DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanA and Lamc1

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_034813.2	Gene:	Lamc1 / 226519	MGIID:	99914	Length:	1607	Species:	Mus musculus

Alignment Length:	2797	Identity:	541/2797 - (19%)
Similarity:	805/2797 - (28%)	Gaps:	1378/2797 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLVILAISYC--------------QAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANT 61
            |.|:.|::.|              .....|.:.|.|....:.||.|||..   ||.||...|
Mouse    21 LAVLAAVAGCVRAAMDECADEGGRPQRCMPEFVNAAFNVTVVATNTCGTP---PEEYCVQTG--- 79

  Fly    62 EHDHIDYSVIQG--QVCDYCDPTVPERNHPP------ENAIDGTEAWWQSPPLSRGMKF-NEVNL 117
                     :.|  :.|..||.......|..      .|..|.|  ||||..:..|::: |.:||
Mouse    80 ---------VTGVTKSCHLCDAGQQHLQHGAAFLTDYNNQADTT--WWQSQTMLAGVQYPNSINL 133

  Fly   118 TINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITR 182
            |::..:.|.:.|:.::...| ||..:.:.|.|.....|.|:|::|   ..||     :||....|
Mouse   134 TLHLGKAFDITYVRLKFHTS-RPESFAIYKRTREDGPWIPYQYYS---GSCE-----NTYSKANR 189

  Fly   183 --------DDDVICTTEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRT 239
                    :...:||.|:|.|.||..|.:....|..|||:.|:.||.|||||..||::|:    |
Mouse   190 GFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRV----T 250

  Fly   240 KNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCG 304
            .|.|.........||.|.:.|:|:|.|.::||||.|||||..|    .|:....|.|.|:|:|.|
Mouse   251 LNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASEC----VKNEFDKLMCNCKHNTYG 311

  Fly   305 IQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQN 369
            :.|.:|.|.|..:.||:.|......|.||:|:|.|.||.:|.|:.|.      .||   ||.|.|
Mouse   312 VDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRS------TGH---GGHCTN 367

  Fly   370 CQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDS 434
            |:.||.|..|.:|:..::|     ...|:.|||
Mouse   368 CRDNTDGAKCERCRENFFR-----LGNTEACSP-------------------------------- 395

  Fly   435 CAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNK 499
                                                                        |.|:.
Mouse   396 ------------------------------------------------------------CHCSP 400

  Fly   500 IGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICRE 564
            :||::..|:                              ||                 |:|.|:.
Mouse   401 VGSLSTQCD------------------------------SY-----------------GRCSCKP 418

  Fly   565 GFGGPRCDQCLPGFYNYPD--CKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYP 627
            |..|.:||:|.|||::..:  |:||:|..:||       |.:||.
Mouse   419 GVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGS-------TDECNV-------------------- 456

  Fly   628 DCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCG 692
                              ..|:|:|:.|.:|..|:.||.||:|..|
Mouse   457 ------------------ETGRCVCKDNVEGFNCERCKPGFFNLES------------------- 484

  Fly   693 SVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKP 757
                                           ||.:||..|.|:...::     ||:..|.
Mouse   485 -------------------------------SNPKGCTPCFCFGHSSV-----CTNAVGY----- 508

  Fly   758 HTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTH 822
                        ..:|:.|.
Mouse   509 ------------SVYDISST--------------------------------------------- 516

  Fly   823 FFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIV 887
                   ||.: |||                                              :|:.
Mouse   517 -------FQID-EDG----------------------------------------------WRVE 527

  Fly   888 LRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFT 952
            .|      :...|::..:||..
Mouse   528 QR------DGSEASLEWSSDRQ------------------------------------------- 543

  Fly   953 TKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENS 1017

Mouse   544 ----------------------------------------------------------------- 543

  Fly  1018 KPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYIN 1082
                                  ||.|:|.|....::|..|...|..:.            ||..|
Mouse   544 ----------------------DIAVISDSYFPRYFIAPVKFLGNQVL------------SYGQN 574

  Fly  1083 LKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVT 1147
            |..                                ||.:::.|.:   :||
Mouse   575 LSF--------------------------------SFRVDRRDTR---LSA-------------- 590

  Fly  1148 AIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKL 1212
                                                         ||
Mouse   591 ---------------------------------------------ED------------------ 592

  Fly  1213 VHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSS 1277
                      :|:|                                                 .:
Mouse   593 ----------LVLE-------------------------------------------------GA 598

  Fly  1278 GCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNC 1342
            |.|                                  |.|||
Mouse   599 GLR----------------------------------VSVPL----------------------- 606

  Fly  1343 GHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGA 1407

Mouse   607 ----------------------------------------------------------------- 606

  Fly  1408 CRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMG 1472

Mouse   607 ----------------------------------------------------------------- 606

  Fly  1473 IANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKK 1537
            ||.|||                             :|
Mouse   607 IAQGNS-----------------------------YP---------------------------- 614

