DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and Ush2a

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_067383.3 Gene:Ush2a / 22283 MGIID:1341292 Length:5193 Species:Mus musculus


Alignment Length:1331 Identity:337/1331 - (25%)
Similarity:536/1331 - (40%) Gaps:340/1331 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 DGPEL----YCKLVGANTEHDHIDYSVIQGQVCDYCDPT----VPERN--------HPPE--NAI 94
            |.|.|    :|:..|:   |..:..||.|     ||.|.    .||..        ||..  |..
Mouse   289 DFPHLHIQPHCRCPGS---HPRVHPSVQQ-----YCIPNGAGDTPEHRMSRLNPEAHPLSFINDD 345

  Fly    95 DGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQ 159
            |...:|......:....:..|.::|:.|...:.....|...:|.:|....:::.......|..||
Mouse   346 DVATSWISHVFTNITQLYEGVAISIDLENGQYQVLKVITQFSSLQPVAIRIQRKKADSSPWEDWQ 410

  Fly   160 HFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPVMLL----NERPSSTNYFNS 220
            :|:   .:|..:..||. :.:...:.|.| .:....:|..:|.:...||    ..||...:::||
Mouse   411 YFA---RNCSVWGMKDN-EDLENPNSVNC-LQLPDFIPFSHGNVTFDLLTSGQKHRPGYNDFYNS 470

  Fly   221 TVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVK 285
            :||||:.|||.:|:.........||.:.        .|..:|::.:|.:.|||.|:|||:|||  
Mouse   471 SVLQEFMRATQIRLHFHGQYYPAGHTVD--------WRHQYYAVDEIIVSGRCQCHGHAETCD-- 525

  Fly   286 DPKSPVRILACRCQHH--TCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEV 348
            ..:.|.|   |.|..|  |.|.||:.|.|.:..|.:|...|...|||:||.||||::.|.||..|
Mouse   526 RTRRPYR---CLCSPHSFTEGPQCDRCSPLYNDKPFRSGDNVNAFNCKPCQCHGHASSCHYDASV 587

  Fly   349 NRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGH 413
            :    ...:..:..|||||.:|||:|.|.:|..|:..:|||.|.                     
Mouse   588 D----PFPLEHNRGGGGVCDDCQHHTTGRHCESCQDYFYRPVGA--------------------- 627

  Fly   414 CEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGT-NG-YHCEAESGQQCPCKINFAG 476
                          .|.:.|:          |:.|:||..|| || .||:...| ||.||...:|
Mouse   628 --------------DPAAPDA----------CKLCDCNRAGTRNGSLHCDPIGG-QCDCKRRVSG 667

  Fly   477 AYCKQCAEGYYGF----PE-CKACECNKIGSITND--CNVTTGECKCLTNFGGDNCERCKHGY-- 532
            ..|.||.:|:|..    |: |:.|.||..|::..|  |:..:|:|.|..|..|..|.||..|:  
Mouse   668 RQCLQCQDGFYDLQALDPDGCRPCNCNPSGTVDGDITCHQNSGQCSCKANVIGLRCNRCNFGFKF 732

  Fly   533 ---FNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYP--DCKPCNCSST 592
               ||...|..|.|:..|:.:::|:..||||.|::...|.:||.|...||..|  .|:.|:||..
Mouse   733 LQSFNGDGCEPCQCNLHGSVNQLCDPLSGQCACKKEAKGLKCDSCRENFYGLPWSACEVCDCSKA 797

  Fly   593 GSSAIT-CD-NTGKCNCLNNFAGKQCTLCTAGYYS-YPD----CLPCHCDSHGSQGVSCNSD--- 647
            ||...| || .||:|.|..|..|:||:.|.|||:: |.:    ||.|:|:..|:...|...|   
Mouse   798 GSQPGTVCDTETGQCVCKPNVGGRQCSQCKAGYFNLYQNDSHLCLTCNCEKMGTVNGSLRCDKST 862

