DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and LanB2

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:XP_308240.3 Gene:LanB2 / 1269597 VectorBaseID:AGAMI1_007290 Length:1624 Species:Anopheles gambiae


Alignment Length:2783 Identity:553/2783 - (19%)
Similarity:817/2783 - (29%) Gaps:1353/2783 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYC-----DPTVPE 85
            |.:.|.|...::.||.|||.:||..  :|...|         ||  ..:.||.|     .|....
Mosquito    52 PEFENAAYQLQVEATNTCGDETDTD--FCVQTG---------YS--NRKSCDVCHAGQHSPQFLT 103

  Fly    86 RNHPPENAIDGTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKST 149
            ..|.|.|     ..||||..:..|::: |:||||:...:.|.:.|:.| :.:||||..:.:.|..
Mosquito   104 DFHDPNN-----PTWWQSETMFEGVQYPNQVNLTLGLGKSFDITYIRI-VFHSPRPESFAIYKRV 162

  Fly   150 DYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDD--VICTTEYSKIVPLENGEIPVMLLNERP 212
            .....|.|:|::|.|..|  ||...|:...:..:|:  .:||:|||.|.||.:|.|....|..||
Mosquito   163 TPNGPWIPYQYYSATCRD--TYGLPDSLSVMNGEDESRALCTSEYSDISPLRDGNIAFSSLEGRP 225

  Fly   213 SSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNG 277
            |:.|:.:...||:|..||::||.|.|.......:..    |..|.:.|||:|.||::|.||.|||
Mosquito   226 SAINFDHHLELQQWVTATDIRITLDRLNTFGDEVFG----DAQVLKSYFYAIADIAVGARCKCNG 286

  Fly   278 HADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNEC 342
            ||..|.........|...|:|.|.|.|..|:.|.|.:....|.:.|:.....|:||||:|:|.:|
Mosquito   287 HASECTTSTALDGQRTRVCKCMHFTDGPDCDRCLPFYNDAPWGRATSKNVHECKPCNCNGYSTKC 351

  Fly   343 KYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDY 407
            .:|..:                                                           
Mosquito   352 FFDRHL----------------------------------------------------------- 357

  Fly   408 FFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKI 472
            :..|||                                           |.||            
Mosquito   358 YNLTGH-------------------------------------------GGHC------------ 367

  Fly   473 NFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPT 537
                                                     ..|..|..|.||||||..:|    
Mosquito   368 -----------------------------------------IDCGANRDGPNCERCKENFF---- 387

  Fly   538 CSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNT 602
                                    .||.                                     
Mosquito   388 ------------------------MRED------------------------------------- 391

  Fly   603 GKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEG 667
                               ||     |:.|.||..||:.:.||::|:|.|:|...|.:||.|...
Mosquito   392 -------------------GY-----CINCGCDPVGSRSLQCNAEGRCQCKPGVTGEKCDRCDSN 432

  Fly   668 FYNF--PSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCE 730
            ::||  ..|:.||||..|.:|                                      ||..|:
Mosquito   433 YFNFGPHGCQPCNCDERGSLD--------------------------------------NTPSCD 459

  Fly   731 ICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQS 795
                             ..:|.|.||.:.:||.|:|||.|.|:||:.:.|||..|.| .|.:   
Mosquito   460 -----------------PVTGVCSCKENVEGRHCRECRLGYFNLDAENKFGCTPCFC-YGHT--- 503

  Fly   796 VCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSK 860
                             |.||                                         |:.
Mosquito   504 -----------------LECT-----------------------------------------SAS 510

  Fly   861 GYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSE 925
            ||.:                                     :|.||                   
Mosquito   511 GYSI-------------------------------------VSTTS------------------- 519

  Fly   926 PQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNM 990
                                                                             
Mosquito   520 ----------------------------------------------------------------- 519

  Fly   991 ELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIV 1055
                                                                             
Mosquito   520 ----------------------------------------------------------------- 519

  Fly  1056 DVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFY 1120
                                                                          :|.
Mosquito   520 --------------------------------------------------------------NFN 522

  Fly  1121 INKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKK 1185
            .:||               ::..||.|.:|||                                 
Mosquito   523 KHKE---------------KWTAISDTGVPVD--------------------------------- 539

  Fly  1186 IEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPK 1250
                                                                   |||  .||.:
Mosquito   540 -------------------------------------------------------VKY--NSHSQ 547

  Fly  1251 YQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLV 1315
                 ::..|.|                                                     
Mosquito   548 -----SIGVGAN----------------------------------------------------- 554

  Fly  1316 VVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYA 1380
                                       ||                                    
Mosquito   555 ---------------------------GH------------------------------------ 556

  Fly  1381 GSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGD 1445
                                        |:.|:                       :.|...:||
Mosquito   557 ----------------------------RTVYF-----------------------LAPDRFLGD 570

  Fly  1446 LCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPH 1510
                                             |...:|...:.|..:.|               
Mosquito   571 ---------------------------------QRASYNRLFKFRLQLVG--------------- 587

