DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8219 and Karybeta3

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001262259.1	Gene:	Karybeta3 / 40581	FlyBaseID:	FBgn0087013	Length:	1105	Species:	Drosophila melanogaster

Alignment Length:	920	Identity:	180/920 - (19%)
Similarity:	331/920 - (35%)	Gaps:	252/920 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ENEATRSMSGLILKN--NIRMHDI--TLQPEHLEYIKHQCLQAV-GDSSPEIRGTVGILITTIAS 94
            ::|..|.|:.::|:.  .....|.  .|..|....:..|.|.|| .:.:|::|..:..::..:|.
  Fly    51 QSEEARQMAAVLLRRLFTTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVAR 115

  Fly    95 NI---GLHN-WPQLLPSLCEMLDNQDYNVCEGA---FSALQKICEDSAGILENMPLNTMIPKFLE 152
            |:   ..:| ||.:|..|.:..::....:.|.|   ||::..|..:......:: :..|:.|.::
  Fly   116 NLIDEDCNNQWPDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDL-IKQMLAKSMD 179

  Fly   153 YFKHSSPKIRSHAIACINQFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHAL---VGLV 214
              ..|.|::|..|:..:..||:...:                  :|:.|:..:....|   :.:.
  Fly   180 --AGSDPEVRVQAVRAVGAFILYHDK------------------ENETAIHKHFADMLPRMIHIT 224

  Fly   215 GVRID--------------------LMMPHMSQIIELIL--LRSQDADENVALQATEFWLSLGKQ 257
            |..|:                    .:.|.:..|.|:.:  ..|||.:::......|..:||.:.
  Fly   225 GETIEAQDDQSLLKLLIEMTENCPKFLRPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAEN 289

  Fly   258 --RNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDKEPDRQQDISPRFHMSRVHGISN 320
              ...|......:..|:|:::......:.|......||.:||.                 |..:|
  Fly   290 APSMIRKRADKYIVALIPLILHMMTDLDDDENWSTADVVDDDD-----------------HSDNN 337

  Fly   321 ELDENSDDDMWDSALNLRKCSACALDIISKIFGDVCLPLMLPILKEALFHQEWVIKESGVMALGA 385
            .:.|:|.|.:           ||.|.      |.:.|||::..|...|.|.:|..:.:.:||:.|
  Fly   338 VIAESSLDRL-----------ACGLG------GKIVLPLVMNALPVMLGHADWKHRFAALMAISA 385

  Fly   386 IAEGCMQGLIPHLPELIPYLITCLSDKKPLVRSITCWTFMRFPKWVLNQPHDKYLEPLIEELLKC 450
            |.|||.:.:...|.|::..::..|||..|.||...|....:...........|:...:|..||..
  Fly   386 IGEGCHKQMEAILDEVMSGVLNFLSDPHPRVRYAACNAIGQMSTDFAQTFEKKFHSQVIPGLLSL 450

  Fly   451 ILD-SNKRVQEAACSAFVALEEEACTQ--LVPYLEN-MLKTFVLAFSKYHQRNLLIMYDVVGLLA 511
            :.| .|.|||..|.:|.|...|: |.:  |..||:. |.|...:..||:.:
  Fly   451 LDDVENPRVQAHAGAALVNFSED-CPKNILTRYLDGIMAKLETILNSKFKE-------------- 500

  Fly   512 ESVGHHLNKPQYIDILMPPLMDKWN-LVKDDDKDIIYLLECLSSIATALQSSFLPYCDSVYRKGI 575
                               |::|.| ||.:.      ::..::|:|...:|.|:.|.|.:.....
  Fly   501 -------------------LVEKGNKLVLEQ------VVTTIASVADTCESEFVAYYDRLMPCLK 540

  Fly   576 SIIEETINQDMMCKQSQSTDYPDKERMVIALDLVS--GLIEGLQSLIEPLVANSKLLQLLCQCMG 638
            .||:...:.|:...:.::            ::.||  ||..|.:..|..              .|
  Fly   541 FIIQNANSDDLRMLRGKT------------IECVSLIGLAVGREKFIGD--------------AG 579

