DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and TNPO2

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001129668.1	Gene:	TNPO2 / 30000	HGNCID:	19998	Length:	897	Species:	Homo sapiens

Alignment Length:	897	Identity:	502/897 - (55%)
Similarity:	648/897 - (72%)	Gaps:	46/897 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWTPRDEGLQQLLPILKDSQSPGKATQLAVQE-----------------------TENEATRSM 42
            |.|.|.::||||:|.:|||||||..|||..||:                       :|:|.|||:
Human     1 MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSL 65

  Fly    43 SGLILKNNIRMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLLPS 107
            ||||||||::.|..:..|...::||.:||..:||:|..||.|:|||||||||...|..||:|||.
Human    66 SGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQ 130

  Fly   108 LCEMLDNQDYNVCEGAFSALQKICEDSAGILE----NMPLNTMIPKFLEYFKHSSPKIRSHAIAC 168
            ||.:|:::|||.|||||.|||||||||:.:|:    |.|||.||||||::|||.|||||||||||
Human   131 LCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIAC 195

  Fly   169 INQFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIELIL 233
            :||||::|:||||.|||:.|::|..:..|:||.||.|||.|||.|:.||||.::|||..||:.:|
Human   196 VNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYML 260

  Fly   234 LRSQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDK 298
            .|:||.||||||:|.||||:|.:|..|:::|:..|.||:|:||:..:|:|.|||||||||.||:.
Human   261 QRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEA 325

  Fly   299 EPDRQQDISPRFHMSRVHGISNELD-----ENSDDDMWDSAL---NLRKCSACALDIISKIFGDV 355
            .||.:|||.||||.||...:.:|.:     |:::||..|.||   |||||||.|||:::.:|.:.
Human   326 VPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREE 390

  Fly   356 CLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPLVRSIT 420
            .||.:||:||..|||.|||:||||::.|||||||||||::|:||||||:||.||||||.|||||.
Human   391 LLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIA 455

  Fly   421 CWTFMRFPKWVLNQPHDKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQLVPYLENML 485
            |||..|:..||::||.|.:|:||:.||||.|||.||||||||||||..|||||||:|||||..:|
Human   456 CWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYIL 520

  Fly   486 KTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDKDIIYLLE 550
            .|.|.||.||..:||||:||.:|.||:|||||||:|:||..|||||:.|||.:||:|||:..|||
Human   521 DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLE 585

  Fly   551 CLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQ-SQSTDYPDKERMVIALDLVSGLIE 614
            ||||:||||||.|||||:.||::.::::::|:.|.||..| .:..:.|||:.|::||||:|||.|
Human   586 CLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAE 650

  Fly   615 GLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFSQVYPYTAHFILILVQNLN 679
            ||...:|.|||.|.::.||.|||.|.|||||||||||||||:.|||..|.|..|.|:.||..|||
Human   651 GLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLN 715

  Fly   680 PSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMNRQDIPKNLSRNA----------AI 734
            |..:.|||||.||||:||:::|.|.:|||:::|:.|:.::||.:.||.|..|.          ||
Human   716 PEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAI 780

  Fly   735 TLGRLGNACPDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVPDFLFFCDA 799
            |:||||..||.||||.|.:|:|.||..||...|::||..:|.|:|.||..||||||.||:|||||
Human   781 TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDA 845

