DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and lam-2

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_509204.3 Gene:lam-2 / 180980 WormBaseID:WBGene00016913 Length:1633 Species:Caenorhabditis elegans


Alignment Length:2831 Identity:533/2831 - (18%)
Similarity:812/2831 - (28%) Gaps:1394/2831 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |.:.|.|...::..|.|||  |..|..:|      .:..|..    |..||:.||......:||.
 Worm    53 PDFVNAAFNLEVQVTNTCG--TKRPTKFC------VQSGHTG----QRSVCETCDDRHEGFSHPA 105

  Fly    91 ENAID----GTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTD 150
            :...|    ..|.||||..:..|.:: ...|||:...:.|.:.|:.::. .||||..:|:.|.|.
 Worm   106 KYLTDFNVGNNETWWQSDTMQEGQQYPTTTNLTLVLGKSFDITYVRLKF-ISPRPESFTIYKKTH 169

  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVI--CTTEYSKIVPLENGEIPVMLLNERPS 213
            ....|.|||.:|   ..|...:|.....||...::..  ||.|:|.|.|:..|.|....|..|||
 Worm   170 TDSEWEPWQFYS---GSCRATYGLSDRAPILPGNEATAQCTKEFSDISPITGGNIAFSTLEGRPS 231

  Fly   214 STNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGH 278
            :..:..|.|||:|..|:.:||.|.| .|..|   ....:||.|.|.|:|:|.|.::||||.||||
 Worm   232 AHAFEESEVLQKWVTASAIRISLNR-MNTFG---DEVFKDPQVLRSYYYAISDFAVGGRCKCNGH 292

  Fly   279 ADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECK 343
            |..|...........|.|||:|:|.|..||||.|.:..:.||..|:.....|..|||...||.|.
 Worm   293 ASECVGSSSVDGENRLVCRCEHNTQGADCNECLPFYNDRPWRSGTSVEANECIACNCSQLSNRCY 357

  Fly   344 YDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYF 408
            :|:::      .:..||   ||.|.:||.||.|::|.:|...::|..|:::              
 Worm   358 FDQQL------FEETGH---GGHCIDCQGNTQGVHCEQCIANHWRRPGENY-------------- 399

  Fly   409 FSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKIN 473
                                                                             
 Worm   400 ----------------------------------------------------------------- 399

  Fly   474 FAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTC 538
                              |.||.||:|||::..                                
 Worm   400 ------------------CVACGCNEIGSLSTQ-------------------------------- 414

  Fly   539 SYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTG 603
                                                                        |||.|
 Worm   415 ------------------------------------------------------------CDNEG 419

  Fly   604 KCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGF 668
            ||.                                             |:|...||.||.|.:||
 Worm   420 KCQ---------------------------------------------CKPGVTGRFCDQCLDGF 439

  Fly   669 YNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICD 733
            |:|                                                     :|.||:.|.
 Worm   440 YDF-----------------------------------------------------STNGCKNCG 451

  Fly   734 CWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCD 798
            |.|.|:::....|.|.||.|.||.:.:||:|.:|:.|.|||.:.:.|||..|.| .|.|  |:|:
 Worm   452 CETSGSLNNQPRCDSSSGSCSCKLNVEGRQCDKCKPGYFDLSTENQFGCTPCFC-FGHS--SICN 513

  Fly   799 KISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYV 863
            .                                   .||.........:|.|:..:.|       
 Worm   514 T-----------------------------------ADGYFAMNVSSVFDQDKQKWAG------- 536

  Fly   864 VFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQF 928
                 ||              ||.|:.......:....:|.|.::|:                  
 Worm   537 -----QN--------------RIGLQDTQWAELDKAVAVSDTDNSPV------------------ 564

  Fly   929 VTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELC 993
                                              |||.                           
 Worm   565 ----------------------------------YFVA--------------------------- 568

  Fly   994 RHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVP 1058
                                               ||                            
 Worm   569 -----------------------------------PE---------------------------- 570

  Fly  1059 RSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNED---GMEKSFY 1120
                     .::.|:                                 |:|.|:|   .::.:.:
 Worm   571 ---------QFLGDQ---------------------------------RSSYNQDLVFTLKVAKH 593

  Fly  1121 INKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKK 1185
            :..:|::.:||                                                      
 Worm   594 VTNQDVKDIII------------------------------------------------------ 604

  Fly  1186 IEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPK 1250
                                       |..|.|..:|                            
 Worm   605 ---------------------------VGADRQELST---------------------------- 614

  Fly  1251 YQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLV 1315
                                                                             
 Worm   615 ----------------------------------------------------------------- 614

  Fly  1316 VVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYA 1380
                                                           |:||..|           
 Worm   615 -----------------------------------------------SITAQGN----------- 621

  Fly  1381 GSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGD 1445
                    ||                                        |||            
 Worm   622 --------PF----------------------------------------PTT------------ 626

