DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and Arts

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	1039	Identity:	191/1039 - (18%)
Similarity:	339/1039 - (32%)	Gaps:	373/1039 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILKDSQSPGK---ATQLA-----VQETENEATRSMSGLILKNNIR--MHDITLQPEHLEYIKHQC 70
            :||..::|..   .||:.     |||      |.::.::||..::  .|...:..||...||...
  Fly    27 MLKAYENPDSLLVLTQIVMSDRPVQE------RQVAAVLLKRRVKKLRHWQLVPAEHQAAIKSNM 85

  Fly    71 LQA-VGDSSPEIRGTVGILITTIA--SNIGLHNW-PQLLPSLCEMLDNQDYNVCE---GAFSALQ 128
            ||. :......::|||..:|.::.  .....::| .::|..:.|...:.|....|   ..||:|.
  Fly    86 LQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYERCSSPDPIESERGSSIFSSLM 150

  Fly   129 KICEDS------------AGILENMPLNTMIPKFLEYFKHSSPKIRSH-AIACI-NQFIINRSQA 179
            ....|.            ||||.....|..:         ::|.:.:. |..|: ..||...|.|
  Fly   151 DAAPDQFSNHTDTIFPLLAGILVTAEANGNM---------ATPTVHNMLAGTCVLLPFISGHSDA 206

  Fly   180 --LMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLM---MPHM-----SQIIE--LI 232
              :|:....||...|...::...:      :..:|...: ||.|   :||:     ..::|  |:
  Fly   207 EQIMVKAVPLILKALAAFAEKGNS------NEFMGAFDI-IDSMAEYVPHLLTGNVKLLLEFCLM 264

  Fly   233 LLRSQDADENVALQATEFWLSLGKQRN----CRDILSPILSQLVPVLVSRTQYTETDIILLKGDV 293
            :.|::..|.::.:|...|..||.:.:.    .:.:|.|.||.|..|:.
  Fly   265 IARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC----------------- 312

  Fly   294 GEDDKEPDRQQDISPRFHMSRVHGISNELDENSDDDMWDSALNL-RKCSACALDIIS-KIFGDVC 356
             :||                        |.|..||.....:||. ...:|..||::: .:..|..
  Fly   313 -QDD------------------------LKEGDDDYFSSESLNSPSNAAAQTLDLMALHMVPDKF 352

  Fly   357 LPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITC-LSDKKPLVRSIT 420
            :|.:|.:|:.||...|.|::.|..:.:|.|||||.:.:.....|::..:|.. :.|....||:..
  Fly   353 IPPLLDLLEPALQSPEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAA 417

  Fly   421 CWTFMRFPKWV------------------LNQ---------PHDKY-------LEPLIEEL---- 447
            .:...:|.:::                  |||         |..|:       ||...|.|
  Fly   418 FFALGQFSEFLQPTICKFAPQILPVLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDI 482

  Fly   448 ---LKCILD---------SNKRVQEAACSAFVALEEEACTQLVPYLENMLKTFVLAFSK------ 494
               |..::|         ::.:::|.|.||..|:...|...|:||...::........|
  Fly   483 VPYLPTLMDRLFGVMEPQNSNQMREMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEM 547

  Fly   495 YHQR---------------------------NLLIM---------------YDVVGLLAESVGHH 517
            |.||                           |..:|               |:::..|:..|...
  Fly   548 YSQRIQAIDTLAALCRELGKDNIIPLADETMNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNES 612

  Fly   518 LNK--PQYIDILMPPLMDKWNLV---------------------------KDDDKDII-----YL 548
            :..  |::||.:|..::...::|                           .:||:|..     |:
  Fly   613 MASVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYI 677

  Fly   549 LE------CLSSIATALQSSFLPYCDSVYRKGISIIEETINQ------DMMC------------- 588
            :|      .|...||...::|.||..|.:.....:|:.....      |.:|
  Fly   678 VEKEEAILSLKEFATHTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKLDDAA 742

  Fly   589 --KQSQSTDYPDKERMVIALDLVSGLIEGLQSLIE-----PLVANSKLLQLLCQCMGDV------ 640
              |::.....|....::...|.|:.::..|..|.:     |.:.:.:..:|:..|:.|:
  Fly   743 GLKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGCIRDIFTNKMA 807

  Fly   641 ----------------------------------------------------------------- 640

  Fly   808 CQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKER 872

  Fly   641 -MPEVRQSSFALLGD----LSGAC---FSQVYPYTAHFILILVQNLNPSVVGVCNNAVWAIGQIC 697
             :||.|...:..|.|    |.|.|   |..:.|       |.:.....|......|:.:|:|:|.
  Fly   873 DLPEQRAYIYGALADCCKALKGCCATYFDALRP-------IFIAGSRDSDAKARQNSYFALGEIV 930

  Fly   698 VKLGE---ETKPYVRLLLSELMILMNRQDIPKNLSRNAAITLGRLGNACPDEVAPYLPEFLRQW 758
            ....|   |:.|.:...|||.::   |:.:|..:. |....:.||....||.|.  |.:.|..|
  Fly   931 FHSEEKSFESYPTILQALSEAIV---RESVPAAMD-NICGAVARLIVTNPDSVP--LGQVLPVW 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	18/70 (26%)
		ARM	104..214	CDD:237987	25/128 (20%)
		HEAT repeat	104..132	CDD:293787	7/30 (23%)
		HEAT repeat	145..175	CDD:293787	5/31 (16%)
		HEAT repeat	186..212	CDD:293787	3/25 (12%)
		HEAT repeat	225..254	CDD:293787	6/35 (17%)
		HEAT repeat	360..388	CDD:293787	9/27 (33%)
		HEAT_2	361..465	CDD:290374	32/154 (21%)
		HEAT_EZ	373..424	CDD:290247	13/51 (25%)
		HEAT repeat	400..430	CDD:293787	6/30 (20%)
		HEAT repeat	442..468	CDD:293787	8/41 (20%)
		HEAT repeat	629..657	CDD:293787	9/103 (9%)
		HEAT_EZ	642..696	CDD:290247	15/60 (25%)
		HEAT repeat	667..699	CDD:293787	6/31 (19%)
		HEAT repeat	710..738	CDD:293787	6/27 (22%)
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/66 (26%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438717
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940