DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8219 and tnpo1

DIOPT Version :9

Sequence 1:	NP_648038.1	Gene:	CG8219 / 38722	FlyBaseID:	FBgn0035693	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_004910877.1	Gene:	tnpo1 / 100492001	XenbaseID:	XB-GENE-493792	Length:	918	Species:	Xenopus tropicalis

Alignment Length:	916	Identity:	517/916 - (56%)
Similarity:	656/916 - (71%)	Gaps:	69/916 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WTPRDEGLQQLLPILKDSQSPGKATQLAVQE-----------------------TENEATRSMSG 44
            |.|.::||||:|.:||:||||...||.|||:                       :|:|.|||:||
Frog     5 WKPDEQGLQQILQLLKESQSPDNNTQRAVQQKLEQLNQFPDFNNYLIFVLTKLKSEDEPTRSLSG 69

  Fly    45 LILKNNIRMHDITLQPEHLEYIKHQCLQAVGDSSPEIRGTVGILITTIASNIGLHNWPQLLPSLC 109
            ||||||::.|.........::||.:||..:||:||.||.|||||||||||...|.|||:|||.||
Frog    70 LILKNNVKAHFQNFPNGVTDFIKSECLNNIGDASPLIRATVGILITTIASKGELQNWPELLPKLC 134

  Fly   110 EMLDNQDYNVCEGAFSALQKICEDSAGILEN----MPLNTMIPKFLEYFKHSSPKIRSHAIACIN 170
            .:||::|||.|||||.||||||||||.||::    .|||.||||||::||||||||||||:||:|
Frog   135 GLLDSEDYNTCEGAFGALQKICEDSAEILDSDILERPLNVMIPKFLQFFKHSSPKIRSHAVACVN 199

  Fly   171 QFIINRSQALMLNIDSLIQNLLDVPSDNDPAVRMNVCHALVGLVGVRIDLMMPHMSQIIELILLR 235
            ||||.|:|||||:|||.|:||..:.:|.:|.||.|||.|||.|:.||:|.::|||..|:|.:|||
Frog   200 QFIIGRTQALMLHIDSFIENLFALATDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLLR 264

  Fly   236 SQDADENVALQATEFWLSLGKQRNCRDILSPILSQLVPVLVSRTQYTETDIILLKGDVGEDDKEP 300
            :||.||||||:|.||||:|.:|..|:|:|...|::|:||||:..:|:|.|||||||||.||:..|
Frog   265 TQDQDENVALEACEFWLTLAEQPICKDVLCRHLAKLIPVLVNGMKYSEIDIILLKGDVEEDEAIP 329

  Fly   301 DRQQDISPRFHMSRV-------HGISNELDENSDDDMWD----SALNLRKCSACALDIISKIFGD 354
            |.:|||.||||.||.       .||  |.|::.||::.|    |..|:|||||.|||:::.:|.:
Frog   330 DSEQDIRPRFHRSRTVAQPHEEDGI--EEDDDDDDELDDDENISDWNIRKCSAAALDVLANVFRE 392

  Fly   355 VCLPLMLPILKEALFHQEWVIKESGVMALGAIAEGCMQGLIPHLPELIPYLITCLSDKKPLVRSI 419
            ..||.:||:|||.|||.|||:||||::.|||||||||||:||:||||||:||.||||||.|||||
Frog   393 ELLPHILPLLKELLFHPEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSI 457

  Fly   420 TCWTFMRFPKWVLNQPHDKYLEPLIEELLKCILDSNKRVQEAACSAFVALEEEACTQLVPYLENM 484
            ||||..|:..||::||.|.||:||:.||||.||||||||||||||||..|||||||:|||||..:
Frog   458 TCWTLSRYAHWVVSQPPDMYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYI 522

  Fly   485 LKTFVLAFSKYHQRNLLIMYDVVGLLAESVGHHLNKPQYIDILMPPLMDKWNLVKDDDKDIIYLL 549
            |.|.|.|||||..:||||:||.:|.||:|||||||||:||.:|||||:.|||::||:|||:..||
Frog   523 LDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNVLKDEDKDLFPLL 587

