DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanA and lama4

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:XP_002936983.2 Gene:lama4 / 100489161 XenbaseID:XB-GENE-1004770 Length:1913 Species:Xenopus tropicalis


Alignment Length:2051 Identity:523/2051 - (25%)
Similarity:857/2051 - (41%) Gaps:320/2051 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  1779 PPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSG 1843
            ||      .:.|..|:|...||.    |:||.|||:::.|...:|.|..||..|.|..|:||..|
 Frog    62 PP------AQRCHMGFYYSVSGE----CLPCNCNGNAQKCLDGSGECLDCQRNTTGKQCDRCPPG 116

  Fly  1844 YYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPE 1908
            |.||...|.|..|:.|.|||||..||||.:|.: :|| .:.|.||..|.||.||.||.|:||.|.
 Frog   117 YLGNVVRGVPKSCLPCPCPLPFSPNNFAIACGV-KSG-SVRCICKDNYAGPNCERCAPGYYGNPL 179

  Fly  1909 SIGQVCKPCECSGNINP----EDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQS 1969
            ..|..||.|:||||.:|    ||   |:..||:|..|:.||.|..|..||.|:||||...|||:.
 Frog   180 LKGSTCKKCDCSGNSDPNLIFED---CNELTGQCNNCMRNTTGFNCERCALGYYGDARVAKNCKE 241

  Fly  1970 CDCDDLGTQTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPHTGH 2034
            |.|...||:||:...|.|.|...|.|..||.|:..:||:.|.:||:.|.|..||....|||.|..
 Frog   242 CRCSKCGTETCNDITGTCQCKPGVTGVFCDHCEAGYYGYTSCLGCQKCMCSPASLDNNCDPETRQ 306

  Fly  2035 CACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGD------- 2092
            |.||.|..|.:|:||...:|.|...||..|:|..|     .||..||:|     ::.|       
 Frog   307 CNCKPGAGGLKCERCKPGYWNYGPSGCQKCDCGDG-----PCNNKTGEC-----LLEDPESPSSS 361

  Fly  2093 ----RCDACPNRW---------VLIKDEGCQECNN-----CHHALLDVTDRMRYQIDSVLEDFNS 2139
                .||.|  .|         .|:.||......|     ..|..|:..:...:.:..:|||.|:
 Frog   362 DCSFDCDKC--IWDLIDDLRIAALLGDETKTTALNISTGVAAHKHLNYINSTLFHLTEMLEDKNN 424

  Fly  2140 VTLAFFTSQKLNYYDQLADELEPKV-KLLDP-NSVDLSPSK--KANSELESDAKSYAKQVNQTLA 2200
            .::  ||...::..:...:.|:.|| :|.|. |..::..|:  |...|....||..|.|||    
 Frog   425 QSI--FTDLMIDNAESKVEALQTKVNELADKGNLAEMKGSRFHKETMETMKRAKMTAGQVN---- 483

  Fly  2201 NAFDIRERSSTTLGNITVAYDEAVK----SADQAKEAIASVEALSKNLEAAASTKIDAALEQAQH 2261
               ||.:.....||.:  .|.|:::    :||:.| ::...|.:.|.:|....:....|||:.: 
 Frog   484 ---DIEDGIQELLGKL--EYYESLQGDLSAADRVK-SVKQAEQMLKEMEELDFSTQRIALEEEE- 541

  Fly  2262 ILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALKN---DIGEFSDHLEDLFN 2323
                           |.|.|..|::.:|..      :.||.:.:.|.|   .|.|..|.|.||:.
 Frog   542 ---------------EYVEELLREILDEWQ------QVQNNTRSLLPNVLEKIAEHDDELADLYE 585

  Fly  2324 WSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDN 2388
            ..|.::........:|.||......|...||     :..|.:::....|...::|||..:..:.:
 Frog   586 ALEEARHDINQTREKNKANIAKLHMSNIQTV-----KLTKEVENVSETLTQANITLNGTHMLISD 645

