DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and FILIP1L

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_001374779.1 Gene:FILIP1L / 11259 HGNCID:24589 Length:1190 Species:Homo sapiens


Alignment Length:1308 Identity:231/1308 - (17%)
Similarity:421/1308 - (32%) Gaps:475/1308 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  2156 LADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLGNITVAY 2220
            |..|.|...||:|.   ::...::...|.|....:..:::.:..:.|..:.:........:|:..
Human   196 LEQECERLKKLIDQ---EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257

  Fly  2221 DEAVKSADQAKEA---IASVEA-----------LSKNLEA-------------AASTKIDAALEQ 2258
            .:..:....|||.   :|..||           |.|.|:.             |..|..|:...|
Human   258 QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQ 322

  Fly  2259 AQHILGQINGTSIELTPNEQVLEKARK---------------------LYEEVNTLVLPIKAQNK 2302
            .|..|..::....||....:.|.||.:                     ..||:...||.::.:::
Human   323 LQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387

  Fly  2303 SLNALKNDIGEFSDHLEDLFNWSEASQAKSADVE-----RRNVANQK---AFDNSKFDTVSEQKL 2359
            .|..::....:.:..||     .|..|:|...:|     :|.:|.:|   ||:.||.:..| .|.
Human   388 ELIKMEEQCRDLNKRLE-----RETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKC 446

  Fly  2360 QAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFNKNVDE-ELPVREDQHK-------- 2415
            ..||.           .:|..|::|:|::|:..:.||.:....::: |..::||..|        
Human   447 NLEKE-----------RMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMF 500

  Fly  2416 --EADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAIS 2478
              |...::::.::...:|...:..|..:...:|...|.          ::|..:.|.|...|...
Human   501 VDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEK----------LIEETKRALKSKTDVEE 555

  Fly  2479 AAGNATDKTDGIEERAHLADTGSTDLLQRAR------QSLQKVQDD-LEPRLNASAGKV------ 2530
            ...:.|.:.|.::.:....:....|||.|..      |||:.::.| |:.:||..:||.      
Human   556 KMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQ 620

  Fly  2531 --QKISAVNNATEH---QLKDINKLIDQL-PAESQRDMWKNSNANASDALEILKNVLE--ILEPV 2587
              .||..::...|.   :|||:..:.|.| ..|.:.:..:...||..|..:.|...||  .:|..
Human   621 ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELA 685

  Fly  2588 SVQTPKELEKAH----------------GINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDI 2636
            ..:..::.|.:|                .::|::|...:.:.:.....|.:.......|.|.:.:
Human   686 KYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750

  Fly  2637 EEQQHRVGSQSRQLGQEIENLKAQVEAARQLANSIKVGVNFKPSTILELKTPEKTKLLATRTNLS 2701
            .:|::|    :|.||:|||||..::|..|..:.|::..:|.:                       
Human   751 NQQENR----NRDLGREIENLTKELERYRHFSKSLRPSLNGR----------------------- 788

  Fly  2702 TYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGNGPERITSDKYVADGRWYQA 2766
               |.::|..|       :|..|       .|.|:..|         |:             |::
Human   789 ---RISDPQVF-------SKEVQ-------TEAVDNEP---------PD-------------YKS 814

  Fly  2767 VVDRMGPNAKLTIREELPNGDVVEHSKSGYLEGSQNILHVDKNSRLFVGGYPGISDFNAPPDLTT 2831
            ::    |..:..|     ||.:.|.|::                                     
Human   815 LI----PLERAVI-----NGQLYEESEN------------------------------------- 833

  Fly  2832 NSFSGDIEDLKIGDESVGLWNFVYGDDNDQGARERDVLLEKKKPVTGLRFKGNGYVQLNATSNLK 2896
                        .||          |.||:|:    ||                           
Human   834 ------------QDE----------DPNDEGS----VL--------------------------- 845

  Fly  2897 SRSSIQFSFKADKDT----SNGLLFFYGRDKHYMSIEMIDGAIFFNISLGEGGGVQSGSQDRYND 2957
                   |||..:.|    :..|...:.:.|.                    |.:|:|       
Human   846 -------SFKCSQSTPCPVNRKLWIPWMKSKE--------------------GHLQNG------- 876

