DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and Lamb2

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_037106.1 Gene:Lamb2 / 25473 RGDID:2988 Length:1801 Species:Rattus norvegicus


Alignment Length:2879 Identity:561/2879 - (19%)
Similarity:836/2879 - (29%) Gaps:1327/2879 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 IGALLVILAISYCQ-----------AELTPPYFNLATGR--KIYATATCGQDTDGPELYCKLVGA 59
            :|.||.:||.:..|           ....|...:|..||  ::.|::|||  ...|:.||.:...
  Rat    23 LGLLLSVLAATLAQVPSLDVPGCSRGSCYPATGDLLVGRADRLTASSTCG--LHSPQPYCIVSHL 85

  Fly    60 NTEHDHIDYSVIQGQVCDYCDPTVP--ERNHPPENAIDGT---------EAWWQSPPLSRGMKFN 113
            ..|           :.|..||...|  .|::|..:.|...         .|||||   ..|:.. 
  Rat    86 QDE-----------KKCFLCDSRRPFSARDNPNSHRIQNVVTSFAPQRRTAWWQS---ENGVPM- 135

  Fly   114 EVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYK 178
             |.:.::.|.|||..:|.:.. .:.||....:|:|.|:|:||..:::||   .||...|......
  Rat   136 -VTIQLDLEAEFHFTHLIMTF-KTFRPAAMLVERSADFGRTWRVYRYFS---YDCGADFPGIPLA 195

  Fly   179 PITRDDDVICTTEYSKIVPLENGEIPVMLLNER-PSSTNYFNSTVLQEWTRATNVRIRLLRTKNL 242
            |..|.|||:|.:.||:|.|...||:...:|:.. |....|  |:.:|...:.||:|:.|.|...|
  Rat   196 PPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPY--SSRIQNLLKITNLRVNLTRLHTL 258

  Fly   243 LGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRIL-----ACRCQHHT 302
            ..:|:...|:   :..:|:|::.::.|.|.|.|.|||..| ...|.:|....     ||.|:|:|
  Rat   259 GDNLLDPRRE---IREKYYYALYELVIRGNCFCYGHASQC-APAPGAPAHAEGMVHGACICKHNT 319

  Fly   303 CGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVC 367
            .|:.|.:|...::...|....:.....|..|.|:|||:.|.:|       :::.:......||||
  Rat   320 RGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHSHSCHFD-------MAVYLASGNVSGGVC 377

  Fly   368 QNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSC 432
            ..|||||.|.:|..|:|.:||...|     |:..|..                            
  Rat   378 DGCQHNTAGRHCELCRPFFYRDPTK-----DMRDPAA---------------------------- 409

  Fly   433 DSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACEC 497
                                                                             
  Rat   410 ----------------------------------------------------------------- 409

  Fly   498 NKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCIC 562
                                                                             
  Rat   410 ----------------------------------------------------------------- 409

  Fly   563 REGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYP 627
                                                                             
  Rat   410 ----------------------------------------------------------------- 409

  Fly   628 DCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPA-GVIDKFAGC 691
             |.||.||..|||                ||.:|||              :.||. |::.     
  Rat   410 -CRPCDCDPMGSQ----------------DGGRCDS--------------HDDPVLGLVS----- 438

  Fly   692 GSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCK 756
                 |: |:|||.|.|..|.:|:..::.|:.||..||:.|.|.:.||:.....|.|.||.|.||
  Rat   439 -----GQ-CRCKEHVVGTRCQQCRDGFFGLSASNPRGCQRCQCNSRGTVPGGTPCDSSSGTCFCK 497

  Fly   757 PHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTT 821
            ....|..|..|..|.:.| |..|.||:.|.|||||:....||:.:|||.|.|.:.|..|.|....
  Rat   498 RLVTGDGCDRCLPGHWGL-SHDLLGCRPCDCDVGGALDPQCDEATGQCPCRPHMIGRRCEQVQPG 561

