DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and Lamc2

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_032511.3 Gene:Lamc2 / 16782 MGIID:99913 Length:1193 Species:Mus musculus


Alignment Length:1448 Identity:340/1448 - (23%)
Similarity:543/1448 - (37%) Gaps:433/1448 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1367 DYNSGALPCNCD-----YAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPD---CKPCKC 1423
            |.|..:..|..|     ..|| .|.|      ..|..|.....|..||..:|...|   |.||.|
Mouse    29 DCNGKSRQCVFDQELHRQTGS-GFRC------LNCNDNTAGVHCERCREGFYRHRDRDRCLPCNC 86

  Fly  1424 PN----SAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQV--IGC--------EECACNPMGIA 1474
            .:    ||.|: .:|:|.|.|.|.|..|::|.|   |||.:  .||        .:|.|:|.|| 
Mouse    87 HSKGSLSAGCD-NSGQCRCKPGVTGQRCDRCQP---GFHMLTDAGCTRDQGQLDSKCDCDPAGI- 146

  Fly  1475 NGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNV 1539
                     :|.|:                                         .|.|.||..|
Mouse   147 ---------SGPCD-----------------------------------------SGRCVCKPAV 161

  Fly  1540 VGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCD-SAYLRVYNVSLLKHVSITTPEFHEESIK 1603
            .|..||:|..|.|:|..:||:|||.|||:|.::.|. ||...|:.:         |..|.::   
Mouse   162 TGERCDRCRPGYYHLDRANPEGCTQCFCYGHSASCHASADFSVHKI---------TSTFSQD--- 214

  Fly  1604 FDMWPVPADEILLNETTLKADFTLR------EVNDERPAYF-GVLDYLLNQNNHISAYGGDLAYT 1661
            .|.|..    :..|....|..::.|      ......|.|| ....:|.||.   .:||..|::.
Mouse   215 VDGWKA----VQRNGAPAKLHWSQRHRDVFSSARRSDPVYFVAPAKFLGNQQ---VSYGQSLSFD 272

  Fly  1662 LHFTSGFDGKYIVAPDVILFSEHNAL-VHTSYEQPSRNEP------FTNRVNIVESNFQTISGKP 1719
            .....|  |:...|.||||  |...| :......|.:..|      :|.|:|...|:..:   ..
Mouse   273 YRVDRG--GRQPSAYDVIL--EGAGLQIRAPLMAPGKTLPCGITKTYTFRLNEHPSSHWS---PQ 330

  Fly  1720 VSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSG 1784
            :|..::..:||:|..:.|||.|.|.: ..::.:|.|..|...:.....:    ||||.||.||.|
Mouse   331 LSYFEYRRLLRNLTALLIRATYGEYS-TGYIDNVTLVSARPVSGAPAPW----VERCVCPAGYKG 390

  Fly  1785 HSCEDCAPGYYRDPS--GPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGD--HCERCVSGYY 1845
            ..|::||.||.||.:  ||:|. |:||.|.| ...||..||   .|..|.|..  .|..|..|:|
Mouse   391 QFCQECASGYKRDSARLGPFGA-CVPCNCQG-GGACDPDTG---DCYSGDENPDIECADCPIGFY 450

  Fly  1846 GNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHC-ECKPGYTGPRCESCANGFYGEPES 1909
            .:..:  |..|..|.|     .|.|  ||.:....:::.| .|.||.||.|||.||:||:|:|  
Mouse   451 NDPHD--PRSCKPCPC-----HNGF--SCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDP-- 504

  Fly  1910 IGQ-----VCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAI---KLKN 1966
            .|:     .|:.|:|:.|::|...|:||..||.||:|:.||.|..|:.|..|::||.:   ....
Mouse   505 FGERGPVRPCQRCQCNNNVDPNASGNCDQLTGRCLKCIYNTAGVYCDQCKAGYFGDPLAPNPADK 569

  Fly  1967 CQSCDCDDLGTQTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPH 2031
            |::|:|..:|::.     |.|.      ||                                   
Mouse   570 CRACNCSPMGSEP-----GECR------GD----------------------------------- 588

  Fly  2032 TGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDA 2096
             |.|.||.|..|..||..|:                                        ..|.|
Mouse   589 -GSCVCKPGFGGLNCDHAAL----------------------------------------TSCPA 612

  Fly  2097 CPNRWVLIKDEGCQECNNCHHALL---------------DVTDRMRYQIDSVLEDF--------- 2137
            |.|:..:..|:..|:..:. .||:               ::..||: |.:..|.|.         
Mouse   613 CYNQVKIQMDQFTQQLQSL-EALVSKAQGGGGGGTVPSGELEGRMQ-QAEQALRDILREAQISEG 675

  Fly  2138 ----NSVTLAFFTSQKLNYYDQLAD-----------------ELEPKVKLLDPNSVDLSPSKKA- 2180
                ....||...||:.:|..:|.|                 .::...:|:....:.|:.|:.: 
Mouse   676 AMRALGFRLAKARSQENDYKTRLDDLKMTAERIRALGSQHQNRVQDTSRLISQMRLSLAGSEASL 740

