Protein Alignment LanA and LanB1

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: XP_061497163.1
• Gene: LanB1 / 1281797
• VectorBaseID: AGAMI1_014157
• Length: 1790
• Species: Anopheles gambiae
• Alignment Length: 2854
• Identity: 585/2854 - (20%)
• Similarity: 897/2854 - (31%)
• Gaps: 1283/2854 - (44%)

  Fly    21 QAELTPPYFNLATGR--KIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCD--- 80
            |:...|...||..||  ::.|::|||  |..||.||.:            |.::.:.|..||
Mosquito    53 QSSCYPATGNLLIGRENRLEASSTCG--TVRPERYCIV------------SHLEEKKCFLCDTRR 103

  Fly    81 --PTVPERNHPPENAI----DGT--EAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNS 137
              ...|.|||.....|    .||  :.||||   ..|.:  .|.:.::.|.|||..:|.|.....
Mosquito   104 ETENDPMRNHRIGQIIYKMQPGTVEQTWWQS---ENGRE--NVTIQLDLEAEFHFTHLIIVFATF 163

  Fly   138 PRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDD--DVICTTEYSKIVPLEN 200
             ||....:|:|.|:||||..:::|:.:   |...|   .:.|:...:  ||||...||.:.|.:|
Mosquito   164 -RPAAMLIERSYDFGKTWHVYKYFAHS---CRESF---PHAPLVARNITDVICDHRYSGVEPSKN 221

  Fly   201 GEIPVMLLNERPSSTNYFN--STVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYS 263
            ||:...:|   |.:.|..|  :..:|...:.||:|:...:..:|..:|:.   ....:..:|:|:
Mosquito   222 GEVIYRVL---PPNMNIENPYAEHVQNMLKMTNLRVNFTKLHSLGDNLLD---DRDEIQEKYYYA 280

  Fly   264 IKDISIGGRCMCNGHADTC-DVKDPKSPVRIL--ACRCQHHTCGIQCNECCPGFEQKKWR----Q 321
            |.::.:.|.|.|.|||..| .::..::.|.::  .|.|.|:|.|:.|.||...|....|:    :
Mosquito   281 ISNMIVRGSCSCYGHASRCLPLEGVRNTVDMVHGRCECTHNTKGLNCEECEDFFNDLPWKPALGK 345

  Fly   322 NTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKY 386
            .|||    |:.|||:.|:..|.:|:.|..       |.....||||.||||||.|.:|.:|.|.:
Mosquito   346 QTNA----CKKCNCNNHATSCHFDQAVYE-------HSGRVSGGVCDNCQHNTQGYHCEECAPFF 399

  Fly   387 YRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECN 451
            ||...:......||.||.||                .|.:.....|||.|
Mosquito   400 YRDPNEDIQSPYVCKPCDCD----------------PRGSLDDGICDSIA--------------- 433

  Fly   452 LNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKC 516
                     :.|:|                                           :..|.|.|
Mosquito   434 ---------DEENG-------------------------------------------IVAGACHC 446

  Fly   517 LTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNY 581
            ..|..|..|:.|:.|::|:
Mosquito   447 KRNVNGRRCDHCREGFWNF---------------------------------------------- 465

  Fly   582 PDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNS 646
                                                                 |.|       |.
Mosquito   466 -----------------------------------------------------DEH-------NP 470

  Fly   647 DGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRIC 711
            ||   |||                      |.|:..|.::. :|| :|..|| |.||..||||.|
Mosquito   471 DG---CQP----------------------CTCNTLGTVNN-SGC-NVYTGE-CICKRLVTGRDC 507

  Fly   712 NECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDS 776
            |:|.|..:.|                                                      |
Mosquito   508 NQCMPETYGL------------------------------------------------------S 518

  Fly   777 ASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQ-FQYEYEDGSLP 840
            .||.||..|||..|||..:.||.|:|||:|.|.:.|..|::|...:|.||||: .:.|.......
Mosquito   519 DSLEGCTPCSCHPGGSLDNSCDVITGQCRCRPHMQGRDCSEPKQHYFIPTLHRILEAEVPSTFCE 583

  Fly   841 SG--------TQVRYDYDEAAF--PGF--SSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRY--- 890
            ||        .:.|.:..:|.|  |||  :|:|.|:...: :|:...:|      |.:::||
Mosquito   584 SGGGQNCSVVVRERANDRDADFTGPGFIRASEGTVLKFTV-DDIPKTMN------YDVMVRYQPQ 641

  Fly   891 VNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKA 955
            :..:.|||..|:                                  ::|.  |.||
Mosquito   642 MKGDWENVRMTV----------------------------------IRPE--VYDP--------- 661

  Fly   956 NKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSKPT 1020
                                      ..||                             .||.|:
Mosquito   662 --------------------------EGPC-----------------------------ANSHPS 671

  Fly  1021 NPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINLKL 1085
                                                            |..|.....|.|
Mosquito   672 ------------------------------------------------YERDITTTLSEY----- 683