  Fly   822 HFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSL--- 883
            :|.|.|....:|.|.........|.........|.::..|:|.....|     ||....:||   
  Rat   562 YFRPFLDHLTWEAEGAHGQVLEVVERLVTNRETPSWTGVGFVRLREGQ-----EVEFLVTSLPRA 621

  Fly   884 --YRIVLRYVNPNAENVTATISVTSDNP------------LEVDQHVKVLLQPTSEPQFVTVAGP 934
              |.::||: .|......|.:.:....|            |..|..::.:|.|.:.         
  Rat   622 MDYDLLLRW-EPQVPEQWAELELVVQRPGPVSAHSPCGHVLPRDDRIQGMLHPNTR--------- 676

  Fly   935 LGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYA 999
            :.|.|..:.|:||             |.|.:.|.                               
  Rat   677 VLVFPRPVCLEPG-------------LSYKLKLK------------------------------- 697

  Fly  1000 SVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYI 1064
                                                        |:|:....|  .:.|.||..|
  Rat   698 --------------------------------------------LTGTGGRAH--PETPYSGSGI 716

  Fly  1065 FVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPV 1129
            .:...:                                                       |||.
  Rat   717 LIDSLV-------------------------------------------------------LQPH 726

  Fly  1130 IISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETD--- 1191
            ::..::..|.                                          |:..:|..|.   
  Rat   727 VLMLEMFSGG------------------------------------------DAAALERRTTFER 749

  Fly  1192 ---HEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQV 1253
               ||:.:..:|.|.                                                  
  Rat   750 YRCHEEGLMPSKTPL-------------------------------------------------- 764

  Fly  1254 YYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVP 1318
                                  |..|                                     ||
  Rat   765 ----------------------SEAC-------------------------------------VP 770

  Fly  1319 LKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGST 1383
                   ||:                               |..||.  || |||||.||..||.
  Rat   771 -------LLI-------------------------------SASSLV--YN-GALPCQCDPQGSL 794

  Fly  1384 SFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCE 1448
            |.||:|.||||:|||.|:.|.|.||.:.||||...                              
  Rat   795 SSECNPHGGQCRCKPGVVGRRCDACATGYYGFGPA------------------------------ 829

  Fly  1449 KCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQ 1513
                         ||:.|.|:|.|..  ::.|:..:|.|.||....|..||.|..|.:.||:|. 
  Rat   830 -------------GCQACQCSPDGAL--SALCEGTSGQCLCRTGAFGLRCDHCQRGQWGFPNCR- 878

  Fly  1514 CSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAY 1578
                                                                             
  Rat   879 ----------------------------------------------------------------- 878

  Fly  1579 LRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDY 1643
                                                                             
  Rat   879 ----------------------------------------------------------------- 878

  Fly  1644 LLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIV 1708
                                                                             
  Rat   879 ----------------------------------------------------------------- 878

  Fly  1709 ESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAV 1773
                                                                             
  Rat   879 ----------------------------------------------------------------- 878

  Fly  1774 ERCSCPPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCE 1838
                                              ||.|||.::.||..||.|..|:..|.|:|||
  Rat   879 ----------------------------------PCVCNGRADECDAHTGACLGCRDYTGGEHCE 909

  Fly  1839 RCVSGYYGNATNGTPGDCMICACPL-PFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANG 1902
            ||::|::|:......|.|..|.||. |....:|||||.......||.|.|:.||||.|||:||.|
  Rat   910 RCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHRDGYSQQIVCHCRAGYTGLRCEACAPG 974

  Fly  1903 FYGEPESIGQVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNC 1967
            .:|:|...|..|:.|||||||:|.|.|:||..||:|||||::|.|..|..|.|||:|.|.: ::|
  Rat   975 HFGDPSKPGGRCQLCECSGNIDPTDPGACDPHTGQCLRCLHHTEGPHCGHCKPGFHGQAAR-QSC 1038