  Fly  2389 LRDALNELNSFNKNVD-------EELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMT 2446
            :.|....::..:..||       |.|   |:..:..:.:.::|...:..|..:|..|.:....:.
 Frog   646 ISDITKNMSGHHAEVDGAYTGLKERL---ENLSRNVENIVEEAVAHSLTLQREASGLTSDLKGID 707

  Fly  2447 AS--AEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRAR 2509
            |:  .:.||.|:..:..||..:|||.:.|..|:|.|....|.|||::.:.....|.|..||.:|:
 Frog   708 ANGFVQKAIDASNVHESIVNMIEAANETSFIALSTAERVIDATDGMDNQIKYQMTESEKLLVQAK 772

  Fly  2510 QSLQKVQDDLEPRLNASAGKVQKISAVNNAT--EHQLKD-INKLIDQLPA---ESQRDMWKNSNA 2568
            :  .|...|....|..|..|    ..||:||  :..|.| |...|.|:..   |:.|...:.|..
 Frog   773 E--LKGASDSSKDLGISETK----QHVNSATLRKDALSDKIENAISQIEVHEDENTRKRLEKSKL 831

  Fly  2569 NASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELA 2633
            :|.:||.|...:.::.:|:|       :.|...:.:|..|:.|.|..||.::....:|..|:|:.
 Frog   832 DAEEALNITAIISKVTDPMS-------KNAKIWSENLSNTDFDASAYNKVVNSAGEAVRNLTEVV 889

  Fly  2634 EDIEEQQHRVGSQ--SRQLGQEIENLKAQVEAARQLANSIKVGVNFKPSTILELKTPEKTKLLAT 2696
            ..:..:...|..:  :..:...|..::..:...|.:|:.::|.:.|...:.:::........|..
 Frog   890 PLLLNKLRTVDYKWPTNNISSSILRIRELIAQTRSVASKVQVSMRFGGKSAVDVNLKTNAADLNA 954

  Fly  2697 RTNLSTYF----RTTEP-SGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGNGPERITSDK 2756
            .:::|.|.    ...:| ..|::|.||.|.|    :|::.:.|.:...:...:||:|...|..|.
 Frog   955 FSSISLYLNPIAHQEKPHDKFIMYFGNKNST----SDYMGLAIKSNNLVYVYNLGSGDVEIPLDS 1015

  Fly  2757 YVAD---GRWYQAVVDRMGPNAKLTIREELPNGDVVE-HSKSGYLEGSQNILHVDKNSRLF-VGG 2816
            ...:   |.:....::|:|.:.|:.:....|:....| ..|.|...|..::|.:|.:|.:| |||
 Frog  1016 KPVNSWPGYFSLIKIERLGRHGKVLLTVPSPSSTAEEKFIKKGEATGRDSVLDLDPSSMVFYVGG 1080

  Fly  2817 YPGISDFNAPPDLTTNSFSGDIEDLKIGDESVGLWNF--VYGDDNDQG---ARERDVLLEKKKPV 2876
            .|  |.|..|..|....|.|.:|...:.|:.|.|:||  :|..:....   ||.:....:.:  .
 Frog  1081 VP--SGFQLPASLDLPGFVGCLELSTVNDDVVSLYNFKNIYNLNTATAPPCARNKLAFTQSR--A 1141

  Fly  2877 TGLRFKGNGYVQLNATSNLKSRSSI----QFSFKADKDTSNGLLFFYGRDKHYMSIEMIDGAIFF 2937
            ....|.|.||..:.   |::.|...    :|..:......|.|:|.......:.|:|:.||.:..
 Frog  1142 ASYFFDGTGYAVIR---NMERRGRFTQVTRFDIEVRTPVDNALIFLMVNGTKFFSMELQDGYLRL 1203

