DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and Lamc2

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_032511.3 Gene:Lamc2 / 16782 MGIID:99913 Length:1193 Species:Mus musculus


Alignment Length:1448 Identity:340/1448 - (23%)
Similarity:543/1448 - (37%) Gaps:433/1448 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1367 DYNSGALPCNCD-----YAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPD---CKPCKC 1423
            |.|..:..|..|     ..|| .|.|      ..|..|.....|..||..:|...|   |.||.|
Mouse    29 DCNGKSRQCVFDQELHRQTGS-GFRC------LNCNDNTAGVHCERCREGFYRHRDRDRCLPCNC 86

  Fly  1424 PN----SAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQV--IGC--------EECACNPMGIA 1474
            .:    ||.|: .:|:|.|.|.|.|..|::|.|   |||.:  .||        .:|.|:|.|| 
Mouse    87 HSKGSLSAGCD-NSGQCRCKPGVTGQRCDRCQP---GFHMLTDAGCTRDQGQLDSKCDCDPAGI- 146

  Fly  1475 NGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNV 1539
                     :|.|:                                         .|.|.||..|
Mouse   147 ---------SGPCD-----------------------------------------SGRCVCKPAV 161

  Fly  1540 VGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCD-SAYLRVYNVSLLKHVSITTPEFHEESIK 1603
            .|..||:|..|.|:|..:||:|||.|||:|.::.|. ||...|:.:         |..|.::   
Mouse   162 TGERCDRCRPGYYHLDRANPEGCTQCFCYGHSASCHASADFSVHKI---------TSTFSQD--- 214

  Fly  1604 FDMWPVPADEILLNETTLKADFTLR------EVNDERPAYF-GVLDYLLNQNNHISAYGGDLAYT 1661
            .|.|..    :..|....|..::.|      ......|.|| ....:|.||.   .:||..|::.
Mouse   215 VDGWKA----VQRNGAPAKLHWSQRHRDVFSSARRSDPVYFVAPAKFLGNQQ---VSYGQSLSFD 272

  Fly  1662 LHFTSGFDGKYIVAPDVILFSEHNAL-VHTSYEQPSRNEP------FTNRVNIVESNFQTISGKP 1719
            .....|  |:...|.||||  |...| :......|.:..|      :|.|:|...|:..:   ..
Mouse   273 YRVDRG--GRQPSAYDVIL--EGAGLQIRAPLMAPGKTLPCGITKTYTFRLNEHPSSHWS---PQ 330

  Fly  1720 VSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSG 1784
            :|..::..:||:|..:.|||.|.|.: ..::.:|.|..|...:.....:    ||||.||.||.|
Mouse   331 LSYFEYRRLLRNLTALLIRATYGEYS-TGYIDNVTLVSARPVSGAPAPW----VERCVCPAGYKG 390

  Fly  1785 HSCEDCAPGYYRDPS--GPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGD--HCERCVSGYY 1845
            ..|::||.||.||.:  ||:|. |:||.|.| ...||..||   .|..|.|..  .|..|..|:|
Mouse   391 QFCQECASGYKRDSARLGPFGA-CVPCNCQG-GGACDPDTG---DCYSGDENPDIECADCPIGFY 450

  Fly  1846 GNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHC-ECKPGYTGPRCESCANGFYGEPES 1909
            .:..:  |..|..|.|     .|.|  ||.:....:::.| .|.||.||.|||.||:||:|:|  
Mouse   451 NDPHD--PRSCKPCPC-----HNGF--SCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDP-- 504

  Fly  1910 IGQ-----VCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAI---KLKN 1966
            .|:     .|:.|:|:.|::|...|:||..||.||:|:.||.|..|:.|..|::||.:   ....
Mouse   505 FGERGPVRPCQRCQCNNNVDPNASGNCDQLTGRCLKCIYNTAGVYCDQCKAGYFGDPLAPNPADK 569

  Fly  1967 CQSCDCDDLGTQTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPH 2031
            |::|:|..:|::.     |.|.      ||                                   
Mouse   570 CRACNCSPMGSEP-----GECR------GD----------------------------------- 588

  Fly  2032 TGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDA 2096
             |.|.||.|..|..||..|:                                        ..|.|
Mouse   589 -GSCVCKPGFGGLNCDHAAL----------------------------------------TSCPA 612

  Fly  2097 CPNRWVLIKDEGCQECNNCHHALL---------------DVTDRMRYQIDSVLEDF--------- 2137
            |.|:..:..|:..|:..:. .||:               ::..||: |.:..|.|.         
Mouse   613 CYNQVKIQMDQFTQQLQSL-EALVSKAQGGGGGGTVPSGELEGRMQ-QAEQALRDILREAQISEG 675

  Fly  2138 ----NSVTLAFFTSQKLNYYDQLAD-----------------ELEPKVKLLDPNSVDLSPSKKA- 2180
                ....||...||:.:|..:|.|                 .::...:|:....:.|:.|:.: 
Mouse   676 AMRALGFRLAKARSQENDYKTRLDDLKMTAERIRALGSQHQNRVQDTSRLISQMRLSLAGSEASL 740

