Protein Alignment LanA and ntng2b

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: XP_073791807.1
• Gene: ntng2b / 101885039
• ZFINID: ZDB-GENE-110502-1
• Length: 1880
• Species: Danio rerio
• Alignment Length: 2324
• Identity: 431/2324 - (18%)
• Similarity: 668/2324 - (28%)
• Gaps: 894/2324 - (38%)

  Fly    19 YCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVC-DYCDPT 82
            |.:..:.||            ..|||   :.||.:|.|     |:.::         | |.||.:
Zfish    52 YMRIRVEPP------------GITCG---NPPERFCTL-----ENPYL---------CSDECDAS 87

  Fly    83 VPERNHPPENAID----GTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVA---YLFIRMGNSPRP 140
            .|:..|||:...|    |...:||:....|..:..:.|:|:::.:...:.   .:....|   ||
Zfish    88 NPDLAHPPQLMQDRERSGLITYWQTVTWRRYPQPLQANITLSWNKTLELTDDIQITFEYG---RP 149

  Fly   141 GLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDD--------VICTTEYSKIVP 197
            .:..||||.::|:||.|:|:::|   ||...|.    .|..|..|        ||||.:||:.|.
Zfish   150 TVMVLEKSLNFGRTWQPYQYYAD---DCVDAFN----MPAGRVRDLNAANAMRVICTEQYSRWVG 207

  Fly   198 LENGEI--------------PVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLR---------T 239
            .:|.::              | .|||.....|...:...|:::...|::|:||||         .
Zfish   208 SKNEKVVRFEVRSRFAIFAGP-RLLNMEGLYTRMESMKGLRDFFSFTSLRLRLLRPALGGTYVQR 271

  Fly   240 KNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCG 304
            .|||               :|||:|.::.:..||.||.|:..|...|..     |.|:|:|:|.|
Zfish   272 DNLL---------------KYFYAISNVEVLARCKCNLHSSQCVYMDGN-----LQCQCEHNTTG 316

  Fly   305 IQCNECCPGFEQKKWRQNT-----NARPFNCEPC---NCHGHSNECKYDE-----------EVNR 350
            ..|..|..|::.|.|:..:     |..|..|...   :..|...:...:|           :.:.
Zfish   317 QDCQRCKKGYKAKTWKPGSYLPTPNGSPNTCSQALAGSSSGSMTDTSAEEFTTVVTESPVLDTDA 381

  Fly   351 KGLSLDIHGHYDGGGVCQNCQHNT-------------------------VGINCNKCKP------ 384
            ....:|...|.....:.....:.|                         |.|:.....|
Zfish   382 PPAHVDTVNHVPSAEIDPKALYTTPKATPPSHIFREDTPRTATPPEEEPVHIHIQSKAPPVEDSG 446

  Fly   385 -------KYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEET-----GNCECRAAFQPPSCD---- 433
                   |.....|:|....||   .:.:.|.......|||     |:....|..:|.|..
Zfish   447 EVEEISEKKEMTSGRHEVSEDV---KRVETFLEHNRHREETAPEPVGSVRESAEPKPESIPKPIL 508

  Fly   434 -------------SCAYGYYGYPNCREC--------------------------------ECNLN 453
                         |.|..:.......|.                                |..:|
Zfish   509 ETHKPLHKPQVHVSTAESHGAAQTSHESVTKHHEPIQKLHESTVKPHSMHTTHETIQKPHEPKVN 573

  Fly   454 GTNGYH--------------------CEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECN 498
            .....|                    .:..|..|.|.:.|                       .|
Zfish   574 SHESMHKPHEQIVNLNESMYKPHQPIWDPHSSPQKPFEPN-----------------------VN 615

  Fly   499 KIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICR 563
            .:.|:.|....|....:.:.|         .....|.|..|..:....|      :...|..:..
Zfish   616 PLESVVNIHESTHKSHEAVVN---------PQESMNNPHGSVVNPHKSG------HNPHGSVVNP 665

  Fly   564 EGFGGPRCDQCLPGFYNYPDCKPCNCSSTG----SSAITCDNTGKCNCLNNFAGKQCTLCTAGYY 624
            .|.|            :.|.....|...:|    .|.:....:|     :|..|.......:|:.
Zfish   666 HGSG------------HNPHGSVVNPHESGHNPHGSVVNPHESG-----HNPHGSVVNPHESGHN 713

  Fly   625 SYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFA 689
            .:...:..:...|.|.|...|..|. :..|:..|..    ..|....|  .:...:|.|.|....
Zfish   714 PHGSIVNPYESGHNSYGSVVNPHGS-VVNPHGSGHN----PHGSVVNP--HESGHNPHGSIVNPH 771

