DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and lamc1

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_001090659.1 Gene:lamc1 / 100036631 XenbaseID:XB-GENE-478553 Length:1592 Species:Xenopus tropicalis


Alignment Length:2812 Identity:563/2812 - (20%)
Similarity:831/2812 - (29%) Gaps:1357/2812 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ASIGALLVIL-------AISYCQAE-----LTPPYFNLATGRKIYATATCGQDTDGPELYCKLVG 58
            |.:.|:|.:|       |:..|..|     ..|.:.|.|....:.||.|||..   ||.||...|
 Frog     3 APVLAVLAVLLLGTVRAAMDECYEEGSPQRCMPEFVNAAFNATVVATNTCGTP---PEEYCVQTG 64

  Fly    59 ANTEHDHIDYSVIQG--QVCDYCDPTVPERNHPPENAIDGTE----AWWQSPPLSRGMKF-NEVN 116
                        :.|  :.|..||.......|..|...|...    .||||..:..|::: :.:|
 Frog    65 ------------VTGVTKSCHICDSGQFHLQHGAEYLTDYNNQAEITWWQSQTMLAGIQYPSTIN 117

  Fly   117 LTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPIT 181
            ||::..:.|.:.|:.::...| ||..:.|.|.|.....|.|:|::|   ..||     .||:...
 Frog   118 LTLHLGKAFDITYVRLKFHTS-RPESFALYKRTHEDGPWIPYQYYS---GSCE-----KTYQKFN 173

  Fly   182 R--------DDDVICTTEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLR 238
            |        :...:||.|:|.|.||..|.:....|..|||:.|:.||.|||||..||::|:.|.|
 Frog   174 RGFIRTGEDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNR 238

  Fly   239 TKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTC 303
            .......:.|    ||.|.:.|:|:|.|.::||||.|||||..|    .::....:.|.|:|:|.
 Frog   239 LNTFGDEVFS----DPKVLKSYYYAISDFAVGGRCKCNGHASEC----VRNEFEKIVCNCKHNTF 295

  Fly   304 GIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQ 368
            |..|.:|.|.:..:.||::|...|..|.||||:|.|.||.:|.|:.|.      .||   ||.|.
 Frog   296 GSDCEKCLPFYNDRPWRRSTADSPNECLPCNCNGRSQECYFDPELYRS------TGH---GGHCT 351

  Fly   369 NCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCD 433
            .|..||.|.||.:|:..|||...   ||                                     
 Frog   352 GCADNTDGPNCERCRENYYRQDN---NE------------------------------------- 376

  Fly   434 SCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECN 498
                                                                     .|.||:||
 Frog   377 ---------------------------------------------------------PCHACQCN 384

  Fly   499 KIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICR 563
            .:||::..|:                         ||                      |:|.|:
 Frog   385 PVGSLSTQCD-------------------------NY----------------------GRCSCK 402

  Fly   564 EGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPD 628
            .|..|.:||:|.|||:                                     :|..||      
 Frog   403 PGVMGEKCDRCQPGFH-------------------------------------SLTEAG------ 424

  Fly   629 CLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGS 693
                                                         |..|.|:|||          
 Frog   425 ---------------------------------------------CRPCACNPAG---------- 434

  Fly   694 VPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPH 758
                                                            :.|.|..::|:|.||.:
 Frog   435 ------------------------------------------------STDECNVETGRCSCKDN 451

  Fly   759 TQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHF 823
            .:|..|:.|:.|.|.||.|:..||..|.| .|.|  |||....|                     
 Frog   452 VEGFNCERCKPGFFHLDEANPRGCTPCFC-YGHS--SVCSSAEG--------------------- 492

  Fly   824 FPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVL 888
                                                                        ||:  
 Frog   493 ------------------------------------------------------------YRV-- 495

  Fly   889 RYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTT 953
                                                               |:||          
 Frog   496 ---------------------------------------------------SSIV---------- 499

  Fly   954 KANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSK 1018
                            :.:|:|                                           
 Frog   500 ----------------STFESG------------------------------------------- 505

  Fly  1019 PTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINL 1083
                ||.:|..:.             .||:..|.::.|..       .:..||:..||..:....
 Frog   506 ----VEGWTAQQR-------------DGSEYSLSWVSDSS-------AVSVISESYFPIYFIAPA 546

  Fly  1084 KLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTA 1148
            |...|..:...                  ..:..||.:.:.|.:   :||               
 Frog   547 KFLGNQGASYG------------------QNLTFSFRVERRDTR---LSA--------------- 575

  Fly  1149 IPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLV 1213
                                                        ||                   
 Frog   576 --------------------------------------------ED------------------- 577

  Fly  1214 HLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSG 1278
                     :|:|                                                 .:|
 Frog   578 ---------LVLE-------------------------------------------------GAG 584

  Fly  1279 CRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCG 1343
            .|                                  |.|||                        
 Frog   585 LR----------------------------------VSVPL------------------------ 591

  Fly  1344 HDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGAC 1408
                                                                             
 Frog   592 ----------------------------------------------------------------- 591

  Fly  1409 RSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGI 1473
                                                                            |
 Frog   592 ----------------------------------------------------------------I 592

