DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanA and Lamc3

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_035966.2 Gene:Lamc3 / 23928 MGIID:1344394 Length:1581 Species:Mus musculus


Alignment Length:2740 Identity:521/2740 - (19%)
Similarity:792/2740 - (28%) Gaps:1308/2740 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |.:.|.|.||:..|:.|||:.   ||.:|..|||..          .|..|..||...|.|.|..
Mouse    46 PEFENAAFGRRAEASHTCGRP---PEDFCPHVGAPG----------AGLQCQRCDDADPGRRHDA 97

  Fly    91 ENAID----GTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTD 150
            ....|    ....|||||.::.|::: ..||||::..:.:.:.|:.::...| ||..:.:.|.|.
Mouse    98 SYLTDFHSPDDSTWWQSPSMAFGVQYPTSVNLTLSLGKAYEITYVRLKFHTS-RPESFAIYKRTY 161

  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDD---VICTTEYSKIVPLENGEIPVMLLNERP 212
            ....|.|:|::|   |.|:..:|:.....:...:|   ..||:|:|.|.||..|.:....|..||
Mouse   162 ASGPWEPYQYYS---ASCQKTYGRPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRP 223

  Fly   213 SSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNG 277
            |:.|:..|.|||||..:|::.|.|.|.......:.    :||.|.:.|:|::.|.|:||||.|||
Mouse   224 SAYNFEESPVLQEWVTSTDILISLDRLNTFGDDIF----KDPRVLQSYYYAVSDFSVGGRCKCNG 284

  Fly   278 HADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNEC 342
            ||..|   :|.:..: |||||||:|.|:.|..|.|.|:.:.|.:.|......|.||||.|||.||
Mouse   285 HASEC---EPNAAGQ-LACRCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEEC 345

  Fly   343 KYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDY 407
            .:|.|:.|.      .||   ||.||.|:.:|.|.:|.:|:..|||     |:....|.|     
Mouse   346 TFDRELYRS------TGH---GGHCQRCRDHTTGPHCERCEKNYYR-----WSPKTPCQP----- 391

  Fly   408 FFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKI 472
                                                                             
Mouse   392 ----------------------------------------------------------------- 391

  Fly   473 NFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPT 537
                                  |:|:..||::                                 
Mouse   392 ----------------------CDCHPAGSLS--------------------------------- 401

  Fly   538 CSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPD--CKPCNCSSTGSSAITCD 600
               ..|||           ||.|.|:....|.:||:|||||::..:  |:||.|:..||      
Mouse   402 ---LQCDN-----------SGVCPCKPTVTGWKCDRCLPGFHSLSEGGCRPCACNVAGS------ 446

  Fly   601 NTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCK 665
                                                                             
Mouse   447 ----------------------------------------------------------------- 446

  Fly   666 EGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCE 730
                                                                             
Mouse   447 ----------------------------------------------------------------- 446

  Fly   731 ICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQS 795
                        |.||..:||.||||.:.:|..|..||.|||:|...:..||..|.| .|.|  .
Mouse   447 ------------LGTCDPRSGNCPCKENVEGSLCDRCRPGTFNLQPHNPVGCSSCFC-YGHS--K 496

  Fly   796 VCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSK 860
            ||...:|..:                      |..:.::..|:  .|.|:|            |.
Mouse   497 VCSPAAGFQE----------------------HHIRSDFRHGA--GGWQIR------------SM 525

  Fly   861 GYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSE 925
            |                                           .|..||:              
Mouse   526 G-------------------------------------------VSKRPLQ-------------- 533

  Fly   926 PQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNM 990
                                                         :.::|:|         ||  
Mouse   534 ---------------------------------------------WSQSGLL---------LG-- 542

  Fly   991 ELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIV 1055
                                                                 |.|.:.     :
Mouse   543 -----------------------------------------------------LRGGEE-----L 549

  Fly  1056 DVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFY 1120
            ..|:.        ::.|:..  ||.                                        
Mouse   550 SAPKK--------FLGDQRL--SYG---------------------------------------- 564

  Fly  1121 INKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKK 1185
                  ||||::..:..|.                      ||                      
Mouse   565 ------QPVILTLQVPPGG----------------------SP---------------------- 579

  Fly  1186 IEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPK 1250
                           ||                                                
Mouse   580 ---------------PP------------------------------------------------ 581

  Fly  1251 YQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLV 1315
                               ||.....:|....:||:...|.:         .|.:.:.|.|.:  
Mouse   582 -------------------IQLRLEGAGLALSLRPSSLPSPQ---------DTRQPRRVQLQF-- 616

  Fly  1316 VVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYA 1380
                       |::||.::.:..:..     ||.....|:....|::                  
Mouse   617 -----------LLQETSEEAESPLPT-----FHFQRLLSNLTALSIW------------------ 647

