DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanA and Agrn

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:XP_017448655.1 Gene:Agrn / 25592 RGDID:2067 Length:2066 Species:Rattus norvegicus


Alignment Length:2522 Identity:479/2522 - (18%)
Similarity:731/2522 - (28%) Gaps:999/2522 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1353 ASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPD 1417
            ||..|||:....|.     |..|..| |.:.|.||.....||..:..:.....|.|.||    ..
  Rat   195 ASCVCKKNACPATV-----APVCGSD-ASTYSNECELQRAQCNQQRRIRLLRQGPCGSR----DP 249

  Fly  1418 CKPCKCPNSAMCEPT----TGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNS 1478
            |....|...:.|.|:    |..|:||....|      ||           :...|...|: :..|
  Rat   250 CANVTCSFGSTCVPSADGQTASCLCPTTCFG------AP-----------DGTVCGSDGV-DYPS 296

  Fly  1479 QCDLFNGTCECRQNIEGR---ACDVCSNGYFNFPH-C---------------EQCSCHKPGTELE 1524
            :|.|.:..|..:::|..:   .||.|.....:..| |               |.|    |.....
  Rat   297 ECQLLSHACASQEHIFKKFNGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENC----PAQHTP 357

  Fly  1525 VCDKIDGACF---CKKNVVGR------------DC---DQCVDGTYNLQESNPDGCT-TCFCFGK 1570
            :|.. ||..:   |..:.:|.            .|   |||           |:.|. ...|..:
  Rat   358 ICGD-DGVTYENDCVMSRIGATRGLLLQKVRSGQCQTRDQC-----------PETCQFNSVCLSR 410

  Fly  1571 TSR---------CDSAYLRV-------YNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNET 1619
            ..|         ||.:|..|       ||                    .|.|...|:       
  Rat   411 RGRPHCSCDRVTCDGSYRPVCAQDGHTYN--------------------NDCWRQQAE------- 448

  Fly  1620 TLKADFTLREVNDERPAYFGVLDYLLNQNNHIS-AYGGDLAYTLHFTSGFDGKYIVAPDVILFSE 1683
                   .|:.....|.:.|..|...:..:.:. |:|......       :||            
  Rat   449 -------CRQQRAIPPKHQGPCDQTPSPCHGVQCAFGAVCTVK-------NGK------------ 487

  Fly  1684 HNALVHTSYEQPSRNEPFTNRVNIVESNFQTI-SG--KPVSRADFMMVLRDLKVIFIRANYWEQT 1745
                                    .|...|.: ||  .||..:|             ...|..  
  Rat   488 ------------------------AECECQRVCSGIYDPVCGSD-------------GVTYGS-- 513

  Fly  1746 LVTHLSDVYLTLADE-------DADGTGEYQF-----LAVERCSCPP----------GYSGHSCE 1788
             |..|..:..||..|       ..|..|:.:|     :...||.||.          |..||:  
  Rat   514 -VCELESMACTLGREIQVARRGPCDPCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHT-- 575

  Fly  1789 DCAPGYYRDPSGPYGGYCIPCECN---------------GHSETCD---------CATG--ICSK 1827
                            |...||.:               ||.:||.         |:.|  :|.:
  Rat   576 ----------------YASECELHVHACTHQISLYVASAGHCQTCGEKVCTFGAVCSAGQCVCPR 624

  Fly  1828 CQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHCECKPGYT 1892
            |:|...|..|             |:             |...:.::||:.|:..|...:.:..:.
  Rat   625 CEHPPPGPVC-------------GS-------------DGVTYLSACELREAACQQQVQIEEAHA 663

  Fly  1893 GPRCE--SCANGFYGEPESIGQVCKP--CECSGNINPEDQGS----CDTRTGECLR---CLNN-- 1944
            || ||  .|.:|..|..|.  ..|:.  |...|.|..||...    ||.......|   |.::  
  Rat   664 GP-CEPAECGSGGSGSGED--DECEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPRSPVCGSDGV 725