  Fly   639 DVMPEVRQSSFALLGDLSGACFSQVYPYTAHFILILVQNLNPSVVGVCNNAVWAIGQICVKLGEE 703
            :||      ...|:....|...:...|.|::.|                 ..||  ::|..||::
  Fly   580 EVM------DMLLVNHTEGGELADDDPQTSYLI-----------------TAWA--RMCKILGKQ 619

  Fly   704 TKPYVRLLLSELM--------ILMNRQDIPKNLSRN---AAITLGRLGN-------------AC- 743
            .:.|:.|::..:|        :.|...|..:::..:   :.|.||...|             ||
  Fly   620 FEQYLPLVMGPVMRTATMKPEVAMLDNDEVEDIDGDVDWSFINLGEQQNFAIRTAGMDDKASACE 684

  Fly   744 ---------PDEVAPYLPEFLRQWCLLLRYAYDHD------EKYLSFMGMCHMIRENPGGVVPDF 793
                     .:..|.|..:.:||...:|:: |.||      .:.|.::..|..|: .|..:...:
  Fly   685 MLVCYARELKEGFAEYAEDVVRQMLPMLKF-YFHDGVRTAAAESLPYLLDCAKIK-GPQYLEGMW 747

  Fly   794 LFFC----DAIASWDNP--PQDLRQMIRRIIE----GFKNQTGAENWLIFLGKF--------PQP 840
            :|.|    ..|.:...|  ..:|...:.:.||    ...|:...:..|..:.|:        .:.
  Fly   748 MFICPELLKVIVTEPEPDVQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKR 812

  Fly   841 LACRLIELYD 850
            ||.|..|.||
  Fly   813 LAARNEEDYD 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	11/45 (24%)
		ARM	104..214	CDD:237987	18/115 (16%)
		HEAT repeat	104..132	CDD:293787	7/30 (23%)
		HEAT repeat	145..175	CDD:293787	8/29 (28%)
		HEAT repeat	186..212	CDD:293787	3/28 (11%)
		HEAT repeat	225..254	CDD:293787	6/30 (20%)
		HEAT repeat	360..388	CDD:293787	8/27 (30%)
		HEAT_2	361..465	CDD:290374	30/104 (29%)
		HEAT_EZ	373..424	CDD:290247	17/50 (34%)
		HEAT repeat	400..430	CDD:293787	8/29 (28%)
		HEAT repeat	442..468	CDD:293787	10/26 (38%)
		HEAT repeat	629..657	CDD:293787	4/27 (15%)
		HEAT_EZ	642..696	CDD:290247	7/53 (13%)
		HEAT repeat	667..699	CDD:293787	5/31 (16%)
		HEAT repeat	710..738	CDD:293787	6/38 (16%)
Karybeta3	NP_001262259.1	HEAT repeat	129..157	CDD:293787	6/27 (22%)
		HEAT repeat	165..216	CDD:293787	10/71 (14%)
		HEAT repeat	235..261	CDD:293787	2/25 (8%)
		HEAT repeat	272..305	CDD:293787	4/32 (13%)
		HEAT repeat	357..385	CDD:293787	9/27 (33%)
		HEAT_2	364..467	CDD:290374	30/102 (29%)
		HEAT_EZ	373..427	CDD:290247	17/53 (32%)
		HEAT repeat	401..429	CDD:293787	7/27 (26%)
		ARM	405..503	CDD:237987	29/131 (22%)
		HEAT repeat	442..473	CDD:293787	11/30 (37%)
		HEAT repeat	485..519	CDD:293787	9/72 (13%)
		HEAT repeat	532..565	CDD:293787	6/44 (14%)
		HEAT repeat	867..894	CDD:293787
		HEAT repeat	906..936	CDD:293787
		HEAT repeat	947..979	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940