  Fly  1446 LCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPH 1510
                 ...||.|.                                                    
 Worm   627 -----EAQTYRFR---------------------------------------------------- 634

  Fly  1511 CEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCD 1575
                                                                             
 Worm   635 ----------------------------------------------------------------- 634

  Fly  1576 SAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGV 1640
                                             |.||                       .||| 
 Worm   635 ---------------------------------VHAD-----------------------PYFG- 642

  Fly  1641 LDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRV 1705
                                                                        :..|:
 Worm   643 ------------------------------------------------------------WYPRI 647

  Fly  1706 NIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQF 1770
            |               ..||:.:|.::..|.||..|..:. :.:||:|.|..|..........|.
 Worm   648 N---------------ELDFIGILSNITAIKIRGTYSYKD-IGYLSNVNLGTAGVAPSAANPKQA 696

  Fly  1771 LAVERCSCPPGYSGHSCEDCAPGYYRDP--SGPYGGYCIPCECNGHSETCDCATGICSKCQHGTE 1833
            ..:|.|.|.||:.|..||.|..|:.|:.  .||: .:||.|:|:.||.:|:..:|.|. |:|.|.
 Worm   697 TWIEHCECLPGFVGQFCESCESGFRRETKFGGPF-NHCIKCDCHNHSNSCEAESGSCI-CEHNTA 759

  Fly  1834 GDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHCECKPGYTGPRCES 1898
            ||.||||..||||:|..||..||..|.||     |:  ..|.:...||.|..||..||||.||:.
 Worm   760 GDTCERCARGYYGDALQGTEEDCQKCPCP-----ND--GPCILHADGDVICTECPNGYTGRRCDE 817

  Fly  1899 CANGFYGEPESIGQVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDA-I 1962
            |::|::|.|:. |..|..|.||||.:|...|:||..||||.:|:.||.|..|..|.||::||| |
 Worm   818 CSDGYFGNPKD-GTECVECACSGNTDPNSIGNCDKITGECKKCIFNTHGFNCENCKPGYWGDALI 881

  Fly  1963 KLK-NCQSCDCDDLGTQ---------TCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRAC 2017
            :.| |||||.|...||:         .|:...|.|.|..||||.:||:|....|...||:||:.|
 Worm   882 EPKGNCQSCGCFAAGTRRPNNDYTLLECNQQDGQCDCLPNVIGIQCDQCAHGFYNITSGLGCQEC 946

  Fly  2018 DC---GAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPN 2079
            :|   |:..|:  ||.:||.|.||.||||::|||||..|:.:..:||.||:|....|....|:.|
 Worm   947 NCDPLGSEGNT--CDVNTGQCQCKPGVTGQRCDRCADYHFGFSANGCQPCDCEYIGSENQQCDVN 1009

  Fly  2080 TGKCQCLPGVIGDRCDAC-PNRWVLIKDEGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLA 2143
            :|:|.|...|.|.|||.| .||:.:  .:||..|::|:..:                        
 Worm  1010 SGQCLCKENVEGRRCDQCAENRYGI--TQGCLPCDDCYTLI------------------------ 1048

  Fly  2144 FFTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRER 2208
               ..::|.:.:       |||.||....::..:....::.:.|.|  .|:.::..:..::..::
 Worm  1049 ---QSRVNVFRE-------KVKSLDNTLQEIIENPAPVNDTKFDEK--VKETSRAASEVWEAVKQ 1101

  Fly  2209 SSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIEL 2273
            .:...|.......:|:|.     |.:|::|.|:...|:.|..|:.|  :.|::          ::
 Worm  1102 KTKEGGGTIKTKSKAIKD-----EIVAALEKLTSIDESVAQAKVGA--DAAEN----------DM 1149

  Fly  2274 TPNEQVLEKARKLYEEVNTLVLPIKAQNK-----SLNALKNDIGEFSDHLEDLFNWSEASQAKSA 2333
            ...|.::|.||:   |:..::..::.:.:     :.|| ....||.|..:.:|.:.:        
 Worm  1150 KRWEIIIENARR---EIENVLHYLETEGEERAQIAYNA-SQKYGEQSKRMSELASGT-------- 1202

  Fly  2334 DVERRNVANQKAFDNSKFDTVSEQKL----QAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALN 2394
                |..|.:.....|:.:.:|||.:    ||.|...||   :..|:    ||::::..|::..|
 Worm  1203 ----REEAEKHLKQASEIEQLSEQAIANATQANKEASDA---IYGGE----QISKQIAELKEKQN 1256

  Fly  2395 ELNSFNKNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAA-QYTDMTASAEPAIKAATA 2458
            :|   |:::...|.:.|:|.|.||               :|.:||| ..|::.|...|::.....
 Worm  1257 QL---NESIHRTLDLAEEQKKSAD---------------EANNLAAVSLTNVEAVKIPSVDPKEL 1303

