DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and Ccdc186

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_739563.1	Gene:	Ccdc186 / 213993	MGIID:	2445022	Length:	917	Species:	Mus musculus

Alignment Length:	728	Identity:	144/728 - (19%)
Similarity:	275/728 - (37%)	Gaps:	182/728 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2154 DQLADELEPK----------VKLLDPNSVDLSPSKKANSE----LESDAKSYAKQVNQTLANAFD 2204
            |.|.:||..:          :|.|:....:|:...||:.:    .:..||:..:|:::.:|...|
Mouse   250 DSLREELRKRTETEKQHMNTIKQLELRIEELNKEIKASKDQLVAQDVTAKNAIQQIHKEMAQRMD 314

  Fly  2205 IRERSSTTLGNITVAYDEAVKSADQAKEAI------ASVEALS--KNLEAAASTKIDAALEQAQH 2261
                          ..::..:.|.|.|||:      ...|||.  |..|.......||:.|..::
Mouse   315 --------------QANKKCEEARQEKEAMVMKYVRGEKEALDLRKEKETLERKLRDASKELEKN 365

  Fly  2262 I-----LGQINGTSIELTPNEQ-----VLEKARKLYEEVNTLVLPIK-AQNKSLNALKNDIGEFS 2315
            .     |.|..|...:|..:::     ::.:..||.||:|:.|:.:| |||| |.|..:...|..
Mouse   366 TNKIKQLSQEKGRLQQLYESKEGETTRLIREIEKLKEEMNSQVIKVKWAQNK-LKAEMDSHKETK 429

  Fly  2316 DHLEDLFNWSEASQAK-SADVERRNVANQ-KAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLT 2378
            |.|::  ..::.:||| .|:..|:|..:. |.:..|:         :.:.|..||...:..|:|.
Mouse   430 DKLKE--TTTKLTQAKEEAEQIRQNCQDMIKTYQESE---------EIKSNELDAKLRVTKGELE 483

  Fly  2379 LNQINQKLDNL---RDALNELNSFNKNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAA 2440
             .|:.:|.|.|   ...:.||....:...|.:........:|..|.|:        .::.:|..:
Mouse   484 -KQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKAKCLEDE--------RLRTEDELS 539

  Fly  2441 QYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLL 2505
            :|.::....:..|:      .:::.|:...:|.:...|          |.:|..|         |
Mouse   540 KYREIINRQKSEIQ------NLLDKVKITDQLHEQLQS----------GKQEIEH---------L 579

  Fly  2506 QRARQSLQKVQDDLEPRLNASAGK-------VQKISAVNNATEHQLKDINKLIDQLPA-----ES 2558
            :...:||..:.:||:..:..|..:       .:|:::.|...:.:...:...:|.|..     :|
Mouse   580 KEEMESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESSALQSQVDNLSCTESQLQS 644

  Fly  2559 QRDMWKNSNANASDALEILKNVLEILEPVSVQT-PKELEKAHGINRDL-----DLTNKDVSQANK 2617
            |......:|.|...  ::||.  |.|....||| ..||..|....:.|     :|.::.|:|..|
Mouse   645 QCQQMGQANRNLES--KLLKE--EELRKEEVQTLQAELSAAQTEVKALSTQVEELKDELVTQRRK 705

  Fly  2618 QLDDVEGSVSKLSELAEDIEEQQH--------RVGSQSRQLGQEIENLKAQVEAARQLANSIKVG 2674
            ...:|:....:|.:....:|:.::        .:||:|...|.....:.|:..:....::|:.|.
Mouse   706 HASNVKDLSKQLQQARRKLEQTENGNHDKDISSMGSRSSSSGSLNARISAEDRSPENTSSSVAVD 770

  Fly  2675 ---------------------------VNFKPSTILEL--KTPEKTKLLATRTNLSTYFRTTEPS 2710
                                       :.|....|.:|  :..:|||::.:       :...|.|
Mouse   771 NFPEVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQS-------YVLREES 828

  Fly  2711 GFLLYLGND-NKTAQKNNDFVAVEIVNGYPI---LTIDLGNGPERITSDKYVADGRWYQAVV-DR 2770
            |.|....:| ||........:...:...:|.   ||::|.           :...|..|||: |.
Mouse   829 GTLSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELS-----------LEINRKLQAVLEDT 882

  Fly  2771 MGPNAKLTIREEL 2783
            :..|  :|::|.|
Mouse   883 LLKN--ITLKENL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		EGF_Lam	448..491	CDD:238012
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627	61/265 (23%)
		Tar	2278..2662	CDD:223910	85/420 (20%)
		Laminin_II	2566..2700	CDD:283628	33/176 (19%)
		LamG	2674..2843	CDD:238058	26/144 (18%)
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
Ccdc186	NP_739563.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..118
		Taxilin	315..645	CDD:286771	75/375 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..769		11/67 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810