  Fly   550 ECLSSIATALQSSFLPYCDSVYRKGISIIEETINQDM---------------------MCKQSQS 593
            |||||:||||||.|||||:.||::.::::::|:.|.|                     :|..||:
Frog   588 ECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLQQSMTDQLQSDRCTVSPVENNPRPDVCPDSQA 652

  Fly   594 T--------DYPDKERMVIALDLVSGLIEGLQSLIEPLVANSKLLQLLCQCMGDVMPEVRQSSFA 650
            .        :.|||:.|::||||:|||.|||...||.|||.|.:|.|:.|||.|.||||||||||
Frog   653 LHNAQPDQYESPDKDFMIVALDLLSGLAEGLGGHIEQLVARSNILTLMYQCMQDKMPEVRQSSFA 717

  Fly   651 LLGDLSGACFSQVYPYTAHFILILVQNLNPSVVGVCNNAVWAIGQICVKLGEETKPYVRLLLSEL 715
            |||||:.|||..|....|.|:.||..||||.::.|||||.||||:|.:::|.|.:||:.::|.:|
Frog   718 LLGDLTKACFQHVKSCIADFMPILGTNLNPELISVCNNATWAIGEISIQMGIEMQPYIPMVLHQL 782

  Fly   716 MILMNRQDIPKNLSRNAAITLGRLGNACPDEVAPYLPEFLRQWCLLLRYAYDHDEKYLSFMGMCH 780
            :.::||.:.||.|..|.|||:||||..||.||||.|.:|:|.||..||...|::||..:|.|:|.
Frog   783 VEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICT 847

  Fly   781 MIRENPGGVVPDFLFFCDAIASWDNPPQDLRQMIRRIIEGFKNQTGAENWLIFLGKFPQPLACRL 845
            ||..||||||.||:|||||:|||.||.:|||.|..:|:.|||||.|.|||..|..:||.||..||
Frog   848 MISVNPGGVVQDFIFFCDAVASWINPKEDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERL 912

  Fly   846 IELYDI 851
            ...|.:
Frog   913 AAYYGV 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8219	NP_648038.1	IBN_N	11..76	CDD:281761	32/87 (37%)
		ARM	104..214	CDD:237987	77/113 (68%)
		HEAT repeat	104..132	CDD:293787	20/27 (74%)
		HEAT repeat	145..175	CDD:293787	24/29 (83%)
		HEAT repeat	186..212	CDD:293787	13/25 (52%)
		HEAT repeat	225..254	CDD:293787	19/28 (68%)
		HEAT repeat	360..388	CDD:293787	19/27 (70%)
		HEAT_2	361..465	CDD:290374	78/103 (76%)
		HEAT_EZ	373..424	CDD:290247	41/50 (82%)
		HEAT repeat	400..430	CDD:293787	22/29 (76%)
		HEAT repeat	442..468	CDD:293787	22/25 (88%)
		HEAT repeat	629..657	CDD:293787	21/27 (78%)
		HEAT_EZ	642..696	CDD:290247	35/53 (66%)
		HEAT repeat	667..699	CDD:293787	18/31 (58%)
		HEAT repeat	710..738	CDD:293787	11/27 (41%)
tnpo1	XP_004910877.1	KAP95	24..787	CDD:227540	432/764 (57%)
		HEAT repeat	95..116	CDD:293787	14/20 (70%)
		HEAT repeat	129..157	CDD:293787	20/27 (74%)
		HEAT repeat	174..204	CDD:293787	24/29 (83%)
		HEAT repeat	215..241	CDD:293787	13/25 (52%)
		HEAT repeat	254..283	CDD:293787	19/28 (68%)
		HEAT repeat	398..426	CDD:293787	19/27 (70%)
		HEAT repeat	438..471	CDD:293787	24/32 (75%)
		HEAT repeat	480..506	CDD:293787	22/25 (88%)
		HEAT repeat	562..593	CDD:293787	20/30 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10527
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110