  Fly  2181 -NSELESDAKSYA-----KQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSA-DQAKEAIAS-- 2236
             |:.:.| ::.|.     |.:.|......|....|:..:..:....::..|.| ..|::|::.  
Mouse   741 QNTNIHS-SEHYVGPNGFKSLAQEATRLADSHAESANAMKQLARETEDYSKQALSLARKALSGGG 804

  Fly  2237 ---------VEALSKNLEAAAS---------TKIDAALEQA-QHIL------GQINGTSIELTPN 2276
                     |:.|...||...|         |:.|...::: ||.|      .|:.|.| :|  :
Mouse   805 GSGVLDSSVVQGLMGKLEKTKSLSQQLSREGTQADIEADRSYQHSLRLLDSASQLQGVS-DL--S 866

  Fly  2277 EQVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLEDLFNW-SEASQAKSADVERRNV 2340
            .||  :|:::.::.::|...:..|..:...::|::|          || .|..|......:||..
Mouse   867 FQV--EAKRIRQKADSLSNLVTRQTDAFTRVRNNLG----------NWEKETRQLLQTGKDRRQT 919

  Fly  2341 ANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFNKNVDE 2405
            ::|         .:|...| |:...::|   |..|:.|..::...|.|||:       |:..|  
Mouse   920 SDQ---------LLSRANL-AKNRAQEA---LSMGNATFYEVENILKNLRE-------FDLQV-- 962

  Fly  2406 ELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAAT-----AYSGIVEA 2465
                 ||:..||    ::|.::.:.::.|..|.    :|.|..||.|:.:||     |.:...||
Mouse   963 -----EDRKAEA----EEAMKRLSSISQKVADA----SDKTQQAETALGSATADTQRAKNAAREA 1014

  Fly  2466 VEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDL---EPRLNASA 2527
            :|.:.::.|:..|....|....||    |...:.|    |...:..:::::.:|   |...:...
Mouse  1015 LEISSEIEQEIGSLNLEANVTADG----ALAMEKG----LATLKSEMREMEGELARKELEFDTDK 1071

  Fly  2528 GKVQKISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEIL-EPVSVQT 2591
            ..||.:     .||.|..|...              .::.....|.|..|..:|.:: :|.||. 
Mouse  1072 DTVQLV-----ITEAQQADARA--------------TSAGVTIQDTLNTLDGILHLIDQPGSVD- 1116

  Fly  2592 PKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIEN 2656
                      ...:.|..:.:.||..|::      |:|..|..|:||:..|..:....|...|:.
Mouse  1117 ----------EEGMMLLEQGLFQAKTQIN------SRLRPLMSDLEERVRRQRNHLHLLETSIDG 1165

  Fly  2657 LKAQVEAARQLANSIKVG 2674
            :.|.|:....:.:::..|
Mouse  1166 ILADVKNLENIRDNLPPG 1183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
Laminin_EGF 448..497 CDD:395007
Laminin_EGF 495..543 CDD:395007
Laminin_EGF 541..589 CDD:395007
Laminin_EGF 587..634 CDD:395007
Laminin_EGF 632..679 CDD:395007
Laminin_EGF 677..729 CDD:395007
Laminin_EGF 732..782 CDD:395007
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:395007 16/55 (29%)
EGF_Lam 1420..1457 CDD:238012 15/40 (38%)
Laminin_EGF 1466..1516 CDD:395007 7/49 (14%)
Laminin_EGF 1514..1562 CDD:395007 14/47 (30%)
LamB 1632..1760 CDD:214597 36/135 (27%)
Laminin_EGF <1775..1801 CDD:395007 14/27 (52%)
EGF_Lam 1808..1851 CDD:238012 15/44 (34%)
EGF_Lam 1859..1907 CDD:214543 20/48 (42%)
EGF_Lam 1916..1968 CDD:238012 20/54 (37%)
EGF_Lam 1969..2015 CDD:238012 7/45 (16%)
EGF_Lam 2016..>2054 CDD:238012 9/37 (24%)
EGF_Lam 2063..>2097 CDD:238012 1/33 (3%)
Laminin_I 2134..2385 CDD:310534 58/316 (18%)
SMC_prok_B 2356..>2705 CDD:274008 69/328 (21%)
Laminin_II 2566..2700 CDD:368703 23/110 (21%)
LamG 2674..2843 CDD:238058 1/1 (100%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Lamc2NP_032511.3 Laminin_EGF 28..86 CDD:395007 18/63 (29%)
EGF_Lam 83..127 CDD:238012 18/47 (38%)
Laminin_EGF 139..184 CDD:395007 21/95 (22%)
Laminin_B 250..380 CDD:459652 35/144 (24%)
EGF_Lam 461..509 CDD:238012 22/56 (39%)
Laminin_EGF 517..564 CDD:395007 20/46 (43%)
EGF_Lam 572..>604 CDD:238012 14/78 (18%)
Cell attachment site. /evidence=ECO:0000255 586..588 0/7 (0%)
SMC_prok_B <614..1181 CDD:274008 128/663 (19%)
Blue background indicates that the domain is not in the aligned region.

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