  Fly  1538 NVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESI 1602

Mouse   615 ----------------------------------------------------------------- 614

  Fly  1603 KFDMWPVPADEILLNETTLKADFTLREVNDE--RPAYFGVLDYLLNQNNHISAYGGDLAYTLHFT 1665
                          :|||:|..|.|.|..|.  |||.
Mouse   615 --------------SETTVKYIFRLHEATDYPWRPAL---------------------------- 637

  Fly  1666 SGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLR 1730
                                             .||                      :|..:|.
Mouse   638 ---------------------------------SPF----------------------EFQKLLN 647

  Fly  1731 DLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYY 1795
            :|..|.||..|.|:: ..:|.||.|..|   ..|.| .....||.|:||.||.|..||.|.|||.
Mouse   648 NLTSIKIRGTYSERS-AGYLDDVTLQSA---RPGPG-VPATWVESCTCPVGYGGQFCETCLPGYR 707

  Fly  1796 RD-PS-GPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMI 1858
            |: || |||.. |:.|.|||||||||..||:|. |:..|.|.|||:|..||||::|.||..||..
Mouse   708 RETPSLGPYSP-CVLCTCNGHSETCDPETGVCD-CRDNTAGPHCEKCSDGYYGDSTLGTSSDCQP 770

  Fly  1859 CACPLPFDSNNFATSCEISESGDQIHC-ECKPGYTGPRCESCANGFYGEPESIG-----QVCKPC 1917
            |.||       ..:||.|.....::.| .|..|..|.|||.|.:|::|:|  :|     ::|:||
Mouse   771 CPCP-------GGSSCAIVPKTKEVVCTHCPTGTAGKRCELCDDGYFGDP--LGSNGPVRLCRPC 826

  Fly  1918 ECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAI---KLKNCQSCDCDDLGT-- 1977
            :|:.||:|...|:|:..|||||:|:.||.|..|:.|..||:|:.:   ....|::|.|:..||
Mouse   827 QCNDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKEGFFGNPLAPNPADKCKACACNPYGTVQ 891

  Fly  1978 --QTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGA-ASNSTQCDPHTGHCACKS 2039
              .:|:|..|.|.|..:|.|..|..|.|.:|..:||.||..|||.| .|.:.|||..||.|.|:.
Mouse   892 QQSSCNPVTGQCQCLPHVSGRDCGTCDPGYYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQP 956

  Fly  2040 GVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLI 2104
            |:||:.|:||..:|:.:..:||.||:|:...|....|..: |:|:|..|.:|:|||.|...:...
Mouse   957 GITGQHCERCETNHFGFGPEGCKPCDCHHEGSLSLQCKED-GRCECREGFVGNRCDQCEENYFYN 1020

  Fly  2105 KD-EGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQKLNYYDQLADE-LEPKVKLL 2167
            :. .|||||..|:..:.|.....|.:    |::..|:.....|..     |.:.|: .|.::|..
Mouse  1021 RSWPGCQECPACYRLVKDKVAEHRVK----LQELESLIANLGTGD-----DMVTDQAFEDRLKEA 1076

  Fly  2168 DPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKE 2232
            :....||....:...:::.:.....::||.:|.:..       :.|.||....:|....|::|:.
Mouse  1077 EREVTDLLREAQEVKDVDQNLMDRLQRVNSSLHSQI-------SRLQNIRNTIEETGILAERARS 1134

  Fly  2233 AIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELT--PNEQVL--EKARKLYE----E 2289
            .:.|.|.|   :|.|:     ..||:|:.....::.|..|.|  ||...|  |:||||.|    |
Mouse  1135 RVESTEQL---IEIAS-----RELEKAKMAAANVSITQPESTGEPNNMTLLAEEARKLAERHKQE 1191

  Fly  2290 VNTLVLPIKAQNKSL--------------NALKNDIGEFSDHLEDLFNWSEASQAKSADV-ERRN 2339
            .:.:|...|..|::.              |....:|.|.:...|...|.|:..:.::|.| |...
Mouse  1192 ADDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAK 1256

  Fly  2340 VANQKAFD----NSKFDTVSEQKLQAEKN-IKDAGNFLINGDLTLNQINQKLDNLRDALNELNSF 2399
            .|..||.:    .::...|..:.|:.|.| ||...     .||. ..|:|||.:..|...::...
Mouse  1257 RAGDKAVEIYASVAQLTPVDSEALENEANKIKKEA-----ADLD-RLIDQKLKDYEDLREDMRGK 1315

  Fly  2400 NKNVDEELPVREDQHKEADALTDQAE-----------------QKAAELAIKAQDLAAQYTDMTA 2447
            ...|...|...:.:.:.||.|..:|:                 |:|.::....:|...:..|...
Mouse  1316 EHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRSTLQEANDILNNLKDFDRRVNDNKT 1380

