DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and KAP104

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_009573.1	Gene:	KAP104 / 852305	SGDID:	S000000221	Length:	918	Species:	Saccharomyces cerevisiae

Alignment Length:	889	Identity:	254/889 - (28%)
Similarity:	441/889 - (49%)	Gaps:	147/889 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WTPRDEGLQQLLPILKDSQSP-------------------------------GKATQL-----AV 31
            |.|.::.:.||..:|::..||                               |::..:     ::
Yeast     5 WKPAEDYVLQLATLLQNCMSPNPEIRNNAMEAMENFQLQPEFLNYLCYILIEGESDDVLKQHYSL 69

  Fly    32 QETENEATRSMSGLILKNNI---------RMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTV-G 86
            |:.:|  .|:.:|::|||::         ..||       |.|:|...:..:.:|:..:...| |
Yeast    70 QDLQN--NRATAGMLLKNSMLGGNNLIKSNSHD-------LGYVKSNIIHGLYNSNNNLVSNVTG 125

  Fly    87 ILITTIASN---------IGLHNWPQLLPSLCEMLDNQDYNVCEGAFSALQKICEDSAGILE--- 139
            |:|||:.|.         .||    |:|..|.|:..|.:    |.:..||.||.||||...:
Yeast   126 IVITTLFSTYYRQHRDDPTGL----QMLYQLLELTSNGN----EPSIKALSKIMEDSAQFFQLEW 182

  Fly   140 ---NMPLNTMIPKFLEYFKHS--SPKIRSHAIACINQFIINRSQALMLNIDSLIQNLLDV-PSDN 198
               ..|:..::..|..:..:.  ||.|||.::.|||..|..::|:.::.:|..::.:..: .:|.
Yeast   183 SGNTKPMEALLDSFFRFISNPNFSPVIRSESVKCINTVIPLQTQSFIVRLDKFLEIIFQLAQNDE 247

  Fly   199 DPAVRMNVCHALVGLVGVRIDLMMPHMSQIIELIL-LRSQDADENVALQATEFWLSLGKQRNCRD 262
            :..||..:|.:...|:..|.|.::.|:..|::.:| |.:...:|.||::|.||..:.....|..:
Yeast   248 NDLVRAQICISFSFLLEFRPDKLVSHLDGIVQFMLHLITTVNEEKVAIEACEFLHAFATSPNIPE 312

  Fly   263 -ILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDKEPDRQQD---ISPRFHMSRVHGISNELD 323
             ||.|.:..:||:|:|:..|.|..|:||:....:|....|:.:|   |:||....:..|...:.|
Yeast   313 HILQPYVKDIVPILLSKMVYNEESIVLLEASNDDDAFLEDKDEDIKPIAPRIVKKKEAGNGEDAD 377

  Fly   324 ENSDDD--------MWDSALNLRKCSACALDIISKIFGDVCLPLMLPILKEALFHQEWVIKESGV 380
            :|.|||        ..|:..|||||||..||:::.|.....:.:..|.|:|.|....|.|:|:.:
Yeast   378 DNEDDDDDDDDEDGDVDTQWNLRKCSAATLDVMTNILPHQVMDIAFPFLREHLGSDRWFIREATI 442

  Fly   381 MALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPLVRSITCWTFMRFPKWVLNQPHDKYLEPLIE 445
            :||||:|||.|:.....||.|||:|:..|:||...||.:||||..||..|:| |.|.::|.|::|
Yeast   443 LALGAMAEGGMKYFNDGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPWIL-QDHTEFLIPVLE 506

  Fly   446 ELLKCILDSNKRVQEAACSAFVALEEEACTQLVP--YLENMLKTFVLAFSKYHQRNLLIMYDVVG 508
            .::..::|..|.|||||.|:.....|.|.::||.  :...:|.:|......|.::||:|:||.:|
Yeast   507 PIINTLMDKKKDVQEAAISSVAVFIENADSELVETLFYSQLLTSFDKCLKYYKKKNLIILYDAIG 571

