Protein Alignment CG8219 and kap104

DIOPT Version :10

• Sequence 1: NP_648038.1
• Gene: CG8219 / 38722
• FlyBaseID: FBgn0035693
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_594385.1
• Gene: kap104 / 2542046
• PomBaseID: SPAC2F3.06C
• Length: 910
• Species: Schizosaccharomyces pombe
• Alignment Length: 885
• Identity: 348/885 - (39%)
• Similarity: 533/885 - (60%)
• Gaps: 74/885 - (8%)

  Fly     3 WTPRDEGLQQLLPILKDSQSPGKATQ----------------------LAVQETE-NEATRSMSG 44
            |..:::.|.:|..::|:|.|....|:                      :.:..|| :.:.||.:|
pombe     6 WVLQEQVLVELSEVIKNSLSENSQTRNAALNLLEKAKDIPDLNNYLTCILINATELSVSIRSAAG 70

  Fly    45 LILKNNIRMHDIT----LQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLL 105
            |:||||:|:..:.    ||  .|:|.|...::.:.|....|||..|.:||||.|..|:..||::|
pombe    71 LLLKNNVRVSSLESGSGLQ--SLDYTKSTVIRGLCDPEQLIRGISGNVITTIISRWGISTWPEVL 133

  Fly   106 PSLCEMLDNQDYNVCEGAFSALQKICEDSAGILE-----NMPLNTMIPKFLEYFKHSSPKIRSHA 165
            |.|.|||.:......|||||||.|||||||..|:     ..||:.|||:|:|..:|.:||||:.|
pombe   134 PQLMEMLSSPASTTQEGAFSALTKICEDSAQELDRDFNGTRPLDFMIPRFIELARHENPKIRTDA 198

  Fly   166 IACINQFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIE 230
            :.|:|||::.:||:|..:||:.::....:.:|..|.||.|||.|||.|:.||.|.:.|.:..|:|
pombe   199 LFCLNQFVLIQSQSLYAHIDTFLETCYALATDVSPNVRKNVCQALVYLLDVRPDKIAPSLGSIVE 263

  Fly   231 LILLRSQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGE 295
            .:|..:||:|:||||:|.||||::.:|.:....|.|.|.::||:|:....|::.|::||..|..:
pombe   264 YMLYSTQDSDQNVALEACEFWLAIAEQPDLCSALGPYLDKIVPMLLQGMVYSDMDLLLLGNDADD 328

  Fly   296 DDKEPDRQQDISPRFH---MSRV----------HGISN----EL-DENSDDDMWDS------ALN 336
            .|.| ||::||.|: |   .||:          .|.||    || ||:.|||.:|.      ..|
pombe   329 YDVE-DREEDIRPQ-HAKGKSRITLNTQGPITQQGSSNADADELEDEDEDDDEFDEDDDAFMDWN 391

  Fly   337 LRKCSACALDIISKIFGDVCLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPEL 401
            ||||||.|||::|..:....|.::||.||::|..::|.::|:||:|:||||||||.|::.:||||
pombe   392 LRKCSAAALDVLSSFWKQRLLEIILPHLKQSLTSEDWKVQEAGVLAVGAIAEGCMDGMVQYLPEL 456

  Fly   402 IPYLITCLSDKKPLVRSITCWTFMRFPKWV--LNQPHD--KYLEPLIEELLKCILDSNKRVQEAA 462
            .||.::.|..||||||:|||||..|:.||.  |....|  ||..||::.||:.::|:||:||||.
pombe   457 YPYFLSLLDSKKPLVRTITCWTLGRYSKWASCLESEEDRQKYFVPLLQGLLRMVVDNNKKVQEAG 521

  Fly   463 CSAFVALEEEACTQLVPYLENMLKTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDIL 527
            ||||..|||:|...||||||.:|.....||.||.::|:||:||.|..||:.||..||..:||::|
pombe   522 CSAFAILEEQAGPSLVPYLEPILTNLAFAFQKYQRKNVLILYDAVQTLADYVGSALNDKRYIELL 586

  Fly   528 MPPLMDKWNLVKDDDKDIIYLLECLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQSQ 592
            :.||:.||:::.|||.::..|.|||||:|.||:..|.|:....|.:...|:..|:......:...
pombe   587 ITPLLQKWSMIPDDDPNLFPLFECLSSVAVALRDGFAPFAAETYARTFRILRNTLYLITTAQNDP 651

  Fly   593 STDYPDKERMVIALDLVSGLIEGLQSLIEPLVANS--KLLQLLCQCMGDVMPEVRQSSFALLGDL 655
            :.|.||::.:|..||||||:|:.|.|.:.||:|.:  .|.|::..|..|.:||||||::|||||:
pombe   652 TVDVPDRDFLVTTLDLVSGIIQALGSQVSPLLAQADPPLGQIIGICAKDEVPEVRQSAYALLGDM 716

  Fly   656 SGACFSQVYPY-TAHFILILVQNLNPSV-VGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMIL 718
            ...||.|:.|| .|..:.:|.|...|.: |...|||:|:.|::.::||::.:.:|:.||..|:.:
pombe   717 CMYCFDQIRPYCDALLVDMLPQMQLPLLHVSASNNAIWSAGEMALQLGKDMQQWVKPLLERLICI 781

  Fly   719 MNRQDIPKNLSRNAAITLGRLGNACPDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIR 783
            :..:.....:..|.|||:||||...|:.|||:|..|.:.|..:::...:::||..:|.|.|:::.
pombe   782 LKSKKSNTTVLENVAITIGRLGVYNPELVAPHLELFYQPWFEIIKTVGENEEKDSAFRGFCNILA 846

  Fly   784 ENPGG---VVPDFLFFCDAIASWDNPPQDLRQMIRRIIEG 820
            .||..   ::|.|:.   .:|.::||..:||.|.::|::|
pombe   847 CNPQALSYLLPMFVL---CVAEYENPSAELRDMFQKILQG 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	KAP95	28..728	CDD:227540	309/763 (40%)
		HEAT repeat	104..132	CDD:293787	15/27 (56%)
		HEAT repeat	145..175	CDD:293787	15/29 (52%)
		HEAT repeat	186..212	CDD:293787	9/25 (36%)
		HEAT repeat	225..254	CDD:293787	15/28 (54%)
		HEAT repeat	360..388	CDD:293787	13/27 (48%)
		HEAT repeat	400..430	CDD:293787	17/29 (59%)
		HEAT repeat	442..468	CDD:293787	15/25 (60%)
		HEAT repeat	629..657	CDD:293787	15/27 (56%)
		HEAT repeat	667..699	CDD:293787	10/32 (31%)
		HEAT repeat	710..738	CDD:293787	7/27 (26%)
kap104	NP_594385.1	HEAT repeat	51..83	CDD:293787	11/31 (35%)
		KAP95	65..791	CDD:227540	307/729 (42%)
		HEAT repeat	93..120	CDD:293787	9/26 (35%)
		HEAT repeat	132..160	CDD:293787	15/27 (56%)
		HEAT repeat	178..208	CDD:293787	15/29 (52%)
		HEAT repeat	219..245	CDD:293787	9/25 (36%)
		HEAT repeat	258..283	CDD:293787	11/24 (46%)
		HEAT repeat	415..443	CDD:293787	13/27 (48%)
		HEAT_EZ	428..482	CDD:463906	32/53 (60%)
		HEAT repeat	455..485	CDD:293787	17/29 (59%)
		HEAT repeat	498..527	CDD:293787	16/28 (57%)