  Fly  1511 CEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCD 1575
                   :|..|:...|.:                        ||..|.                
Mosquito   588 -------QPRVEVSPYDVV------------------------LQGGNS---------------- 605

  Fly  1576 SAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGV 1640
                           ||:.|.|.:..      .:|::|        ..:|..|            
Mosquito   606 ---------------SISLPIFAQNQ------RMPSEE--------SHEFAFR------------ 629

  Fly  1641 LDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRV 1705
                |::|..         ||.|                               ||.        
Mosquito   630 ----LHENPE---------YTWH-------------------------------PSN-------- 642

  Fly  1706 NIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQF 1770
                      ||:     .||.:|.:|..:.|||.|.:..... |.||.|..|...|.|.   |.
Mosquito   643 ----------SGR-----GFMSILSNLTAVKIRAIYGDYGEAI-LDDVELQTAHRGAAGR---QA 688

  Fly  1771 LAVERCSCPPGYSGHSCEDCAPGYYRDPS--GPYGGYCIPCECNGHSETCDCATGICSKCQHGTE 1833
            ..:|:|:||.||.|..||.|||||..:|:  ||:.. |:||:||.|:|.||..||.|. |||.|.
Mosquito   689 TWIEQCTCPEGYLGQFCESCAPGYRHNPARGGPFMP-CVPCDCNKHAEICDSETGRCI-CQHNTA 751

  Fly  1834 GDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHC-ECKPGYTGPRCE 1897
            ||.|::|..||||||..|||.||..|.||     ||.|  | :..:||.:.| ||..||.|||||
Mosquito   752 GDTCDQCAKGYYGNALGGTPYDCKRCPCP-----NNGA--C-MQMAGDTVICLECPVGYFGPRCE 808

  Fly  1898 SCANGFYGEPESI-GQV--CKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYG 1959
            .|::|:||:|..: |.|  |:||:|:||::|...|:|:..|||||:|::||.|..|:.|.||.:|
Mosquito   809 LCSDGYYGDPTGVYGSVRMCQPCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGPHCDQCLPGHFG 873

  Fly  1960 DAIKLK--NCQSCDCDDLGTQ-------TCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCR 2015
            |.:...  :|:.|.|...||:       .||...|.|.|..||||..|:.||..::...||.||.
Mosquito   874 DPLAEPHGSCEECSCYPRGTEQTEKGISICDAINGNCHCKPNVIGRTCNECKNGYWNIVSGNGCE 938

  Fly  2016 ACDCG-AASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPN 2079
            :|:|. ..|.:..||.::|.|.||.||.|::||:||..::.:.:|||..|:|:...|:|..|| .
Mosquito   939 SCNCDPIGSYNASCDTYSGDCFCKPGVVGKKCDKCAPAYYGFSEDGCHACDCDPSGSKGSQCN-Q 1002

  Fly  2080 TGKCQCLPGVIGDRCDAC-PNRWVLIKDEGCQECNNCHHALLDVTDRMR---YQIDSVLEDFNSV 2140
            .|:|.|...|.|.|||.| .|::  .:.:||.:|..|::.:.|..:..|   .:::.:|:|..|.
Mosquito  1003 YGQCPCNDNVEGRRCDRCKENKY--DRHQGCLDCPACYNLVQDAANDHRAKLAELNQILQDIQSK 1065

  Fly  2141 TLAFFTSQ---KLNYYDQLAD----------------------ELEPKV----KLLDPNSVDLSP 2176
            .:....|:   ||:...:..|                      |||.::    ||||  :.|.|.
Mosquito  1066 PIVIDDSEFAGKLHAVQEKIDILVEDAKSGSGGGEKTLNEILRELEARLQEVQKLLD--NADQSQ 1128

  Fly  2177 S--------------------KKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYD 2221
            .                    :.|..:|::..:....:.|..||.|.||..........|:....
Mosquito  1129 EVTNHKISKGGYNATLANGKIQDARRQLDNAIELLQTEGNTALARAKDISGHLGNQTNQISGISR 1193

  Fly  2222 EAVKSADQAK-EAIASV-----------EALSK---------NLEAAASTKIDAALEQAQHILGQ 2265
            ||.:.||:.| ||.|::           |||.|         |:.....|.|.:.:.||:..|..
Mosquito  1194 EARQYADRFKAEADANMKQAQEAHKKASEALKKANDAFNQQANITKELDTSISSEIAQAREKLNT 1258

  Fly  2266 INGTSIELTPNEQVLEKARKLYEEVNTLVLPIK---AQNKSLNALKNDIGEFS------------ 2315
            ::    :||  ||.|.:||::.:|..||...:.   ..|..::.:|.:..:::            
Mosquito  1259 VS----KLT--EQALTRAREVNDEALTLFAAVNRTAPPNIDIDKIKKEANQYNREADRIAEDLAN 1317

