DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanA and Lamb2

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_032509.2 Gene:Lamb2 / 16779 MGIID:99916 Length:1799 Species:Mus musculus


Alignment Length:2866 Identity:554/2866 - (19%)
Similarity:842/2866 - (29%) Gaps:1303/2866 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 IGALLVILAISYCQA-----------ELTPPYFNLATGR--KIYATATCGQDTDGPELYCKLVGA 59
            :|.||.:||.:..||           ...|...:|..||  ::.|::|||  ...|:.||.:...
Mouse    23 LGLLLSVLAATLAQAPSLDVPGCSRGSCYPATGDLLVGRADRLTASSTCG--LHSPQPYCIVSHL 85

  Fly    60 NTEHDHIDYSVIQGQVCDYCDPTVP--ERNHPPENAIDGT---------EAWWQSPPLSRGMKFN 113
            ..|           :.|..||...|  .|::|..:.|...         .|||||   ..|:.. 
Mouse    86 QDE-----------KKCFLCDSRRPFSARDNPNSHRIQNVVTSFAPQRRTAWWQS---ENGVPM- 135

  Fly   114 EVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYK 178
             |.:.::.|.|||..:|.:.. .:.||....:|:|.|:|:||..:::||   .||...|......
Mouse   136 -VTIQLDLEAEFHFTHLIMTF-KTFRPAAMLVERSADFGRTWHVYRYFS---YDCGADFPGIPLA 195

  Fly   179 PITRDDDVICTTEYSKIVPLENGEIPVMLLNER-PSSTNYFNSTVLQEWTRATNVRIRLLRTKNL 242
            |..|.|||:|.:.||:|.|...||:...:|:.. |....|  |:.:|...:.||:|:.|.|...|
Mouse   196 PPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPY--SSRIQNLLKITNLRVNLTRLHTL 258

  Fly   243 LGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRIL-----ACRCQHHT 302
            ..:|:...|:   :..:|:|::.::.|.|.|.|.|||..| ...|.:|....     ||.|:|:|
Mouse   259 GDNLLDPRRE---IREKYYYALYELVIRGNCFCYGHASQC-APAPGAPAHAEGMVHGACICKHNT 319

  Fly   303 CGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVC 367
            .|:.|.:|...::...|....:.....|..|.|:||::.|.:|       :::.:......||||
Mouse   320 RGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHTHSCHFD-------MAVYLASGNVSGGVC 377

  Fly   368 QNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSC 432
            ..|||||.|.:|..|:|.:||...|...:..||.|                              
Mouse   378 DGCQHNTAGRHCEFCRPFFYRDPTKDMRDPAVCRP------------------------------ 412

  Fly   433 DSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACEC 497
                                                                             
Mouse   413 ----------------------------------------------------------------- 412

  Fly   498 NKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCIC 562
                                                       ||||..|::.            
Mouse   413 -------------------------------------------CDCDPMGSQD------------ 422

  Fly   563 REGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYP 627
                ||                                                           
Mouse   423 ----GG----------------------------------------------------------- 424

  Fly   628 DCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPA-GVIDKFAGC 691
                 .||||.                                         ||. |::.     
Mouse   425 -----RCDSHD-----------------------------------------DPVLGLVS----- 438

  Fly   692 GSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCK 756
                 |: |:|||.|.|..|.:|:..::.|:.|:..||:.|.|.:.||:.....|.|.||.|.||
Mouse   439 -----GQ-CRCKEHVVGTRCQQCRDGFFGLSASDPRGCQRCQCNSRGTVPGSSPCDSSSGTCFCK 497

  Fly   757 PHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTT 821
            ....|..|..|..|.:.| |..|.||:.|.|||||:....||:.:|||:|...:.|..|.|....
Mouse   498 RLVTGHGCDRCLPGHWGL-SHDLLGCRPCDCDVGGALDPQCDEATGQCRCRQHMIGRRCEQVQPG 561

