DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and Ush2a

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_067383.3 Gene:Ush2a / 22283 MGIID:1341292 Length:5193 Species:Mus musculus


Alignment Length:1331 Identity:337/1331 - (25%)
Similarity:536/1331 - (40%) Gaps:340/1331 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 DGPEL----YCKLVGANTEHDHIDYSVIQGQVCDYCDPT----VPERN--------HPPE--NAI 94
            |.|.|    :|:..|:   |..:..||.|     ||.|.    .||..        ||..  |..
Mouse   289 DFPHLHIQPHCRCPGS---HPRVHPSVQQ-----YCIPNGAGDTPEHRMSRLNPEAHPLSFINDD 345

  Fly    95 DGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQ 159
            |...:|......:....:..|.::|:.|...:.....|...:|.:|....:::.......|..||
Mouse   346 DVATSWISHVFTNITQLYEGVAISIDLENGQYQVLKVITQFSSLQPVAIRIQRKKADSSPWEDWQ 410

  Fly   160 HFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPVMLL----NERPSSTNYFNS 220
            :|:   .:|..:..||. :.:...:.|.| .:....:|..:|.:...||    ..||...:::||
Mouse   411 YFA---RNCSVWGMKDN-EDLENPNSVNC-LQLPDFIPFSHGNVTFDLLTSGQKHRPGYNDFYNS 470

  Fly   221 TVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVK 285
            :||||:.|||.:|:.........||.:.        .|..:|::.:|.:.|||.|:|||:|||  
Mouse   471 SVLQEFMRATQIRLHFHGQYYPAGHTVD--------WRHQYYAVDEIIVSGRCQCHGHAETCD-- 525

  Fly   286 DPKSPVRILACRCQHH--TCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEV 348
            ..:.|.|   |.|..|  |.|.||:.|.|.:..|.:|...|...|||:||.||||::.|.||..|
Mouse   526 RTRRPYR---CLCSPHSFTEGPQCDRCSPLYNDKPFRSGDNVNAFNCKPCQCHGHASSCHYDASV 587

  Fly   349 NRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGH 413
            :    ...:..:..|||||.:|||:|.|.:|..|:..:|||.|.                     
Mouse   588 D----PFPLEHNRGGGGVCDDCQHHTTGRHCESCQDYFYRPVGA--------------------- 627

  Fly   414 CEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGT-NG-YHCEAESGQQCPCKINFAG 476
                          .|.:.|:          |:.|:||..|| || .||:...| ||.||...:|
Mouse   628 --------------DPAAPDA----------CKLCDCNRAGTRNGSLHCDPIGG-QCDCKRRVSG 667

  Fly   477 AYCKQCAEGYYGF----PE-CKACECNKIGSITND--CNVTTGECKCLTNFGGDNCERCKHGY-- 532
            ..|.||.:|:|..    |: |:.|.||..|::..|  |:..:|:|.|..|..|..|.||..|:  
Mouse   668 RQCLQCQDGFYDLQALDPDGCRPCNCNPSGTVDGDITCHQNSGQCSCKANVIGLRCNRCNFGFKF 732

  Fly   533 ---FNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYP--DCKPCNCSST 592
               ||...|..|.|:..|:.:::|:..||||.|::...|.:||.|...||..|  .|:.|:||..
Mouse   733 LQSFNGDGCEPCQCNLHGSVNQLCDPLSGQCACKKEAKGLKCDSCRENFYGLPWSACEVCDCSKA 797

  Fly   593 GSSAIT-CD-NTGKCNCLNNFAGKQCTLCTAGYYS-YPD----CLPCHCDSHGSQGVSCNSD--- 647
            ||...| || .||:|.|..|..|:||:.|.|||:: |.:    ||.|:|:..|:...|...|   
Mouse   798 GSQPGTVCDTETGQCVCKPNVGGRQCSQCKAGYFNLYQNDSHLCLTCNCEKMGTVNGSLRCDKST 862

