DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and imb-2

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001309574.1	Gene:	imb-2 / 175094	WormBaseID:	WBGene00002076	Length:	889	Species:	Caenorhabditis elegans

Alignment Length:	901	Identity:	372/901 - (41%)
Similarity:	559/901 - (62%)	Gaps:	62/901 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWTPRDEGLQQLLPILKDSQSPGKATQLAVQ------------------------ETENEATRS 41
            ||:.|....|:|::.:|:.:.|..:..|..||                        |..:..:||
Worm     1 MAFQPDQHELEQVIQLLQHAHSTDRDVQRNVQVQLVQLNEHQKFCCYLVYILSDMKEMIDATSRS 65

  Fly    42 MSGLILKNNIRM------HDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHN 100
            ::||:||||||.      .|:..      :::..||:::||..|.||.||||::|||.....:.:
Worm    66 LAGLLLKNNIRAKWNKYPQDVKF------FVRTTCLKSIGDQEPLIRATVGIIVTTIVMEENMCD 124

  Fly   101 WPQLLPSLCEMLDNQDYNVCEGAFSALQKICEDSAGILENMPLNTMIPKFLEYFKHSSPKIRSHA 165
            ||.||.:|..:|...|..:.|||..||||:.||||...|:..|..::||.|.:::|.:.|:|:.|
Worm   125 WPDLLDTLATVLMQPDELMQEGALGALQKVFEDSADRYESEFLRPIMPKLLVFYEHHAAKMRALA 189

  Fly   166 IACINQFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIE 230
            :.|:|..::..:..:...||..:.:|....:|||..|:..:|.:|..|:...|:.||||:..:||
Worm   190 MNCVNCILMVNNDPIDFAIDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEKMMPHLPNVIE 254

  Fly   231 LILLRSQDADENVALQATEFWLSLGKQRN-CRDILSPILSQLVPVLVSRTQYTETDIILLKGDVG 294
            .|:.::||.:|::||:|.|||||:.:..: ||.::.|.|.:|:|||:...:|:|||..|...|
Worm   255 YIIKKTQDHNESIALEACEFWLSIAENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKAND-- 317

  Fly   295 EDDKEPDRQQDISPRFHMSRVHGI------SNELDENSDDD---MWDSALNLRKCSACALDIISK 350
            ||...|||::||.||||.|:.||:      .:|.||:.|||   .|    |:|:|||.:||:::.
Worm   318 EDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDDDDGGGDW----NIRRCSAASLDVLAS 378

  Fly   351 IFGDVCLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPL 415
            |||...|..:.|:||:.|.:..|::||||::||||||||||.|::|||.||||:::..:.|||||
Worm   379 IFGKDLLDKLFPLLKDTLMNDNWLVKESGILALGAIAEGCMDGVVPHLGELIPFMLAMMFDKKPL 443

  Fly   416 VRSITCWTFMRFPKWVLNQPH--DKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQLV 478
            ||||||||..|:...:.:..:  .::.:.::..||:|.||.||:|||||||||..|||||..||:
Worm   444 VRSITCWTLSRYSSHIASDENFRQQFFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLI 508

  Fly   479 PYLENMLKTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDK 543
            |:|..:|...|.||..|..:||||:||.:|.||.|||..|:.|.|:.:||||||:||..:.|:||
Worm   509 PFLGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDALSHPVYVQMLMPPLMEKWERLSDEDK 573

  Fly   544 DIIYLLECLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMM-CKQSQSTDYPDKERMVIALD 607
            ::..||||:|:|.:|:..|||||...|:.:..|:||:.:.|:.. .......:.|:.:.:::|||
Worm   574 ELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNQQHIMAPDQVEAPETDFIIVALD 638

  Fly   608 LVSGLIEGLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFSQVYP------Y 666
            |:|||.|.|...::||||||||::|:..|..||.|:||||.|||||||:.||..:|.|      :
Worm   639 LLSGLAESLPEHMDPLVANSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSKILQF 703

  Fly   667 TAHFILILVQNLNPSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMN-RQDIPKNLSR 730
            ..:||..|.|||:||.:.|||||:||:|::.:|:|...|.::..::..|::::| :|::.:.|..
Worm   704 AGNFIFFLAQNLDPSKISVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQNMQRTLLE 768

  Fly   731 NAAITLGRLGNACPDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVPDFLF 795
            |.|||:||||..|.:|:||::..|:|..|..||...|:.||..:|:|:|:||..||.||:.||:|
Worm   769 NTAITIGRLGQCCGEELAPHISRFVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVGVLNDFIF 833

  Fly   796 FCDAIASWDNPPQDLRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRLIELYDI 851
            :|||||||..|...||.:...|::.||.|.|..||..|:.:.|.||..||...|.|
Worm   834 WCDAIASWTVPTDSLRVLFAGILQSFKQQVGDFNWNNFILQLPPPLRERLSAFYQI 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	20/94 (21%)
		ARM	104..214	CDD:237987	36/109 (33%)
		HEAT repeat	104..132	CDD:293787	12/27 (44%)
		HEAT repeat	145..175	CDD:293787	9/29 (31%)
		HEAT repeat	186..212	CDD:293787	7/25 (28%)
		HEAT repeat	225..254	CDD:293787	13/28 (46%)
		HEAT repeat	360..388	CDD:293787	14/27 (52%)
		HEAT_2	361..465	CDD:290374	54/105 (51%)
		HEAT_EZ	373..424	CDD:290247	35/50 (70%)
		HEAT repeat	400..430	CDD:293787	18/29 (62%)
		HEAT repeat	442..468	CDD:293787	16/25 (64%)
		HEAT repeat	629..657	CDD:293787	17/27 (63%)
		HEAT_EZ	642..696	CDD:290247	32/59 (54%)
		HEAT repeat	667..699	CDD:293787	16/31 (52%)
		HEAT repeat	710..738	CDD:293787	8/28 (29%)
imb-2	NP_001309574.1	KAP95	15..764	CDD:227540	309/760 (41%)
		HEAT repeat	128..156	CDD:293787	12/27 (44%)
		HEAT repeat	169..201	CDD:293787	9/31 (29%)
		HEAT repeat	210..236	CDD:293787	7/25 (28%)
		HEAT repeat	249..278	CDD:293787	13/28 (46%)
		HEAT repeat	388..416	CDD:293787	14/27 (52%)
		HEAT repeat	428..458	CDD:293787	18/29 (62%)
		HEAT repeat	467..498	CDD:293787	16/30 (53%)
		HEAT repeat	512..539	CDD:293787	11/26 (42%)
		HEAT repeat	554..585	CDD:293787	16/30 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156342
Domainoid	1	1.000	449	1.000	Domainoid score	I266
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	862	1.000	Inparanoid score	I212
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm14523
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910