  Fly   822 HFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSL--- 883
            :|.|.|....:|.|.........|.........|.::..|:|.....|     ||....:||   
Mouse   562 YFRPFLDHLTWEAEAAQGQGLEVVERLVTNRETPSWTGPGFVRLREGQ-----EVEFLVTSLPRA 621

  Fly   884 --YRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDP 946
              |.::||: .|......|.:.:....|..|..|                               
Mouse   622 MDYDLLLRW-EPQVPEQWAELELMVQRPGPVSAH------------------------------- 654

  Fly   947 GRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPF 1011
                                                :||                          
Mouse   655 ------------------------------------SPC-------------------------- 657

  Fly  1012 VIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFP 1076
                                    .||                  :|:                 
Mouse   658 ------------------------GHV------------------LPK----------------- 663

  Fly  1077 DSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRF 1141
                         |.....:|:|                                      .:||
Mouse   664 -------------DDRIQGMLHP--------------------------------------NTRF 677

  Fly  1142 PIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASL 1206
            .:.                |.|||:                                  .|..|.
Mouse   678 LVF----------------PRPVCL----------------------------------EPGISY 692

  Fly  1207 DERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQ 1271
            ..::||:.                                           |.|:.|        
Mouse   693 KLKLKLIG-------------------------------------------TGGRAQ-------- 706

  Fly  1272 HCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVP----LKQYN--DDLLVEE 1330
              |.:|                            ...:.:|.||:.|    |:.::  |...:|.
Mouse   707 --PETS----------------------------YSGLLIDSLVLQPHVLVLEMFSGGDAAALER 741

  Fly  1331 --TFDQTKEFIQNCGHDHFHITHNA--SDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFG 1391
              ||::.:     | |:...:...|  |:.|...:.|::|...:|||||.||..||.|.||.|.|
Mouse   742 RTTFERYR-----C-HEEGLMPSKAPLSETCAPLLISVSALIYNGALPCQCDPQGSLSSECSPHG 800

  Fly  1392 GQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYG 1456
            |||:|||.|:.|.|..|.:.||||...                                      
Mouse   801 GQCRCKPGVVGRRCDVCATGYYGFGPA-------------------------------------- 827

  Fly  1457 FHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGT 1521
                 ||:.|.|:|.|..  ::.|:..:|.|.||....|..||.|..|.:.||:|.         
Mouse   828 -----GCQACQCSPDGAL--SALCEGTSGQCPCRPGAFGLRCDHCQRGQWGFPNCR--------- 876

  Fly  1522 ELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSL 1586
                                                                             
Mouse   877 ----------------------------------------------------------------- 876

  Fly  1587 LKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHI 1651
                                                                             
Mouse   877 ----------------------------------------------------------------- 876

  Fly  1652 SAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTIS 1716
                                                                             
Mouse   877 ----------------------------------------------------------------- 876

  Fly  1717 GKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPG 1781
                                                                             
Mouse   877 ----------------------------------------------------------------- 876

  Fly  1782 YSGHSCEDCAPGYYRDPSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYG 1846
                                      ||.|||.::.||..||.|..|:..|.|:|||||::|::|
Mouse   877 --------------------------PCVCNGRADECDTHTGACLGCRDYTGGEHCERCIAGFHG 915

  Fly  1847 NATNGTPGDCMICACPL-PFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESI 1910
            :......|.|..|.||. |....:|||||.......||.|:|:.||||.|||:||.|.:|:|...
Mouse   916 DPRLPYGGQCRPCPCPEGPGSQRHFATSCHRDGYSQQIVCQCREGYTGLRCEACAPGHFGDPSKP 980

  Fly  1911 GQVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDL 1975
            |..|:.|||||||:|.|..:||..||:|||||:||.|..|..|.|||:|.|.: ::|..|.|:.|
Mouse   981 GGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHNTEGPHCGYCKPGFHGQAAR-QSCHRCTCNLL 1044

  Fly  1976 GTQT----------CDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDC-GAASNSTQCD 2029
            ||..          |||..|.|.|..:|.|..||.|.|:.:.|.||.||:.|.| .:.:....|:
Mouse  1045 GTDPRRCPSTDLCHCDPSTGQCPCLPHVQGLNCDHCAPNFWNFTSGRGCQPCACHPSRARGPTCN 1109