  Fly   509 LLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDKDIIYLLECLSSIATALQSSFLPYCDSVYRK 573
            ..||...  |::.. :.|::|||::||.|:.|.||::..||||||.:|::|...|:|....||.:
Yeast   572 RFAEKCA--LDETA-MQIILPPLIEKWALLSDSDKELWPLLECLSCVASSLGERFMPMAPEVYNR 633

  Fly   574 GISIIEETINQDMMCKQSQSTDYPDKERMVIALDLVSGLIEGL----QSLIEPL-VANSKLLQLL 633
            ...|:...:..:....|..:...|:|:.::.:|||:.||::||    |.|:.|. ..:..:|:::
Yeast   634 AFRILCHCVELEAKSHQDPTIVVPEKDFIITSLDLIDGLVQGLGAHSQDLLFPQGTKDLTILKIM 698

  Fly   634 CQCMGDVMPEVRQSSFALLGDLSGACFSQVYPYTAHFILILVQNL----------------NPSV 682
            .:|:.|.:.|||||.||||||:       ||.:.:..::..:::.                .|:|
Yeast   699 LECLQDPVHEVRQSCFALLGDI-------VYFFNSELVIGNLEDFLKLIGTEIMHNDDSDGTPAV 756

  Fly   683 VGVCNNAVWAIGQICVKLGEETKPYV----RLLLSELMILMNRQDIPKNLSRNAAITLGRLGNAC 743
            :    ||:||:|.|..::...|  |:    |::|.  :...|.|.:..::..|.::|:|::|...
Yeast   757 I----NAIWALGLISERIDLNT--YIIDMSRIILD--LFTTNTQIVDSSVMENLSVTIGKMGLTH 813

  Fly   744 PDEVAPYLPEFL-----RQWCLLLRYAYDHDEKYLSFMGMCHMI 782
            |:..:.  ..|.     .:|||.:....|.:||..::||...:|
Yeast   814 PEVFSS--GAFANDSNWNKWCLSVNALDDVEEKSSAYMGFLKII 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	18/109 (17%)
		ARM	104..214	CDD:237987	30/118 (25%)
		HEAT repeat	104..132	CDD:293787	9/27 (33%)
		HEAT repeat	145..175	CDD:293787	10/31 (32%)
		HEAT repeat	186..212	CDD:293787	4/26 (15%)
		HEAT repeat	225..254	CDD:293787	9/29 (31%)
		HEAT repeat	360..388	CDD:293787	11/27 (41%)
		HEAT_2	361..465	CDD:290374	46/103 (45%)
		HEAT_EZ	373..424	CDD:290247	25/50 (50%)
		HEAT repeat	400..430	CDD:293787	15/29 (52%)
		HEAT repeat	442..468	CDD:293787	10/25 (40%)
		HEAT repeat	629..657	CDD:293787	14/27 (52%)
		HEAT_EZ	642..696	CDD:290247	20/69 (29%)
		HEAT repeat	667..699	CDD:293787	8/47 (17%)
		HEAT repeat	710..738	CDD:293787	5/27 (19%)
KAP104	NP_009573.1	HEAT repeat	191..225	CDD:293787	10/33 (30%)
		HEAT repeat	234..261	CDD:293787	4/26 (15%)
		HEAT repeat	272..301	CDD:293787	9/28 (32%)
		HEAT repeat	422..450	CDD:293787	11/27 (41%)
		HEAT_2	424..528	CDD:290374	47/104 (45%)
		HEAT_EZ	435..489	CDD:290247	26/53 (49%)
		HEAT repeat	462..492	CDD:293787	15/29 (52%)
		HEAT repeat	500..529	CDD:293787	11/28 (39%)
		HEAT repeat	546..572	CDD:293787	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341446
Domainoid	1	1.000	174	1.000	Domainoid score	I744
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I243
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53589
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm46943
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
TreeFam	1	0.960	-	-
	13	12.760