DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and LAMC3

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:XP_011516423.1 Gene:LAMC3 / 10319 HGNCID:6494 Length:1581 Species:Homo sapiens


Alignment Length:2746 Identity:515/2746 - (18%)
Similarity:764/2746 - (27%) Gaps:1356/2746 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |.:.|.|.||...|:.|||..   ||.:|..|||.....|          |..||...|:|:|..
Human    37 PVFENAAFGRLAQASHTCGSP---PEDFCPHVGAAGAGAH----------CQRCDAADPQRHHNA 88

  Fly    91 ENAID----GTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTD 150
            ....|    ....|||||.::.|::: ..||:|:...:.:.:.|:.::...| ||..:.:.|.:.
Human    89 SYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTS-RPESFAIYKRSR 152

  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDD---VICTTEYSKIVPLENGEIPVMLLNERP 212
            ....|.|:|.:|   |.|:..:|:...:.:...:|   ..||:|:|.|.||..|.:....|..||
Human   153 ADGPWEPYQFYS---ASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRP 214

  Fly   213 SSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNG 277
            |:.|:..|..||||..:|.:.|.|.|.......:.    :||.|.:.|:|::.|.|:||||.|||
Human   215 SAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIF----KDPKVLQSYYYAVSDFSVGGRCKCNG 275

  Fly   278 HADTC--DVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSN 340
            ||..|  ||...      |||||||:|.|..|..|.|.|:.:.|.:.|......|.||||.|.|.
Human   276 HASECGPDVAGQ------LACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSE 334

  Fly   341 ECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQC 405
            ||.:|.|:.|.      .||   ||.|.:|:.:|.|.:|.:|:..:|     ||:          
Human   335 ECTFDRELFRS------TGH---GGRCHHCRDHTAGPHCERCQENFY-----HWD---------- 375

  Fly   406 DYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPC 470
                                                                             
Human   376 ----------------------------------------------------------------- 375

  Fly   471 KINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNY 535
                                                                             
Human   376 ----------------------------------------------------------------- 375

  Fly   536 PTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCD 600
                                             ||    :|       |:||:|.|.||..:.||
Human   376 ---------------------------------PR----MP-------CQPCDCQSAGSLHLQCD 396

  Fly   601 NTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCK 665
            :|                                             |.|.|:|...|.:||.|.
Human   397 DT---------------------------------------------GTCACKPTVTGWKCDRCL 416

  Fly   666 EGFYNFP--SCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEG 728
            .||::..  .|..|.|:|||                                             
Human   417 PGFHSLSEGGCRPCTCNPAG--------------------------------------------- 436

  Fly   729 CEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSW 793
                         :||||..:||:||||.:.:|..|..||.|||:|...:..||..|.| .|.| 
Human   437 -------------SLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFC-YGHS- 486

  Fly   794 QSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFS 858
             .||.. :.|.:.|              |.....||                             
Human   487 -KVCAS-TAQFQVH--------------HILSDFHQ----------------------------- 506

  Fly   859 SKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPT 923
                                               .||...|.....|::|              
Human   507 -----------------------------------GAEGWWARSVGGSEHP-------------- 522

  Fly   924 SEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELG 988
              ||:         .|:.::|.|                                          
Human   523 --PQW---------SPNGVLLSP------------------------------------------ 534

  Fly   989 NMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHY 1053
                                            ...|..|.||                       
Human   535 --------------------------------EDEEELTAPE----------------------- 544

  Fly  1054 IVDVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKS 1118
                          .::.|:.|  ||.                                      
Human   545 --------------KFLGDQRF--SYG-------------------------------------- 555

  Fly  1119 FYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDS 1183
                    ||:|::..:..|.                    :|.||                   
Human   556 --------QPLILTFRVPPGD--------------------SPLPV------------------- 573

  Fly  1184 KKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSH 1248
                                                                             
Human   574 ----------------------------------------------------------------- 573

  Fly  1249 PKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDY 1313
                                             .:|..|.|                        
Human   574 ---------------------------------QLRLEGTG------------------------ 581

  Fly  1314 LVVVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCD 1378
             :.:.|:                              |:          ||:...::|       
Human   582 -LALSLR------------------------------HS----------SLSGPQDAG------- 598

