DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and TRN1

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_179287.3	Gene:	TRN1 / 816198	AraportID:	AT2G16950	Length:	895	Species:	Arabidopsis thaliana

Alignment Length:	915	Identity:	394/915 - (43%)
Similarity:	579/915 - (63%)	Gaps:	58/915 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTWEPQGEGLQQIIAILKESQSPDTATQMA-VQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRS 64
            :.|:|:.:||.:|.::|::..||.:....: :..:|:.|:::|||||||:::|.:.:.:....|.
plant     6 VVWQPRDDGLAEICSLLEQQISPSSVVDKSQIWKQLQHFSQFPDFNNYLVFILVRAEGKSVEVRQ 70

  Fly    65 LSGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLP 129
            .:||:||||:|....::..|..:|||.|.|..:|.|...||.|||.:|:.|.:..|:..|.:|||
plant    71 AAGLLLKNNLRGAYPSMTQENQKYIKSELLPCLGAADRNIRTTVGTIISVIVNIEGVSGWHELLP 135

  Fly   130 SLCEMLDNQDYNVCEGAFSALQKICEDSAEILDS---AALNRPLNIMIPKFLEYFKHSSPKIRSH 191
            :|...||:.|.|..:||..||.|||||...:||:   ....||:||.:|:.|::|:.....:|..
plant   136 ALVTCLDSNDLNHMDGAMDALSKICEDIPHVLDTEVPGLAERPINIFLPRLLQFFQSPHASLRKL 200

  Fly   192 AIACINQFIINRS----QALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHM 252
            |:..:||:||...    |||..::|.:::.||.|::|...||||.||...|.|.||....:.||:
plant   201 ALGSVNQYIIIMPAVIWQALYNSLDKYLQGLFVLANDPVPEVRKLVCAAFVHLTEVLPSSIEPHL 265

  Fly   253 SQIIEYMLLRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLK 317
            ..::||||...:|.||.|:|||.|||.:..:..:..:.|..:|.:|.|||:..|.|::.|..||
plant   266 RNVMEYMLQVNRDPDEEVSLEACEFWSAYCDAQLPPENLKEFLPRLIPVLLENMAYADDDESLL- 329

  Fly   318 GNVEEDDMVPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKC 382
             :.|||:..|||::|::||||.||.|             |.:|.|:     |||.|.:.||||||
plant   330 -DAEEDESQPDRDQDLKPRFHTSRLH-------------GSEDFDD-----DDDDSFNVWNLRKC 375

  Fly   383 SAAALDVLANVFREDCLPVVLPILKETLF---HQEWVIKESGVLALGAIAEGCMQGMIQHLPELI 444
            ||||:|||:|||.::.||.::|::::.|.   .:.|..:|:.||||||||||||.|:..||.|::
plant   376 SAAAIDVLSNVFGDEILPALMPLIQKNLSASGDEAWKQREAAVLALGAIAEGCMNGLYPHLSEIV 440

  Fly   445 PYLISCLSDKKALVRSITCWTLSRYANWVVNQP-----HDQYLKPLMEELLKRILDSNKRVQEAA 504
            .:|:..|.||..|:|||:||||||:..:::.:.     ::|:.|.|| .||:|:||:||||||||
plant   441 AFLLPLLDDKFPLIRSISCWTLSRFGKYLIQESGNPKGYEQFEKVLM-GLLRRLLDTNKRVQEAA 504

  Fly   505 CSAFATLEEEACTELVPYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDIL 569
            ||||||:||:|..||||:|..||:.|:.||.|||.:||.|:|||:|||||||...||||.|::||
plant   505 CSAFATVEEDAAEELVPHLGVILQHLMCAFGKYQRRNLRIVYDAIGTLADSVREELNKPAYLEIL 569

  Fly   570 MPPLIDKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCKQNQ 634
            ||||:.||..|.:.||||||||||.:||:.||..||.|:..||::||:.:|:    .:.|.|.|.
plant   570 MPPLVAKWQQLSNSDKDLFPLLECFTSISQALGVGFAPFAQPVFQRCMDIIQ----LQQLAKVNP 630

  Fly   635 T-----YDHPDKERMIVALDLLSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALL 694
            .     |   |:|.::.:|||||||||||...||:||..||:..||..|..|...:||||:|||:
plant   631 ASAGAQY---DREFIVCSLDLLSGLAEGLGSGIESLVQQSNLRDLLLNCCIDEAADVRQSAFALM 692

  Fly   695 GDLTKACFP-HVHPFMADFFPILGQ----NLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVL 754
            |||.:. || ::.|.:.||..|..|    |||.:.:||.|||.|||||:.:|:.:|....:..|:
plant   693 GDLARV-FPVYLQPRLLDFLEIASQQLSANLNRENLSVANNACWAIGELAVKVRQEVSPIVAKVV 756

  Fly   755 SDLFIIINR-PNTPKTLLENTAITIGRLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFR 818
            |.|.:|:.. ....|.|:||:|||:|||.::.|..|||::..|::.||.:|..:||:.||:.|||
plant   757 SSLGLILQHGEGVNKALVENSAITLGRLAWIRPDLVAPHMDHFMKPWCMALSMVRDDIEKEDAFR 821

  Fly   819 GMCHMITVNPAGVVADFIFFCDAIASWVN-PPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPT 882
            |:|.::.|||:|.|:..:|.|.|||||.. ..||:...:.::|:|:|..:| .:|...:....|.
plant   822 GLCAVVKVNPSGGVSSLVFICQAIASWHEIRSEDVQTEVSQVLNGYKHMLG-NSWAECLSALDPP 885

  Fly   883 LAERL 887
            :.|||
plant   886 VKERL 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	24/66 (36%)
		ARM	127..234	CDD:237987	44/113 (39%)
		HEAT repeat	127..155	CDD:293787	14/27 (52%)
		HEAT repeat	172..202	CDD:293787	9/29 (31%)
		HEAT repeat	213..239	CDD:293787	10/25 (40%)
		HEAT repeat	252..281	CDD:293787	14/28 (50%)
		HEAT_2	399..507	CDD:290374	54/115 (47%)
		HEAT repeat	402..430	CDD:293787	11/30 (37%)
		HEAT_EZ	415..469	CDD:290247	31/53 (58%)
		HEAT repeat	442..472	CDD:293787	15/29 (52%)
		HEAT repeat	481..510	CDD:293787	20/28 (71%)
		HEAT repeat	670..702	CDD:293787	15/31 (48%)
		HEAT repeat	711..737	CDD:293787	15/29 (52%)
TRN1	NP_179287.3	IBN_N	38..104	CDD:281761	24/65 (37%)
		HEAT repeat	99..120	CDD:293787	9/20 (45%)
		HEAT repeat	133..161	CDD:293787	14/27 (52%)
		HEAT repeat	181..211	CDD:293787	9/29 (31%)
		HEAT repeat	226..252	CDD:293787	10/25 (40%)
		HEAT repeat	265..293	CDD:293787	14/27 (52%)
		HEAT_2	392..507	CDD:290374	54/115 (47%)
		HEAT repeat	395..426	CDD:293787	11/30 (37%)
		HEAT_EZ	411..465	CDD:290247	31/53 (58%)
		HEAT repeat	438..468	CDD:293787	15/29 (52%)
		HEAT repeat	484..510	CDD:293787	20/26 (77%)
		HEAT repeat	527..552	CDD:293787	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	368	1.000	Domainoid score	I179
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5358
Inparanoid	1	1.050	725	1.000	Inparanoid score	I116
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm3156
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.930