DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and TRN1

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_179287.3	Gene:	TRN1 / 816198	AraportID:	AT2G16950	Length:	895	Species:	Arabidopsis thaliana

Alignment Length:	895	Identity:	346/895 - (38%)
Similarity:	518/895 - (57%)	Gaps:	60/895 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWTPRDEGLQQLLPILKDSQSPGKATQ------------------------LAVQETENEATRS 41
            :.|.|||:||.::..:|:...||.....                        |...|.::...|.
plant     6 VVWQPRDDGLAEICSLLEQQISPSSVVDKSQIWKQLQHFSQFPDFNNYLVFILVRAEGKSVEVRQ 70

  Fly    42 MSGLILKNNIRMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLLP 106
            .:||:||||:|....::..|:.:|||.:.|..:|.:...||.|||.:|:.|.:..|:..|.:|||
plant    71 AAGLLLKNNLRGAYPSMTQENQKYIKSELLPCLGAADRNIRTTVGTIISVIVNIEGVSGWHELLP 135

  Fly   107 SLCEMLDNQDYNVCEGAFSALQKICEDSAGILE-------NMPLNTMIPKFLEYFKHSSPKIRSH 164
            :|...||:.|.|..:||..||.|||||...:|:       ..|:|..:|:.|::|:.....:|..
plant   136 ALVTCLDSNDLNHMDGAMDALSKICEDIPHVLDTEVPGLAERPINIFLPRLLQFFQSPHASLRKL 200

  Fly   165 AIACINQFIINRS----QALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHM 225
            |:..:||:||...    |||..::|..:|.|..:.:|..|.||..||.|.|.|..|....:.||:
plant   201 ALGSVNQYIIIMPAVIWQALYNSLDKYLQGLFVLANDPVPEVRKLVCAAFVHLTEVLPSSIEPHL 265

  Fly   226 SQIIELILLRSQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLK 290
            ..::|.:|..::|.||.|:|:|.|||.:....:...:.|...|.:|:|||:....|.:.|..||
plant   266 RNVMEYMLQVNRDPDEEVSLEACEFWSAYCDAQLPPENLKEFLPRLIPVLLENMAYADDDESLL- 329

  Fly   291 GDVGEDDKEPDRQQDISPRFHMSRVHGISNELDENSDD--DMWDSALNLRKCSACALDIISKIFG 353
             |..||:.:|||.||:.||||.||:|| |.:.|::.||  ::|    |||||||.|:|::|.:||
plant   330 -DAEEDESQPDRDQDLKPRFHTSRLHG-SEDFDDDDDDSFNVW----NLRKCSAAAIDVLSNVFG 388

  Fly   354 DVCLPLMLPILKEALF---HQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPL 415
            |..||.::|::::.|.   .:.|..:|:.|:||||||||||.||.|||.|::.:|:..|.||.||
plant   389 DEILPALMPLIQKNLSASGDEAWKQREAAVLALGAIAEGCMNGLYPHLSEIVAFLLPLLDDKFPL 453

  Fly   416 VRSITCWTFMRFPKWVLNQPHD----KYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQ 476
            :|||:|||..||.|:::.:..:    :..|.::..||:.:||:||||||||||||..:||:|..:
plant   454 IRSISCWTLSRFGKYLIQESGNPKGYEQFEKVLMGLLRRLLDTNKRVQEAACSAFATVEEDAAEE 518

  Fly   477 LVPYLENMLKTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDD 541
            |||:|..:|:..:.||.||.:|||.|:||.:|.||:||...||||.|::||||||:.||..:.:.
plant   519 LVPHLGVILQHLMCAFGKYQRRNLRIVYDAIGTLADSVREELNKPAYLEILMPPLVAKWQQLSNS 583

  Fly   542 DKDIIYLLECLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQSQSTDYPDKERMVIAL 606
            |||:..||||.:||:.||...|.|:...|:::.:.||:  :.|......:.:....|:|.:|.:|
plant   584 DKDLFPLLECFTSISQALGVGFAPFAQPVFQRCMDIIQ--LQQLAKVNPASAGAQYDREFIVCSL 646

  Fly   607 DLVSGLIEGLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFSQVYPYTAHFI 671
            ||:|||.|||.|.||.||..|.|..||..|..|...:||||:|||:|||:......:.|....|:
plant   647 DLLSGLAEGLGSGIESLVQQSNLRDLLLNCCIDEAADVRQSAFALMGDLARVFPVYLQPRLLDFL 711

  Fly   672 LILVQ----NLNPSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSEL-MILMNRQDIPKNLSRN 731
            .|..|    |||...:.|.|||.||||::.||:.:|..|.|..::|.| :||.:.:.:.|.|..|
plant   712 EIASQQLSANLNRENLSVANNACWAIGELAVKVRQEVSPIVAKVVSSLGLILQHGEGVNKALVEN 776

  Fly   732 AAITLGRLGNACPDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVPDFLFF 796
            :|||||||....||.|||::..|::.||:.|....|..||..:|.|:|.:::.||.|.|...:|.
plant   777 SAITLGRLAWIRPDLVAPHMDHFMKPWCMALSMVRDDIEKEDAFRGLCAVVKVNPSGGVSSLVFI 841

  Fly   797 CDAIASW-DNPPQDLRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRL 845
            |.||||| :...:|::..:.:::.|:|:..| .:|...|.....|:..||
plant   842 CQAIASWHEIRSEDVQTEVSQVLNGYKHMLG-NSWAECLSALDPPVKERL 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	18/88 (20%)
		ARM	104..214	CDD:237987	43/120 (36%)
		HEAT repeat	104..132	CDD:293787	14/27 (52%)
		HEAT repeat	145..175	CDD:293787	8/29 (28%)
		HEAT repeat	186..212	CDD:293787	9/25 (36%)
		HEAT repeat	225..254	CDD:293787	11/28 (39%)
		HEAT repeat	360..388	CDD:293787	10/30 (33%)
		HEAT_2	361..465	CDD:290374	50/110 (45%)
		HEAT_EZ	373..424	CDD:290247	30/50 (60%)
		HEAT repeat	400..430	CDD:293787	15/29 (52%)
		HEAT repeat	442..468	CDD:293787	16/25 (64%)
		HEAT repeat	629..657	CDD:293787	15/27 (56%)
		HEAT_EZ	642..696	CDD:290247	25/57 (44%)
		HEAT repeat	667..699	CDD:293787	14/35 (40%)
		HEAT repeat	710..738	CDD:293787	11/28 (39%)
TRN1	NP_179287.3	IBN_N	38..104	CDD:281761	15/65 (23%)
		HEAT repeat	99..120	CDD:293787	8/20 (40%)
		HEAT repeat	133..161	CDD:293787	14/27 (52%)
		HEAT repeat	181..211	CDD:293787	8/29 (28%)
		HEAT repeat	226..252	CDD:293787	9/25 (36%)
		HEAT repeat	265..293	CDD:293787	11/27 (41%)
		HEAT_2	392..507	CDD:290374	52/114 (46%)
		HEAT repeat	395..426	CDD:293787	10/30 (33%)
		HEAT_EZ	411..465	CDD:290247	31/53 (58%)
		HEAT repeat	438..468	CDD:293787	15/29 (52%)
		HEAT repeat	484..510	CDD:293787	16/25 (64%)
		HEAT repeat	527..552	CDD:293787	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	368	1.000	Domainoid score	I179
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	725	1.000	Inparanoid score	I116
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm3156
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.930