQPCTCNALG-------------------------------TVPGGSPCDTDSGN----- 474

  Fly   644 CNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTG 708
                                                                    |.||..|||
Zfish   475 --------------------------------------------------------CYCKRLVTG 483

  Fly   709 RICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFD 773
            |.|::|.|.:|.|  ||                                               |
Zfish   484 RNCDQCLPQHWGL--SN-----------------------------------------------D 499

  Fly   774 LDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGS 838
            :|     ||:.|.||.||:..:.|..:||||:|...:.|..|.|..:..:|..|..:.||.|:..
Zfish   500 MD-----GCRPCDCDHGGAINNNCSPVSGQCQCREHMFGRRCDQVESGFYFIALDHYTYEAEEAK 559

  Fly   839 L-PSGTQVRYDYDEAAFPGFSSKGYV-----VFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAEN 897
            . |..|.|..::.:...|.::..|:|     .|.....|     |:..|..|.:::||       
Zfish   560 FGPGVTVVPRNHPQDRSPTWTGIGFVNVPEGAFLEFSID-----NIPYSMEYDLIIRY------- 612

  Fly   898 VTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLD 962
                                       |||                                   
Zfish   613 ---------------------------EPQ----------------------------------- 615

  Fly   963 YFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYT 1027
                ||..:                             .||......|.||..:|:..|      
Zfish   616 ----LPEQW-----------------------------EEVLMTVIRPRVITADSRCAN------ 641

  Fly  1028 DPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSE 1092
                                                          ..||            |..
Zfish   642 ----------------------------------------------TMPD------------DDN 648

  Fly  1093 TSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSID 1157
            ..|.|:|                                      |||:.::             
Zfish   649 QMVSLHP--------------------------------------GSRYVVL------------- 662

  Fly  1158 YINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEAT 1222
               |.|||                      ||......:..:...|::|.               
Zfish   663 ---PRPVC----------------------FEEGLNYTVRLSLSLYSALS--------------- 687

  Fly  1223 IVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCP-----SSSGCRG- 1281
                   |...|                    |||      .|....:.||.     |.||..| 
Zfish   688 -------DVQSP--------------------YTL------IDSIVLMPHCKNLDIFSGSGTEGG 719

  Fly  1282 --VIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGH 1344
              |...|.|       .|:.....:.||:|     |..|:                         
Zfish   720 NLVTNSAWE-------NFQRYRCLENSQAV-----VKTPM------------------------- 747

  Fly  1345 DHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACR 1409
                     :|.|:..:||::|..:.|...|.||..||.|..|.|.||||||:|||:.|.     
Zfish   748 ---------TDICRNYIFSVSALLHQGVKACQCDPQGSLSTVCDPSGGQCQCRPNVVGRN----- 798

  Fly  1410 SRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIA 1474
                                                 |::|||.|:.|... ||..|.|:|.|  
Zfish   799 -------------------------------------CDRCAPATFLFXPQ-GCRPCDCSPEG-- 823

  Fly  1475 NGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNV 1539
            :.:|.|....|.|||.....||.||.|..||:.||:|.                           
Zfish   824 SVHSYCHEATGQCECIAGAYGRQCDRCLPGYWGFPNCR--------------------------- 861

  Fly  1540 VGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKF 1604
                                                                             
Zfish   862 ----------------------------------------------------------------- 861

  Fly  1605 DMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFD 1669
                                                                             
Zfish   862 ----------------------------------------------------------------- 861

  Fly  1670 GKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKV 1734
                                                                             
Zfish   862 ----------------------------------------------------------------- 861

  Fly  1735 IFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRDPS 1799
                                                                             
Zfish   862 ----------------------------------------------------------------- 861

  Fly  1800 GPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACP-L 1863
                    ||.||||:|.||..||.|..|:..|.|.:||||:.||||:...|:...|..|.|| .
Zfish   862 --------PCTCNGHAEQCDPQTGQCLSCRDHTTGHNCERCLGGYYGDPVLGSGDHCRPCMCPDG 918

  Fly  1864 PFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSGNINPEDQ 1928
            |.....|:.:|..|....|:.|.|..||.|.|||.||.|:||.|..:|..|:||:|:.||:..|.
Zfish   919 PGSGRQFSGACYKSPDSSQVFCVCNQGYKGARCEECAPGYYGNPHEVGGECRPCQCNSNIDMMDP 983