  Fly  2958 NQWHKVQAERENRNGLLKVDDIVISRTNAPLEADLELPKLRRLYFGGHPRRLNTSISLQPNFDGC 3022
                |:|. :.|.| .::..|:|:|.|                  .|.|..:.            
Human   877 ----KMQT-KPNAN-FVQPGDLVLSHT------------------PGQPLHIK------------ 905

  Fly  3023 IDNVVINQGVVDLTEYVTGGGVEEGCSAKFSTVVSYAPHEYGFLRMNNVSSDNNLHVVLHFKTTQ 3087
                            ||...|:...:.:.::..:.:||.|           .:..|:       
Human   906 ----------------VTPDHVQNTATLEITSPTTESPHSY-----------TSTAVI------- 936

  Fly  3088 PNGVLFYAANHDQSSTIGLSLQDGLLKLNSMGSQLVIDDRI-LNDGEDHVVTVQHTQGELRLTVD 3151
            ||     .....|..||   ||:.  .:..:.|:...:|.: |..|...:......:.:...:..
Human   937 PN-----CGTPKQRITI---LQNA--SITPVKSKTSTEDLMNLEQGMSPITMATFARAQTPESCG 991

  Fly  3152 DVDNKRLGSP-QPLILEGGDIFFAGLPDNYRTPRNALASLAYFVGCISDVTVNEEIINFANSAEK 3215
            .:..:|..|| |.|.:.|.    |..|:..|:|.....|..:.:..:|.        :..:|.:.
Human   992 SLTPERTMSPIQVLAVTGS----ASSPEQGRSPEPTEISAKHAIFRVSP--------DRQSSWQF 1044

  Fly  3216 KNGNINGCPPHVLAYEPSLVPSYYPSGDNEVE----SPWSNADTLPPLKPDIESTLPPTTPTTTT 3276
            :..|.|.             .|...:.||::.    ||:..| ...|::|     ..|:.|....
Human  1045 QRSNSNS-------------SSVITTEDNKIHIHLGSPYMQA-VASPVRP-----ASPSAPLQDN 1090

  Fly  3277 TT--------TTTTTSTTTTSTTTTTTTPSP----IVIDE--EKEIEAKTPQ-------KILTTR 3320
            .|        ..||...|::.|.|.|.||.|    |.|.|  ::.|.|:.|:       ||.|..
Human  1091 RTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITIKEVCKQRIPARIPKPKSTGITKISTKA 1155

  Fly  3321 PPAKLNLP 3328
            |...::.|
Human  1156 PTVPMDKP 1163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
Laminin_EGF 448..497 CDD:395007
Laminin_EGF 495..543 CDD:395007
Laminin_EGF 541..589 CDD:395007
Laminin_EGF 587..634 CDD:395007
Laminin_EGF 632..679 CDD:395007
Laminin_EGF 677..729 CDD:395007
Laminin_EGF 732..782 CDD:395007
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:395007
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:395007
Laminin_EGF 1514..1562 CDD:395007
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:395007
EGF_Lam 1808..1851 CDD:238012
EGF_Lam 1859..1907 CDD:214543
EGF_Lam 1916..1968 CDD:238012
EGF_Lam 1969..2015 CDD:238012
EGF_Lam 2016..>2054 CDD:238012
EGF_Lam 2063..>2097 CDD:238012
Laminin_I 2134..2385 CDD:310534 54/284 (19%)
SMC_prok_B 2356..>2705 CDD:274008 75/396 (19%)
Laminin_II 2566..2700 CDD:368703 28/151 (19%)
LamG 2674..2843 CDD:238058 17/168 (10%)
LamG 2878..3029 CDD:238058 19/154 (12%)
LamG 3078..3205 CDD:214598 24/128 (19%)
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
FILIP1LNP_001374779.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
CortBP2 66..248 CDD:462860 9/54 (17%)
SMC_prok_B 224..>773 CDD:274008 112/579 (19%)
Blue background indicates that the domain is not in the aligned region.

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