  Fly  1968 QSCDCDDLGTQT----------CDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDC-GA 2021
            ..|.|:.|||..          |||..|.|.|..:|.|..||||.|:.:.|.||.||:.|.| .:
  Rat  1039 HRCTCNLLGTDPQRCPSTDLCHCDPSTGQCPCLPHVQGLSCDRCAPNFWNFTSGRGCQPCACHPS 1103

  Fly  2022 ASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFG---CNPNTGKC 2083
            .:....|:..||.|.|.:|..||.|..|...||......|..|:|:   .||..   |:.:||.|
  Rat  1104 RARGPTCNEFTGQCHCHAGFGGRTCSECQELHWGDPGLQCRACDCD---PRGIDKPQCHRSTGHC 1165

  Fly  2084 QCLPGVIGDRCDACPNRWVLIKDEGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQ 2148
            .|.|||.|.|||.|...:..:    ...|:.||....|                           
  Rat  1166 SCRPGVSGVRCDQCARGFSGV----FPACHPCHACFGD--------------------------- 1199

  Fly  2149 KLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQT-LANAFDIRERSSTT 2212
                :|::..:|..:.:.|:                     .:|:::.|| :..||   |.|...
  Rat  1200 ----WDRVVQDLAARTRRLE---------------------QWAQELQQTGVLGAF---ESSFLN 1236

  Fly  2213 LGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNE 2277
            |               |.|..:......::|..||::.|:..|.|..:|.:|:   |:..||..|
  Rat  1237 L---------------QGKLGMVQAIVAARNTSAASTAKLVEATEGLRHEIGK---TTERLTQLE 1283

  Fly  2278 QVLEKARKLYEEVNTLVLPIKAQNKSLNALKND-------IGEFSDHLEDLFN------------ 2323
            ..|...:.  |..|.        |.:|:.|:.|       :.:...||:.|.:            
  Rat  1284 AELTDVQD--ENFNA--------NHALSGLERDGLALNLTLRQLDQHLDILKHSNFLGAYDSIRH 1338

  Fly  2324 -WSEASQAK----------------SADVERR---------------NVANQKAFDNSKFDT--- 2353
             .|::::|:                |||..||               ::|||:|.......|   
  Rat  1339 AHSQSTEAERRANASTFAIPSPVSNSADTRRRAEVLMGAQRENFNRQHLANQQALGRLSTHTHTL 1403

  Fly  2354 ----VSEQKLQA------------------EKNIKDAGNFLING-----DLTLNQINQKLDNLRD 2391
                |:|....|                  |......|....:|     ||.|.:.......|:.
  Rat  1404 SLTGVNELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGGLGCSGAAATADLALGRARHTQAELQR 1468

  Fly  2392 ALNELNSFNKNVDEELPVREDQHKEADALTD----------QAEQKAAELAIKAQD--------- 2437
            ||.|.......|.|.....|:..:.|.|..|          ||.|:..||....:|         
  Rat  1469 ALVEGGGILSRVSETRRQAEEAQQRAQAALDKANASRGQVEQANQELRELIQNVKDFLSQEGADP 1533

  Fly  2438 -----LAAQYTDMTASAEP------AIKAATAYSGIVEA----------VEAAQKLSQDA----- 2476
                 :|.:..|::..|.|      |.:.|.....:.:.          |..|::|.|||     
  Rat  1534 DSIEMVATRVLDISIPASPEQIQRLASEIAERVRSLADVDTILAHTMGDVRRAEQLLQDAQRARS 1598

  Fly  2477 -----------ISAAGNATDKTDGIEE---RAHLADTGSTDLLQRARQSLQKVQDDL---EPRLN 2524
                       :.||.....:..|..:   |..:.||.:|:      |:||:||:.:   |..||
  Rat  1599 RAEGERQKAETVQAALEEAQRAQGAAQGAIRGAVVDTKNTE------QTLQQVQERMAGTEQSLN 1657

  Fly  2525 ASAGKVQKISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPV-- 2587
            :::.:.:::.|:..|.:     :.:..:.|.|.:..:...::.:.|.:|.:.|:      |.|  
  Rat  1658 SASERARQLHALLEALK-----LKRAGNSLAASTAEETAGSAQSRAREAEKQLR------EQVGD 1711