  Fly   648 GQCLCQPNFDGRQCDSCKEGFYNF-----PSCEDCNCDPAGVIDKFAGCGSV--PVGELCKCKER 705
            |||.|:....|.:|..||...:|.     ..|:.|:||..|.:.     ||:  |:...|.|...
Mouse   863 GQCPCKLGVTGLRCHQCKPHRFNLTMDNPQGCQACDCDSLGTLP-----GSMCDPISGQCLCLPH 922

  Fly   706 VTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPC-KPHTQGRRCQECRD 769
            ..||.|.:|:|.::: :.||..||..|.|.|.|.:|.:  |.|.:|||.| .|.|.||.|.:|::
Mouse   923 RQGRRCEQCQPGFYS-SPSNATGCLPCLCHTAGAVSHI--CNSVTGQCSCHDPSTTGRSCHQCQE 984

  Fly   770 GTFDLDSASLFG-CKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQ--PLTTHF-------- 823
            ..|..|  .|.| |:.|.|.|.|:....||.::|||.|...:||..|..  |..:|.        
Mouse   985 SYFRFD--PLTGRCRPCHCHVAGASNGTCDAVTGQCFCKEFVTGSKCDTCVPGASHLDVNNLLGC 1047

  Fly   824 ----------------------------FPTLHQFQYE-YEDGSLPSGTQVRYDY------DEAA 853
                                        .|..|...|. :.:||....|:..:.|      |.:.
Mouse  1048 SKTPSQQPPPRGWVQSSSTINVSWSPPECPNAHWLTYTLFRNGSEIYTTEDEHPYYTQYFLDTSL 1112

  Fly   854 FPGFSSKGYVVFNAIQNDVRNEVNVFKS----SLYRIVLRYVNP-NAENVTATISVTSDNPLEVD 913
            .|..:...|:..:.:.:..|:...::::    |...:.|.::.| .::::|.|.:..|::...|.
Mouse  1113 SPHTAYSYYIETSNVHSSTRSIPVIYETKPEVSEGHLNLTHIIPVGSDSITLTWTGLSNSSDPVA 1177

  Fly   914 QHVKVLLQPTSEPQFVTVAGPLGVKPSAIV--LDP-GRYVFTTKANKN----------------- 958
            ::|.......|....|:..||   :.||.:  |.| .:|.|:.:...|                 
Mouse  1178 KYVLSCTPVDSTEPCVSYEGP---ETSATIWNLVPFTQYCFSVQGCTNESCFYSLPIIVTTAQAP 1239

  Fly   959 -----------------------------VMLDYFVLL-------PAAYYEA-GILTRHIS---- 982
                                         :::.|.:.:       .:..:|: |:::.|.:    
Mouse  1240 PQTQGPPTVWKISPTELRIEWSPPVDSNGIIISYELYMRRWLSTEESLVFESHGLVSSHSALQSV 1304

  Fly   983 NPCE-----------LGNMELCRHYKYA-----------------------SVEVF--SPAATPF 1011
            ||.:           :..:|  .|.:||                       ||.||  .|:.:| 
Mouse  1305 NPSKNLLQQPQASTFISGLE--PHTEYAFRVLAVNMAGRVSSAWASERTGESVPVFMAPPSVSP- 1366

  Fly  1012 VIGENSKPTN---PVETYTDPE----HLQIVSH---VGDIPVLSGSQNELHYIVDVPRSGRYIFV 1066
             :..:|...:   |.|.:|..|    .:.:||.   :.|:||:....  :|:.....:|      
Mouse  1367 -LSPHSLSVSWEKPAENFTRGEIIGYKISMVSEHFPLHDVPVMCSKM--VHFAKSQDQS------ 1422

  Fly  1067 IDYISDRNFP-DSYYINLKLKDNPDSETSVL------------LYPCLYSTICRTSVN------- 1111
              ||.....| .:|...:.|.|:....||.|            |.|.:.:.:..|:|:       
Mouse  1423 --YIVRGLEPYRTYSFTVSLCDSVGCVTSALGSGQTLAAAPAQLRPPMVTGVNSTTVHIRWLPPA 1485