  Fly  2316 ---DHLEDLFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDL 2377
               ||.:.|.|.....:.....::|.::..:.|.|..|  .:...|.||||.:.:       ||.
Mosquito  1318 KMRDHAQLLENVGTNIELAETLLDRASLQKEDAVDALK--QLKYAKEQAEKAVAE-------GDG 1373

  Fly  2378 TLNQINQKLDNLRDALNELNSFNKNVDEEL---PVREDQHKEADALTDQAEQKAAELAIKAQDLA 2439
            ||.:.|.....|....|::...::..:|.|   |..|.|...:..|..:||              
Mosquito  1374 TLQKANYTYQTLAGFKNQVEESSRRAEEALNLVPNIERQIVNSRDLLQRAE-------------- 1424

  Fly  2440 AQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDK--------TDGIEERAHL 2496
                                    ||:.||.:.::||...|..|.||        .:.|::||:.
Mosquito  1425 ------------------------EALYAASRNAEDARKNAQTAQDKYAEEASKLAENIKKRANA 1465

  Fly  2497 ADTGSTDLLQRARQ---SLQKVQDDLEPRLNASAGKVQKISAVNNATEHQL-KDINKLIDQLPAE 2557
            ....:.||...|.|   .|.|..:.||.|                  |.|: ||:|...:.....
Mosquito  1466 TKNTARDLHHEADQLNGRLAKTDNRLEER------------------EAQIRKDLNLTNEAKEKV 1512

  Fly  2558 SQRDMWKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGIN-RDLDLTNKDVSQANKQLDD 2621
            .|..:  |||...|...:.::.|..|:        .||.....|: ..||...:.:|.|.|:|:|
Mosquito  1513 GQAQL--NSNEAKSQVDKAMREVSLIM--------SELANLREIDVNSLDDLERRLSAAEKELED 1567

  Fly  2622 VEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIENLKAQVEAARQLANSIKVG 2674
            .: ...:||.|.|....|...:    |...:|:.:|:.:|.....:|||:..|
Mosquito  1568 AQ-LTKRLSSLVEAKNIQNQNI----RSYQKELADLRLEVANIELIANSLPPG 1615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 81/252 (32%)
EGF_Lam 272..>314 CDD:238012 17/41 (41%)
EGF_Lam 332..389 CDD:238012 8/56 (14%)
EGF_Lam 402..443 CDD:238012 3/40 (8%)
Laminin_EGF 448..497 CDD:395007 3/48 (6%)
Laminin_EGF 495..543 CDD:395007 10/47 (21%)
Laminin_EGF 541..589 CDD:395007 2/47 (4%)
Laminin_EGF 587..634 CDD:395007 4/46 (9%)
Laminin_EGF 632..679 CDD:395007 19/48 (40%)
Laminin_EGF 677..729 CDD:395007 8/51 (16%)
Laminin_EGF 732..782 CDD:395007 15/49 (31%)
EGF_Lam 785..828 CDD:238012 6/42 (14%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 6/134 (4%)
Laminin_EGF 1375..1423 CDD:395007 2/47 (4%)
EGF_Lam 1420..1457 CDD:238012 3/36 (8%)
Laminin_EGF 1466..1516 CDD:395007 4/49 (8%)
Laminin_EGF 1514..1562 CDD:395007 6/47 (13%)
LamB 1632..1760 CDD:214597 22/127 (17%)
Laminin_EGF <1775..1801 CDD:395007 14/27 (52%)
EGF_Lam 1808..1851 CDD:238012 25/42 (60%)
EGF_Lam 1859..1907 CDD:214543 23/48 (48%)
EGF_Lam 1916..1968 CDD:238012 23/53 (43%)
EGF_Lam 1969..2015 CDD:238012 19/52 (37%)
EGF_Lam 2016..>2054 CDD:238012 16/38 (42%)
EGF_Lam 2063..>2097 CDD:238012 14/33 (42%)
Laminin_I 2134..2385 CDD:310534 73/338 (22%)
SMC_prok_B 2356..>2705 CDD:274008 77/335 (23%)
Laminin_II 2566..2700 CDD:368703 28/110 (25%)
LamG 2674..2843 CDD:238058 1/1 (100%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
LanB2XP_308240.3 Laminin_N 50..280 CDD:459653 81/252 (32%)
EGF_Lam 281..328 CDD:238012 17/46 (37%)
Laminin_EGF 342..397 CDD:395007 28/298 (9%)
EGF_Lam 397..441 CDD:214543 17/43 (40%)
Laminin_EGF 444..494 CDD:395007 24/104 (23%)
Laminin_B 560..692 CDD:459652 47/361 (13%)
EGF_Lam 727..769 CDD:238012 25/42 (60%)
Laminin_EGF 831..881 CDD:395007 22/49 (45%)
Laminin_EGF 886..937 CDD:395007 18/50 (36%)
EGF_Lam 940..985 CDD:214543 17/44 (39%)
Laminin_EGF 988..1030 CDD:395007 16/44 (36%)
SMC_prok_B <1046..>1606 CDD:274008 137/647 (21%)
Blue background indicates that the domain is not in the aligned region.

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