  Fly   690 GCGSVPVGELCKCKERVT----------GRICNE-----------CKPLYWNLN----ISNTEGC 729
            |.|..|.|.:.|....|.          |.:.|.           ..||....|    :.|..|
Zfish   772 GSGHNPHGSVVKPHGSVVNPHESGHNPHGTVVNPHESGHNPHGSIVNPLESGHNPHGSVVNPHG- 835

  Fly   730 EICDCWTDGTISALDTCTS-----KSGQCP----CKPHTQGRRCQECRDGTFDLDSASLFGCKDC 785
                       |.|:...|     :||..|    ..||..|..           ...|:....:.
Zfish   836 -----------SGLNPHGSVVNPHESGHNPHGSVVNPHESGHN-----------PHGSVVNPHES 878

  Fly   786 SCDVGGSWQSVCDKISGQ----CKCHPRITGLACTQPLTTHFFPTLHQFQYE--------YEDGS 838
            ..:..||  .|....||.    ...:|..:|   ..|..|...|  |:..:.        :|.|.
Zfish   879 GHNPHGS--VVNPHESGHNPHGSVVNPHESG---HNPHGTVVNP--HESGHNPHGSVVNPHESGH 936

  Fly   839 LPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATIS 903
            .|.||.|.        |  ...|:....:|.|.:.:..|...|        .|||:...:....|
Zfish   937 NPHGTVVN--------P--HESGHNPHGSIVNPLDSGHNPHGS--------VVNPHGSGLNPHGS 983

  Fly   904 VTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDP--------GRYVFTTKANKNVM 960
            |.:.:....:.|..|:....|           |..|...|::.        |..|.|.::..|.
Zfish   984 VVNPHESGHNPHGSVVNPHES-----------GHNPHGSVVNSHESGHNPHGSVVNTHESGHNP- 1036

  Fly   961 LDYFVLLPAAYYEAG------ILTRHIS-----NPCELGNMELCRHYKYASVEV---------FS 1005
             ...|:.|   :|:|      ::..|.|     :|  :||.....|..:.| ||         ..
Zfish  1037 -HGSVVNP---HESGHNPHGSVVNIHSSEQKSHDP--VGNPHGSEHNLHGS-EVNHHGSEHKSHE 1094

  Fly  1006 PAATPF----------------VI---GENSKPTNPVETYTDP----------EHLQIVSHVGDI 1041
            |...|.                |:   |...|..:||....||          .|..:|:|.|.:
Zfish  1095 PLVNPHGSEHSPHRSEVDPHGSVVNPHGSGHKSHDPVMNPHDPVVNPHGSEHKSHDAVVNHHGSV 1159

  Fly  1042 -----PVLS--GSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYP 1099
                 ||::  ||:::.|.....|.
Zfish  1160 DKSHEPVVNAHGSEHKPHGSGHKPH---------------------------------------- 1184

  Fly  1100 CLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIE---DGSRFPIISVTAIPVDQWSIDYINP 1161
                   .:.||..|:|..             |.|:|   .||:..    |..|:       :||
Zfish  1185 -------ESVVNPHGLEHK-------------SHDLEVNPHGSKHN----THEPI-------VNP 1218

  Fly  1162 SPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKP---PYASLDERVKLVHLDSQNEATI 1223
                  |..:      .:...|.....|:||:    :::|   |:.|...    .|....|....
Zfish  1219 ------HGTE------HNPHGSSANPHESDHK----SHEPVVNPHGSGHN----PHGSGHNPHNP 1263

  Fly  1224 VIESKVDATKPNLFVILVKYYQPSHPKYQ-VYYTLTAGKNQYDGKFD---IQHCPSSSGCRGVIR 1284
            |:...|...|.:..|  |..:...|.|:: :...:.:|.|.:....:   .:|.|..|    |:.
Zfish  1264 VVNPHVSEHKSHDPV--VHPHGSGHNKHEPIVNPIGSGHNSHGSVVNPHGSEHNPHGS----VVN 1322

  Fly  1285 PAG-----EGSFEIDDEFKFTITTDRSQSVWLDYLVVVPL-KQYNDDLLVEETFDQTKEFIQNCG 1343
            |.|     .||                        ||.|. .::|....|..|        ...|
Zfish  1323 PHGSEHNPHGS------------------------VVNPHGSEHNPHGSVVNT--------HGSG 1355

  Fly  1344 HD-HFHIT--HNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTC 1405
            |: |..:.  |.:.:....|      ::||.....|...:|      |.|.|.. ..|:|
Zfish  1356 HNSHGSVANPHGSENNPHGS------EHNSHGSVANPHGSG------HTFHGSI-ANPHV----- 1402

  Fly  1406 GACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGF-HQVIGCEECACN 1469
                          ..:.|:.::..|...|    .|..|.:.     |.:|. |...|.|   .|
Zfish  1403 --------------SAENPHGSVANPHGSE----HNSHGSVA-----NPHGSEHNPHGSE---AN 1441