  Fly  2030 PHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFG---CNPNTGKCQCLPGVIG 2091
            ..||.|.|.:|..||.|..|...:|......|..|:|:   .||..   |:.:||.|.|.|||.|
Mouse  1110 EFTGQCHCHAGFGGRTCSECQELYWGDPGLQCRACDCD---PRGIDKPQCHRSTGHCSCRPGVSG 1171

  Fly  2092 DRCDACPNRWVLIKDEGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQKLNYYDQL 2156
            .|||.|...:..:    ...|:.||....|                               :|::
Mouse  1172 VRCDQCARGFSGV----FPACHPCHACFGD-------------------------------WDRV 1201

  Fly  2157 ADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQT-LANAFDIRERSSTTLGNITVAY 2220
            ..:|..:.:.|:                     .:|:::.|| :..||:      ::..|:    
Mouse  1202 VQDLAARTRRLE---------------------QWAQELQQTGVLGAFE------SSFLNM---- 1235

  Fly  2221 DEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARK 2285
                    |.|..:......::|..||::.|:..|.|..:|.:|:   |:..||..|..|...:.
Mouse  1236 --------QGKLGMVQAIMSARNASAASTAKLVEATEGLRHEIGK---TTERLTQLEAELTAVQD 1289

  Fly  2286 LYEEVNTLVLPIKAQNKSLNALKND-------IGEFSDHLEDLFN-------------WSEASQA 2330
              |..|.        |.:|:.|:.|       :.:...|||.|.:             .|::::|
Mouse  1290 --ENFNA--------NHALSGLERDGLALNLTLRQLDQHLEILKHSNFLGAYDSIRHAHSQSTEA 1344

  Fly  2331 K----------------SADVERR---------------NVANQKAFD--NSKFDTVSEQKL--- 2359
            :                |||..||               ::|||:|..  ::...|:|...:   
Mouse  1345 ERRANASTFAVPSPVSNSADTRRRTEVLMGAQKENFNRQHLANQQALGRLSAHAHTLSLTGINEL 1409

  Fly  2360 --------------------QAEKNIKDAGNFLING-----DLTLNQINQKLDNLRDALNELNSF 2399
                                :.|......|....:|     ||.|.:.......|:.||.|....
Mouse  1410 VCGAPGDAPCATSPCGGAGCRDEDGQPRCGGLGCSGAAATADLALGRARHTQAELQRALVEGGGI 1474

  Fly  2400 NKNVDEELPVREDQHKEADALTD----------QAEQKAAELAIKAQD--------------LAA 2440
            ...|.|.....|:..:.|.|..|          ||.|:..||....:|              :|.
Mouse  1475 LSRVSETRRQAEEAQQRAQAALDKANASRGQVEQANQELRELIQNVKDFLSQEGADPDSIEMVAT 1539

  Fly  2441 QYTDMTASAEP------AIKAATAYSGIVEA----------VEAAQKLSQDAISAAGNATDKTDG 2489
            :..|::..|.|      |.:.|.....:.:.          |..|::|.|||..|...|..:...
Mouse  1540 RVLDISIPASPEQIQRLASEIAERVRSLADVDTILAHTMGDVRRAEQLLQDAHRARSRAEGERQK 1604

  Fly  2490 IE---------ERAHLADTGS-----TDLLQRARQSLQKVQDDL---EPRLNASAGKVQKISAVN 2537
            .|         :||..|..|:     .| .|...|:||:||:.:   |..||::..:.:::.|:.
Mouse  1605 AETVQAALEEAQRAQGAAQGAIWGAVVD-TQNTEQTLQRVQERMAGAEKSLNSAGERARQLDALL 1668

  Fly  2538 NATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPV--SVQTPKEL--EKA 2598
            .|.:     :.:..:.|.|.:..:...::.:.|.:|.:.|:      |.|  ..||.:.|  .||
Mouse  1669 EALK-----LKRAGNSLAASTAEETAGSAQSRAREAEKQLR------EQVGDQYQTVRALAERKA 1722