  Fly  1379 YAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVI 1443
                     ||                                                      
Human   599 ---------HP------------------------------------------------------ 600

  Fly  1444 GDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNF 1508
                                                                             
Human   601 ----------------------------------------------------------------- 600

  Fly  1509 PHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSR 1573
                        .|:|:                         .::|||::.|             
Human   601 ------------REVEL-------------------------RFHLQETSED------------- 615

  Fly  1574 CDSAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYF 1638
                            |:...|.||.:            .:|.|.|:|:    ||          
Human   616 ----------------VAPPLPPFHFQ------------RLLANLTSLR----LR---------- 638

  Fly  1639 GVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTN 1703
                                               |:|.                 ||...|   
Human   639 -----------------------------------VSPG-----------------PSPAGP--- 648

  Fly  1704 RVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEY 1768
                                           :|             |::|.||.|.........:
Human   649 -------------------------------VF-------------LTEVRLTSARPGLSPPASW 669

  Fly  1769 QFLAVERCSCPPGYSGHSCEDCAPGYYRD--PSGPYGGYCIPCECNGHSETCDCATGICSKCQHG 1831
                ||.||||.||:|..||.|||||.|:  ..|||.. |:||.||.|. |||..|||| .|.|.
Human   670 ----VEICSCPTGYTGQFCESCAPGYKREMPQGGPYAS-CVPCTCNQHG-TCDPNTGIC-VCSHH 727

  Fly  1832 TEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSC-EISESGDQIHCECKPGYTGPR 1895
            |||..||||:.|:|||...|...||..|.||       ..::| .|.||.:.:...|.||..|.|
Human   728 TEGPSCERCLPGFYGNPFAGQADDCQPCPCP-------GQSACTTIPESREVVCTHCPPGQRGRR 785

  Fly  1896 CESCANGFYGEPESI---GQVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGF 1957
            ||.|.:||:|:|..:   .|.|..|:||||::|...|:||..:|.|||||:||.|..|..|..||
Human   786 CEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGF 850

  Fly  1958 YGDAIKLK---NCQSCDCDDLGT----QTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCR 2015
            ||.|:..:   .|..|.|...|:    ..|||..|.|:|..:|....|.||.|..:..:.|.|||
Human   851 YGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCR 915

  Fly  2016 ACDC-GAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPN 2079
            :|.| ...|...||.|.||.|.|:.||||:.||||.:..:.:...||..|.|:...:....|:.|
Human   916 SCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHEN 980

  Fly  2080 TGKCQCLPGVIGDRCDACPNRWVLIKD-EGCQECNNCHHALLDVTDRMRYQI------------- 2130
             |.|.|.||..|.:||.|.:.:.|..| ..||:|.:|:..:.:...:::.::             
Human   981 -GTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCG 1044

  Fly  2131 -----------------------------DSVLEDFNS----VTLAFFTSQKLN----------- 2151
                                         ::.||...|    |..|....|:||           
Human  1045 SPWGPLDILLGEAPRGDVYQGHHLLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQ 1109

  Fly  2152 -YYDQLADELEPKVK---------------LLDPNSVDLSPSKKAN--SELESDAKSYAKQVNQT 2198
             ...|||| ||..::               |..|......|:|.::  :|..:.|:|:.....:.
Human  1110 KTCTQLAD-LEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEARALARSHRDTATKI 1173

  Fly  2199 LANAFDIRERSSTT---LGNI---TVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALE 2257
            .|.|:.....|:|:   |.|:   .||.:......|:.:|..|:.:||        .|.:...|.
Human  1174 AATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKAL--------RTAVAEVLP 1230

  Fly  2258 QAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHL--ED 2320
            :|:.:|..:.....:..|...:|.....|.::.....|.:||:     ||:..:..: .|:  |.
Human  1231 EAESVLATVQQVGADTAPYLALLASPGALPQKSRAEDLGLKAK-----ALEKTVASW-QHMATEA 1289

  Fly  2321 LFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLTL------ 2379
            ......|:||.....|.....:|:|         .....||..::: |....:.|..||      
Human  1290 ARTLQTAAQATLRQTEPLTKLHQEA---------RAALTQASSSVQ-AATVTVMGARTLLADLEA 1344