  Fly  1945 TFGAACNL----------------------------------CAPGFYG---------DAIKLKN 1966
            |:|..|:|                                  ||...||         ..:.|..
  Rat   726 TYGTECDLKKARCESQQELYVAAQGACRGPTLAPLLPVAFPHCAQTPYGCCQDNFTAAQGVGLAG 790

  Fly  1967 CQS-CDCDDLGTQ--TCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGV-----GCRACDC---G 2020
            |.| |.|:..|:.  ||||..|.|:|...|.|.|||||:|..:.|...|     ||..|.|   |
  Rat   791 CPSTCHCNPHGSYSGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRG 855

  Fly  2021 AASNSTQCDPHTGHCACKSGVTGRQCDRC----AVDHWKYEKDGCTPCNCNQGYSR-GFGCNPNT 2080
            |..:  .|:..||.|:|:.||.|.:|.:|    .:.|...|.|..||..|.:.:.. |..|....
  Rat   856 AVRD--DCEQMTGLCSCRPGVAGPKCGQCPDGQVLGHLGCEADPMTPVTCVEIHCEFGASCVEKA 918

  Fly  2081 GKCQCLPGVIGDRCDACP--NRWVLIKDEGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTL- 2142
            |..||:...:     .||  |...:...:|....|.|....:....|:.....|:.....|||. 
  Rat   919 GFAQCICPTL-----TCPEANSTKVCGSDGVTYGNECQLKAIACRQRLDISTQSLGPCQESVTPG 978

  Fly  2143 AFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRE 2207
            |..||..:.....:..:..|    ...||:.|||....:........|....|:...:.|:.:  
  Rat   979 ASPTSASMTTPRHILSKTLP----FPHNSLPLSPGSTTHDWPTPLPISPHTTVSIPRSTAWPV-- 1037

  Fly  2208 RSSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHILGQINGT-SI 2271
                    :||          ....|.:.|.:|:.::.:.:               |..||: ..
  Rat  1038 --------LTV----------PPTAAASDVTSLATSIFSES---------------GSANGSGDE 1069

  Fly  2272 ELTPNEQV-------LEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLEDLFNWSEASQ 2329
            ||:.:|:.       ||      ..|.::|:......:..:...:.:|..||           .:
  Rat  1070 ELSGDEEASGGGSGGLE------PPVGSIVVTHGPPIERASCYNSPLGCCSD-----------GK 1117

  Fly  2330 AKSADVERRNVANQKAFDN-SKFDTVSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDAL 2393
            ..|.|.|..|....|||.. .:.:.|..|:|.....:.|..:.|. |: |...|...||:|    
  Rat  1118 TPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELF-GE-TARSIESTLDDL---- 1176

  Fly  2394 NELNSFNKNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAATA 2458
                                .:.:|...|....:..||.  ...|.....|:......|.:|:..
  Rat  1177 --------------------FRNSDVKKDFWSVRLRELG--PGKLVRAIVDVHFDPTTAFQASDV 1219

  Fly  2459 YSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLAD------------TGSTDLLQRARQS 2511
            ...::..::.::..          |......::|.....|            ||:|..:..||.:
  Rat  1220 GQALLRQIQVSRPW----------ALAVRRPLQEHVRFLDFDWFPTFFTGAATGTTAAMATARAT 1274

  Fly  2512 LQKVQDDLEPRLNASAGKVQKISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEI 2576
                                                  .:.:|||.|.......|:.:       
  Rat  1275 --------------------------------------TVSRLPASSVTPRVYPSHTS------- 1294

  Fly  2577 LKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKD------VSQANKQLDDVEGSVSKLSELAED 2635
             :.|.....|.:.:.|           ....||.|      ..|.:|..|.              
  Rat  1295 -RPVGRTTAPPTTRRP-----------PTTATNMDRPRTPGHQQPSKSCDS-------------- 1333