  Fly  1470 PMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKP-GTELEVCDKIDGAC 1533
            |.| :..||...:.|                        ||   .|.||| |:|......:....
Zfish  1442 PHG-SEHNSHGSVAN------------------------PH---GSGHKPHGSEYNPHGSVANPL 1478

  Fly  1534 FCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTP--- 1595
            ..:.|..|             ..:||.|              ||:        ..|.|:..|
Zfish  1479 VSEYNTHG-------------SVANPHG--------------SAH--------NPHGSVANPHGS 1508

  Fly  1596 -------EFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLN-----QN 1648
                   |::...                        ::.......|...|   .:.|     :|
Zfish  1509 GHDPHGSEYNPHG------------------------SVENPQGSAPNSHG---SVANPHGSVEN 1546

  Fly  1649 NHISAYG--GDLAY---TLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPS------------ 1696
            .|.||:.  |.:|.   :.|.:.|    .:.:|.   .|.||:  |.|...|.
Zfish  1547 PHASAHNSHGSVANPHGSAHNSHG----SVASPH---GSAHNS--HGSGHNPHGSGHNPHESGHK 1602

  Fly  1697 --------------RNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLV 1747
                          .:||..|....:.:..::.|..|:..:........|.:..:.::...:.:.
Zfish  1603 THGPRHKPHGSVVYPHEPMHNPHGHLHNEPKSESHGPIPESARTTDESVLPISALESDPNIEMVS 1667

  Fly  1748 THLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCECN 1812
            .|:|      .:|..:|   |...|:.:.....|......:......::|           ||||
Zfish  1668 IHMS------PEEKKEG---YTHKALMKFLLSGGKQTVQLKGIIYDDFQD-----------CECN 1712

  Fly  1813 GHSETCDCATGI----CSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATS 1873
            |||..|.....:    |..|:|.|.|.:||.|...||.|          :.|.|   |..|....
Zfish  1713 GHSNRCSYIDFLNIVTCVSCKHNTRGQNCEHCRMSYYKN----------MSAEP---DDENVCIE 1764

  Fly  1874 CEISESGDQIH--------CECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSGNINPEDQGS 1930
            |..:..| .:|        |:||.|.||.:|:.|..|:|.:     |.|.|     |:
Zfish  1765 CNCNALG-SVHDRCNGTGFCQCKEGTTGVKCDECLPGYYWK-----QGCLP-----NV------- 1811

  Fly  1931 CDTRTGECLRCLNNTFGAAC-----NLCAPGFYGDAIKLKNCQSCDCDD 1974
            ||   .|.|.|.|   |..|     .:|.|.|.|..     ||...|::
Zfish  1812 CD---DELLLCQN---GGTCVQNQRCICTPDFKGVL-----CQHSRCEE 1849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	72/290 (25%)
		EGF_Lam	272..>314	CDD:238012	15/41 (37%)
		EGF_Lam	332..389	CDD:238012	9/108 (8%)
		EGF_Lam	402..443	CDD:238012	10/62 (16%)
		Laminin_EGF	448..497	CDD:395007	7/100 (7%)
		Laminin_EGF	495..543	CDD:395007	8/47 (17%)
		Laminin_EGF	541..589	CDD:395007	5/47 (11%)
		Laminin_EGF	587..634	CDD:395007	7/50 (14%)
		Laminin_EGF	632..679	CDD:395007	9/46 (20%)
		Laminin_EGF	677..729	CDD:395007	15/76 (20%)
		Laminin_EGF	732..782	CDD:395007	10/58 (17%)
		EGF_Lam	785..828	CDD:238012	10/46 (22%)
		CBM6-CBM35-CBM36_like	831..966	CDD:271143	27/150 (18%)
		Laminin_EGF	1375..1423	CDD:395007	7/47 (15%)
		EGF_Lam	1420..1457	CDD:238012	6/36 (17%)
		Laminin_EGF	1466..1516	CDD:395007	8/49 (16%)
		Laminin_EGF	1514..1562	CDD:395007	10/48 (21%)
		LamB	1632..1760	CDD:214597	26/163 (16%)
		Laminin_EGF	<1775..1801	CDD:395007	2/25 (8%)
		EGF_Lam	1808..1851	CDD:238012	19/46 (41%)
		EGF_Lam	1859..1907	CDD:214543	17/55 (31%)
		EGF_Lam	1916..1968	CDD:238012	14/56 (25%)
		EGF_Lam	1969..2015	CDD:238012	1/6 (17%)
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534
		SMC_prok_B	2356..>2705	CDD:274008
		Laminin_II	2566..2700	CDD:368703
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntng2b	XP_073791807.1	None