  Fly  1112 -EDGMEKSFYINKEDLQPVIISADIEDGSRF 1141
             .:|....:::.::.......:|.:..|:||
Mouse  1486 GVNGPPPLYHLERKKSSLPAATAAVTKGTRF 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 55/244 (23%)
EGF_Lam 272..>314 CDD:238012 20/43 (47%)
EGF_Lam 332..389 CDD:238012 23/56 (41%)
EGF_Lam 402..443 CDD:238012 2/40 (5%)
EGF_Lam 448..491 CDD:238012 20/48 (42%)
Laminin_EGF 495..543 CDD:278482 19/54 (35%)
Laminin_EGF 541..589 CDD:278482 18/49 (37%)
Laminin_EGF 587..634 CDD:278482 24/53 (45%)
EGF_Lam 631..673 CDD:238012 14/49 (29%)
Laminin_EGF 677..729 CDD:278482 16/53 (30%)
Laminin_EGF 732..782 CDD:278482 21/51 (41%)
EGF_Lam 785..828 CDD:238012 16/80 (20%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 29/195 (15%)
Laminin_EGF 1375..1423 CDD:278482
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:278482
Laminin_EGF 1514..1562 CDD:278482
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:278482
EGF_Lam 1808..1851 CDD:238012
EGF_Lam 1859..1907 CDD:214543
EGF_Lam 1916..1968 CDD:238012
EGF_Lam 1969..2015 CDD:238012
EGF_Lam 2016..>2054 CDD:238012
EGF_Lam 2063..>2097 CDD:238012
Laminin_I 2129..2385 CDD:283627
Tar 2278..2662 CDD:223910
Laminin_II 2566..2700 CDD:283628
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Ush2aNP_067383.3 LamGL 145..280 CDD:214722
Laminin_N 313..513 CDD:295486 47/217 (22%)
EGF_Lam 514..562 CDD:238012 22/52 (42%)
EGF_Lam 571..636 CDD:238012 28/113 (25%)
Laminin_EGF 638..688 CDD:278482 21/50 (42%)
Laminin_EGF 691..741 CDD:278482 17/49 (35%)
EGF_Lam 743..788 CDD:238012 16/44 (36%)
EGF_Lam 792..832 CDD:214543 20/39 (51%)
Laminin_EGF 844..894 CDD:278482 14/49 (29%)
EGF_Lam 896..945 CDD:238012 16/54 (30%)
EGF_Lam 947..997 CDD:238012 21/53 (40%)
EGF_Lam 998..>1035 CDD:238012 13/36 (36%)
fn3 1055..1128 CDD:278470 10/72 (14%)
FN3 1153..1235 CDD:238020 17/84 (20%)
FN3 1239..1351 CDD:238020 10/113 (9%)
FN3 1362..1445 CDD:214495 20/94 (21%)
Laminin_G_2 1539..1669 CDD:280389
LamG 1707..1857 CDD:238058
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1931..1955
FN3 1947..2042 CDD:238020
FN3 2134..2230 CDD:238020
FN3 2232..2304 CDD:238020
FN3 2320..2419 CDD:238020
FN3 2423..2516 CDD:238020
FN3 2524..2610 CDD:238020
FN3 2612..2710 CDD:238020
FN3 2715..2807 CDD:238020
FN3 2809..2911 CDD:238020
FN3 2916..2993 CDD:238020
FN3 <3441..3486 CDD:238020
FN3 3582..3668 CDD:238020
FN3 3672..3753 CDD:238020
FN3 3769..3854 CDD:238020
FN3 3867..3952 CDD:238020
FN3 3956..4053 CDD:238020
FN3 4153..4239 CDD:238020
FN3 4260..4343 CDD:238020
FN3 4348..4431 CDD:238020
FN3 4435..4519 CDD:238020
FN3 4521..4619 CDD:238020
FN3 4645..4722 CDD:238020
FN3 4724..4800 CDD:238020
FN3 4817..4918 CDD:238020
PDZ-binding 5191..5193
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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