DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and ntn4

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	XP_031754773.1	Gene:	ntn4 / 100379839	XenbaseID:	XB-GENE-5823493	Length:	636	Species:	Xenopus tropicalis

Alignment Length:	660	Identity:	176/660 - (26%)
Similarity:	257/660 - (38%)	Gaps:	181/660 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GALLVILAI--------------SYCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGA 59
            |.|||:|..              |:|:....|...|||.||.::...|||.  :..||.|
Frog    14 GWLLVLLGSFSLTAGLNSMVKIGSHCEKACNPRMGNLAIGRSLWTETTCGH--NNTELSC----- 71

  Fly    60 NTEHDHIDYSVIQGQVCDYCDPTVPERNHPPENAIDGT----EAWWQSPPLSRGMKFNEVNLTIN 120
             |...:|:.:..:.: ||.|:..:|..:|||....|.:    ..||||     ....:...:.::
Frog    72 -TYQGYIEQTCTEPK-CDKCNAALPRLSHPPSAMADSSFKIPRTWWQS-----AKDIHREVIRLD 129

  Fly   121 FEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDD 185
            .|.||:..:| |.:..||||....||:|.|:|.||.|:::||   .:|...|        ..:||
Frog   130 LETEFYFTHL-IMVFKSPRPAAMILERSQDFGVTWMPYKYFS---INCSATF--------AMEDD 182

  Fly   186 V-----ICTTEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGH 245
            :     :||:.||...|...||:....::. |.|.....|...|:..:.||:|::||:.:
Frog   183 IQEKGALCTSRYSHAFPCTGGEVIYRTMSP-PYSAQDPYSKEAQDQLKITNLRVQLLKQQ----- 241

  Fly   246 LMSVARQDPTVTRRYF--YSIKDISIGGRCMCNGHADTCDVKDPKSPVRILA--------CRCQH 300
            ......::..:..:||  |::.|..:.|.|.||||||.|...|....||..:        |.|:|
Frog   242 ACPCQEKNSDIKPQYFTHYAVYDFIVKGSCFCNGHADHCVAADGFRQVRTTSKIQVVHGRCICKH 306

  Fly   301 HTCGIQCNECCPGFEQKKWR--QNTNARPFNCEPCNCHGHSNECKYDEEV-----NRKGLSLDIH 358
            :|.|..|..|.|.:..:.|.  .........|:.|.|:||::.|.:|.:|     ||.
Frog   307 NTAGPHCEHCAPLYNDQLWEAANGKTGEANTCKKCKCNGHADSCHFDMDVWLGSGNRT------- 364

  Fly   359 GHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCEC 423
                 ||||.||||||.|..|.:|||.::|.....::..|.|..|.|   ...|......||...
Frog   365 -----GGVCDNCQHNTEGSQCQRCKPGFFRDLKMPFSAPDACKACSC---HPIGSAVLPFGNITL 421

  Fly   424 RAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYG 488
                    ||.                    |||         .||||...||.:|.||..||:|
Frog   422 --------CDP--------------------TNG---------DCPCKPGVAGPHCDQCMVGYWG 449

  Fly   489 FPE--CKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESE 551
            |.|  |:.|:|      ...|:..||:  |:||...|       .|..:|     :..:...||:
Frog   450 FGEYGCRPCDC------AGSCDPFTGD--CITNLDID-------WYREFP-----ELLSVYNESQ 494

  Fly   552 ICNKQSGQCICREGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQC 616
            :......:    :||...|                              ::|||.|.....||..
Frog   495 LSRTWEDE----QGFSALR------------------------------HSGKCECKEQVLGKPE 525

  Fly   617 TLCTAGYYSY 626
            ..| ...|||
Frog   526 VFC-GMKYSY 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	71/263 (27%)
		EGF_Lam	272..>314	CDD:238012	19/49 (39%)
		EGF_Lam	332..389	CDD:238012	24/61 (39%)
		EGF_Lam	402..443	CDD:238012	7/40 (18%)
		EGF_Lam	448..491	CDD:238012	16/42 (38%)
		Laminin_EGF	495..543	CDD:278482	11/47 (23%)
		Laminin_EGF	541..589	CDD:278482	5/47 (11%)
		Laminin_EGF	587..634	CDD:278482	10/40 (25%)
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntn4	XP_031754773.1	Laminin_N	44..269	CDD:395009	69/256 (27%)
		EGF_Lam	270..322	CDD:238012	19/51 (37%)
		Laminin_EGF	341..394	CDD:395007	25/64 (39%)
		EGF_Lam	404..455	CDD:214543	24/90 (27%)
		NTR_netrin-4_like	526..634	CDD:239633	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910