DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and lamc1

DIOPT Version :10

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_001090659.1 Gene:lamc1 / 100036631 XenbaseID:XB-GENE-478553 Length:1592 Species:Xenopus tropicalis


Alignment Length:2812 Identity:563/2812 - (20%)
Similarity:831/2812 - (29%) Gaps:1357/2812 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ASIGALLVIL-------AISYCQAE-----LTPPYFNLATGRKIYATATCGQDTDGPELYCKLVG 58
            |.:.|:|.:|       |:..|..|     ..|.:.|.|....:.||.|||..   ||.||...|
 Frog     3 APVLAVLAVLLLGTVRAAMDECYEEGSPQRCMPEFVNAAFNATVVATNTCGTP---PEEYCVQTG 64

  Fly    59 ANTEHDHIDYSVIQG--QVCDYCDPTVPERNHPPENAIDGTE----AWWQSPPLSRGMKF-NEVN 116
                        :.|  :.|..||.......|..|...|...    .||||..:..|::: :.:|
 Frog    65 ------------VTGVTKSCHICDSGQFHLQHGAEYLTDYNNQAEITWWQSQTMLAGIQYPSTIN 117

  Fly   117 LTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPIT 181
            ||::..:.|.:.|:.::...| ||..:.|.|.|.....|.|:|::|   ..||     .||:...
 Frog   118 LTLHLGKAFDITYVRLKFHTS-RPESFALYKRTHEDGPWIPYQYYS---GSCE-----KTYQKFN 173

  Fly   182 R--------DDDVICTTEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLR 238
            |        :...:||.|:|.|.||..|.:....|..|||:.|:.||.|||||..||::|:.|.|
 Frog   174 RGFIRTGEDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNR 238

  Fly   239 TKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTC 303
            .......:.|    ||.|.:.|:|:|.|.::||||.|||||..|    .::....:.|.|:|:|.
 Frog   239 LNTFGDEVFS----DPKVLKSYYYAISDFAVGGRCKCNGHASEC----VRNEFEKIVCNCKHNTF 295

  Fly   304 GIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQ 368
            |..|.:|.|.:..:.||::|...|..|.||||:|.|.||.:|.|:.|.      .||   ||.|.
 Frog   296 GSDCEKCLPFYNDRPWRRSTADSPNECLPCNCNGRSQECYFDPELYRS------TGH---GGHCT 351

  Fly   369 NCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCD 433
            .|..||.|.||.:|:..|||...   ||                                     
 Frog   352 GCADNTDGPNCERCRENYYRQDN---NE------------------------------------- 376

  Fly   434 SCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECN 498
                                                                     .|.||:||
 Frog   377 ---------------------------------------------------------PCHACQCN 384

  Fly   499 KIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICR 563
            .:||::..|:                         ||                      |:|.|:
 Frog   385 PVGSLSTQCD-------------------------NY----------------------GRCSCK 402

  Fly   564 EGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPD 628
            .|..|.:||:|.|||:                                     :|..||      
 Frog   403 PGVMGEKCDRCQPGFH-------------------------------------SLTEAG------ 424

  Fly   629 CLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGS 693
                                                         |..|.|:|||          
 Frog   425 ---------------------------------------------CRPCACNPAG---------- 434

  Fly   694 VPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPH 758
                                                            :.|.|..::|:|.||.:
 Frog   435 ------------------------------------------------STDECNVETGRCSCKDN 451

  Fly   759 TQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHF 823
            .:|..|:.|:.|.|.||.|:..||..|.| .|.|  |||....|                     
 Frog   452 VEGFNCERCKPGFFHLDEANPRGCTPCFC-YGHS--SVCSSAEG--------------------- 492

  Fly   824 FPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVL 888
                                                                        ||:  
 Frog   493 ------------------------------------------------------------YRV-- 495

  Fly   889 RYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTT 953
                                                               |:||          
 Frog   496 ---------------------------------------------------SSIV---------- 499

  Fly   954 KANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSK 1018
                            :.:|:|                                           
 Frog   500 ----------------STFESG------------------------------------------- 505

  Fly  1019 PTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINL 1083
                ||.:|..:.             .||:..|.::.|..       .:..||:..||..:....
 Frog   506 ----VEGWTAQQR-------------DGSEYSLSWVSDSS-------AVSVISESYFPIYFIAPA 546

  Fly  1084 KLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTA 1148
            |...|..:...                  ..:..||.:.:.|.:   :||               
 Frog   547 KFLGNQGASYG------------------QNLTFSFRVERRDTR---LSA--------------- 575

  Fly  1149 IPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLV 1213
                                                        ||                   
 Frog   576 --------------------------------------------ED------------------- 577

  Fly  1214 HLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSG 1278
                     :|:|                                                 .:|
 Frog   578 ---------LVLE-------------------------------------------------GAG 584

  Fly  1279 CRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCG 1343
            .|                                  |.|||                        
 Frog   585 LR----------------------------------VSVPL------------------------ 591