  Fly  2448 SAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLAD----------TGS- 2501
            :||.|::...|   |...:..|.:.:::|..|.|||.......:.:||.|:          |.:
Mouse  1381 AAEEALRRIPA---INRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASAVQKNATSTK 1442

  Fly  2502 ----------TDL----------LQRARQSLQKVQDDL---------------EPRLNASAGKVQ 2531
                      |||          |:.|...|:|.|||.               |..|||...|
Mouse  1443 ADAERTFGEVTDLDNEVNGMLRQLEEAENELKKKQDDADQDMMMAGMASQAAQEAELNARKAK-- 1505

  Fly  2532 KISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPVSVQTPKELE 2596
                  |:....|..:|.|:|||   .|.|
Mouse  1506 ------NSVSSLLSQLNNLLDQL---GQLD----------------------------------- 1526

  Fly  2597 KAHGINRDLDLTNKDVSQANKQLDDVEGS--VSKLSELAEDIEEQQHRVGSQSRQLGQ---EIEN 2656
                 ..||:..|:.....||..|:::.|  ..|:|:|..:..:|:..:...:|.:.:   :|.|
Mouse  1527 -----TVDLNKLNEIEGSLNKAKDEMKASDLDRKVSDLESEARKQEAAIMDYNRDIAEIIKDIHN 1586

  Fly  2657 LK 2658
            |:
Mouse  1587 LE 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	80/283 (28%)
		EGF_Lam	272..>314	CDD:238012	18/41 (44%)
		EGF_Lam	332..389	CDD:238012	22/56 (39%)
		EGF_Lam	402..443	CDD:238012	1/40 (3%)
		EGF_Lam	448..491	CDD:238012	0/42 (0%)
		Laminin_EGF	495..543	CDD:278482	7/47 (15%)
		Laminin_EGF	541..589	CDD:278482	14/49 (29%)
		Laminin_EGF	587..634	CDD:278482	7/46 (15%)
		EGF_Lam	631..673	CDD:238012	11/41 (27%)
		Laminin_EGF	677..729	CDD:278482	2/51 (4%)
		Laminin_EGF	732..782	CDD:278482	7/49 (14%)
		EGF_Lam	785..828	CDD:238012	0/42 (0%)
		CBM6-CBM35-CBM36_like	831..966	CDD:271143	9/134 (7%)
		Laminin_EGF	1375..1423	CDD:278482	0/47 (0%)
		EGF_Lam	1420..1457	CDD:238012	0/36 (0%)
		Laminin_EGF	1466..1516	CDD:278482	6/49 (12%)
		Laminin_EGF	1514..1562	CDD:278482	0/47 (0%)
		LamB	1632..1760	CDD:214597	19/129 (15%)
		Laminin_EGF	<1775..1801	CDD:278482	15/27 (56%)
		EGF_Lam	1808..1851	CDD:238012	25/42 (60%)
		EGF_Lam	1859..1907	CDD:214543	16/48 (33%)
		EGF_Lam	1916..1968	CDD:238012	22/54 (41%)
		EGF_Lam	1969..2015	CDD:238012	18/49 (37%)
		EGF_Lam	2016..>2054	CDD:238012	18/38 (47%)
		EGF_Lam	2063..>2097	CDD:238012	13/33 (39%)
		Laminin_I	2129..2385	CDD:283627	63/284 (22%)
		Tar	2278..2662	CDD:223910	100/475 (21%)
		Laminin_II	2566..2700	CDD:283628	15/98 (15%)
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
Lamc1	NP_034813.2	LamNT	42..282	CDD:214532	79/269 (29%)
		EGF_Lam	283..328	CDD:238012	20/48 (42%)
		Laminin_EGF	340..394	CDD:278482	23/67 (34%)
		Laminin_EGF	396..443	CDD:278482	19/93 (20%)
		Laminin_EGF	443..490	CDD:278482	21/141 (15%)
		LamB	551..676	CDD:214597	55/717 (8%)
		Laminin_EGF	722..761	CDD:278482	24/39 (62%)
		EGF_Lam	770..818	CDD:238012	18/56 (32%)
		Laminin_EGF	826..873	CDD:278482	21/46 (46%)
		Laminin_EGF	882..930	CDD:278482	17/47 (36%)
		EGF_Lam	933..978	CDD:214543	19/44 (43%)
		EGF_Lam	980..1027	CDD:238012	15/47 (32%)
		Domain II and I	1029..1607		135/644 (21%)
		SPEC	1047..1252	CDD:295325	49/224 (22%)
		MA	1089..1300	CDD:214599	54/231 (23%)
		V_Alix_like	1178..>1310	CDD:187408	35/137 (26%)
		DUF5089	1198..1403	CDD:293607	43/213 (20%)
		SH3BP5	1359..1585	CDD:283045	55/279 (20%)
		ATP-synt_B	<1391..1503	CDD:304375	26/114 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810