  Fly   648 GQCLCQPNFDGRQCDSCKEGFYNF-----PSCEDCNCDPAGVIDKFAGCGSV--PVGELCKCKER 705
            |||.|:....|.:|..||...:|.     ..|:.|:||..|.:.     ||:  |:...|.|...
Mouse   863 GQCPCKLGVTGLRCHQCKPHRFNLTMDNPQGCQACDCDSLGTLP-----GSMCDPISGQCLCLPH 922

  Fly   706 VTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPC-KPHTQGRRCQECRD 769
            ..||.|.:|:|.::: :.||..||..|.|.|.|.:|.:  |.|.:|||.| .|.|.||.|.:|::
Mouse   923 RQGRRCEQCQPGFYS-SPSNATGCLPCLCHTAGAVSHI--CNSVTGQCSCHDPSTTGRSCHQCQE 984

  Fly   770 GTFDLDSASLFG-CKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQ--PLTTHF-------- 823
            ..|..|  .|.| |:.|.|.|.|:....||.::|||.|...:||..|..  |..:|.        
Mouse   985 SYFRFD--PLTGRCRPCHCHVAGASNGTCDAVTGQCFCKEFVTGSKCDTCVPGASHLDVNNLLGC 1047

  Fly   824 ----------------------------FPTLHQFQYE-YEDGSLPSGTQVRYDY------DEAA 853
                                        .|..|...|. :.:||....|:..:.|      |.:.
Mouse  1048 SKTPSQQPPPRGWVQSSSTINVSWSPPECPNAHWLTYTLFRNGSEIYTTEDEHPYYTQYFLDTSL 1112

  Fly   854 FPGFSSKGYVVFNAIQNDVRNEVNVFKS----SLYRIVLRYVNP-NAENVTATISVTSDNPLEVD 913
            .|..:...|:..:.:.:..|:...::::    |...:.|.::.| .::::|.|.:..|::...|.
Mouse  1113 SPHTAYSYYIETSNVHSSTRSIPVIYETKPEVSEGHLNLTHIIPVGSDSITLTWTGLSNSSDPVA 1177

  Fly   914 QHVKVLLQPTSEPQFVTVAGPLGVKPSAIV--LDP-GRYVFTTKANKN----------------- 958
            ::|.......|....|:..||   :.||.:  |.| .:|.|:.:...|                 
Mouse  1178 KYVLSCTPVDSTEPCVSYEGP---ETSATIWNLVPFTQYCFSVQGCTNESCFYSLPIIVTTAQAP 1239

  Fly   959 -----------------------------VMLDYFVLL-------PAAYYEA-GILTRHIS---- 982
                                         :::.|.:.:       .:..:|: |:::.|.:    
Mouse  1240 PQTQGPPTVWKISPTELRIEWSPPVDSNGIIISYELYMRRWLSTEESLVFESHGLVSSHSALQSV 1304

  Fly   983 NPCE-----------LGNMELCRHYKYA-----------------------SVEVF--SPAATPF 1011
            ||.:           :..:|  .|.:||                       ||.||  .|:.:| 
Mouse  1305 NPSKNLLQQPQASTFISGLE--PHTEYAFRVLAVNMAGRVSSAWASERTGESVPVFMAPPSVSP- 1366

  Fly  1012 VIGENSKPTN---PVETYTDPE----HLQIVSH---VGDIPVLSGSQNELHYIVDVPRSGRYIFV 1066
             :..:|...:   |.|.:|..|    .:.:||.   :.|:||:....  :|:.....:|      
Mouse  1367 -LSPHSLSVSWEKPAENFTRGEIIGYKISMVSEHFPLHDVPVMCSKM--VHFAKSQDQS------ 1422