  Fly  1344 HDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGAC 1408
                                                                             
 Frog   592 ----------------------------------------------------------------- 591

  Fly  1409 RSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGI 1473
                                                                            |
 Frog   592 ----------------------------------------------------------------I 592

  Fly  1474 ANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKN 1538
            |.|||                             :|                             
 Frog   593 AQGNS-----------------------------YP----------------------------- 599

  Fly  1539 VVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIK 1603
                                                                             
 Frog   600 ----------------------------------------------------------------- 599

  Fly  1604 FDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGF 1668
                         :|||.:..|.:.|..|                                    
 Frog   600 -------------SETTQRYIFRMHEATD------------------------------------ 615

  Fly  1669 DGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLK 1733
               |...|.|                    .||                      :|..:|::|.
 Frog   616 ---YPWRPSV--------------------SPF----------------------EFQKMLQNLT 635

  Fly  1734 VIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRD- 1797
            .|.||.:|.|:: ...|.:|.|..|...|..:..:    ||.||||.||.|..||.|||||.|: 
 Frog   636 AIKIRGSYSERS-AGFLEEVSLVTAVAGAGPSAPW----VEICSCPTGYIGQFCERCAPGYRREN 695

  Fly  1798 PS-GPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICAC 1861
            || |||.. |:.|.|||||:|||..:|:|. |||.|.|.|||||..||||::|.|:..||..|.|
 Frog   696 PSQGPYSP-CVLCTCNGHSDTCDPESGVCD-CQHNTAGPHCERCSEGYYGDSTTGSASDCQPCPC 758

  Fly  1862 PLPFDSNNFATSCEISESGDQIHC-ECKPGYTGPRCESCANGFYGEPESIGQ-----VCKPCECS 1920
            |       ..:||.:.....::.| .|..|.||.|||.|.:|::|:|  :|:     .|:.||||
 Frog   759 P-------GGSSCAVVPRTKEVVCTNCPLGTTGKRCELCDDGYFGDP--LGENGAPRPCRICECS 814

  Fly  1921 GNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAI----KLKNCQSCDCDDLGT---- 1977
            .||:|...|:||..|||||:|:.||.|..|:.|..||||:.:    .|| |::|.|:..||    
 Frog   815 NNIDPNAVGNCDRLTGECLKCIYNTGGFYCDRCRDGFYGNPLAQNPDLK-CRACSCNPYGTVKGQ 878

  Fly  1978 QTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDC-GAASNSTQCDPHTGHCACKSGV 2041
            ..|:...|.|.|..:|....|..|:|..|...||.||..||| ...|.|.|||..||.|.|..|:
 Frog   879 SGCNQVTGQCECLPHVTERDCSACEPGFYNLLSGRGCERCDCHSLGSTSGQCDVRTGQCECHPGI 943

  Fly  2042 TGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKD 2106
            :|:||.:|..:|:.:..:||.||:|:...|....|..: |:|:|..|.:|.|||.|...:...:.
 Frog   944 SGQQCQQCEPNHFGFGPEGCKPCDCDPEGSGSLQCKED-GRCECKSGFVGTRCDQCEENYFYNRS 1007

  Fly  2107 -EGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPN 2170
             .|||||..|:..:.|..:..|.::.. |||.    |...::.:.|..||..:|           
 Frog  1008 GPGCQECPACYRLVKDKVNEQRGKLQE-LEDL----LKNLSTGEENITDQAFEE----------- 1056

  Fly  2171 SVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLG-------NITVAYDEAVKSAD 2228
              .|..::||.::|..||:| :|.|:|.:   .|.....:|||.       ||.....:..|.|.
 Frog  1057 --RLREAEKAVNDLLLDAQS-SKDVDQGM---LDRLAEINTTLSFQLERLQNIRDMIRDTDKQAQ 1115

  Fly  2229 QAKEAIASVEALSKNLEAAASTKIDAA---LEQAQHILGQINGTSIELT--PNEQVL--EKARKL 2286
            :|::.:.:.|.:           ||:|   ||:|:..:..::.|..|.|  ||...|  |:||||
 Frog  1116 EARDRVENTEFI-----------IDSARVQLEKAKMAIANVSITPPESTGDPNNMTLLAEEARKL 1169

  Fly  2287 YE----EVNTLVLPIKAQNKSLN-ALKNDIGEFSDHLEDLFNWSEASQAKSA-DVERRNVANQKA 2345
            .|    |...:....|..|.:.| ||:            |...:.||:.::| |:|..|    :.
 Frog  1170 AERHMQEARDIEKAAKEANDTANEALR------------LLQKTLASENQTALDIEELN----RK 1218

  Fly  2346 FDNSKFDTVSEQKLQAEK---NIKDAGN--FLINGDLT------LNQINQKLDNLRDALNELNSF 2399
            :..:| |...|.:.||.|   ..::|||  ..|..:||      ...:..:.|.::....||:|.
 Frog  1219 YAQAK-DIARELEKQASKVHAEAEEAGNRALQIYANLTSVPSIDTTALQNEADKIQKEAEELDSL 1282