  Fly  2599 HGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIENLKAQVEA 2663
            .|:........:...:|...|...:..:.:|.||....||.:..:..::.||    :.|:|::.:
Mouse  1723 EGVLAAQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALEGKAAQL----DGLEARMRS 1783

  Fly  2664 ARQLAN 2669
            ..|..|
Mouse  1784 VLQAIN 1789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 74/277 (27%)
EGF_Lam 272..>314 CDD:238012 16/46 (35%)
EGF_Lam 332..389 CDD:238012 20/56 (36%)
EGF_Lam 402..443 CDD:238012 1/40 (3%)
Laminin_EGF 448..497 CDD:395007 0/48 (0%)
Laminin_EGF 495..543 CDD:395007 1/47 (2%)
Laminin_EGF 541..589 CDD:395007 7/47 (15%)
Laminin_EGF 587..634 CDD:395007 0/46 (0%)
Laminin_EGF 632..679 CDD:395007 4/46 (9%)
Laminin_EGF 677..729 CDD:395007 14/52 (27%)
Laminin_EGF 732..782 CDD:395007 18/49 (37%)
EGF_Lam 785..828 CDD:238012 17/42 (40%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 19/139 (14%)
Laminin_EGF 1375..1423 CDD:395007 24/47 (51%)
EGF_Lam 1420..1457 CDD:238012 0/36 (0%)
Laminin_EGF 1466..1516 CDD:395007 17/49 (35%)
Laminin_EGF 1514..1562 CDD:395007 0/47 (0%)
LamB 1632..1760 CDD:214597 0/127 (0%)
Laminin_EGF <1775..1801 CDD:395007 0/25 (0%)
EGF_Lam 1808..1851 CDD:238012 20/42 (48%)
EGF_Lam 1859..1907 CDD:214543 24/48 (50%)
EGF_Lam 1916..1968 CDD:238012 28/51 (55%)
EGF_Lam 1969..2015 CDD:238012 21/55 (38%)
EGF_Lam 2016..>2054 CDD:238012 12/38 (32%)
EGF_Lam 2063..>2097 CDD:238012 16/36 (44%)
Laminin_I 2134..2385 CDD:310534 53/332 (16%)
SMC_prok_B 2356..>2705 CDD:274008 79/403 (20%)
Laminin_II 2566..2700 CDD:368703 24/108 (22%)
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Lamb2NP_032509.2 Laminin_N 50..284 CDD:459653 72/260 (28%)
EGF_Lam 286..338 CDD:238012 17/52 (33%)
Laminin_EGF 350..401 CDD:395007 21/57 (37%)
Laminin_EGF 413..470 CDD:395007 25/188 (13%)
Laminin_EGF 473..527 CDD:395007 21/54 (39%)
EGF_Lam 524..565 CDD:238012 16/40 (40%)
EGF_Lam 784..829 CDD:214543 24/87 (28%)
Laminin_EGF 832..880 CDD:395007 19/344 (6%)
Laminin_EGF 878..925 CDD:395007 20/46 (43%)
EGF_Lam 927..985 CDD:238012 26/57 (46%)
Laminin_EGF 987..>1029 CDD:395007 26/41 (63%)
Laminin_EGF 1039..1093 CDD:395007 20/53 (38%)
Laminin_EGF 1096..1144 CDD:395007 14/47 (30%)
Laminin_EGF 1144..1191 CDD:395007 18/53 (34%)
Domain II 1191..1410 50/301 (17%)
SMC_prok_B <1204..1571 CDD:274008 74/418 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1339..1365 4/25 (16%)
Domain alpha 1411..1443 2/31 (6%)
Domain I 1444..1799 77/362 (21%)
Smc <1446..>1787 CDD:440809 74/356 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1679..1701 4/21 (19%)
cc_LAMB2_C 1728..1799 CDD:411970 13/66 (20%)
Blue background indicates that the domain is not in the aligned region.

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