  Fly  1381 GSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGD 1445
                                                               |:|:          
Mouse   648 ---------------------------------------------------TSGQ---------- 651

  Fly  1446 LCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPH 1510
                 .|...|  ||:.||                                              
Mouse   652 -----GPGHSG--QVLLCE---------------------------------------------- 663

  Fly  1511 CEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCD 1575
                                                                             
Mouse   664 ----------------------------------------------------------------- 663

  Fly  1576 SAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGV 1640
                          |.:|:           .||                  .||           
Mouse   664 --------------VQLTS-----------AWP------------------QRE----------- 674

  Fly  1641 LDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRV 1705
                                             :||                             
Mouse   675 ---------------------------------LAP----------------------------- 677

  Fly  1706 NIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQF 1770
                         |.|                    |                            
Mouse   678 -------------PAS--------------------W---------------------------- 681

  Fly  1771 LAVERCSCPPGYSGHSCEDCAPGYYRD--PSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTE 1833
              ||.|.||.||:|..||.||.||.|:  ..|||.. ||||.||.|. |||..|||| .|.|.||
Mouse   682 --VETCLCPQGYTGQFCEFCALGYKREIPHGGPYAN-CIPCTCNQHG-TCDPNTGIC-LCGHHTE 741

  Fly  1834 GDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHCECKPGYTGPRCES 1898
            |..||||:.|:||||.:|...||..|.||      ..:....|.||||.:...|.||..|.||||
Mouse   742 GPSCERCMPGFYGNAFSGRADDCQPCPCP------GQSACATIPESGDVVCTHCPPGQRGRRCES 800

  Fly  1899 CANGFYGEPESIG---QVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGD 1960
            |.:||:|:|..:.   |.|:.|:||||::....|:||..:|.|||||.||.||.|..|..||||.
Mouse   801 CEDGFFGDPLGLSGAPQPCRRCQCSGNVDLNAVGNCDPHSGHCLRCLYNTTGAHCEHCREGFYGS 865

  Fly  1961 AIKLK---NCQSCDCDDLGT---QTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDC 2019
            |:..:   .|..|.||..|:   :||:|..|.|.|...|.|..|.||.|..|..:||.||::|.|
Mouse   866 AVATRPVDKCAPCSCDLRGSVSEKTCNPVTGQCVCLPYVSGRDCSRCSPGFYDLQSGRGCQSCKC 930

  Fly  2020 ---GAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTG 2081
               |:..|  :|.|.||.|.|:.||||:.||||.:..:.:...||..|.|:...:....|:.|: 
Mouse   931 HPLGSLEN--KCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGCRDCRCSPLGAASSQCHENS- 992

  Fly  2082 KCQCLPGVIGDRCDACPNRWVLIK-DEGCQECNNCHHALLDVTDRMR------------------ 2127
            .|.|.||.:|.:||.|.:.:.|.. |.|||||..|:..:.:...:::                  
Mouse   993 TCVCRPGFVGYKCDRCQDNFFLADGDTGCQECPTCYALVKEEAAKLKARLMLMEGWLQRSDCGSP 1057

  Fly  2128 ----------------YQIDSVLEDFNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSP 2176
                            ||...:|::    |...|..|.:...|.:....|....|........:.
Mouse  1058 WGPLDILQGEAPLGDVYQGHHLLQE----TRGTFLQQMVGLEDSVKATWEQLQVLRGHVHCAQAG 1118

  Fly  2177 SKKA---NSELESDAKSYAKQVNQTLANAFDI---RERSSTTLGNITVAYDEAVKSADQAKEAIA 2235
            ::|.   .:|||...:|..::|.:. |:|...   .::.|:|..|.:....||...|...::...
Mouse  1119 AQKTCIQLAELEETLQSSEEEVLRA-ASALSFLASLQKGSSTPTNWSHLASEAQILARSHRDTAT 1182

  Fly  2236 SVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTL------- 2293
            .:||.|:....|:    :|:.|..:.:.|::...:      :|.||..   |:||...       
Mouse  1183 KIEATSERALLAS----NASYELLKLMEGRVASEA------QQELEDR---YQEVQAAQTALGIA 1234

  Fly  2294 ---VLPIKAQNKSLNALKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVA-NQKAFDNSKFDTV 2354
               .|| ||: |:|..:|..||:.:.||..|..      .::.:.:.|.:: ..||.        
Mouse  1235 VAEALP-KAE-KALATVKQVIGDAAPHLGLLVT------PEAMNFQARGLSWKVKAL-------- 1283

