DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanA and mcp3

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_594851.1	Gene:	mcp3 / 2543146	PomBaseID:	SPAC1006.04c	Length:	952	Species:	Schizosaccharomyces pombe

Alignment Length:	777	Identity:	160/777 - (20%)
Similarity:	292/777 - (37%)	Gaps:	176/777 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2111 ECNNCHHALLDVTDRM---RYQIDSVLEDFNSVTLAFFTS--QKLNYYDQLADELEPKVKLLDPN 2170
            :...||.  |:.|.:.   .|::..||:|..|....:..:  :::.|...|.:||:....:::..
pombe   198 QLRRCHS--LEKTWKFLFGDYELPDVLKDMESSNSDWSDTSLKRIAYLCSLVEELKLHSSIMNDK 260

  Fly  2171 SVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIA 2235
            .|.|  ..|.|:.||....|.|  ..|.|..:..|...:.....|.|::|:|.:..   |:.:|.
pombe   261 YVCL--VSKHNNALEDKFNSEA--ARQLLQKSLSIVASNLKQAENKTISYEEKLSI---AQNSIN 318

  Fly  2236 SVEALSKNLEAAA---STKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPI 2297
            .::..:::|:...   ..:|.|.||:.|.:              ::.||..:...:.:..:....
pombe   319 EIQTQNRDLKLETEKLQDQIKALLERNQSL--------------QEALETVKNDEKNLREMNANY 369

  Fly  2298 KAQNKSLNALKNDIGEFSDHLEDLFNWSEASQAKSADVER-----RNVANQKAFDNSKFDTVSEQ 2357
            :.:.|......|:......|.:|.|      :||...:.|     |..|....|.:|    ||||
pombe   370 ETEMKEARQKLNNKEALISHYDDDF------RAKELKISRLSESLREKAGLLEFQSS----VSEQ 424

  Fly  2358 K-----LQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFN-KNVDEELP-VREDQHK 2415
            :     .|.:.:|||..|.....:..:.::|:..:||     |:.|.. ..:|||:. ::::|..
pombe   425 RDLLYQEQIQSSIKDMENVFRKNEYLMEELNELKNNL-----EVESSKVLRLDEEMKCLKDEQLS 484

  Fly  2416 EAD---ALTDQAEQKAAELAI----------KAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVE 2467
            :.|   :|||:.:....:|..          ::..|.:|..|...:.|             :..:
pombe   485 QFDTVFSLTDERDGLQKDLKNTKGNLDDEIGRSAFLKSQIRDQELTIE-------------KLHD 536

  Fly  2468 AAQKLSQDAISAAGNATDKTDGI--------EERAHLADTGSTDLLQRARQSLQKVQDDLEPRLN 2524
            :.:.|||...|.....::|...:        |.||||             ::..|..:.|:.:|.
pombe   537 SLETLSQTNNSLQCEISEKNAELNSVNSKLSEGRAHL-------------ETANKENEILKQQLE 588

  Fly  2525 ASAGKVQKI----SAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILE 2585
            .|..|:..:    .:..|..|| |....:|::  |:.::.|   :|||..|...|.::..:.|..
pombe   589 LSESKLASLLNSYQSFINKKEH-LYSFLQLVE--PSFAKSD---SSNATESQISESVRKGISIFN 647

  Fly  2586 PVSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDV-EGSVSKLSEL-AEDIEEQQHRVGSQS- 2647
            .:.:.......:| |||....|.:.|....:.:|..: :..|.|..|. .::||.:.:::..||
pombe   648 LLFIVYKNVCSQA-GINPSTKLEDLDEHTLSDELTYITKKFVQKDQEYQTKEIELRNYKITLQSL 711

  Fly  2648 --------------------RQLGQEIEN----------LKAQVEAARQLANSIKVGVNFKPSTI 2682
                                .|||||.||          |......:..::|:.|:.:...||
pombe   712 LEDKLIGVNTDCRSPSCSDFEQLGQESENNTSISGRVSKLVKSFNDSSSISNNTKISITKSPS-- 774

  Fly  2683 LELKTPEKTKLLATRTNLSTYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGN 2747
                 .||..:....::::           |..:..:.|...:|.| |...:|.....|.|||.|
pombe   775 -----GEKVSVFKEMSDIA-----------LRDMDKNRKLLGENVD-VRNIVVQKDESLNIDLQN 822

  Fly  2748 G---PERITSDKYVAD----GRWYQAVVDRMGPNAKLTIREELPNGDV-VEHSKSGYLEGSQ 2801
            .   ||....:..|.|    ...|.|...||..|.....:|:|....: :|..|..:||..|
pombe   823 NAVVPELHFKEGMVYDSLENAYTYLAESKRMLANELQMKQEDLEKVILELEAYKEIFLEEKQ 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		EGF_Lam	448..491	CDD:238012
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627	55/270 (20%)
		Tar	2278..2662	CDD:223910	91/453 (20%)
		Laminin_II	2566..2700	CDD:283628	34/166 (20%)
		LamG	2674..2843	CDD:238058	31/136 (23%)
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
mcp3	NP_594851.1	Lebercilin	314..504	CDD:292252	43/218 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2298
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030