  Fly  2459 YSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEPRL 2523
            .:.:...:|.::.|...::. ..:|.|:... |....:||         ||..||..||.     
 Worm  1304 RNDVAGVLEESENLVDSSVK-ENSANDELFD-EVNRSVAD---------ARNELQSSQDQ----- 1352

  Fly  2524 NASAGKVQKISAVNNATEHQLKDINKLIDQ--LPAESQRDMWKNSNANASDALEILKNVLEILEP 2586
                   |::|                 ||  |..|..|:...:|.:.|...|:..:..|::||.
 Worm  1353 -------QRVS-----------------DQLMLELEKSRERIVDSVSTADKTLKDAEAALQVLEE 1393

  Fly  2587 VSVQTPK-------ELEKAHGINRDLD-----------------------------LTNKDVSQA 2615
            ...:..|       |.....|||:.||                             |.|:..:.|
 Worm  1394 FGAKIEKSRNDAVAEFAGVEGINQRLDDIIDAQDKRRNSLPIDKQFVIDYRKSADVLLNETHALA 1458

  Fly  2616 NKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIENL---KAQVEAARQLA--------- 2668
            ::..|.:...|    :..:..|..|:.:.....:|....|||   |.|.|..:|:|         
 Worm  1459 DRYKDIIHSDV----DTRDSTEAVQYDIEQLMEELTDSNENLQYYKKQAEDDKQMATEAVRKATL 1519

  Fly  2669 ----------------NSIKVGVNFKPSTILELKTPEKTKL---------LATRTNLS----TY- 2703
                            :.||..:| ...|:.|:...|..:|         |..:..|:    || 
 Worm  1520 AKNSAIEANATILAEEDEIKKIIN-SLDTMEEVNNAELDELEEEIDRLDQLLAQAQLAKEVPTYQ 1583

  Fly  2704 -FRTTEPSGFLLYLGNDNKTAQKNNDF--VAVEIVN 2736
             :|..|          |.|.||..||.  :..|::|
 Worm  1584 QYRADE----------DVKVAQLKNDISELQKEVLN 1609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 78/251 (31%)
EGF_Lam 272..>314 CDD:238012 20/41 (49%)
EGF_Lam 332..389 CDD:238012 19/56 (34%)
EGF_Lam 402..443 CDD:238012 0/40 (0%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 6/47 (13%)
Laminin_EGF 541..589 CDD:278482 0/47 (0%)
Laminin_EGF 587..634 CDD:278482 6/46 (13%)
EGF_Lam 631..673 CDD:238012 11/41 (27%)
Laminin_EGF 677..729 CDD:278482 1/51 (2%)
Laminin_EGF 732..782 CDD:278482 20/49 (41%)
EGF_Lam 785..828 CDD:238012 6/42 (14%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 15/134 (11%)
Laminin_EGF 1375..1423 CDD:278482 2/47 (4%)
EGF_Lam 1420..1457 CDD:238012 5/36 (14%)
Laminin_EGF 1466..1516 CDD:278482 0/49 (0%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 17/127 (13%)
Laminin_EGF <1775..1801 CDD:278482 10/27 (37%)
EGF_Lam 1808..1851 CDD:238012 21/42 (50%)
EGF_Lam 1859..1907 CDD:214543 19/47 (40%)
EGF_Lam 1916..1968 CDD:238012 27/53 (51%)
EGF_Lam 1969..2015 CDD:238012 20/54 (37%)
EGF_Lam 2016..>2054 CDD:238012 20/40 (50%)
EGF_Lam 2063..>2097 CDD:238012 14/33 (42%)
Laminin_I 2129..2385 CDD:283627 46/264 (17%)
Tar 2278..2662 CDD:223910 87/434 (20%)
Laminin_II 2566..2700 CDD:283628 37/206 (18%)
LamG 2674..2843 CDD:238058 19/80 (24%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lam-2NP_509204.3 LamNT 45..285 CDD:214532 78/251 (31%)
EGF_Lam 286..337 CDD:238012 22/50 (44%)
Laminin_EGF 347..405 CDD:278482 24/163 (15%)
EGF_Lam 403..447 CDD:214543 24/233 (10%)
LamB 560..684 CDD:214597 49/854 (6%)
EGF_Lam 736..783 CDD:238012 24/47 (51%)
EGF_Lam 785..833 CDD:238012 21/55 (38%)
Laminin_EGF 835..890 CDD:278482 29/54 (54%)
EGF_Lam 889..944 CDD:238012 20/54 (37%)
EGF_Lam 946..991 CDD:214543 21/46 (46%)
EGF_Lam 993..1041 CDD:238012 19/49 (39%)
MA 1048..1262 CDD:214599 50/292 (17%)
CM_2 1109..>1165 CDD:294459 16/75 (21%)
MCP_signal 1179..1358 CDD:304920 52/256 (20%)
MA 1190..1424 CDD:214599 67/310 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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