  Fly   800 IASWDNPPQDLRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRLIELYDI 851
            :|||.:|..|||.|..:|:.|||:|.|.:||..|..:||..|..||...|.:
Human   846 VASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	34/87 (39%)
		ARM	104..214	CDD:237987	73/113 (65%)
		HEAT repeat	104..132	CDD:293787	19/27 (70%)
		HEAT repeat	145..175	CDD:293787	24/29 (83%)
		HEAT repeat	186..212	CDD:293787	12/25 (48%)
		HEAT repeat	225..254	CDD:293787	18/28 (64%)
		HEAT repeat	360..388	CDD:293787	18/27 (67%)
		HEAT_2	361..465	CDD:290374	73/103 (71%)
		HEAT_EZ	373..424	CDD:290247	39/50 (78%)
		HEAT repeat	400..430	CDD:293787	21/29 (72%)
		HEAT repeat	442..468	CDD:293787	21/25 (84%)
		HEAT repeat	629..657	CDD:293787	21/27 (78%)
		HEAT_EZ	642..696	CDD:290247	36/53 (68%)
		HEAT repeat	667..699	CDD:293787	19/31 (61%)
		HEAT repeat	710..738	CDD:293787	11/37 (30%)
TNPO2	NP_001129668.1	HEAT 1. /evidence=ECO:0000250\|UniProtKB:Q92973	9..36		17/26 (65%)
		KAP95	22..756	CDD:227540	419/733 (57%)
		HEAT 2. /evidence=ECO:0000250\|UniProtKB:Q92973	41..79		14/37 (38%)
		HEAT 3. /evidence=ECO:0000250\|UniProtKB:Q92973	88..121		19/32 (59%)
		HEAT repeat	93..114	CDD:293787	12/20 (60%)
		HEAT 4. /evidence=ECO:0000250\|UniProtKB:Q92973	127..164		24/36 (67%)
		HEAT repeat	127..155	CDD:293787	19/27 (70%)
		HEAT repeat	165..202	CDD:293787	28/36 (78%)
		HEAT 5. /evidence=ECO:0000250\|UniProtKB:Q92973	171..201		24/29 (83%)
		HEAT repeat	213..239	CDD:293787	12/25 (48%)
		HEAT 6. /evidence=ECO:0000250\|UniProtKB:Q92973	214..241		13/26 (50%)
		HEAT repeat	252..281	CDD:293787	18/28 (64%)
		HEAT 7. /evidence=ECO:0000250\|UniProtKB:Q92973	253..280		16/26 (62%)
		HEAT 8. /evidence=ECO:0000250\|UniProtKB:Q92973	296..386		46/89 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..364		15/38 (39%)
		HEAT 9. /evidence=ECO:0000250\|UniProtKB:Q92973	394..422		17/27 (63%)
		HEAT 10. /evidence=ECO:0000250\|UniProtKB:Q92973	434..461		21/26 (81%)
		HEAT repeat	436..464	CDD:293787	20/27 (74%)
		HEAT 11. /evidence=ECO:0000250\|UniProtKB:Q92973	475..508		25/32 (78%)
		HEAT repeat	477..507	CDD:293787	23/29 (79%)
		HEAT 12. /evidence=ECO:0000250\|UniProtKB:Q92973	516..549		17/32 (53%)
		HEAT repeat	518..544	CDD:293787	13/25 (52%)
		HEAT 13. /evidence=ECO:0000250\|UniProtKB:Q92973	557..595		25/37 (68%)
		HEAT repeat	559..590	CDD:293787	20/30 (67%)
		HEAT 14. /evidence=ECO:0000250\|UniProtKB:Q92973	603..654		21/50 (42%)
		HEAT repeat	664..696	CDD:293787	22/31 (71%)
		HEAT 15. /evidence=ECO:0000250\|UniProtKB:Q92973	665..696		22/30 (73%)
		HEAT 16. /evidence=ECO:0000250\|UniProtKB:Q92973	704..737		19/32 (59%)
		HEAT repeat	705..731	CDD:293787	15/25 (60%)
		HEAT 17. /evidence=ECO:0000250\|UniProtKB:Q92973	745..790		15/44 (34%)
		HEAT 18. /evidence=ECO:0000250\|UniProtKB:Q92973	798..831		14/32 (44%)
		HEAT 19. /evidence=ECO:0000250\|UniProtKB:Q92973	840..871		17/30 (57%)
		HEAT 20. /evidence=ECO:0000250\|UniProtKB:Q92973	874..894		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.790