  Fly  2938 NISLGEGGG----VQSGSQDRYNDNQWHKVQAERENRNGLLKVDD------IVISRTNAPLEADL 2992
            :...|...|    ..|..:.:.||.::|::.....|...::.|.|      :...:|:.|..   
 Frog  1204 HYDFGFAKGPVLLEDSAKKFQVNDARYHEISVIYHNSKKMILVVDRRHVKSVDNEKTSIPFS--- 1265

  Fly  2993 ELPKLRRLYFGGHP----RRLNTSISLQPNFDGCIDNVVINQGVVDLTEYVTGGGVEEGCS---- 3049
                  .:|.||.|    :.:.:.:.....|.|||......:...:|.|.....|:..||.    
 Frog  1266 ------DIYIGGAPSLVLQSVKSHLGADIAFKGCIKGFQFQKKDFNLLEEPDTLGISYGCPEESL 1324

  Fly  3050 -------------AKFSTVVSYAPHEYGFLRMNNVSSDNNLHVVLHFKTTQPNGVLFYAANHDQS 3101
                         |....:..:...|.||                .|||.||:|:|.|   |.:.
 Frog  1325 MSRRAYFNGQSFIASSQKLAPFDSFEGGF----------------SFKTLQPSGLLLY---HSEG 1370

  Fly  3102 STI-GLSLQDGLLKLNSMGSQLVIDDRILNDGEDHVVTVQHTQGELRLTVDDVDNKRLGSPQP-- 3163
            :.: .:|:..|.:.|.....::...:|..:||:.|.|....:....:|.||:.|.......:|  
 Frog  1371 ADVFSVSMDKGSVVLRIKDIKVQSKNRKYSDGQSHFVVASVSPTRYQLLVDETDASVQDRQKPGA 1435

  Fly  3164 LILEGGDIFFAGLPDNYRTPRNALASLAYFVGCISD-----VTVNEEIINFANSAEKKNGNINGC 3223
            ..|.....:|.|.|..        .|.|.|.||||:     |..:.|:.:|....||...::.||
 Frog  1436 SSLVARTFYFGGTPVG--------ISQANFTGCISNAYFTRVDRDVEVEDFQKYTEKVQSSLYGC 1492

  Fly  3224 PPHVLAYEPSLVPSYYPSGDNEVESPWSNADTLPPLKPDIESTLPPTTPTTTTTTTTTTTSTTTT 3288
            |     .|...|..:..:|.|..:.......::     .::.||.......:..|...:...|..
 Frog  1493 P-----VESPPVALFQKNGKNSSKDKGKLRKSV-----GMDKTLESHAAFGSKETEEDSEEVTLC 1547

  Fly  3289 STTTTTTTPSPIVIDEEKEIEAKTPQKILTTRPPAKLNLPSDERCKLPEQPNFDVDFTEAGYRFY 3353
            |                           |::||.|                      ....:.:.
 Frog  1548 S---------------------------LSSRPKA----------------------ARQAHLYG 1563

  Fly  3354 GLREQRLQINSLPVKVRRHHDIGISFRTERPNGLLIYAGSKQRDDFIAVYLLDGRVTYEIRVGAQ 3418
            |:...|.:.|.:|.......::.:..:|...||::.|...|:.|:|:.::|..||:|:....|.|
 Frog  1564 GIANSRQEFNHIPNGFNEKSELFVRLKTHSSNGMIFYVSDKEEDNFMTLFLSHGRLTFMFNNGQQ 1628

  Fly  3419 LQAKITTEAELNDGTWHTVEVVRTQRKVSLLIDKLEQPGSVDLNAERSAPVLAVELPIYLGGVNK 3483
             :.:|.::.:.|||.||:|..:|.:.|..|:|:.|.   .::.:...:|....|:.|.|||||..
 Frog  1629 -KLRIKSQEKYNDGLWHSVLCIREKNKGRLIINGLR---VLEDSISAAAVTWTVDAPFYLGGVAP 1689