  Fly  1929 GSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQ----------TCDPF 1983
            .|||.|||.|::||.:|.|.:||.|..|:||:|: .::|:.|.|:.:||.          .||..
Zfish   984 ESCDARTGACVKCLYHTEGESCNRCRLGYYGNAL-TQSCRKCVCNQMGTVEEMCPSPGNCNCDLT 1047

  Fly  1984 VGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGA-ASNSTQCDPHTGHCACKSGVTGRQCD 2047
            .|.|.|..||:|..||:|.||.:...||.||..|||.. .|..:.|:...|.|:||.|..||.|.
Zfish  1048 SGQCLCLPNVVGQHCDQCAPDTWNMASGKGCEDCDCDPNHSFGSSCNEIMGQCSCKPGFGGRTCR 1112

  Fly  2048 RCAVDHWKYEKDGCTPCNCNQGYSRGFG---CNPNTGKCQCLPGVIGDRCDACPNRWVLIKDEG- 2108
            .|....|...:..|..|:|:   .||..   ||..||.|.|:.||.|.|||.|...:.     | 
Zfish  1113 ECRELFWGNPEVKCHACDCD---PRGIAEQQCNKVTGHCVCVEGVSGPRCDTCARGYT-----GE 1169

  Fly  2109 ---CQECNNCH--------------HALLDVTDRMR-------YQ--IDSVLEDFNSVTLAFFTS 2147
               |:.|:.|.              |.|:...:.::       ||  |::|....||:......:
Zfish  1170 FPQCERCHQCFAEWDIIVGDLTNQTHRLVQKVNTIKATGITGPYQATINNVENSANSIRNILAQN 1234

  Fly  2148 QKLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELESD----------AKSYAKQVNQTLANA 2202
            .......::...||....|:...:.:|:.:::..||:.||          .|..|:::.||:.  
Zfish  1235 PATQPLTEIQGLLEQATALMAEMNSNLNLTEETLSEISSDNNSTDTKLKSLKEEAQKLEQTVK-- 1297

  Fly  2203 FDIRERSSTTLGNITVAYDEAVKSAD--QAKEAIASVEALSKNLE--AAASTKIDAALEQAQHIL 2263
             |:||:.            |.||::|  .|:.::......|:|.|  |.|||.....|       
Zfish  1298 -DLREQV------------EFVKNSDIRGARASVTRYYEQSQNAEIRANASTTDPYNL------- 1342

  Fly  2264 GQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLE--DLFNWSE 2326
              :|.::...|..|:::.:.:   ||.|      :.|::....|.|..|:    ||  ||...||
Zfish  1343 --VNQSATLRTETEELMNQTK---EEFN------QRQDEFSKKLDNLAGQ----LETLDLSELSE 1392

  Fly  2327 ASQAKSADVERRNVAN---------------------------------QKAFDNSKFD------ 2352
            .:....|..|  |.|:                                 |||.|   ||      
Zfish  1393 KTCGSPAGSE--NCADSRCGGLSCVDMQGSRKCGGEGCDGLTTLAHNAWQKAKD---FDLEIISA 1452

  Fly  2353 ---------TVSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSF--------- 2399
                     .|||.|::|::...:|...|...:.|..:::...:.||..:.::..|         
Zfish  1453 MEEVDKLSKMVSEAKVKADEAKLNAQEVLAKTNETKKRVDSSNEELRQLIKQIRDFLTQDGADLE 1517

  Fly  2400 ------NKNVDEELP--------VREDQHKEADALTDQAE---QKAAELAIKAQDLAAQYTDMTA 2447
                  |:.:..::|        :.|:..:...:|||..:   |.||:: ::|:.|..|      
Zfish  1518 SIEAVANEVLQMQMPTTPAQLQNLTEEIRERVGSLTDVEDILNQSAADI-LRAESLLEQ------ 1575

  Fly  2448 SAEPAIKAATAYSGIVEAVE------------AAQKLSQDAISAAGNATDKTDGIEERAHLADTG 2500
             |..|.|.|:......|.|:            .|:.|.|.|:...| ..|....:|     ::|.
Zfish  1576 -ARKARKEASDVKSTAEMVKEALQHAERAQNSVAEALKQAAVDIKG-TQDLLVSVE-----SETS 1633