  Fly  1474 ANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKN 1538
            |.|||                             :|                             
 Frog   593 AQGNS-----------------------------YP----------------------------- 599

  Fly  1539 VVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIK 1603
                                                                             
 Frog   600 ----------------------------------------------------------------- 599

  Fly  1604 FDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGF 1668
                         :|||.:..|.:.|..|                                    
 Frog   600 -------------SETTQRYIFRMHEATD------------------------------------ 615

  Fly  1669 DGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLK 1733
               |...|.|                    .||                      :|..:|::|.
 Frog   616 ---YPWRPSV--------------------SPF----------------------EFQKMLQNLT 635

  Fly  1734 VIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRD- 1797
            .|.||.:|.|:: ...|.:|.|..|...|..:..:    ||.||||.||.|..||.|||||.|: 
 Frog   636 AIKIRGSYSERS-AGFLEEVSLVTAVAGAGPSAPW----VEICSCPTGYIGQFCERCAPGYRREN 695

  Fly  1798 PS-GPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICAC 1861
            || |||.. |:.|.|||||:|||..:|:|. |||.|.|.|||||..||||::|.|:..||..|.|
 Frog   696 PSQGPYSP-CVLCTCNGHSDTCDPESGVCD-CQHNTAGPHCERCSEGYYGDSTTGSASDCQPCPC 758

  Fly  1862 PLPFDSNNFATSCEISESGDQIHC-ECKPGYTGPRCESCANGFYGEPESIGQ-----VCKPCECS 1920
            |       ..:||.:.....::.| .|..|.||.|||.|.:|::|:|  :|:     .|:.||||
 Frog   759 P-------GGSSCAVVPRTKEVVCTNCPLGTTGKRCELCDDGYFGDP--LGENGAPRPCRICECS 814

  Fly  1921 GNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAI----KLKNCQSCDCDDLGT---- 1977
            .||:|...|:||..|||||:|:.||.|..|:.|..||||:.:    .|| |::|.|:..||    
 Frog   815 NNIDPNAVGNCDRLTGECLKCIYNTGGFYCDRCRDGFYGNPLAQNPDLK-CRACSCNPYGTVKGQ 878

  Fly  1978 QTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDC-GAASNSTQCDPHTGHCACKSGV 2041
            ..|:...|.|.|..:|....|..|:|..|...||.||..||| ...|.|.|||..||.|.|..|:
 Frog   879 SGCNQVTGQCECLPHVTERDCSACEPGFYNLLSGRGCERCDCHSLGSTSGQCDVRTGQCECHPGI 943

  Fly  2042 TGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKD 2106
            :|:||.:|..:|:.:..:||.||:|:...|....|..: |:|:|..|.:|.|||.|...:...:.
 Frog   944 SGQQCQQCEPNHFGFGPEGCKPCDCDPEGSGSLQCKED-GRCECKSGFVGTRCDQCEENYFYNRS 1007

  Fly  2107 -EGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPN 2170
             .|||||..|:..:.|..:..|.::.. |||.    |...::.:.|..||..:|           
 Frog  1008 GPGCQECPACYRLVKDKVNEQRGKLQE-LEDL----LKNLSTGEENITDQAFEE----------- 1056

  Fly  2171 SVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLG-------NITVAYDEAVKSAD 2228
              .|..::||.::|..||:| :|.|:|.:   .|.....:|||.       ||.....:..|.|.
 Frog  1057 --RLREAEKAVNDLLLDAQS-SKDVDQGM---LDRLAEINTTLSFQLERLQNIRDMIRDTDKQAQ 1115

  Fly  2229 QAKEAIASVEALSKNLEAAASTKIDAA---LEQAQHILGQINGTSIELT--PNEQVL--EKARKL 2286
            :|::.:.:.|.:           ||:|   ||:|:..:..::.|..|.|  ||...|  |:||||
 Frog  1116 EARDRVENTEFI-----------IDSARVQLEKAKMAIANVSITPPESTGDPNNMTLLAEEARKL 1169

  Fly  2287 YE----EVNTLVLPIKAQNKSLN-ALKNDIGEFSDHLEDLFNWSEASQAKSA-DVERRNVANQKA 2345
            .|    |...:....|..|.:.| ||:            |...:.||:.::| |:|..|    :.
 Frog  1170 AERHMQEARDIEKAAKEANDTANEALR------------LLQKTLASENQTALDIEELN----RK 1218

  Fly  2346 FDNSKFDTVSEQKLQAEK---NIKDAGN--FLINGDLT------LNQINQKLDNLRDALNELNSF 2399
            :..:| |...|.:.||.|   ..::|||  ..|..:||      ...:..:.|.::....||:|.
 Frog  1219 YAQAK-DIARELEKQASKVHAEAEEAGNRALQIYANLTSVPSIDTTALQNEADKIQKEAEELDSL 1282