  Fly  1086 KDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIP 1150
                  |||.:   .|:. ||                            :|.|..:..|
Mosquito   684 ------ETSAI---ALHD-IC----------------------------LESGKTYKFI------ 704

  Fly  1151 VDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHL 1215
                                               :.|:. ||        ||
Mosquito   705 -----------------------------------VSFQR-HE--------PY------------ 713

  Fly  1216 DSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCR 1280
            |....|.|:|:|          ::|:       |:.:
Mosquito   714 DDNPTAQILIDS----------IVLI-------PRIE---------------------------- 733

  Fly  1281 GVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQ-NCGH 1344
              |.|..:||.:.:                                      .:.:|::. .|.|
Mosquito   734 --ITPIMQGSHQAE--------------------------------------VRHREYVNLGCNH 758

  Fly  1345 DHFHITH--NASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGA 1407
            .::.:.:  ||.:.||..:.:::...|:||:||.|:..||.|.:|...||.|.||
Mosquito   759 TYYDVNYILNAPEECKDLLKTISVYINNGAMPCECNPTGSKSKKCAESGGFCTCK---------- 813

  Fly  1408 CRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMG 1472
                                            .||:|..|::|||.||||... ||:.|.||.:|
Mosquito   814 --------------------------------TNVVGRQCDRCAPGTYGFGPE-GCKACDCNSIG 845

  Fly  1473 IANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKK 1537
              :.::.|||..|.|.|..|..||.||.|..|::|||:|:
Mosquito   846 --SKDNDCDLITGQCNCHPNTYGRECDQCQPGFWNFPNCQ------------------------- 883

  Fly  1538 NVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESI 1602
                                                                             
Mosquito   884 ----------------------------------------------------------------- 883

  Fly  1603 KFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSG 1667
                                                                             
Mosquito   884 ----------------------------------------------------------------- 883

  Fly  1668 FDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDL 1732
                                                                             
Mosquito   884 ----------------------------------------------------------------- 883

  Fly  1733 KVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRD 1797
                                                                             
Mosquito   884 ----------------------------------------------------------------- 883

  Fly  1798 PSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACP 1862
                      .||||||:.||:..||.|..||..|:|..|:|||.|||||...|:...|..|.||
Mosquito   884 ----------ICECNGHTPTCNSKTGECLHCQDFTQGWKCDRCVDGYYGNPLLGSSIGCRPCRCP 938

  Fly  1863 LPFDS-NNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSGNINPE 1926
            ....| :::|..|.:..|.:.:.|.|:.||:|.||:.||:.:||.||..|..|:.|:||.|::|:
Mosquito   939 DTVASGHSYANECYLHPSTNDVICSCEEGYSGARCDVCADNYYGNPEKPGGQCQSCDCSNNVDPK 1003

  Fly  1927 DQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGT----QTCDPFVGVC 1987
            ..|:||:::|:||:||.||.|..|..|..||||||:: ::|::|||:.|||    |.||.:.|.|
Mosquito  1004 RPGNCDSKSGKCLQCLYNTEGDHCEYCRDGFYGDALR-QDCRACDCNLLGTNQTIQHCDRYTGQC 1067

  Fly  1988 TCHENVIGDRCDRCKPDHYGFESGVGCRACDC---GAASNSTQCDPHTGHCACKSGVTGRQCDRC 2049
            .|..||.|..||.|..:|:...||.||.||||   ||.|.  ||:|:.|.|:||.|..||||::|
Mosquito  1068 PCLRNVKGQYCDECIENHWKIASGEGCEACDCDPVGALSE--QCNPYDGQCSCKPGFGGRQCNQC 1130

  Fly  2050 AVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKDEGCQECNN 2114
            ....|......|.||.||...|....|:..||||.|..|:.|.:||.| :|..|.:...|:.|..
Mosquito  1131 EAYFWGDPNVECKPCECNAYGSATQQCDRTTGKCACKSGIGGYKCDQC-DRGYLGQAPYCEPCGE 1194

  Fly  2115 CHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSKK 2179
            |......:.|.:|.:.|..:|:..::.....|......:|.::.::.....||: |::
Mosquito  1195 CFDNWDMILDGLRNETDRTIEEAKTIKKLGATGAYKKEFDSMSKKIAQIEGLLN-NTI------- 1251

  Fly  2180 ANSELES---DAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASVEALS 2241
            ::.|:|:   :.......:.::|.|..:...:...|..||.:|..|.|....:|.:.......|.
Mosquito  1252 SDREIEAIGGEIDRIRNHLQESLHNLEESERKLQETDSNIKLANIEIVNLGRRADDVKQMTNYLK 1316

  Fly  2242 KNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNA 2306
            .|     :||:     |..:|.|.:|.|              |..:..|:.|    ...|.::.|
Mosquito  1317 DN-----ATKL-----QEGNIEGALNLT--------------RDAWYRVSML----GETNMNITA 1353