  Fly  2501 STDL-LQRARQSLQKVQDDL----EPRLNASAGKVQKISAVNNATEHQLKDINKLIDQLP----- 2555
            .::| |..|.:.|.|::.|:    |..||.|      |||  |:||.:.:.||.|.:||.     
Zfish  1634 DSELKLSNATRRLLKLESDVALLKEKALNTS------ISA--NSTEKEAESINALAEQLKKDLDS 1690

  Fly  2556 --------------------------AESQRDMWKNSNANASDALEILKNVLEILEPVSVQTPKE 2594
                                      ||..::..:|....||:.|::|||               
Zfish  1691 ELKDKYSTVEELITQKAEGVAEAKKRAEKLQEEARNLLLQASEKLQLLKN--------------- 1740

  Fly  2595 LEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRV 2643
            |||.:..|:.| |.:|    || :|.|:|.:|.:|      ::|..|:|
Zfish  1741 LEKNYDQNQKL-LEDK----AN-ELVDLEKAVKEL------LQEISHKV 1777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 73/264 (28%)
EGF_Lam 272..>314 CDD:238012 15/45 (33%)
EGF_Lam 332..389 CDD:238012 23/56 (41%)
EGF_Lam 402..443 CDD:238012 4/40 (10%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 5/47 (11%)
Laminin_EGF 541..589 CDD:278482 16/51 (31%)
Laminin_EGF 587..634 CDD:278482 6/46 (13%)
EGF_Lam 631..673 CDD:238012 4/41 (10%)
Laminin_EGF 677..729 CDD:278482 14/51 (27%)
Laminin_EGF 732..782 CDD:278482 2/49 (4%)
EGF_Lam 785..828 CDD:238012 15/42 (36%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 19/140 (14%)
Laminin_EGF 1375..1423 CDD:278482 18/47 (38%)
EGF_Lam 1420..1457 CDD:238012 5/36 (14%)
Laminin_EGF 1466..1516 CDD:278482 20/49 (41%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 0/127 (0%)
Laminin_EGF <1775..1801 CDD:278482 0/25 (0%)
EGF_Lam 1808..1851 CDD:238012 23/42 (55%)
EGF_Lam 1859..1907 CDD:214543 21/48 (44%)
EGF_Lam 1916..1968 CDD:238012 24/51 (47%)
EGF_Lam 1969..2015 CDD:238012 20/55 (36%)
EGF_Lam 2016..>2054 CDD:238012 14/38 (37%)
EGF_Lam 2063..>2097 CDD:238012 16/36 (44%)
Laminin_I 2129..2385 CDD:283627 67/321 (21%)
Tar 2278..2662 CDD:223910 107/490 (22%)
Laminin_II 2566..2700 CDD:283628 23/78 (29%)
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamb1aNP_775382.1 Laminin_N 40..266 CDD:278484 71/257 (28%)
EGF_Lam 268..320 CDD:238012 16/51 (31%)
Laminin_EGF <353..382 CDD:278482 15/35 (43%)
EGF_Lam 394..452 CDD:238012 22/186 (12%)
EGF_Lam 453..504 CDD:238012 26/196 (13%)
EGF_Lam 505..548 CDD:238012 15/42 (36%)
CBM6-CBM35-CBM36_like 552..>612 CDD:301364 14/64 (22%)
EGF_Lam 769..814 CDD:214543 24/87 (28%)
Laminin_EGF 817..865 CDD:278482 22/344 (6%)
EGF_Lam 862..907 CDD:238012 24/44 (55%)
Laminin_EGF <934..969 CDD:278482 16/34 (47%)
Laminin_EGF 972..1018 CDD:278482 23/46 (50%)
Laminin_EGF 1024..1078 CDD:278482 19/53 (36%)
Laminin_EGF 1081..1129 CDD:278482 16/47 (34%)
Laminin_EGF 1129..>1168 CDD:278482 17/46 (37%)
Apolipoprotein 1246..1393 CDD:279749 43/183 (23%)
SynN 1256..>1374 CDD:294095 32/150 (21%)
COG1340 1441..1730 CDD:224259 66/313 (21%)
MCP_signal 1448..1630 CDD:304920 36/195 (18%)
NusB_Sun 1530..>1611 CDD:294154 18/88 (20%)
Uso1_p115_C 1672..1774 CDD:282695 29/128 (23%)
IncA <1697..>1774 CDD:282066 24/103 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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