  Fly  2636 IEEQQHRVGSQSRQLGQEIENLKAQVEAARQLANSIKVGVN------FKPSTILELKTPEKTKLL 2694
             :...|....|.:..|   :.......|.|  ..|:...|.      ||..:.|...|     |.
  Rat  1334 -QPCLHGGTCQDQDSG---KGFTCSCTAGR--GGSVCEKVQPPSMPAFKGHSFLAFPT-----LR 1387

  Fly  2695 ATRT-NLSTYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGNGPERITSDKYV 2758
            |..| .|:..||..|..|.|||.||     .:..||:|:.:::|......|.|:||..:||...|
  Rat  1388 AYHTLRLALEFRALETEGLLLYNGN-----ARGKDFLALALLDGRVQFRFDTGSGPAVLTSLVPV 1447

  Fly  2759 ADGRWYQAVVDRMGPNAKLTIREELPNGDVVEHSKSGYLEGSQNILHVDKNSRLFVGGYP----- 2818
            ..|||::..:.|......|::..|.|   ||..|.|| .:|    |::|.|  |:|||.|     
  Rat  1448 EPGRWHRLELSRHWRQGTLSVDGETP---VVGESPSG-TDG----LNLDTN--LYVGGIPEEQVA 1502

  Fly  2819 --------GISDFNAPPDLTTNSFSGDIEDLKIGDESVGL--WNFVYGDDNDQG----------- 2862
                    |:            ...|.|..|.|.::.:.|  |.......:..|           
  Rat  1503 MVLDRTSVGV------------GLKGCIRMLDINNQQLELSDWQRAAVQSSGVGECGDHPCLPNP 1555

  Fly  2863 --------ARERDVLL-------------EKKKP------------------------------- 2875
                    |.|..:.|             ::|.|                               
  Rat  1556 CHGGALCQALEAGMFLCQCPPGRFGPTCADEKSPCQPNPCHGAAPCRVLSSGGAKCECPLGRSGT 1620

  Fly  2876 -------VTGLR-----FKGNGYVQLNA----TSNLKSRSSIQFSFKADKDTSNGLLFFYGRDK- 2923
                   ..|.|     |.|..|::|..    ..:|..:.:::..|.|  ...:|||.:.|:.. 
  Rat  1621 FCQTVLETAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLA--RGPSGLLLYNGQKTD 1683

  Fly  2924 ---HYMSIEMIDGAIFFNISLGEGGGVQSGSQDRYNDNQWHKVQAERENRNGLLKVDDIVISRTN 2985
               .::|:.:.:..:.|...||:|..| ..|::......|.:|..||..|.|.|:|.|       
  Rat  1684 GKGDFVSLALHNRHLEFCYDLGKGAAV-IRSKEPIALGTWVRVFLERNGRKGALQVGD------- 1740

  Fly  2986 APLEADLELPKLRR-----------LYFGGHPRRLNTSISLQPNFDGCIDNVVINQGVVDLTEYV 3039
            .|.... |.||.|:           ||.||.|                           |.::..
  Rat  1741 GPRVLG-ESPKSRKVPHTMLNLKEPLYIGGAP---------------------------DFSKLA 1777

  Fly  3040 TGGGVEEGCSAKFSTVVSYAPHEYGFLRMNNVSSDNNLHVVLHFKTTQPNGVLFYAANHDQSSTI 3104
            .|..|..|.                                                        
  Rat  1778 RGAAVSSGF-------------------------------------------------------- 1786

  Fly  3105 GLSLQDGLLKLNSM-GSQLVIDDRILNDGE-----DHVVTVQHTQGELRLTVDDVDNKRLGSPQP 3163
                 :|:::|.|: |.||:..:.:|...:     ||..|                 :.||:|  
  Rat  1787 -----NGVIQLVSLRGHQLLTQEHVLRAVDVSPFADHPCT-----------------QALGNP-- 1827