  Fly  2307 LKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDA-GN 2370
            :.:....:....|.|.|.::      |||.|.:..|:.||            |:.::.:.|. ||
Mosquito  1354 INSRAENYCRRAEHLINKNQ------ADVVRNHENNEAAF------------LKYQEELNDLNGN 1400

  Fly  2371 F--------------------------------LINGDLTLNQ------------INQKLDNLRD 2391
            .                                ..||.|||::            |.:|.:...|
Mosquito  1401 MPDLNQRICDRHGDPCDEFCGGAGCKNGCGGLRCENGALTLSEKALDFAKKTEQNIKEKEELADD 1465

  Fly  2392 ALNELNSFNKNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAA 2456
            .|..::....|..|.....:..|.|..|..:..:    :|..:|..|..:.|||       |:..
Mosquito  1466 ILRSMSQAKANASESYKKAKRTHDETQAHLEDTK----DLIDRANILVVKLTDM-------IENT 1519

  Fly  2457 TAYSG----IVEAV-------------EAAQKLSQDAISAAGNATD---------------KTDG 2489
            ||..|    ::|.|             :.|||: |||:|...|...               |:|.
Mosquito  1520 TASPGEMRELIEQVMSYTLQLDPEQIDDLAQKI-QDAVSHLVNVESIIRNTENDLRRVEMLKSDA 1583

  Fly  2490 IE--ERAHLADTG----------STDLLQRARQSLQKVQDDL-----------------EPRLNA 2525
            ::  |||.....|          :.|..::||||:::...|:                 :.|.|:
Mosquito  1584 LDKKERAEKVLAGVLNITRALDDADDAQKKARQSIKQANADIASAKIDLEEIDKETEEAQKRANS 1648

  Fly  2526 SA-------GKVQKISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEI 2583
            :|       .:::::...|...|...|||||     .||..:|...|::..|:......|...|.
Mosquito  1649 TANAVLALQSRLEQLQKDNIRNELDAKDINK-----QAEDVKDSANNAHERATQLKNDFKTANES 1708

  Fly  2584 LEPVSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSR 2648
            |...:.::....|:|..:          :::|:|...|....:|.|..: :||.:...:
Mosquito  1709 LTAQARRSESARERAQNL----------LNRASKITVDTTTQLSALQSM-DDIYKSNEK------ 1756

  Fly  2649 QLGQEIENLKAQVEAARQLANSIKVGVNFKPSTILELKTPEKTKLLATRTNLSTYFRTT 2707
                ||:||:|::       |.:...:.|...||              :||...|.:.|
Mosquito  1757 ----EIQNLEAEL-------NDLTGKITFYLQTI--------------QTNAERYRQCT 1790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	74/266 (28%)
		EGF_Lam	272..>314	CDD:238012	15/44 (34%)
		EGF_Lam	332..389	CDD:238012	23/56 (41%)
		EGF_Lam	402..443	CDD:238012	9/40 (23%)
		Laminin_EGF	448..497	CDD:395007	2/48 (4%)
		Laminin_EGF	495..543	CDD:395007	9/47 (19%)
		Laminin_EGF	541..589	CDD:395007	0/47 (0%)
		Laminin_EGF	587..634	CDD:395007	0/46 (0%)
		Laminin_EGF	632..679	CDD:395007	9/46 (20%)
		Laminin_EGF	677..729	CDD:395007	20/51 (39%)
		Laminin_EGF	732..782	CDD:395007	3/49 (6%)
		EGF_Lam	785..828	CDD:238012	20/42 (48%)
		CBM6-CBM35-CBM36_like	831..966	CDD:271143	25/149 (17%)
		Laminin_EGF	1375..1423	CDD:395007	11/47 (23%)
		EGF_Lam	1420..1457	CDD:238012	9/36 (25%)
		Laminin_EGF	1466..1516	CDD:395007	21/49 (43%)
		Laminin_EGF	1514..1562	CDD:395007	0/47 (0%)
		LamB	1632..1760	CDD:214597	0/127 (0%)
		Laminin_EGF	<1775..1801	CDD:395007	0/25 (0%)
		EGF_Lam	1808..1851	CDD:238012	24/42 (57%)
		EGF_Lam	1859..1907	CDD:214543	18/48 (38%)
		EGF_Lam	1916..1968	CDD:238012	24/51 (47%)
		EGF_Lam	1969..2015	CDD:238012	22/49 (45%)
		EGF_Lam	2016..>2054	CDD:238012	20/40 (50%)
		EGF_Lam	2063..>2097	CDD:238012	15/33 (45%)
		Laminin_I	2134..2385	CDD:310534	51/298 (17%)
		SMC_prok_B	2356..>2705	CDD:274008	89/461 (19%)
		Laminin_II	2566..2700	CDD:368703	23/133 (17%)
		LamG	2674..2843	CDD:238058	7/34 (21%)
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
LanB1	XP_061497163.1	None