DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and tnpo1

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_021327307.1	Gene:	tnpo1 / 562607	ZFINID:	ZDB-GENE-080819-1	Length:	891	Species:	Danio rerio

Alignment Length:	888	Identity:	520/888 - (58%)
Similarity:	655/888 - (73%)	Gaps:	40/888 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WTPRDEGLQQLLPILKDSQSPGKATQLAVQE-----------------------TENEATRSMSG 44
            |.|.::||||:|.:||:||||..:||.:||:                       ||:|.|||:||
Zfish     5 WKPDEQGLQQILQLLKESQSPDTSTQRSVQQKLEQLNQYPDFNNYLIFVLTKLKTEDEPTRSLSG 69

  Fly    45 LILKNNIRMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLLPSLC 109
            ||||||::.|.........::||::|||::|||||.||.|||||||||||...|.|||:|||.||
Zfish    70 LILKNNVKAHYQNFPNGVSDFIKNECLQSIGDSSPLIRATVGILITTIASKGELQNWPELLPKLC 134

  Fly   110 EMLDNQDYNVCEGAFSALQKICEDSAGILEN----MPLNTMIPKFLEYFKHSSPKIRSHAIACIN 170
            .:||::|||.|||||.||||||||||.||::    .|||.||||||::|||||||||||||||:|
Zfish   135 LLLDSEDYNTCEGAFGALQKICEDSAEILDSDMLERPLNVMIPKFLQFFKHSSPKIRSHAIACVN 199

  Fly   171 QFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIELILLR 235
            ||||:|:|||||:||..|:||..:..|.:|.||.|||.|||.|:.||:|.::|||..|||.:|.|
Zfish   200 QFIISRTQALMLHIDPFIENLFALAGDEEPEVRKNVCRALVMLLEVRLDRLLPHMHNIIEYMLQR 264

  Fly   236 SQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDKEP 300
            :||.||||||:|.||||:|.:|..|:::|...|.:|.||||:..:|:|.|||||||||.||:..|
Zfish   265 TQDQDENVALEACEFWLTLAEQPVCKEVLCGHLPKLTPVLVNGMKYSEIDIILLKGDVEEDEAIP 329

  Fly   301 DRQQDISPRFHMSRV----H--GISNELDENSDDDMWD----SALNLRKCSACALDIISKIFGDV 355
            |.:|||.||||.||.    |  |.|.|.|::.:||:.|    |..|||||||.|||:::.:|.|.
Zfish   330 DNEQDIRPRFHRSRTVAQQHEGGDSIEEDDDDEDDLDDDETISDWNLRKCSAAALDVLANVFRDD 394

  Fly   356 CLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPLVRSIT 420
            .|..:||:|||.|||.||:|||||::.|||||||||||:||:||||||:|:.||||||.||||||
Zfish   395 LLLHILPLLKELLFHPEWLIKESGILVLGAIAEGCMQGMIPYLPELIPHLVLCLSDKKALVRSIT 459

  Fly   421 CWTFMRFPKWVLNQPHDKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQLVPYLENML 485
            |||..|:..||::||.|.||:||:.||||.||||||||||||||||..|||||||:|||||..:|
Zfish   460 CWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYIL 524

  Fly   486 KTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDKDIIYLLE 550
            .|.|.|||||..:||||:||.:|.||:|||||||||:||.:|||||:.|||.:||:|||:..|||
Zfish   525 DTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNQLKDEDKDLFPLLE 589

  Fly   551 CLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQSQSTDY--PDKERMVIALDLVSGLI 613
            ||||:||||||.|||||:.||::.::::::|:.|.:: .|:|...|  |||:.|::||||:|||.
Zfish   590 CLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAVL-HQNQPEYYEAPDKDFMIVALDLLSGLA 653

  Fly   614 EGLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFSQVYPYTAHFILILVQNL 678
            |||...||.|||.|.:|.|:.|||.|.|||||||||||||||:.|.|..|.|..|:|:.||..||
Zfish   654 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKASFQHVKPCIANFMPILGTNL 718

  Fly   679 NPSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMNRQDIPKNLSRNAAITLGRLGNAC 743
            ||.::.|||||.||||:|.:::|.|.:|||.|:|.:|:.::||.:.||.|..|.|||:||||..|
Zfish   719 NPELISVCNNATWAIGEISIQMGSEMQPYVPLVLQQLVEIINRPNTPKTLLENTAITIGRLGYVC 783

  Fly   744 PDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVPDFLFFCDAIASWDNPPQ 808
            |.||||.|.:|:|.||..||...|::||..:|.|:|.||..||||||.||:|||||:|||.||..
Zfish   784 PQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMITVNPGGVVQDFIFFCDAVASWMNPKD 848

  Fly   809 DLRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRLIELYDI 851
            |||:|..:|:.|||||.|.|||..|..:||.||..||...|.:
Zfish   849 DLREMFYKILHGFKNQVGDENWRRFSDQFPPPLKERLAAFYGV 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	33/87 (38%)
		ARM	104..214	CDD:237987	77/113 (68%)
		HEAT repeat	104..132	CDD:293787	20/27 (74%)
		HEAT repeat	145..175	CDD:293787	25/29 (86%)
		HEAT repeat	186..212	CDD:293787	12/25 (48%)
		HEAT repeat	225..254	CDD:293787	19/28 (68%)
		HEAT repeat	360..388	CDD:293787	19/27 (70%)
		HEAT_2	361..465	CDD:290374	77/103 (75%)
		HEAT_EZ	373..424	CDD:290247	40/50 (80%)
		HEAT repeat	400..430	CDD:293787	21/29 (72%)
		HEAT repeat	442..468	CDD:293787	22/25 (88%)
		HEAT repeat	629..657	CDD:293787	21/27 (78%)
		HEAT_EZ	642..696	CDD:290247	35/53 (66%)
		HEAT repeat	667..699	CDD:293787	18/31 (58%)
		HEAT repeat	710..738	CDD:293787	12/27 (44%)
tnpo1	XP_021327307.1	KAP95	24..760	CDD:227540	435/736 (59%)
		HEAT repeat	129..157	CDD:293787	20/27 (74%)
		HEAT repeat	174..204	CDD:293787	25/29 (86%)
		HEAT repeat	215..241	CDD:293787	12/25 (48%)
		HEAT repeat	254..283	CDD:293787	19/28 (68%)
		HEAT repeat	404..424	CDD:293787	13/19 (68%)
		HEAT repeat	440..468	CDD:293787	20/27 (74%)
		HEAT repeat	481..511	CDD:293787	24/29 (83%)
		HEAT repeat	522..548	CDD:293787	14/25 (56%)
		HEAT repeat	563..594	CDD:293787	20/30 (67%)
		HEAT repeat	663..699	CDD:293787	25/35 (71%)
		HEAT repeat	709..739	CDD:293787	17/29 (59%)
		HEAT repeat	750..778	CDD:293787	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590849
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720