  Fly  3164 LILEGGDIFFAGLPDNYRTPRNALASLAYFVGC---ISDVTVNEEIINFANSAEKKNGNINGCPP 3225
             .|.||..          .||.|    .|...|   .|.:...:.::      ||..|::     
  Rat  1828 -CLNGGSC----------VPREA----TYECLCPGGFSGLHCEKGLV------EKSVGDL----- 1866

  Fly  3226 HVLAYEPSLVPSYYPSGDNEVESPWSNADTLPPLKPDIESTLPPTTPTTTTTTTTTTTSTTTTST 3290
            ..||::......|                    |...|||.|                       
  Rat  1867 ETLAFDGRTYIEY--------------------LNAVIESEL----------------------- 1888

  Fly  3291 TTTTTTPSPIVIDEEKEIEAKTPQKILTTRPPAKLNLPSDERCKLPEQPNFDVDFTEAGYRFYGL 3355
              |...|:|..:|......                                              
  Rat  1889 --TNEIPAPETLDSRALFS---------------------------------------------- 1905

  Fly  3356 REQRLQINSLPVKVRRHHDIGISFRTERPNGLLIYAG-SKQRDDFIAVYLLDGRVTYEIRVGAQL 3419
             |:.||.|        |.:  :|.|||...||:::.| :.:|.|::|:.::||.:.....:|:| 
  Rat  1906 -EKALQSN--------HFE--LSLRTEATQGLVLWIGKAAERADYMALAIVDGHLQLSYDLGSQ- 1958

  Fly  3420 QAKITTEAELNDGTWHTVEVVRTQRKVSLLIDKLEQP--GSVDLNAERSAPVLAVELPIYLGGVN 3482
            ...:.:..::|...|..:...|..|:.||.:.. |.|  ||..|.|.:    |..:..::|||:.
  Rat  1959 PVVLRSTVKVNTNRWLRIRAHREHREGSLQVGN-EAPVTGSSPLGATQ----LDTDGALWLGGLQ 2018

  Fly  3483 KFLESEVKNLTDFKTEVPYFNGCLKNIKFDAMDLE------TPPEEFGVVPC 3528
            |....:...    |.....|.|||:::......|.      |.||   :.||
  Rat  2019 KLPVGQALP----KAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPE---LRPC 2063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
EGF_Lam 448..491 CDD:238012
Laminin_EGF 495..543 CDD:278482
Laminin_EGF 541..589 CDD:278482
Laminin_EGF 587..634 CDD:278482
EGF_Lam 631..673 CDD:238012
Laminin_EGF 677..729 CDD:278482
Laminin_EGF 732..782 CDD:278482
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:278482 13/47 (28%)
EGF_Lam 1420..1457 CDD:238012 10/40 (25%)
Laminin_EGF 1466..1516 CDD:278482 14/68 (21%)
Laminin_EGF 1514..1562 CDD:278482 12/65 (18%)
LamB 1632..1760 CDD:214597 19/131 (15%)
Laminin_EGF <1775..1801 CDD:278482 7/35 (20%)
EGF_Lam 1808..1851 CDD:238012 13/68 (19%)
EGF_Lam 1859..1907 CDD:214543 12/49 (24%)
EGF_Lam 1916..1968 CDD:238012 18/105 (17%)
EGF_Lam 1969..2015 CDD:238012 22/53 (42%)
EGF_Lam 2016..>2054 CDD:238012 14/44 (32%)
EGF_Lam 2063..>2097 CDD:238012 7/34 (21%)
Laminin_I 2129..2385 CDD:283627 49/265 (18%)
Tar 2278..2662 CDD:223910 58/409 (14%)
Laminin_II 2566..2700 CDD:283628 24/146 (16%)
LamG 2674..2843 CDD:238058 54/188 (29%)
LamG 2878..3029 CDD:238058 39/174 (22%)
LamG 3078..3205 CDD:214598 22/135 (16%)
LamG 3349..3512 CDD:238058 41/165 (25%)
LamG 3535..3689 CDD:238058
AgrnXP_017448655.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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