  Fly  2400 NKNVDEEL----PVREDQH------------------------KEADALTDQAE----------Q 2426
               :|.:|    .:|||..                        ..|||...|||          |
 Frog  1283 ---IDRKLRDYEDLREDMRGREMEVKNLLDKGKTEQQTADQLLARADAAKAQAEEAAKKGRETLQ 1344

  Fly  2427 KAAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIE 2491
            :|.::..|.:|...:..|...:||.|::....   |.:.:..|...::.|.||.|||.....|.:
 Frog  1345 EANDILNKLRDFDKRVNDNKTAAEAALRKIPM---IAQTIAEANNKTRQAESALGNANADARGAK 1406

  Fly  2492 ERAHLADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQLKDINKLIDQLPA 2556
            .:|..|: ...:.:|:...:.:...|:....:....|::|.:.......|:|||.     .|..|
 Frog  1407 SKAEEAE-ALANTVQKKAATARAEADNTFKEVTDLDGELQDMLQQLQEAENQLKK-----KQAEA 1465

  Fly  2557 ESQRDM-------WKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQ 2614
            ||...|       .|::.:||:::.:.:..||..::.:             ::|...|.:.||.|
 Frog  1466 ESDEKMAEMASNATKDAESNANNSKKSVNGVLATIDEL-------------LSRLGQLDSVDVGQ 1517

  Fly  2615 ---ANKQLDDVEGSV------SKLSELAEDIEEQQHRVGSQSRQLGQ---EIENLKAQVEAARQL 2667
               ..|.|||.:..:      .||:||.|....|:..:.|.||.:.|   :|.||:       .:
 Frog  1518 LTVLEKTLDDAKNQLRDSDLDRKLAELQESSNLQRVALDSYSRDIDQILRDIANLE-------DI 1575

  Fly  2668 ANSIKVGVNFKPSTILE 2684
            .|::..|....|  |:|
 Frog  1576 KNTLPAGCYNTP--IIE 1590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 80/272 (29%)
EGF_Lam 272..>314 CDD:238012 16/41 (39%)
EGF_Lam 332..389 CDD:238012 25/56 (45%)
EGF_Lam 402..443 CDD:238012 0/40 (0%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 8/47 (17%)
Laminin_EGF 541..589 CDD:278482 11/47 (23%)
Laminin_EGF 587..634 CDD:278482 3/46 (7%)
EGF_Lam 631..673 CDD:238012 0/41 (0%)
Laminin_EGF 677..729 CDD:278482 5/51 (10%)
Laminin_EGF 732..782 CDD:278482 14/49 (29%)
EGF_Lam 785..828 CDD:238012 8/42 (19%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 5/134 (4%)
Laminin_EGF 1375..1423 CDD:278482 0/47 (0%)
EGF_Lam 1420..1457 CDD:238012 0/36 (0%)
Laminin_EGF 1466..1516 CDD:278482 6/49 (12%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 18/127 (14%)
Laminin_EGF <1775..1801 CDD:278482 17/27 (63%)
EGF_Lam 1808..1851 CDD:238012 26/42 (62%)
EGF_Lam 1859..1907 CDD:214543 16/48 (33%)
EGF_Lam 1916..1968 CDD:238012 27/55 (49%)
EGF_Lam 1969..2015 CDD:238012 16/49 (33%)
EGF_Lam 2016..>2054 CDD:238012 17/38 (45%)
EGF_Lam 2063..>2097 CDD:238012 13/33 (39%)
Laminin_I 2129..2385 CDD:283627 71/286 (25%)
Tar 2278..2662 CDD:223910 106/459 (23%)
Laminin_II 2566..2700 CDD:283628 31/131 (24%)
LamG 2674..2843 CDD:238058 4/11 (36%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamc1NP_001090659.1 LamNT 27..267 CDD:214532 79/267 (30%)
EGF_Lam 268..313 CDD:238012 17/48 (35%)
Laminin_EGF 325..381 CDD:278482 28/161 (17%)
Laminin_EGF 381..428 CDD:278482 23/181 (13%)
Laminin_EGF 428..475 CDD:278482 19/104 (18%)
Laminin_B 541..662 CDD:278481 46/682 (7%)
Laminin_EGF 707..753 CDD:278482 27/46 (59%)
EGF_Lam 755..803 CDD:238012 18/56 (32%)
Laminin_EGF 811..855 CDD:278482 25/43 (58%)
EGF_Lam 866..916 CDD:238012 16/49 (33%)
EGF_Lam 918..963 CDD:214543 18/44 (41%)
EGF_Lam 965..1012 CDD:238012 15/47 (32%)
Domain II and I. /evidence=ECO:0000250 1013..1592 155/662 (23%)
SPX <1017..1073 CDD:271919 16/73 (22%)
COG1340 1023..1322 CDD:224259 82/351 (23%)
ATP-synt_B <1100..1229 CDD:304375 39/156 (25%)
COG1340 1259..1546 CDD:224259 65/311 (21%)
DUF3829 1347..1571 CDD:289644 55/245 (22%)
ATP-synt_B <1376..1479 CDD:304375 24/111 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1489 11/37 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 76 1.000 Domainoid score I8809
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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