  Fly  2181 -NSELESDAKSYA-----KQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSA-DQAKEAIAS-- 2236
             |:.:.| ::.|.     |.:.|......|....|:..:..:....::..|.| ..|::|::.  
Mouse   741 QNTNIHS-SEHYVGPNGFKSLAQEATRLADSHAESANAMKQLARETEDYSKQALSLARKALSGGG 804

  Fly  2237 ---------VEALSKNLEAAAS---------TKIDAALEQA-QHIL------GQINGTSIELTPN 2276
                     |:.|...||...|         |:.|...::: ||.|      .|:.|.| :|  :
Mouse   805 GSGVLDSSVVQGLMGKLEKTKSLSQQLSREGTQADIEADRSYQHSLRLLDSASQLQGVS-DL--S 866

  Fly  2277 EQVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLEDLFNW-SEASQAKSADVERRNV 2340
            .||  :|:::.::.::|...:..|..:...::|::|          || .|..|......:||..
Mouse   867 FQV--EAKRIRQKADSLSNLVTRQTDAFTRVRNNLG----------NWEKETRQLLQTGKDRRQT 919

  Fly  2341 ANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFNKNVDE 2405
            ::|         .:|...| |:...::|   |..|:.|..::...|.|||:       |:..|  
Mouse   920 SDQ---------LLSRANL-AKNRAQEA---LSMGNATFYEVENILKNLRE-------FDLQV-- 962

  Fly  2406 ELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAAT-----AYSGIVEA 2465
                 ||:..||    ::|.::.:.::.|..|.    :|.|..||.|:.:||     |.:...||
Mouse   963 -----EDRKAEA----EEAMKRLSSISQKVADA----SDKTQQAETALGSATADTQRAKNAAREA 1014

  Fly  2466 VEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDL---EPRLNASA 2527
            :|.:.::.|:..|....|....||    |...:.|    |...:..:::::.:|   |...:...
Mouse  1015 LEISSEIEQEIGSLNLEANVTADG----ALAMEKG----LATLKSEMREMEGELARKELEFDTDK 1071

  Fly  2528 GKVQKISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEIL-EPVSVQT 2591
            ..||.:     .||.|..|...              .::.....|.|..|..:|.:: :|.||. 
Mouse  1072 DTVQLV-----ITEAQQADARA--------------TSAGVTIQDTLNTLDGILHLIDQPGSVD- 1116

  Fly  2592 PKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIEN 2656
                      ...:.|..:.:.||..|::      |:|..|..|:||:..|..:....|...|:.
Mouse  1117 ----------EEGMMLLEQGLFQAKTQIN------SRLRPLMSDLEERVRRQRNHLHLLETSIDG 1165

  Fly  2657 LKAQVEAARQLANSIKVG 2674
            :.|.|:....:.:::..|
Mouse  1166 ILADVKNLENIRDNLPPG 1183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
EGF_Lam 448..491 CDD:238012
Laminin_EGF 495..543 CDD:278482
Laminin_EGF 541..589 CDD:278482
Laminin_EGF 587..634 CDD:278482
EGF_Lam 631..673 CDD:238012
Laminin_EGF 677..729 CDD:278482
Laminin_EGF 732..782 CDD:278482
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:278482 16/55 (29%)
EGF_Lam 1420..1457 CDD:238012 15/40 (38%)
Laminin_EGF 1466..1516 CDD:278482 7/49 (14%)
Laminin_EGF 1514..1562 CDD:278482 14/47 (30%)
LamB 1632..1760 CDD:214597 36/135 (27%)
Laminin_EGF <1775..1801 CDD:278482 14/27 (52%)
EGF_Lam 1808..1851 CDD:238012 15/44 (34%)
EGF_Lam 1859..1907 CDD:214543 20/48 (42%)
EGF_Lam 1916..1968 CDD:238012 20/54 (37%)
EGF_Lam 1969..2015 CDD:238012 7/45 (16%)
EGF_Lam 2016..>2054 CDD:238012 9/37 (24%)
EGF_Lam 2063..>2097 CDD:238012 1/33 (3%)
Laminin_I 2129..2385 CDD:283627 59/321 (18%)
Tar 2278..2662 CDD:223910 82/393 (21%)
Laminin_II 2566..2700 CDD:283628 23/110 (21%)
LamG 2674..2843 CDD:238058 1/1 (100%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Lamc2NP_032511.3 Laminin_EGF 28..86 CDD:365839 18/63 (29%)
EGF_Lam 83..127 CDD:238012 18/47 (38%)
Laminin_EGF 139..184 CDD:365839 21/95 (22%)
Laminin_B 245..370 CDD:383018 36/135 (27%)
EGF_Lam 461..509 CDD:238012 22/56 (39%)
Laminin_EGF 517..564 CDD:365839 20/46 (43%)
EGF_Lam 572..>604 CDD:238012 14/78 (18%)
Cell attachment site. /evidence=ECO:0000255 586..588 0/7 (0%)
SMC_prok_B <614..1192 CDD:274008 129/667 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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