  Fly  1067 IDYISDRNFP-DSYYINLKLKDNPDSETSVL------------LYPCLYSTICRTSVN------- 1111
              ||.....| .:|...:.|.|:....||.|            |.|.:.:.:..|:|:       
Mouse  1423 --YIVRGLEPYRTYSFTVSLCDSVGCVTSALGSGQTLAAAPAQLRPPMVTGVNSTTVHIRWLPPA 1485

  Fly  1112 -EDGMEKSFYINKEDLQPVIISADIEDGSRF 1141
             .:|....:::.::.......:|.:..|:||
Mouse  1486 GVNGPPPLYHLERKKSSLPAATAAVTKGTRF 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 55/244 (23%)
EGF_Lam 272..>314 CDD:238012 20/43 (47%)
EGF_Lam 332..389 CDD:238012 23/56 (41%)
EGF_Lam 402..443 CDD:238012 2/40 (5%)
Laminin_EGF 448..497 CDD:395007 23/55 (42%)
Laminin_EGF 495..543 CDD:395007 19/54 (35%)
Laminin_EGF 541..589 CDD:395007 18/49 (37%)
Laminin_EGF 587..634 CDD:395007 24/53 (45%)
Laminin_EGF 632..679 CDD:395007 16/54 (30%)
Laminin_EGF 677..729 CDD:395007 16/53 (30%)
Laminin_EGF 732..782 CDD:395007 21/51 (41%)
EGF_Lam 785..828 CDD:238012 16/80 (20%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 29/195 (15%)
Laminin_EGF 1375..1423 CDD:395007
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:395007
Laminin_EGF 1514..1562 CDD:395007
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:395007
EGF_Lam 1808..1851 CDD:238012
EGF_Lam 1859..1907 CDD:214543
EGF_Lam 1916..1968 CDD:238012
EGF_Lam 1969..2015 CDD:238012
EGF_Lam 2016..>2054 CDD:238012
EGF_Lam 2063..>2097 CDD:238012
Laminin_I 2134..2385 CDD:310534
SMC_prok_B 2356..>2705 CDD:274008
Laminin_II 2566..2700 CDD:368703
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Ush2aNP_067383.3 LamGL 145..280 CDD:214722
Laminin_N 313..513 CDD:470680 47/217 (22%)
EGF_Lam 514..562 CDD:238012 22/52 (42%)
EGF_Lam 571..636 CDD:238012 28/113 (25%)
Laminin_EGF 638..688 CDD:395007 21/50 (42%)
Laminin_EGF 691..741 CDD:395007 17/49 (35%)
EGF_Lam 743..788 CDD:238012 16/44 (36%)
EGF_Lam 792..832 CDD:214543 20/39 (51%)
Laminin_EGF 844..894 CDD:395007 14/49 (29%)
EGF_Lam 896..945 CDD:238012 16/54 (30%)
EGF_Lam 947..997 CDD:238012 21/53 (40%)
EGF_Lam 998..>1035 CDD:238012 13/36 (36%)
FN3 1055..1128 CDD:473895 10/72 (14%)
fn3 1153..1223 CDD:394996 16/72 (22%)
FN3 1239..1351 CDD:238020 10/113 (9%)
FN3 1362..1445 CDD:214495 20/94 (21%)
Laminin_G_2 1539..1669 CDD:460494
LamG 1707..1857 CDD:238058
FN3 <1895..>2118 CDD:442628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1931..1955
FN3 2134..2230 CDD:238020
FN3 <2199..>2456 CDD:442628
FN3 <2390..2730 CDD:442628
FN3 <2676..3065 CDD:442628
FN3 3099..>3148 CDD:473895
FN3 <3446..3646 CDD:442628
FN3 3620..>4047 CDD:442628
FN3 3926..>4371 CDD:442628
FN3 <4317..>4526 CDD:442628
FN3 4521..4619 CDD:238020
FN3 4645..4722 CDD:238020
FN3 4724..4800 CDD:238020
FN3 4817..4918 CDD:238020
PDZ-binding 5191..5193
Blue background indicates that the domain is not in the aligned region.

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