Protein Alignment CG8219 and Tnpo

DIOPT Version :10

• Sequence 1: NP_648038.1
• Gene: CG8219 / 38722
• FlyBaseID: FBgn0035693
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_315921.4
• Gene: Tnpo / 1276558
• VectorBaseID: AGAMI1_015114
• Length: 904
• Species: Anopheles gambiae
• Alignment Length: 905
• Identity: 529/905 - (58%)
• Similarity: 670/905 - (74%)
• Gaps: 55/905 - (6%)

  Fly     1 MAWTPRDEGLQQLLPILKDSQSPGKATQLAVQ-----------------------ETENEATRSM 42
            |:|.|:.:||.|::.:||.|||.....|.|||                       .:|:|.|||:
Mosquito     1 MSWEPQPDGLSQIITLLKQSQSTDNMVQRAVQLKLEELNQYPDFNNYLIYVLTKLTSEDEPTRSL 65

  Fly    43 SGLILKNNIRMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLLPS 107
            ||||||||||:|...|||..:||||.:||.|:||.||.||.|.||||||||:..||.|||:|||:
Mosquito    66 SGLILKNNIRIHGTELQPAIIEYIKQECLMALGDPSPLIRATAGILITTIANKGGLQNWPELLPT 130

  Fly   108 LCEMLDNQDYNVCEGAFSALQKICEDSAGILE----NMPLNTMIPKFLEYFKHSSPKIRSHAIAC 168
            ||:|||:|||:||||||.||||||||||.:|:    |.|||.||||||::|:||||||||:||||
Mosquito   131 LCDMLDSQDYSVCEGAFGALQKICEDSADVLDSSALNRPLNIMIPKFLQFFRHSSPKIRSNAIAC 195

  Fly   169 INQFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIELIL 233
            ||||||||:||||::||:.|:||..:.||:|..||.|||..||.|:.||:|.:||||:.|||.:|
Mosquito   196 INQFIINRTQALMVHIDTFIENLFHLSSDDDREVRKNVCRGLVMLLDVRMDRLMPHMNSIIEYML 260

  Fly   234 LRSQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDK 298
            :|:||:|| .:|:|.||||:|.:|..|:::|:|.|.:||||||...:|::.|||:|||||.||:.
Mosquito   261 IRTQDSDE-TSLEACEFWLTLAEQSICKEVLTPHLPRLVPVLVRGMKYSDIDIIILKGDVEEDEM 324

  Fly   299 EPDRQQDISPRFHMSRVH--------GIS-----------NELDENSD---DDMWD----SALNL 337
            .|||::||.||||.||.|        |.|           |:.||:.|   |:|.|    |..||
Mosquito   325 IPDREEDIKPRFHKSRTHTQKPSLGGGASGADGAVRAMEGNDDDEDIDDPYDEMDDDSNLSDWNL 389

  Fly   338 RKCSACALDIISKIFGDVCLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELI 402
            |||||.|||:::.:|.|..||::||||||.|||:||||||||::||||||||||.|::|||||||
Mosquito   390 RKCSAAALDVLANVFKDDFLPILLPILKETLFHEEWVIKESGILALGAIAEGCMNGMVPHLPELI 454

  Fly   403 PYLITCLSDKKPLVRSITCWTFMRFPKWVLNQPHDKYLEPLIEELLKCILDSNKRVQEAACSAFV 467
            ||||.||||||.|||||||||..|:..||::||||:||:||::||||.|||:||||||||||||.
Mosquito   455 PYLIVCLSDKKALVRSITCWTLSRYAHWVVSQPHDQYLKPLMKELLKRILDANKRVQEAACSAFA 519

  Fly   468 ALEEEACTQLVPYLENMLKTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLM 532
            .|||||||:|||||..:|.|.|.||.||..:||||:||.:|.||:|||||||||:||.:|||||:
Mosquito   520 TLEEEACTELVPYLGFILDTLVFAFRKYQHKNLLILYDAIGTLADSVGHHLNKPEYISMLMPPLI 584

  Fly   533 DKWNLVKDDDKDIIYLLECLSSIATALQSSFLPYCDSVYRKGISIIEETINQDMMCKQSQST-DY 596
            :|||.:||:|||:..|||||||:||||.|.||||.:.|||:.||:|::|:|||:....|... :.
Mosquito   585 EKWNNLKDEDKDLFPLLECLSSVATALHSGFLPYSEPVYRRCISLIQQTLNQDLASTTSPGQFEQ 649

  Fly   597 PDKERMVIALDLVSGLIEGLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFALLGDLSGACFS 661
            |||:.|::||||:|||.|||...||.||::|.::|||.|||.|.|||||||||||||||:.|||.
Mosquito   650 PDKDFMIVALDLLSGLAEGLDCYIESLVSSSNIMQLLYQCMQDSMPEVRQSSFALLGDLTKACFQ 714

  Fly   662 QVYPYTAHFILILVQNLNPSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSELMILMNRQDIPK 726
            .|:|:.|.|:.||..||||..:.|||||.||||:|.:||.|:||||:.::|:.|:.::|..:.||
Mosquito   715 HVHPHIADFLPILGHNLNPEYISVCNNATWAIGEISIKLMEDTKPYIPMVLAPLIEIINNTNTPK 779

  Fly   727 NLSRNAAITLGRLGNACPDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCHMIRENPGGVVP 791
            .|..|.|||:||||..||.||||.|.:|:||||..||...|::||..:|.|||.||..||.||||
Mosquito   780 TLLENTAITIGRLGLVCPVEVAPSLQQFVRQWCSSLRNIRDNEEKDSAFRGMCQMITVNPVGVVP 844

  Fly   792 DFLFFCDAIASWDNPPQDLRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRLIELYDI 851
            ||:|||||.|||..|.:||.:|:::|:.|||.|.|.|||..|:.:||..|:.||..:|.|
Mosquito   845 DFIFFCDAAASWMTPKKDLHEMLQKILHGFKMQVGEENWARFVEQFPPQLSERLAVMYSI 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	KAP95	28..728	CDD:227540	449/753 (60%)
		HEAT repeat	104..132	CDD:293787	22/27 (81%)
		HEAT repeat	145..175	CDD:293787	24/29 (83%)
		HEAT repeat	186..212	CDD:293787	12/25 (48%)
		HEAT repeat	225..254	CDD:293787	16/28 (57%)
		HEAT repeat	360..388	CDD:293787	22/27 (81%)
		HEAT repeat	400..430	CDD:293787	23/29 (79%)
		HEAT repeat	442..468	CDD:293787	21/25 (84%)
		HEAT repeat	629..657	CDD:293787	22/27 (81%)
		HEAT repeat	667..699	CDD:293787	18/31 (58%)
		HEAT repeat	710..738	CDD:293787	10/27 (37%)
Tnpo	XP_315921.4	KAP95	11..781	CDD:227540	455/770 (59%)
		HEAT repeat	127..155	CDD:293787	22/27 (81%)
		HEAT repeat	172..204	CDD:293787	26/31 (84%)
		HEAT repeat	213..239	CDD:293787	12/25 (48%)
		HEAT repeat	412..440	CDD:293787	22/27 (81%)
		HEAT repeat	452..482	CDD:293787	23/29 (79%)
		HEAT repeat	491..520	CDD:293787	23/28 (82%)
		HEAT repeat	576..607	CDD:293787	20/30 (67%)
		HEAT repeat	681..713	CDD:293787	23/31 (74%)
		HEAT repeat	722..748	CDD:293787	15/25 (60%)