DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and Fs(2)Ket

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	177/840 - (21%)
Similarity:	316/840 - (37%)	Gaps:	200/840 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QLLPILKDSQSPGK------------------------ATQLAVQETENEATRSMSGLILKNNIR 52
            ||:.||:.:.||.|                        .:::.|....:...|..:||.|||::.
  Fly     8 QLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLT 72

  Fly    53 MHDITLQPEH-----------LEYIKHQCLQAVG--DSSPEIRGTVGILITTIASNIGLHNWPQL 104
            ..|..:..::           .|.||:..|.|:|  ::.|.........:..|  .:.::.||.|
  Fly    73 SKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVI--ELPINRWPML 135

  Fly   105 LPSLCEMLDNQDYNVC--EGAFSALQKICED-SAGILENMPLNTMIPKFLEYFKHSSPKIRSHAI 166
            :.:|...:.::..:..  |.|..|:..||:| ..|::||.. |.::...:...:...|.  :|..
  Fly   136 IQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQS-NDVLTAIIHGMRKVEPS--NHVR 197

  Fly   167 ACINQFIINRSQALMLNIDSLIQN--LLDVPSDNDPAVRMNVCHA----LVGLVGVRIDLMMPHM 225
            ......:.|..:....|.:..::.  :::|..:........:|.|    ||.::.:....|.|:|
  Fly   198 LAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYM 262

  Fly   226 SQIIELILLRSQDADEN-VALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILL 289
            :|.:..|.|.:..:|.: ||||..|||.::     |.:                    |.|:.:.
  Fly   263 AQALFPITLAAMKSDNDAVALQGIEFWSNV-----CDE--------------------EIDLAIE 302

  Fly   290 KGDVGEDDKEPDRQQDISPRFHMSRVHGISNEL-------DENSDDDMWDSALNLRKCSACALDI 347
            ..:..:..:.|.|   :|..:....:..::..|       ||..|:|.|..|    |.::..|.:
  Fly   303 SQEATDQGRAPQR---VSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPA----KAASVCLMV 360

  Fly   348 ISKIFGDVCLPLMLPILKEALFHQEWVIKESGVMALGAIAEGC-MQGLIPHLPELIPYLITCLSD 411
            ::....|..:|.:||.:||.:....|..:::.||..|::..|. ...|.|.:.:.:|.||..:.|
  Fly   361 LATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYD 425

  Fly   412 KKPLVRSITCWTFMR----FPKWVLNQPHDKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEE 472
            ...:||....|||.|    .|:..:|   :.||:.|:|..:|. |.|..||....|.||:.|.:.
  Fly   426 SSVIVRDTIAWTFGRICDIIPEAAIN---ETYLQTLLECFVKS-LKSEPRVAANVCWAFIGLSDA 486

  Fly   473 ACTQLVPYLENMLKTFVLAFSKYHQRNLLIMYDVVGLL-----AESVGHHLNKPQYIDILMPPLM 532
            |....|.......:|:  |.|.|.:      |.:..||     ::....:|....|     ..||
  Fly   487 AWEAAVTNDGETPETY--ALSPYFE------YIITQLLETTDRSDGAQANLRCAAY-----QALM 538

  Fly   533 DKWNLVKDDDKDIIYLLECLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQSQSTDYP 597
            |   ::|:...|                      |..|.::...:|.|.:|| :|..::|..::.
  Fly   539 D---MIKNSPLD----------------------CYLVVQRTTLVILERLNQ-VMQMETQINNHS 577

  Fly   598 DKERMVIALDLVSGLIEGLQSLI-----------------------------------EPLVANS 627
            |:.:.   .||.|.|...|||::                                   |..:|.|
  Fly   578 DRHQF---NDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVS 639

  Fly   628 KLLQLLCQCMGDVMP----------------EVRQSSFALLGDLSGACFSQVYPYTAHFILILVQ 676
            .|::||.......||                :|..::..|.||:..|....:.||:...:.:|:.
  Fly   640 TLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLIN 704

  Fly   677 NLNPSVV--GVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMNRQDIPKNLSRNAAI 734
            ||....:  .|....:.|.|.|.:.:|....||:.::|..|.:..|.|....|...|..|
  Fly   705 NLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYI 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	21/100 (21%)
		ARM	104..214	CDD:237987	21/118 (18%)
		HEAT repeat	104..132	CDD:293787	6/29 (21%)
		HEAT repeat	145..175	CDD:293787	2/29 (7%)
		HEAT repeat	186..212	CDD:293787	4/31 (13%)
		HEAT repeat	225..254	CDD:293787	12/29 (41%)
		HEAT repeat	360..388	CDD:293787	8/27 (30%)
		HEAT_2	361..465	CDD:290374	33/108 (31%)
		HEAT_EZ	373..424	CDD:290247	14/51 (27%)
		HEAT repeat	400..430	CDD:293787	11/33 (33%)
		HEAT repeat	442..468	CDD:293787	10/25 (40%)
		HEAT repeat	629..657	CDD:293787	9/43 (21%)
		HEAT_EZ	642..696	CDD:290247	14/71 (20%)
		HEAT repeat	667..699	CDD:293787	7/33 (21%)
		HEAT repeat	710..738	CDD:293787	7/25 (28%)
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	173/831 (21%)
		IBN_N	27..107	CDD:281761	13/79 (16%)
		HEAT repeat	136..162	CDD:293787	4/25 (16%)
		HEAT repeat	179..209	CDD:293787	3/31 (10%)
		HEAT repeat	223..255	CDD:293787	5/31 (16%)
		HEAT repeat	264..291	CDD:293787	11/26 (42%)
		HEAT repeat	330..360	CDD:293787	9/33 (27%)
		HEAT repeat	373..401	CDD:293787	8/27 (30%)
		HEAT_EZ	386..441	CDD:290247	16/54 (30%)
		HEAT repeat	414..444	CDD:293787	10/29 (34%)
		HEAT repeat	457..482	CDD:293787	10/25 (40%)
		HEAT repeat	508..540	CDD:293787	8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940