Protein Alignment LanA and pibf1

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: NP_001135633.1
• Gene: pibf1 / 100216192
• XenbaseID: XB-GENE-949066
• Length: 755
• Species: Xenopus tropicalis
• Alignment Length: 796
• Identity: 155/796 - (19%)
• Similarity: 301/796 - (37%)
• Gaps: 159/796 - (19%)

  Fly  2177 SKKAN--SELESDAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASVEA 2239
            |||.|  |.|||:..|....|.....::.| ....||.:....:...|.:.:....|..::....
 Frog     6 SKKVNVSSSLESEDLSLETTVPTDDISSSD-EPNGSTKITKQLIERKELLHNLQLLKIELSQKNL 69

  Fly  2240 LSKNLEAAASTKIDAALEQAQHILGQINGTSIEL-TPNEQVLEKARK----LYEEVNTLVLPIKA 2299
            :..||:....|||:...|:....|.|....::.| |.::...|.|||    :.:|:.|::|.::.
 Frog    70 MIDNLKGEYLTKIEELEEKLNDTLHQKQLLALRLDTQSKLQQEDARKHQELMKKEMETILLRLQQ 134

  Fly  2300 QNKSLNALKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKN 2364
            ..::...|:...|:....|.||....|..:..||..|               |.:|..:..|.:.
 Frog   135 SEETNRQLRERAGDVRRSLRDLELTKETYEELSALPE---------------DQLSIPEYVAIRF 184

  Fly  2365 IKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFNKNVDEELPVREDQHKEADALTDQAEQK-- 2427
            .|                  .:..|||..|:|....:.:.|||   .|..|:...:|:..|::
 Frog   185 YK------------------VIQPLRDKSNDLEVTKEKLLEEL---NDYKKQLRTMTEHYEEERK 228

  Fly  2428 -AAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIV---EAVE-----AAQKLSQDAISAAGNA 2483
             .:|:.|:.|.||.|..|.....:........|..:.   :|:|     ..:|.....:|.....
 Frog   229 CRSEMEIRCQRLALQLADTKQLIQQGDYKLENYDKVKSERDAIEHELFKLRKKFEILDVSYKAQT 293

  Fly  2484 TDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQLKDIN 2548
            .|:.|..:|.|.|..  |..|||:.::.|.:...:|..|......:::::.|       |::|..
 Frog   294 KDQNDLAQEVATLRQ--SVSLLQKDKEFLSRQNMELNVRCAHEQDRMERLQA-------QMEDAK 349

  Fly  2549 KLIDQLPAE--SQRDMWKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDL-DLTNK 2610
            |..::...:  :.||.:|....|         .:.:.||.:.::|.:|:|:..|.:::: :..|:
 Frog   350 KAREETYEKYVASRDHYKTEYEN---------KLRDELEQIRMKTNQEIEQLRGASKEMYERENR 405

  Fly  2611 DVSQA-NKQLDDVEGSV-------SKLSELAEDIEEQQHRVGSQSRQL----------------- 2650
            ::.:| :..:.:.|.:|       :|..:|.|...:.|....|:..:|
 Frog   406 NLREARDNAIAEKERAVVAEKDVQAKYDQLLEQYRQLQLSTESKVSELLHQTKLKSFEAERSHIL 470

  Fly  2651 -GQEIENL-KAQVEAARQLANSIKVGVNFKPSTILELKTPEK-TKLLAT----RTNLSTYFRTTE 2708
             .:.:||| |.|:|..:.   ..|:.:..|....|:..|.:: |:|.|.    |..|.||.:..:
 Frog   471 QEEAMENLQKCQLECEKY---QKKLEILTKEFYSLQASTEKRVTELQAQNSEHRARLETYEKLEQ 532

  Fly  2709 PSGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGNGPERITSDKYVADGRWYQAVVDRMGP 2773
            ....::.     ::|:..::..:..::..|       |.|....|:    |..|..|:|     .
 Frog   533 ELDEVIM-----QSAEMQDEAESERVLFSY-------GYGANVPTT----AKRRLRQSV-----H 576

  Fly  2774 NAKLTIREELPNGDVVEHSKSGYLEGSQNILHVDKNSRLFVGGYPGISDFNAPPDLTTNS----- 2833
            .|:..::.|..|..:::..:......:|.:|.:::.:.|       :|....|......|
 Frog   577 LARRLLQTERQNSLLIKEVEQQKANAAQTLLELERANSL-------LSQVQQPYQYLIESVRQRD 634

  Fly  2834 ------------FSGDIEDLKIGDESVGLWNFVYGDDNDQGARERDVLLEKKKPVTGLRFKGNG- 2885
                        ...|:.:|.....||.........|.::....::.|.:.|:.:.|||.:|.|
 Frog   635 TQIDSLKDQISKLEQDVSNLNKEKTSVLRVKNQMAADMEKLLSHQEELAQMKQALLGLRSRGQGR 699

  Fly  2886 --YVQLNATSNLKSRS 2899
              .:......|:|:.|
 Frog   700 SVSIPTEHIRNMKTNS 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		Laminin_EGF	448..497	CDD:395007
		Laminin_EGF	495..543	CDD:395007
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:395007
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534	45/214 (21%)
		SMC_prok_B	2356..>2705	CDD:274008	79/394 (20%)
		Laminin_II	2566..2700	CDD:368703	31/166 (19%)
		LamG	2674..2843	CDD:238058	30/190 (16%)
		LamG	2878..3029	CDD:238058	8/25 (32%)
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
pibf1	NP_001135633.1	Smc	<108..>650	CDD:440809	115/626 (18%)