DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and LOC100494394

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	XP_002938270.2	Gene:	LOC100494394 / 100494394	-ID:	-	Length:	643	Species:	Xenopus tropicalis

Alignment Length:	599	Identity:	168/599 - (28%)
Similarity:	235/599 - (39%)	Gaps:	157/599 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQ-VCDYCDPTVPERNHP 89
            ||..|||.||.....:|||::.  .|.:|.............|.   || .||.|.....:.:||
Frog    39 PPVVNLAAGRTPLTLSTCGKNI--TETFCSYPEQPPSEQVPSYC---GQPKCDKCSVNQLKNSHP 98

  Fly    90 PENAIDGT----EAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYL--FIRMGNSPRPGLWTLEKS 148
            |....|..    ..||||   .:|::..|:.|...     .|.||  .|.:..||||....||:|
Frog    99 PSYMTDDVFSKPATWWQS---EQGIQREEIRLDFG-----TVVYLTHVIMVFKSPRPAAMILERS 155

  Fly   149 TDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDD----DVICTTEYSKIVPLENGEIPVMLLN 209
            .|.||.|.|:::|:   .:|...||       .:||    ..:||:.||...|...||:....|.
Frog   156 HDNGKNWRPYKYFA---TNCTATFG-------LQDDLAEEGTLCTSRYSSAWPCTRGEVIFRALT 210

  Fly   210 -----ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYF--YSIKDI 267
                 |.|.|..      .|:..:.||:|:.||:.:......:..:|:.|    .:|  |:|.|:
Frog   211 PANRIEDPYSPQ------AQDLLKITNLRLLLLKRQECPCLAVPESREKP----HWFAHYAIYDL 265

  Fly   268 SIGGRCMCNGHADTCDVKDPKSPVRILA---CRCQHHTCGIQCNECCPGFEQKKWR--QNTNARP 327
            .:.|.|.|||||:.|.........:.:.   |.|||:|.|..|..|.|.:..:.||  ......|
Frog   266 IVRGSCFCNGHAEHCQQVTHTHGAQTVVHGKCVCQHNTAGDHCERCAPLYNDQPWRPGDGKTGAP 330

  Fly   328 FNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYR-PKG 391
            ..|:.|.||.|::.|.:|       ||:.:......||||:||||:|.|..|.:|:|.||| ||
Frog   331 NECKRCRCHNHAHSCHFD-------LSVWLSSGRTSGGVCENCQHHTEGDRCQRCQPGYYRDPK- 387

  Fly   392 KHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGT- 455
                 ..:.||..                                        |:||.|:..|:
Frog   388 -----EPMASPAA----------------------------------------CKECFCHSTGSA 407

  Fly   456 ----NG-YHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPE--CKACECNKIGSITNDCNVTTGE 513
                || :.|...:| .|.||...||.||..|..|::||.|  |:.|:|      .:.|:..||
Frog   408 PFALNGSWKCHPRTG-FCYCKPGVAGPYCDACRRGFWGFSERGCRPCDC------ASHCDPHTG- 464

  Fly   514 CKCLTNFGGDNCERCKHGYFNYPTCS-------YCDCDNQGTESEICNKQSGQ-----------C 560
                         :|.|...|....|       |...|....|||...|.:|:           |
Frog   465 -------------KCPHSQKNEHLLSIPIGGKIYDVLDAPANESEGEWKWNGEQGFSALRYPEKC 516

  Fly   561 ICREGFGGPRCDQC 574
            ||:|...||..:.|
Frog   517 ICKEQTFGPITELC 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	74/262 (28%)
		EGF_Lam	272..>314	CDD:238012	16/44 (36%)
		EGF_Lam	332..389	CDD:238012	24/57 (42%)
		EGF_Lam	402..443	CDD:238012	1/40 (3%)
		EGF_Lam	448..491	CDD:238012	18/48 (38%)
		Laminin_EGF	495..543	CDD:278482	10/54 (19%)
		Laminin_EGF	541..589	CDD:278482	13/45 (29%)
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
LOC100494394	XP_002938270.2	Laminin_N	38..269	CDD:395009	74/262 (28%)
		EGF_Lam	270..324	CDD:238012	18/53 (34%)
		EGF_Lam	335..389	CDD:238012	26/66 (39%)
		EGF_Lam	399..450	CDD:214543	19/51 (37%)
		NTR_like	529..636	CDD:413349	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910