  Fly  2355 SEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLR----DALNELNSFNKNVDEELPVREDQHK 2415
             ||||:.::                .::.|.:..|:    .||.::.          |..:.::|
Mouse  1284 -EQKLEQKE----------------PEVGQSVGALQVEAGRALEKME----------PFMQLRNK 1321

  Fly  2416 EADALT--DQAEQKAAELAIKAQDLAAQYTDMTASA----EPAIKAATAYSGIVEAVEAAQKLSQ 2474
            ...|.|  ..|.|.|....|.|:.|.|....|...:    |.|.....|.|.....:|..::.::
Mouse  1322 TTAAFTRASSAVQAAKVTVIGAETLLADLEGMKLRSPLPKEQAALKKKAGSIRTRLLEDTKRKTK 1386

  Fly  2475 DAISAAGNATDKTDGIEERAHLADTGSTD-------LLQRARQSLQKVQDDLEPRLNASAGKVQK 2532
            .|....|||...:...::::..|:..|.|       ||:..:|..:.. ..|..:..|:..:..:
Mouse  1387 QAERMLGNAASLSSSTKKKSKEAELMSKDNAKLSRALLREGKQGYRHA-SRLASQTQATLRRASR 1450

  Fly  2533 ISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPVSV-QTPKELE 2596
            :...:.|.:.:|::..::...| :..:|.: :.|..:.....::|..:|..|..:.| |.|.:  
Mouse  1451 LLLTSEAHKQELEEAKQVTSGL-STVERQI-RESRISLEKDTKVLSELLVKLGSLGVHQAPAQ-- 1511

  Fly  2597 KAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIENLKAQV 2661
                   .|:.|.:.:.....|||.......||.:|.|:...|:.::        |..|:..|::
Mouse  1512 -------TLNETQRALESLRLQLDSHGALHHKLRQLEEESARQELQI--------QSFEDDLAEI 1561

  Fly  2662 EAARQLANSI 2671
            .|.:....:|
Mouse  1562 RADKHNLETI 1571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 77/252 (31%)
EGF_Lam 272..>314 CDD:238012 21/41 (51%)
EGF_Lam 332..389 CDD:238012 25/56 (45%)
EGF_Lam 402..443 CDD:238012 1/40 (3%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 4/47 (9%)
Laminin_EGF 541..589 CDD:278482 18/49 (37%)
Laminin_EGF 587..634 CDD:278482 4/46 (9%)
EGF_Lam 631..673 CDD:238012 0/41 (0%)
Laminin_EGF 677..729 CDD:278482 0/51 (0%)
Laminin_EGF 732..782 CDD:278482 17/49 (35%)
EGF_Lam 785..828 CDD:238012 7/42 (17%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 9/134 (7%)
Laminin_EGF 1375..1423 CDD:278482 0/47 (0%)
EGF_Lam 1420..1457 CDD:238012 3/36 (8%)
Laminin_EGF 1466..1516 CDD:278482 0/49 (0%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 5/127 (4%)
Laminin_EGF <1775..1801 CDD:278482 13/27 (48%)
EGF_Lam 1808..1851 CDD:238012 26/42 (62%)
EGF_Lam 1859..1907 CDD:214543 20/47 (43%)
EGF_Lam 1916..1968 CDD:238012 25/54 (46%)
EGF_Lam 1969..2015 CDD:238012 20/48 (42%)
EGF_Lam 2016..>2054 CDD:238012 18/40 (45%)
EGF_Lam 2063..>2097 CDD:238012 11/33 (33%)
Laminin_I 2129..2385 CDD:283627 54/272 (20%)
Tar 2278..2662 CDD:223910 82/412 (20%)
Laminin_II 2566..2700 CDD:283628 22/107 (21%)
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Lamc3NP_035966.2 Laminin_N 53..278 CDD:278484 74/245 (30%)
EGF_Lam 279..326 CDD:238012 23/50 (46%)
Laminin_EGF 336..392 CDD:278482 28/161 (17%)
EGF_Lam 391..437 CDD:238012 20/184 (11%)
Laminin_EGF 439..486 CDD:278482 21/194 (11%)
Laminin_B 550..669 CDD:278481 39/549 (7%)
EGF_Lam 718..765 CDD:238012 28/48 (58%)
EGF_Lam 766..814 CDD:238012 21/53 (40%)
Laminin_EGF 822..>864 CDD:278482 22/41 (54%)
Laminin_EGF 878..925 CDD:278482 19/46 (41%)
Laminin_EGF 928..976 CDD:278482 20/49 (41%)
EGF_Lam 976..1022 CDD:238012 15/46 (33%)
Domain II and I 1025..1581 115/628 (18%)
Laminin_I 1225..1470 CDD:283627 54/288 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1413 5/30 (17%)
GluZincin 1433..>1506 CDD:301352 10/75 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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