Protein Alignment CG8219 and imb-2

DIOPT Version :10

• Sequence 1: NP_648038.1
• Gene: CG8219 / 38722
• FlyBaseID: FBgn0035693
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001309574.1
• Gene: imb-2 / 175094
• WormBaseID: WBGene00002076
• Length: 889
• Species: Caenorhabditis elegans
• Alignment Length: 901
• Identity: 372/901 - (41%)
• Similarity: 559/901 - (62%)
• Gaps: 62/901 - (6%)

  Fly     1 MAWTPRDEGLQQLLPILKDSQSPGKATQLAVQ------------------------ETENEATRS 41
            ||:.|....|:|::.:|:.:.|..:..|..||                        |..:..:||
 Worm     1 MAFQPDQHELEQVIQLLQHAHSTDRDVQRNVQVQLVQLNEHQKFCCYLVYILSDMKEMIDATSRS 65

  Fly    42 MSGLILKNNIRM------HDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHN 100
            ::||:||||||.      .|:..      :::..||:::||..|.||.||||::|||.....:.:
 Worm    66 LAGLLLKNNIRAKWNKYPQDVKF------FVRTTCLKSIGDQEPLIRATVGIIVTTIVMEENMCD 124

  Fly   101 WPQLLPSLCEMLDNQDYNVCEGAFSALQKICEDSAGILENMPLNTMIPKFLEYFKHSSPKIRSHA 165
            ||.||.:|..:|...|..:.|||..||||:.||||...|:..|..::||.|.:::|.:.|:|:.|
 Worm   125 WPDLLDTLATVLMQPDELMQEGALGALQKVFEDSADRYESEFLRPIMPKLLVFYEHHAAKMRALA 189

  Fly   166 IACINQFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIE 230
            :.|:|..::..:..:...||..:.:|....:|||..|:..:|.:|..|:...|:.||||:..:||
 Worm   190 MNCVNCILMVNNDPIDFAIDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEKMMPHLPNVIE 254

  Fly   231 LILLRSQDADENVALQATEFWLSLGKQRN-CRDILSPILSQLVPVLVSRTQYTETDIILLKGDVG 294
            .|:.::||.:|::||:|.|||||:.:..: ||.::.|.|.:|:|||:...:|:|||..|...|
 Worm   255 YIIKKTQDHNESIALEACEFWLSIAENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKAND-- 317

  Fly   295 EDDKEPDRQQDISPRFHMSRVHGI------SNELDENSDDD---MWDSALNLRKCSACALDIISK 350
            ||...|||::||.||||.|:.||:      .:|.||:.|||   .|    |:|:|||.:||:::.
 Worm   318 EDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDDDDGGGDW----NIRRCSAASLDVLAS 378

  Fly   351 IFGDVCLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPL 415
            |||...|..:.|:||:.|.:..|::||||::||||||||||.|::|||.||||:::..:.|||||
 Worm   379 IFGKDLLDKLFPLLKDTLMNDNWLVKESGILALGAIAEGCMDGVVPHLGELIPFMLAMMFDKKPL 443

  Fly   416 VRSITCWTFMRFPKWVLNQPH--DKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQLV 478
            ||||||||..|:...:.:..:  .::.:.::..||:|.||.||:|||||||||..|||||..||:
 Worm   444 VRSITCWTLSRYSSHIASDENFRQQFFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLI 508

  Fly   479 PYLENMLKTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDK 543
            |:|..:|...|.||..|..:||||:||.:|.||.|||..|:.|.|:.:||||||:||..:.|:||
 Worm   509 PFLGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDALSHPVYVQMLMPPLMEKWERLSDEDK 573

  Fly   544 DIIYLLECLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMM-CKQSQSTDYPDKERMVIALD 607
            ::..||||:|:|.:|:..|||||...|:.:..|:||:.:.|:.. .......:.|:.:.:::|||
 Worm   574 ELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNQQHIMAPDQVEAPETDFIIVALD 638

  Fly   608 LVSGLIEGLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFSQVYP------Y 666
            |:|||.|.|...::||||||||::|:..|..||.|:||||.|||||||:.||..:|.|      :
 Worm   639 LLSGLAESLPEHMDPLVANSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSKILQF 703

  Fly   667 TAHFILILVQNLNPSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMN-RQDIPKNLSR 730
            ..:||..|.|||:||.:.|||||:||:|::.:|:|...|.::..::..|::::| :|::.:.|..
 Worm   704 AGNFIFFLAQNLDPSKISVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQNMQRTLLE 768

  Fly   731 NAAITLGRLGNACPDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVPDFLF 795
            |.|||:||||..|.:|:||::..|:|..|..||...|:.||..:|:|:|:||..||.||:.||:|
 Worm   769 NTAITIGRLGQCCGEELAPHISRFVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVGVLNDFIF 833

  Fly   796 FCDAIASWDNPPQDLRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRLIELYDI 851
            :|||||||..|...||.:...|::.||.|.|..||..|:.:.|.||..||...|.|
 Worm   834 WCDAIASWTVPTDSLRVLFAGILQSFKQQVGDFNWNNFILQLPPPLRERLSAFYQI 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	KAP95	28..728	CDD:227540	307/749 (41%)
		HEAT repeat	104..132	CDD:293787	12/27 (44%)
		HEAT repeat	145..175	CDD:293787	9/29 (31%)
		HEAT repeat	186..212	CDD:293787	7/25 (28%)
		HEAT repeat	225..254	CDD:293787	13/28 (46%)
		HEAT repeat	360..388	CDD:293787	14/27 (52%)
		HEAT repeat	400..430	CDD:293787	18/29 (62%)
		HEAT repeat	442..468	CDD:293787	16/25 (64%)
		HEAT repeat	629..657	CDD:293787	17/27 (63%)
		HEAT repeat	667..699	CDD:293787	16/31 (52%)
		HEAT repeat	710..738	CDD:293787	8/28 (29%)
imb-2	NP_001309574.1	KAP95	15..764	CDD:227540	309/760 (41%)
		HEAT repeat	128..156	CDD:293787	12/27 (44%)
		HEAT repeat	169..201	CDD:293787	9/31 (29%)
		HEAT repeat	210..236	CDD:293787	7/25 (28%)
		HEAT repeat	249..278	CDD:293787	13/28 (46%)
		HEAT repeat	388..416	CDD:293787	14/27 (52%)
		HEAT repeat	428..458	CDD:293787	18/29 (62%)
		HEAT repeat	467..498	CDD:293787	16/30 (53%)
		HEAT repeat	512..539	CDD:293787	11/26 (42%)
		HEAT repeat	554..585	CDD:293787	16/30 (53%)