  Fly  3484 FLESEVKNLTDFKTEVPY-FNGCLKNIKFDAMDLETPPEEFGVVPCSE-QVERGLFFNNQKAFVK 3546
              ...:||:   :....| |||||.|::.:...|.:|.:.|.|.||.| .:|.|.:.:::..:|.
 Frog  1690 --GRAIKNV---QINSAYSFNGCLSNLQLNGRALTSPSQTFSVTPCFEGPMESGTYISSEGGYVI 1749

  Fly  3547 IFDHFDVGTEMKISFDFRPRDPNGLLFSVHGKN-SYAILELVDNTLYFTVKTDLKNIVSTNYKLP 3610
            :.|.|..|...:.:.:.|||:.:|:|..:...| .|..|.:....:...||...:.. ||.. :|
 Frog  1750 LDDSFSTGLTFEFALEVRPRNNSGVLIHIQNVNGEYLNLHMKQGQVIVKVKNGNREF-STRV-IP 1812

  Fly  3611 NNESFCDGKTRNVQAIKSKFVINIAVDFISSNPGVGNEGSVITRTNRPLFLGGHVAFQRAPGIKT 3675
             .:|.|||:...:..|:...|:.:.|| ...|..||...:.:.....|:|:||.......|.:.|
 Frog  1813 -KQSICDGQWHRIAVIRDGNVVQLDVD-SEINHVVGPINTKVLDLKEPVFVGGVPGSLLGPTLTT 1875

  Fly  3676 KKSFKGCISKVEVNQRMINIT-PNMVVGDIWQGYCP 3710
            :.||.|||....:::|.::.. .::|.|.:....||
 Frog  1876 RNSFTGCIRNFVIDERAVSFNKASLVSGAVSINSCP 1911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
EGF_Lam 448..491 CDD:238012
Laminin_EGF 495..543 CDD:278482
Laminin_EGF 541..589 CDD:278482
Laminin_EGF 587..634 CDD:278482
EGF_Lam 631..673 CDD:238012
Laminin_EGF 677..729 CDD:278482
Laminin_EGF 732..782 CDD:278482
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:278482
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:278482
Laminin_EGF 1514..1562 CDD:278482
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:278482 6/21 (29%)
EGF_Lam 1808..1851 CDD:238012 19/42 (45%)
EGF_Lam 1859..1907 CDD:214543 26/47 (55%)
EGF_Lam 1916..1968 CDD:238012 26/55 (47%)
EGF_Lam 1969..2015 CDD:238012 18/45 (40%)
EGF_Lam 2016..>2054 CDD:238012 16/37 (43%)
EGF_Lam 2063..>2097 CDD:238012 11/44 (25%)
Laminin_I 2129..2385 CDD:283627 63/266 (24%)
Tar 2278..2662 CDD:223910 93/403 (23%)
Laminin_II 2566..2700 CDD:283628 24/135 (18%)
LamG 2674..2843 CDD:238058 42/178 (24%)
LamG 2878..3029 CDD:238058 33/168 (20%)
LamG 3078..3205 CDD:214598 34/134 (25%)
LamG 3349..3512 CDD:238058 46/163 (28%)
LamG 3535..3689 CDD:238058 40/154 (26%)
lama4XP_002936983.2 EGF_Lam 81..120 CDD:238012 17/38 (45%)
EGF_Lam 131..186 CDD:238012 28/56 (50%)
EGF_Lam 188..240 CDD:238012 26/54 (48%)
EGF_Lam 242..286 CDD:214543 17/43 (40%)
EGF_Lam 289..333 CDD:214543 18/43 (42%)
Laminin_I 393..649 CDD:310534 66/294 (22%)
SCP-1 <519..>837 CDD:114219 83/353 (24%)
Laminin_II 829..958 CDD:368703 24/135 (18%)
LamG 975..1106 CDD:214598 37/136 (27%)
LamG 1143..1299 CDD:238058 33/167 (20%)
LamG 1329..1466 CDD:238058 37/163 (23%)
LamG 1582..1714 CDD:238058 42/140 (30%)
LamG 1743..1889 CDD:238058 39/149 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 70 1.000 Domainoid score I9377
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1919at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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