  Fly  2400 NKNVDEEL----PVREDQH------------------------KEADALTDQAE----------Q 2426
               :|.:|    .:|||..                        ..|||...|||          |
 Frog  1283 ---IDRKLRDYEDLREDMRGREMEVKNLLDKGKTEQQTADQLLARADAAKAQAEEAAKKGRETLQ 1344

  Fly  2427 KAAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIE 2491
            :|.::..|.:|...:..|...:||.|::....   |.:.:..|...::.|.||.|||.....|.:
 Frog  1345 EANDILNKLRDFDKRVNDNKTAAEAALRKIPM---IAQTIAEANNKTRQAESALGNANADARGAK 1406

  Fly  2492 ERAHLADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQLKDINKLIDQLPA 2556
            .:|..|: ...:.:|:...:.:...|:....:....|::|.:.......|:|||.     .|..|
 Frog  1407 SKAEEAE-ALANTVQKKAATARAEADNTFKEVTDLDGELQDMLQQLQEAENQLKK-----KQAEA 1465

  Fly  2557 ESQRDM-------WKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQ 2614
            ||...|       .|::.:||:::.:.:..||..::.:             ::|...|.:.||.|
 Frog  1466 ESDEKMAEMASNATKDAESNANNSKKSVNGVLATIDEL-------------LSRLGQLDSVDVGQ 1517

  Fly  2615 ---ANKQLDDVEGSV------SKLSELAEDIEEQQHRVGSQSRQLGQ---EIENLKAQVEAARQL 2667
               ..|.|||.:..:      .||:||.|....|:..:.|.||.:.|   :|.||:       .:
 Frog  1518 LTVLEKTLDDAKNQLRDSDLDRKLAELQESSNLQRVALDSYSRDIDQILRDIANLE-------DI 1575

  Fly  2668 ANSIKVGVNFKPSTILE 2684
            .|::..|....|  |:|
 Frog  1576 KNTLPAGCYNTP--IIE 1590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 80/272 (29%)
EGF_Lam 272..>314 CDD:238012 16/41 (39%)
EGF_Lam 332..389 CDD:238012 25/56 (45%)
EGF_Lam 402..443 CDD:238012 0/40 (0%)
Laminin_EGF 448..497 CDD:395007 3/48 (6%)
Laminin_EGF 495..543 CDD:395007 8/47 (17%)
Laminin_EGF 541..589 CDD:395007 11/47 (23%)
Laminin_EGF 587..634 CDD:395007 3/46 (7%)
Laminin_EGF 632..679 CDD:395007 2/46 (4%)
Laminin_EGF 677..729 CDD:395007 5/51 (10%)
Laminin_EGF 732..782 CDD:395007 14/49 (29%)
EGF_Lam 785..828 CDD:238012 8/42 (19%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 5/134 (4%)
Laminin_EGF 1375..1423 CDD:395007 0/47 (0%)
EGF_Lam 1420..1457 CDD:238012 0/36 (0%)
Laminin_EGF 1466..1516 CDD:395007 6/49 (12%)
Laminin_EGF 1514..1562 CDD:395007 0/47 (0%)
LamB 1632..1760 CDD:214597 18/127 (14%)
Laminin_EGF <1775..1801 CDD:395007 17/27 (63%)
EGF_Lam 1808..1851 CDD:238012 26/42 (62%)
EGF_Lam 1859..1907 CDD:214543 16/48 (33%)
EGF_Lam 1916..1968 CDD:238012 27/55 (49%)
EGF_Lam 1969..2015 CDD:238012 16/49 (33%)
EGF_Lam 2016..>2054 CDD:238012 17/38 (45%)
EGF_Lam 2063..>2097 CDD:238012 13/33 (39%)
Laminin_I 2134..2385 CDD:310534 71/281 (25%)
SMC_prok_B 2356..>2705 CDD:274008 89/397 (22%)
Laminin_II 2566..2700 CDD:368703 31/131 (24%)
LamG 2674..2843 CDD:238058 4/11 (36%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
lamc1NP_001090659.1 LamNT 27..267 CDD:214532 79/267 (30%)
EGF_Lam 268..313 CDD:238012 17/48 (35%)
Laminin_EGF 325..378 CDD:395007 27/158 (17%)
Laminin_EGF 381..428 CDD:395007 23/181 (13%)
Laminin_EGF 428..475 CDD:395007 19/104 (18%)
Laminin_B 541..671 CDD:459652 47/695 (7%)
Laminin_EGF 707..753 CDD:395007 27/46 (59%)
EGF_Lam 755..803 CDD:238012 18/56 (32%)
Laminin_EGF 811..855 CDD:395007 25/43 (58%)
EGF_Lam 866..916 CDD:238012 16/49 (33%)
EGF_Lam 918..963 CDD:214543 18/44 (41%)
EGF_Lam 965..1012 CDD:238012 15/47 (32%)
Domain II and I. /evidence=ECO:0000250 1013..1592 155/662 (23%)
Smc <1018..>1544 CDD:440809 136/600 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1456..1489 11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

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