  Fly  2380 -----------------NQINQKLDNLRDALNELNSFNKNVDEELPVREDQHKEADALTDQAEQK 2427
                             ..:.:|.|::.|.|  |....|...:    .|.....|..|:..|::|
Human  1345 SAGFAGMKLQFPRPKDQAALQRKADSVSDRL--LADTRKKTKQ----AERMLGNAAPLSSSAKKK 1403

  Fly  2428 AAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEE 2492
            ..|..:.|:|.|.....:....:.|.:.|:..:...:|  ..|:.||..:::.....:.     |
Human  1404 GREAEVLAKDSAKLAKALLRERKQAHRRASRLTSQTQA--TLQQASQQVLASEARRQEL-----E 1461

  Fly  2493 RAHLADTGSTDLLQRARQSLQKVQDDLE--PRLNASAGKVQKISAVNNATEHQLKDINKLIDQLP 2555
            .|.....|.:::.|:.|:|...::.|:|  ..|.|..|.:.                   ..|.|
Human  1462 EAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLD-------------------THQAP 1507

  Fly  2556 AESQRD-MWKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQANKQL 2619
            |::..: .|         |||.|:  |::..|.|:|            |.|.|..::..|...| 
Human  1508 AQALNETQW---------ALERLR--LQLGSPGSLQ------------RKLSLLEQESQQQELQ- 1548

  Fly  2620 DDVEGSVSKLSELAED 2635
              ::|..|.|:|:..|
Human  1549 --IQGFESDLAEIRAD 1562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 74/252 (29%)
EGF_Lam 272..>314 CDD:238012 22/43 (51%)
EGF_Lam 332..389 CDD:238012 22/56 (39%)
EGF_Lam 402..443 CDD:238012 0/40 (0%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 0/47 (0%)
Laminin_EGF 541..589 CDD:278482 6/47 (13%)
Laminin_EGF 587..634 CDD:278482 8/46 (17%)
EGF_Lam 631..673 CDD:238012 10/43 (23%)
Laminin_EGF 677..729 CDD:278482 5/51 (10%)
Laminin_EGF 732..782 CDD:278482 18/49 (37%)
EGF_Lam 785..828 CDD:238012 9/42 (21%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 10/134 (7%)
Laminin_EGF 1375..1423 CDD:278482 2/47 (4%)
EGF_Lam 1420..1457 CDD:238012 0/36 (0%)
Laminin_EGF 1466..1516 CDD:278482 0/49 (0%)
Laminin_EGF 1514..1562 CDD:278482 6/47 (13%)
LamB 1632..1760 CDD:214597 11/127 (9%)
Laminin_EGF <1775..1801 CDD:278482 15/27 (56%)
EGF_Lam 1808..1851 CDD:238012 25/42 (60%)
EGF_Lam 1859..1907 CDD:214543 18/48 (38%)
EGF_Lam 1916..1968 CDD:238012 25/54 (46%)
EGF_Lam 1969..2015 CDD:238012 16/49 (33%)
EGF_Lam 2016..>2054 CDD:238012 18/38 (47%)
EGF_Lam 2063..>2097 CDD:238012 12/33 (36%)
Laminin_I 2129..2385 CDD:283627 60/361 (17%)
Tar 2278..2662 CDD:223910 75/386 (19%)
Laminin_II 2566..2700 CDD:283628 18/70 (26%)
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
LAMC3XP_011516423.1 Laminin_N 44..269 CDD:278484 71/245 (29%)
EGF_Lam 270..317 CDD:238012 24/52 (46%)
Laminin_EGF 327..383 CDD:278482 27/253 (11%)
EGF_Lam 382..428 CDD:238012 19/90 (21%)
Laminin_EGF 430..477 CDD:278482 23/104 (22%)
Laminin_B 541..662 CDD:278481 51/733 (7%)
EGF_Lam 706..753 CDD:238012 27/48 (56%)
EGF_Lam 754..802 CDD:238012 19/54 (35%)
Laminin_EGF 810..857 CDD:278482 25/46 (54%)
EGF_Lam 865..915 CDD:238012 16/49 (33%)
Laminin_EGF 917..965 CDD:278482 20/47 (43%)
EGF_Lam 964..1011 CDD:238012 15/47 (32%)
PspA_IM30 1191..1426 CDD:281941 50/264 (19%)
ATP-synt_B <1360..1453 CDD:304375 21/100 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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