  Fly  2588 SVQTPKEL--EKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQL 2650
            ..||.:.|  .||.|:........:...:|...|...:..:.:|.||....||.:..:..::.||
  Rat  1712 QYQTVRALAERKAEGVLAAQARAEQLRDEARGLLQAAQDKLQRLQELEGTYEENERELEVKAAQL 1776

  Fly  2651 GQEIENLKAQVEAARQLAN 2669
                :.|:|::.:..|..|
  Rat  1777 ----DGLEARMRSVLQAIN 1791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 73/277 (26%)
EGF_Lam 272..>314 CDD:238012 16/46 (35%)
EGF_Lam 332..389 CDD:238012 21/56 (38%)
EGF_Lam 402..443 CDD:238012 1/40 (3%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 0/47 (0%)
Laminin_EGF 541..589 CDD:278482 0/47 (0%)
Laminin_EGF 587..634 CDD:278482 3/46 (7%)
EGF_Lam 631..673 CDD:238012 12/41 (29%)
Laminin_EGF 677..729 CDD:278482 15/52 (29%)
Laminin_EGF 732..782 CDD:278482 18/49 (37%)
EGF_Lam 785..828 CDD:238012 18/42 (43%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 28/151 (19%)
Laminin_EGF 1375..1423 CDD:278482 25/47 (53%)
EGF_Lam 1420..1457 CDD:238012 0/36 (0%)
Laminin_EGF 1466..1516 CDD:278482 17/49 (35%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 0/127 (0%)
Laminin_EGF <1775..1801 CDD:278482 0/25 (0%)
EGF_Lam 1808..1851 CDD:238012 20/42 (48%)
EGF_Lam 1859..1907 CDD:214543 24/48 (50%)
EGF_Lam 1916..1968 CDD:238012 28/51 (55%)
EGF_Lam 1969..2015 CDD:238012 22/55 (40%)
EGF_Lam 2016..>2054 CDD:238012 12/38 (32%)
EGF_Lam 2063..>2097 CDD:238012 16/36 (44%)
Laminin_I 2129..2385 CDD:283627 56/337 (17%)
Tar 2278..2662 CDD:223910 100/530 (19%)
Laminin_II 2566..2700 CDD:283628 24/108 (22%)
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Lamb2NP_037106.1 Laminin_N 60..284 CDD:278484 70/250 (28%)
EGF_Lam 286..338 CDD:238012 17/52 (33%)
EGF_Lam 350..402 CDD:238012 22/58 (38%)
Laminin_EGF 413..470 CDD:278482 26/97 (27%)
EGF_Lam 472..523 CDD:238012 19/51 (37%)
EGF_Lam 524..565 CDD:238012 17/40 (43%)
EGF_Lam 786..831 CDD:214543 25/87 (29%)
Laminin_EGF 834..882 CDD:278482 19/344 (6%)
Laminin_EGF 880..927 CDD:278482 20/46 (43%)
EGF_Lam 929..987 CDD:238012 26/57 (46%)
Laminin_EGF 989..>1031 CDD:278482 26/41 (63%)
Laminin_EGF 1041..1095 CDD:278482 21/53 (40%)
Laminin_EGF 1098..1146 CDD:278482 15/47 (32%)
Laminin_EGF 1146..>1185 CDD:278482 17/41 (41%)
Domain II 1193..1412 52/301 (17%)
Domain alpha 1413..1445 3/31 (10%)
Domain I 1446..1801 75/367 (20%)
DUF4398 <1446..1516 CDD:291044 17/69 (25%)
flagell_FliJ 1477..1617 CDD:131526 26/139 (19%)
HrpJ 1485..1673 CDD:301626 38/193 (20%)
MscS_porin 1582..1776 CDD:289559 43/210 (20%)
ATP-synt_B <1684..1795 CDD:304375 25/118 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1684..1703 3/18 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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