DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and Tnpo2

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001100636.1	Gene:	Tnpo2 / 304670	RGDID:	1310356	Length:	913	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	504/887 - (56%)
Similarity:	649/887 - (73%)	Gaps:	36/887 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWTPRDEGLQQLLPILKDSQSPGKATQLAVQE-----------------------TENEATRSM 42
            |.|.|.::||||:|.:|||||||..|||..||:                       :|:|.|||:
  Rat     1 MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSL 65

  Fly    43 SGLILKNNIRMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLLPS 107
            ||||||||::.|..:..|...::||.:||..:||:|..||.|:|||||||||...|..||:|||.
  Rat    66 SGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQ 130

  Fly   108 LCEMLDNQDYNVCEGAFSALQKICEDSAGILE----NMPLNTMIPKFLEYFKHSSPKIRSHAIAC 168
            ||.:|:::|||.|||||.|||||||||:.:|:    |.|||.||||||::|||.|||||||||||
  Rat   131 LCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIAC 195

  Fly   169 INQFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIELIL 233
            :||||::|:||||.|||:.|::|..:..|:||.||.|||.|||.|:.||||.::|||..||:.:|
  Rat   196 VNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYML 260

  Fly   234 LRSQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDK 298
            .|:||.||||||:|.||||:|.:|..|:::|:..|.||:|:||:..:|:|.|||||||||.||:.
  Rat   261 QRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEA 325

  Fly   299 EPDRQQDISPRFHMSRVHGISNELD-----ENSDDDMWDSAL---NLRKCSACALDIISKIFGDV 355
            .||.:|||.||||.||...:::|.:     |:::||..|.||   |||||||.|||:::.:|.:.
  Rat   326 VPDSEQDIKPRFHKSRTVTLTHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREE 390

  Fly   356 CLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPLVRSIT 420
            .||.:||:||..|||.|||:||||::.|||||||||||::|:||||||:||.||||||.|||||.
  Rat   391 LLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIA 455

  Fly   421 CWTFMRFPKWVLNQPHDKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQLVPYLENML 485
            |||..|:..||::||.|.:|:||:.||||.|||.||||||||||||..|||||||:|||||..:|
  Rat   456 CWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYIL 520

  Fly   486 KTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDKDIIYLLE 550
            .|.|.||.||..:||||:||.:|.||:|||||||:|:||..|||||:.|||.:||:|||:..|||
  Rat   521 DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLE 585

  Fly   551 CLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQ-SQSTDYPDKERMVIALDLVSGLIE 614
            ||||:||||||.|||||:.||::.::::::|:.|.||..| .:..:.|||:.|::||||:|||.|
  Rat   586 CLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAE 650

  Fly   615 GLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFSQVYPYTAHFILILVQNLN 679
            ||...:|.|||.|.::.||.|||.|.|||||||||||||||:.|||..|.|..|.|:.||..|||
  Rat   651 GLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLN 715

  Fly   680 PSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMNRQDIPKNLSRNAAITLGRLGNACP 744
            |..:.|||||.||||:||:::|.|.:|||:::||.|:.::||.:.||.|..|.|||:||||..||
  Rat   716 PEFISVCNNATWAIGEICMQMGAEMQPYVQMVLSNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780

  Fly   745 DEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVPDFLFFCDAIASWDNPPQD 809
            .||||.|.:|:|.||..||...|::||..:|.|:|.||..||||||.||:|||||:|||.:|..|
  Rat   781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWVSPKDD 845

  Fly   810 LRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRLIELYDI 851
            ||.|..:|:.|||:|.|.|||..|..:||..|..||...|.:
  Rat   846 LRDMFYKILHGFKDQVGEENWQQFSEQFPPLLKERLAAFYGV 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	34/87 (39%)
		ARM	104..214	CDD:237987	73/113 (65%)
		HEAT repeat	104..132	CDD:293787	19/27 (70%)
		HEAT repeat	145..175	CDD:293787	24/29 (83%)
		HEAT repeat	186..212	CDD:293787	12/25 (48%)
		HEAT repeat	225..254	CDD:293787	18/28 (64%)
		HEAT repeat	360..388	CDD:293787	18/27 (67%)
		HEAT_2	361..465	CDD:290374	73/103 (71%)
		HEAT_EZ	373..424	CDD:290247	39/50 (78%)
		HEAT repeat	400..430	CDD:293787	21/29 (72%)
		HEAT repeat	442..468	CDD:293787	21/25 (84%)
		HEAT repeat	629..657	CDD:293787	21/27 (78%)
		HEAT_EZ	642..696	CDD:290247	36/53 (68%)
		HEAT repeat	667..699	CDD:293787	19/31 (61%)
		HEAT repeat	710..738	CDD:293787	12/27 (44%)
Tnpo2	NP_001100636.1	KAP95	22..756	CDD:227540	420/733 (57%)
		HEAT repeat	93..114	CDD:293787	12/20 (60%)
		HEAT repeat	127..155	CDD:293787	19/27 (70%)
		HEAT repeat	165..202	CDD:293787	28/36 (78%)
		HEAT repeat	213..239	CDD:293787	12/25 (48%)
		HEAT repeat	252..281	CDD:293787	18/28 (64%)
		HEAT repeat	436..464	CDD:293787	20/27 (74%)
		HEAT repeat	477..507	CDD:293787	23/29 (79%)
		HEAT repeat	518..544	CDD:293787	13/25 (52%)
		HEAT repeat	559..590	CDD:293787	20/30 (67%)
		HEAT repeat	659..693	CDD:293787	25/33 (76%)
		HEAT repeat	705..735	CDD:293787	18/29 (62%)
		HEAT repeat	746..774	CDD:293787	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790